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  1. Article ; Online: Phenomenology's place in the philosophy of medicine.

    Burch, Matthew

    Theoretical medicine and bioethics

    2023  Volume 44, Issue 3, Page(s) 209–227

    Abstract: With its rise in popularity, work in the phenomenology of medicine has also attracted its fair share of criticism. One such criticism maintains that, since the phenomenology of medicine does nothing but describe the experience of illness, it offers ... ...

    Abstract With its rise in popularity, work in the phenomenology of medicine has also attracted its fair share of criticism. One such criticism maintains that, since the phenomenology of medicine does nothing but describe the experience of illness, it offers nothing one cannot obtain more easily by deploying simpler qualitative research methods. Fredrik Svenaeus has pushed back against this charge, insisting that the phenomenology of medicine not only describes but also defines illness. Although I agree with Svenaeus's claim that the phenomenology of medicine does more than merely describe what it is like to be ill, once one acknowledges its more far-reaching theoretical aspirations, one sees that it faces an even more difficult set of objections. Taking a cue from recent work by Rebecca Kukla, Russell Powell, and Eric Scarffe, I argue that the phenomenology of medicine could answer these objections by developing an institutional definition of illness. This not only allows the phenomenology of medicine to answer its critics, but it does so in a way that preserves its major achievements and extends its reach within the philosophy of medicine.
    MeSH term(s) Humans ; Philosophy ; Medicine
    Language English
    Publishing date 2023-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1418481-3
    ISSN 1573-0980 ; 1573-1200 ; 1386-7415
    ISSN (online) 1573-0980 ; 1573-1200
    ISSN 1386-7415
    DOI 10.1007/s11017-023-09619-1
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  2. Article ; Online: PHTS 30 years and still going strong.

    Hollis, Paolo / Burch, Michael

    Pediatric transplantation

    2023  Volume 27, Issue 8, Page(s) e14588

    Language English
    Publishing date 2023-08-07
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14588
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  3. Article: Total neoadjuvant therapy for locally advanced gastric cancer: too much of a good thing?

    DiPeri, Timothy P / Gong, Jun / Burch, Miguel

    Journal of gastrointestinal oncology

    2023  Volume 14, Issue 5, Page(s) 2287–2289

    Language English
    Publishing date 2023-10-10
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2594644-4
    ISSN 2219-679X ; 2078-6891
    ISSN (online) 2219-679X
    ISSN 2078-6891
    DOI 10.21037/jgo-23-682
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  4. Article ; Online: Management of Postoperative Complications Following Bariatric and Metabolic Procedures.

    Feng, Xiaoxi Chelsea / Burch, Miguel

    The Surgical clinics of North America

    2021  Volume 101, Issue 5, Page(s) 731–753

    Abstract: Bariatric and metabolic surgery is a safe and effective treatment of morbid obesity, a disease that continues to increase in prevalence in the United States and worldwide. The two most commonly performed operations are the sleeve gastrectomy and the ... ...

    Abstract Bariatric and metabolic surgery is a safe and effective treatment of morbid obesity, a disease that continues to increase in prevalence in the United States and worldwide. The two most commonly performed operations are the sleeve gastrectomy and the gastric bypass. Early and late complications can occur, and although referral to a bariatric surgeon or center is ideal, emergency management of acute problems is relevant to all general surgeons. Bariatric surgery can have surgical and metabolic consequences. An understanding of the altered anatomy and physiology helps to guide management of morbidities. This article discusses surgical postoperative complications and metabolic complications.
    MeSH term(s) Bariatric Surgery/adverse effects ; Bariatric Surgery/methods ; Humans ; Obesity/complications ; Obesity/metabolism ; Obesity/surgery
    Language English
    Publishing date 2021-08-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 215713-5
    ISSN 1558-3171 ; 0039-6109
    ISSN (online) 1558-3171
    ISSN 0039-6109
    DOI 10.1016/j.suc.2021.05.017
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  5. Article ; Online: Challenges With Robot-Assisted Surgery Setup for Complex Minimally Invasive Upper Gastrointestinal Surgery.

    Kanji, Falisha F / Marselian, Aleeque / Burch, Miguel / Jain, Monica / Cohen, Tara N

    The American surgeon

    2024  , Page(s) 31348241248696

    Abstract: Background: The utilization of robot-assisted approaches to surgery has increased significantly over the last two decades. This has introduced novel complexities into the operating room environment, requiring management of new challenges and workflow ... ...

    Abstract Background: The utilization of robot-assisted approaches to surgery has increased significantly over the last two decades. This has introduced novel complexities into the operating room environment, requiring management of new challenges and workflow adaptation. This study aimed to analyze challenges in the surgical setup for complex upper gastrointestinal robot-assisted surgery (UGI-RAS) and identify opportunities for solutions.
    Methods: Direct observations of surgical setup processes for UGI-RAS were performed by a trained Human Factors researcher at a non-profit academic medical center in Southern California. Setup tasks were subdivided into five phases: (1) before wheels-in; (2) patient transfer and anesthesia induction; (3) patient preparation; (4) surgery preparation; and (5) robot docking. Start/end times for each phase/task were documented along with workflow disruption (FD) narratives and timestamps. Setup tasks and FDs were analyzed using descriptive statistics.
    Results: Twenty UGI-RAS setup procedures were observed between May-November 2023: sleeve gastrectomy +/- hiatal hernia repair (n = 9, 45.00%); para-esophageal hernia repair +/- fundoplication (n = 8, 40.00%); revision to Roux-en-Y gastric bypass (n = 2, 10.00%); and gastric band removal (n = 1, 5.00%). Frequent FDs included planning breakdowns (n = 20, 29.85%), equipment/supply management (n = 17, 25.37%), patient care coordination (n = 8, 11.94%), and equipment challenges (n = 8, 11.94%). Eleven of 20 observations were first-start cases, of which 10 experienced delayed starts.
    Discussion: Interventions aimed at improving workflows during UGI-RAS setup include performing pre-operative team huddles and conducting trainings aimed at team coordination and equipment challenges. These solutions could result in improved teamwork, efficiency, and communication while reducing case start delays and turnover time.
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348241248696
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  6. Article ; Online: Structure-informed clustering for population stratification in association studies.

    Bose, Aritra / Burch, Myson / Chowdhury, Agniva / Paschou, Peristera / Drineas, Petros

    BMC bioinformatics

    2023  Volume 24, Issue 1, Page(s) 411

    Abstract: Background: Identifying variants associated with complex traits is a challenging task in genetic association studies due to linkage disequilibrium (LD) between genetic variants and population stratification, unrelated to the disease risk. Existing ... ...

    Abstract Background: Identifying variants associated with complex traits is a challenging task in genetic association studies due to linkage disequilibrium (LD) between genetic variants and population stratification, unrelated to the disease risk. Existing methods of population structure correction use principal component analysis or linear mixed models with a random effect when modeling associations between a trait of interest and genetic markers. However, due to stringent significance thresholds and latent interactions between the markers, these methods often fail to detect genuinely associated variants.
    Results: To overcome this, we propose CluStrat, which corrects for complex arbitrarily structured populations while leveraging the linkage disequilibrium induced distances between genetic markers. It performs an agglomerative hierarchical clustering using the Mahalanobis distance covariance matrix of the markers. In simulation studies, we show that our method outperforms existing methods in detecting true causal variants. Applying CluStrat on WTCCC2 and UK Biobank cohorts, we found biologically relevant associations in Schizophrenia and Myocardial Infarction. CluStrat was also able to correct for population structure in polygenic adaptation of height in Europeans.
    Conclusions: CluStrat highlights the advantages of biologically relevant distance metrics, such as the Mahalanobis distance, which captures the cryptic interactions within populations in the presence of LD better than the Euclidean distance.
    MeSH term(s) Humans ; Genetic Markers ; Polymorphism, Single Nucleotide ; Linkage Disequilibrium ; Phenotype ; Cluster Analysis
    Chemical Substances Genetic Markers
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-023-05511-w
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  7. Article ; Online: Source Localization of Normal Variants Seen on EEG.

    Rahman, Shareena / Burch, Michael / Parikh, Prachi / Zafar, Muhammad

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2022  Volume 41, Issue 2, Page(s) 155–160

    Abstract: Purpose: The EEG is an essential neurological diagnostic tool. EEG abnormalities can guide diagnosis and management of epilepsy. There are also distinctive EEG waveforms that are seen in healthy individuals. It is critical not to misinterpret these as ... ...

    Abstract Purpose: The EEG is an essential neurological diagnostic tool. EEG abnormalities can guide diagnosis and management of epilepsy. There are also distinctive EEG waveforms that are seen in healthy individuals. It is critical not to misinterpret these as abnormal. To emphasize the importance of these waveforms, we analyzed different normal variants via the source localization technology.
    Methods: This is a retrospective analysis of EEGs performed at the Duke University Hospital between June 2014 and Dec 2019. We selected samples of vertex waves, Mu, lambda, POSTS, wickets, and sleep spindles for analysis. EEG were imported to Curry 8 (Compumedics) to calculate the dipole and current density. The averaged head model from the Montreal Neurological Institute database was used for reconstruction.
    Results: Thirty-four patient EEG samples were selected including five vertex, six Mu, four wicket, seven lambda, five POSTS, and seven spindles. Results from source localization showed that vertex waves are localized in the frontocentral area, whereas spindles in the deep midline central region. Mu were identified in the ipsilateral somatosensory cortex. Lambda and POSTS, on the other hand, had maximum results over the bilateral occipital region and wickets in the ipsilateral temporal lobe.
    Conclusions: Our results confirm and expand previous hypotheses. This allows us to speculate on the origin of these normal EEG variants. Although this study is limited by small sample size, lack of high-density EEG, and patient-specific MRI, our analysis provides an easily replicable three-dimensional visualization of these waveforms.
    MeSH term(s) Humans ; Retrospective Studies ; Electroencephalography/methods ; Epilepsy/diagnosis ; Temporal Lobe ; Occipital Lobe
    Language English
    Publishing date 2022-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000948
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  8. Article: Visualizing dynamic data with heat triangles.

    Hu, Ya Ting / Burch, Michael / Wetering, Huub van de

    Journal of visualization

    2021  Volume 25, Issue 1, Page(s) 15–29

    Language English
    Publishing date 2021-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2094841-4
    ISSN 1875-8975 ; 1343-8875
    ISSN (online) 1875-8975
    ISSN 1343-8875
    DOI 10.1007/s12650-021-00782-y
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  9. Article ; Online: Objectivity in science and law: A shared rescue strategy.

    Burch, Matthew / Furman, Katherine

    International journal of law and psychiatry

    2019  Volume 64, Page(s) 60–70

    Abstract: The ideal of objectivity is in crisis in science and the law, and yet it continues to do important work in both practices. This article describes that crisis and develops a shared rescue strategy for objectivity in both domains. In a recent article, ... ...

    Abstract The ideal of objectivity is in crisis in science and the law, and yet it continues to do important work in both practices. This article describes that crisis and develops a shared rescue strategy for objectivity in both domains. In a recent article, Inkeri Koskinen (2018) attempts to bring unity to the fragmented discourse on objectivity in the philosophy of science with a risk account of objectivity. To put it simply, she argues that we call practitioners, processes, and products of science objective when they identify and manage certain important epistemic risks. We endorse this view and attempt to tailor Koskinen's strategy to the problem of objectivity in the legal context. To do so, we develop a novel notion of phronetic risk, and argue that we call practitioners, processes, and products of law objective when they identify and manage certain important epistemic and/or phronetic risks. Our attempt to rescue objectivity is especially important for work at the intersection of law and psychiatry. For that intersection represents a place where skeptical worries about objectivity in science and law work in tandem to pose serious critical challenges to contemporary practice; and our rescue strategy represents a promising way to negotiate those challenges.
    MeSH term(s) Bias ; Hermeneutics ; Humans ; Jurisprudence ; Knowledge ; Philosophy ; Psychiatry/legislation & jurisprudence ; Psychiatry/standards ; Risk ; Science/standards
    Language English
    Publishing date 2019-02-26
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304429-4
    ISSN 1873-6386 ; 0160-2527
    ISSN (online) 1873-6386
    ISSN 0160-2527
    DOI 10.1016/j.ijlp.2019.02.004
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  10. Article: Pediatric rapid response system innovations.

    Troy, Lindsey / Burch, Mary / Sawicki, Jonathan G / Henricksen, Jared W

    Hospital practice (1995)

    2022  Volume 49, Issue sup1, Page(s) 399–404

    Abstract: Rapid Response Systems (RRSs) are an organizational approach to support the timely recognition and treatment of decompensating patients and are used in many pediatric hospitals. These systems are comprised of afferent and efferent Limbs, as well as ... ...

    Abstract Rapid Response Systems (RRSs) are an organizational approach to support the timely recognition and treatment of decompensating patients and are used in many pediatric hospitals. These systems are comprised of afferent and efferent Limbs, as well as oversight arms. When incorporated into an RRS, standardized care algorithms can be helpful in identifying deteriorating patients and improving behaviors of the multidisciplinary team. The aim of this paper is to provide an overview of pediatric RRS and provide an example in which standardized care algorithms developed for the efferent limb of a pediatric RRS were associated with improvement in early escalation of care.
    MeSH term(s) Child ; Hospital Rapid Response Team ; Hospitals, Pediatric ; Humans ; Intensive Care Units
    Language English
    Publishing date 2022-01-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2570453-9
    ISSN 2377-1003 ; 2154-8331 ; 8750-2836
    ISSN (online) 2377-1003
    ISSN 2154-8331 ; 8750-2836
    DOI 10.1080/21548331.2022.2028468
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