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  1. Article: Metal Homeostasis in Pathogenic Streptococci.

    Akbari, Madeline S / Doran, Kelly S / Burcham, Lindsey R

    Microorganisms

    2022  Volume 10, Issue 8

    Abstract: ... ...

    Abstract Streptococcus
    Language English
    Publishing date 2022-07-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Virtual Streptococcal Seminar Series and Trainee Symposium: Adaptations of a Research Community during the COVID-19 Pandemic.

    Spencer, Brady L / Doran, Kelly S / Burcham, Lindsey R

    Journal of microbiology & biology education

    2021  Volume 22, Issue 1

    Abstract: The COVID-19 pandemic has forced academic research communities to develop online means of learning, networking, and engaging in new research. To allow increased interaction and engagement of the streptococcal research community during the COVID-19 ... ...

    Abstract The COVID-19 pandemic has forced academic research communities to develop online means of learning, networking, and engaging in new research. To allow increased interaction and engagement of the streptococcal research community during the COVID-19 shutdown, we organized the Virtual Streptococcal Seminar Series and Virtual Streptococcal Trainee Symposium and advertised via e-mail and social media outlets. The seminar series initially met weekly on Thursdays at 12 pm Eastern Daylight Time and transitioned to monthly seminars, while the trainee symposium spanned 3 days in September 2020. In this study, we analyzed seminar attendance data and online recording accesses from the first 20 seminars and found community engagement to be independent of speaker gender, career stage, geographic location, and organism of interest, with an average of 124 live attendees and 1,683 recording accesses per seminar. We also report attendance and speaker statistics from the 3-day Virtual Streptococcal Trainee Symposium, which hosted a total of 38 trainees from five continents presenting on
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.v22i1.2479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Metal Homeostasis in Pathogenic Streptococci

    Akbari, Madeline S. / Doran, Kelly S. / Burcham, Lindsey R.

    Microorganisms. 2022 July 25, v. 10, no. 8

    2022  

    Abstract: Streptococcus spp. are an important genus of Gram-positive bacteria, many of which are opportunistic pathogens that are capable of causing invasive disease in a wide range of populations. Metals, especially transition metal ions, are an essential ... ...

    Abstract Streptococcus spp. are an important genus of Gram-positive bacteria, many of which are opportunistic pathogens that are capable of causing invasive disease in a wide range of populations. Metals, especially transition metal ions, are an essential nutrient for all organisms. Therefore, to survive across dynamic host environments, Streptococci have evolved complex systems to withstand metal stress and maintain metal homeostasis, especially during colonization and infection. There are many different types of transport systems that are used by bacteria to import or export metals that can be highly specific or promiscuous. Focusing on the most well studied transition metals of zinc, manganese, iron, nickel, and copper, this review aims to summarize the current knowledge of metal homeostasis in pathogenic Streptococci, and their role in virulence.
    Keywords Streptococcus ; copper ; exports ; homeostasis ; iron ; manganese ; nickel ; virulence ; zinc
    Language English
    Dates of publication 2022-0725
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10081501
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Interrelated Effects of Zinc Deficiency and the Microbiome on Group B Streptococcal Vaginal Colonization.

    Burcham, Lindsey R / Burcham, Zachary M / Akbari, Madeline S / Metcalf, Jessica L / Doran, Kelly S

    mSphere

    2022  Volume 7, Issue 4, Page(s) e0026422

    Abstract: Group B Streptococcus (GBS) in the vaginal tract is a risk factor for preterm birth and adverse pregnancy outcomes. GBS colonization is also transient in nature, which likely reflects the contributions of pathogen determinants, interactions with ... ...

    Abstract Group B Streptococcus (GBS) in the vaginal tract is a risk factor for preterm birth and adverse pregnancy outcomes. GBS colonization is also transient in nature, which likely reflects the contributions of pathogen determinants, interactions with commensal flora, and host factors, making this environment particularly challenging to understand. Additionally, dietary zinc deficiency is a health concern on the global scale that is known to be associated with recurrent bacterial infection and increased rate of preterm birth or stillbirth. However, the impact of zinc deficiency on vaginal health has not yet been studied. Here we use a murine model to assess the role of dietary zinc on GBS burden and the impact of GBS colonization on the vaginal microbiome. We show that GBS vaginal colonization is increased in a zinc-deficient host and that the presence of GBS significantly alters the microbial community structure of the vagina. Using machine learning approaches, we show that vaginal community turnover during GBS colonization is driven by computationally predictable changes in key taxa, including several organisms not previously described in the context of the vaginal microbiota, such as Akkermansia muciniphila. We observed that
    MeSH term(s) Animals ; Female ; Humans ; Infant, Newborn ; Mice ; Microbiota ; Pregnancy ; Premature Birth ; Streptococcal Infections/microbiology ; Streptococcus agalactiae ; Vagina/microbiology ; Zinc
    Chemical Substances Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00264-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Role of MUC5B during Group B Streptococcal Vaginal Colonization.

    Burcham, Lindsey R / Bath, Jade R / Werlang, Caroline A / Lyon, Laurie M / Liu, Naoko / Evans, Christopher / Ribbeck, Katharina / Doran, Kelly S

    mBio

    2022  Volume 13, Issue 2, Page(s) e0003922

    Abstract: The female reproductive tract (FRT) is a complex environment, rich in mucin glycoproteins that form a dense network on the surface of the underlying epithelia. Group B Streptococcus (GBS) asymptomatically colonizes 25-30% of healthy women, but during ... ...

    Abstract The female reproductive tract (FRT) is a complex environment, rich in mucin glycoproteins that form a dense network on the surface of the underlying epithelia. Group B Streptococcus (GBS) asymptomatically colonizes 25-30% of healthy women, but during pregnancy can cause ascending infection
    MeSH term(s) Animals ; Female ; Humans ; Infant, Newborn ; Mice ; Mucin-5B/metabolism ; Mucins/metabolism ; Pregnancy ; Premature Birth ; Streptococcal Infections/microbiology ; Streptococcus agalactiae/metabolism ; Vagina/microbiology
    Chemical Substances MUC5B protein, human ; Muc5b protein, mouse ; Mucin-5B ; Mucins
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00039-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The impact of nutritional immunity on Group B streptococcal pathogenesis during wound infection.

    Akbari, Madeline S / Keogh, Rebecca A / Radin, Jana N / Sanchez-Rosario, Yamil / Johnson, Michael D L / Horswill, Alexander R / Kehl-Fie, Thomas E / Burcham, Lindsey R / Doran, Kelly S

    mBio

    2023  Volume 14, Issue 4, Page(s) e0030423

    Abstract: ... Group ... ...

    Abstract Group B
    MeSH term(s) Mice ; Animals ; Diabetes Mellitus, Experimental ; Neutrophils ; Wound Infection ; Streptococcal Infections/microbiology ; Streptococcus agalactiae/genetics
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00304-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Enhanced Vulnerability of Diabetic Mice to Hypervirulent

    da Conceição Mendonça, Jéssica / Sobral Pena, João Matheus / Dos Santos Macêdo, Noemi / de Souza Rodrigues, Dayane / de Oliveira, Dayane Alvarinho / Spencer, Brady L / Lopes-Torres, Eduardo José / Burcham, Lindsey R / Doran, Kelly S / Nagao, Prescilla Emy

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Streptococcus ... ...

    Abstract Streptococcus agalactiae
    Language English
    Publishing date 2023-04-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12040580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Genomic Analyses Identify Manganese Homeostasis as a Driver of Group B Streptococcal Vaginal Colonization.

    Burcham, Lindsey R / Akbari, Madeline S / Alhajjar, Norhan / Keogh, Rebecca A / Radin, Jana N / Kehl-Fie, Thomas E / Belew, Ashton T / El-Sayed, Najib M / McIver, Kevin S / Doran, Kelly S

    mBio

    2022  Volume 13, Issue 3, Page(s) e0098522

    Abstract: Group B Streptococcus (GBS) is associated with severe ... ...

    Abstract Group B Streptococcus (GBS) is associated with severe infections
    MeSH term(s) Animals ; Female ; Genomics ; Homeostasis ; Hydrogen Peroxide ; Leukocyte L1 Antigen Complex ; Manganese ; Mice ; Paraquat ; Pregnancy ; Streptococcal Infections/genetics ; Streptococcus agalactiae/genetics ; Vagina
    Chemical Substances Leukocyte L1 Antigen Complex ; Manganese (42Z2K6ZL8P) ; Hydrogen Peroxide (BBX060AN9V) ; Paraquat (PLG39H7695)
    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00985-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Streptococcus pneumoniae

    Burcham, Lindsey R / Hill, Rebecca A / Caulkins, Rachel C / Emerson, Joseph P / Nanduri, Bindu / Rosch, Jason W / Fitzkee, Nicholas C / Thornton, Justin A

    Metallomics : integrated biometal science

    2020  Volume 12, Issue 9, Page(s) 1416–1427

    Abstract: Streptococcus pneumoniae colonizes the human nasopharyngeal mucosa and is a leading cause of community-acquired pneumonia, acute otitis media, and bacterial meningitis. Metal ion homeostasis is vital to the survival of this pathogen across diverse ... ...

    Abstract Streptococcus pneumoniae colonizes the human nasopharyngeal mucosa and is a leading cause of community-acquired pneumonia, acute otitis media, and bacterial meningitis. Metal ion homeostasis is vital to the survival of this pathogen across diverse biological sites and contributes significantly to colonization and invasive disease. Microarray and qRT-PCR analysis revealed an upregulation of an uncharacterized operon (SP1433-1438) in pneumococci subjected to metal-chelation by N,N,N',N'-tetrakis-(2-pyridylmethyl)ethylenediamine (TPEN). Supplementation of zinc, cobalt, and nickel following TPEN treatment significantly abrogated induction. BLASTP comparisons and protein topology analysis predicted this locus to encode components of ATP binding cassette (ABC) transporters involved in multidrug resistance (SP1434-1435) and energy-coupling factor (ECF) transporters (SP1436-1438). Inductively coupled plasma mass spectrometry (ICP-MS) analysis identified differences in intracellular metal content in a Δ1434-8 mutant strain compared to parental T4R. Further, analysis of the secreted metabolome of WT and Δ1434-8 strains identified significant changes in pneumococcal glycolytic and amino acid metabolic pathways, indicating a shift towards mixed acid fermentation. Additionally, proteomic analysis revealed differentially expressed proteins in the Δ1434-8 mutant strain, with nearly 20% regulated by the global catabolite repressor, CcpA. Based on these findings, we propose that the transporters encoded by SP1433-1438 are involved in regulating the central metabolism of S. pneumoniae and contributing to bacterial survival during metal stress.
    MeSH term(s) ATP-Binding Cassette Transporters/metabolism ; Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/metabolism ; Humans ; Metabolome/drug effects ; Metals/metabolism ; Pneumococcal Infections/drug therapy ; Pneumococcal Infections/microbiology ; Streptococcus pneumoniae/cytology ; Streptococcus pneumoniae/drug effects ; Streptococcus pneumoniae/metabolism
    Chemical Substances ATP-Binding Cassette Transporters ; Anti-Bacterial Agents ; Bacterial Proteins ; Metals
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2474317-3
    ISSN 1756-591X ; 1756-5901
    ISSN (online) 1756-591X
    ISSN 1756-5901
    DOI 10.1039/d0mt00118j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genome-Wide Mutagenesis Identifies Factors Involved in Enterococcus faecalis Vaginal Adherence and Persistence.

    Alhajjar, Norhan / Chatterjee, Anushila / Spencer, Brady L / Burcham, Lindsey R / Willett, Julia L E / Dunny, Gary M / Duerkop, Breck A / Doran, Kelly S

    Infection and immunity

    2020  Volume 88, Issue 10

    Abstract: Enterococcus ... ...

    Abstract Enterococcus faecalis
    MeSH term(s) Animals ; Bacterial Adhesion/genetics ; Bacterial Adhesion/physiology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Line ; Enterococcus faecalis/genetics ; Enterococcus faecalis/growth & development ; Enterococcus faecalis/physiology ; Ethanolamine/metabolism ; Female ; Fimbriae, Bacterial/genetics ; Fimbriae, Bacterial/metabolism ; Genitalia, Female/microbiology ; Genome, Bacterial/genetics ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Mice ; Mutagenesis ; Mutation ; Type VII Secretion Systems/genetics ; Type VII Secretion Systems/metabolism ; Vagina/microbiology
    Chemical Substances Bacterial Proteins ; Type VII Secretion Systems ; Ethanolamine (5KV86114PT)
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00270-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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