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Article ; Online: Avrupalılaşma Araştırma Programını Kamu Politikaları Yazınıyla Yeniden Düşünmek

Burcu B. Göğüş Doğan

Çukurova Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi, Vol 22, Iss 2, Pp 283-

‘Politika Transfer Eden Devlet’ olarak Avrupa Birliği

2018 Volume 304

Abstract: Avrupa Birliği'nin (AB) üye ve aday ülkelerin politik, ekonomik ve sosyal yapıları üzerindeki etkisi “Avrupalılaşma” olarak tanımlanmaktadır. 1990'lardan itibaren, ulusal ve uluslararası yazında Avrupalılaşma ve etkilerine yönelik pekçok çalışma ... ...

Abstract	Avrupa Birliği'nin (AB) üye ve aday ülkelerin politik, ekonomik ve sosyal yapıları üzerindeki etkisi “Avrupalılaşma” olarak tanımlanmaktadır. 1990'lardan itibaren, ulusal ve uluslararası yazında Avrupalılaşma ve etkilerine yönelik pekçok çalışma mevcuttur. Bir politika, idari düzenleme, kurum ve düşüncenin başka bir politika, idari düzenleme, kurum ve düşüncenin gelişiminde kullanılma süreci olarak tanımlanan politika transferine ait yazın ise kamu politikaları çalışmalarına son yıllarda önemli katkı sunmuştur. Bu iki yazının örtüştüğü bir alan olarak ortaya çıkan AB yönetişim süreci ise araştırmacılara politika transferinin yeni ve özgün araçları yoluyla benzersiz uygulamaların ortaya konduğu önemli bir araştırma zemini sunmaktadır. Bu yeni bakış açısı ile politika transferi ve araçlarını Avrupalılaşma analizinin merkezine oturtan ve AB’yi politika transfer eden devlet niteliği ile yeniden düşünmeyi amaçlayan bu makale ile aynı zamanda ulusal yazındaki mevcut boşluğun doldurulmasına da katkı sağlanması hedeflenmiştir.
Keywords	Europeanization ; Policy Transfer ; Policy-Making State ; Policy-Transfer State ; EU Policy Transfer ; Avrupalılaşma ; Politika Transferi ; Politika Yapan Devlet ; Politika Transfer Eden Devlet ; AB Politika Transferi ; Management. Industrial management ; HD28-70 ; Economics as a science ; HB71-74
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	Cukurova University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Feasibility and accuracy of targeted axillary dissection in breast cancer patients; single center experience.

Kaya, Cemal / Burcu, Büşra / Çetinoğlu, Işık / Uçak, Ramazan / Çerekçi, Esma / Şahin, Cennet / Demircioğlu, Zeynep Gül / Şener, Aziz / Halil, Süleyman

Frontiers in surgery

2024 Volume 10, Page(s) 1332142

Abstract: Introduction: Axillary complete response (pCR) was observed in approximately half of breast cancer patients who received neoadjuvant chemotherapy (NAC) due to axillary positivity. Preventing axillary morbidity due to unnecessary axillary lymph node ... ...

Abstract	Introduction: Axillary complete response (pCR) was observed in approximately half of breast cancer patients who received neoadjuvant chemotherapy (NAC) due to axillary positivity. Preventing axillary morbidity due to unnecessary axillary lymph node dissection (ALND) is extremely important for patients' quality of life. Targeted axillary dissection (TAD) is a technique developed to improve axillary staging and reduce the false negative rate in sentinel lymph node biopsy. Methods: Patients with cN1-N2 (clinically node) breast cancer whose axillary lymph node metastasis was confirmed by biopsy and who received NAC marked with a clip were included in the study. Patients who achieved clinical response after systemic treatment underwent sentinel lymph node biopsy (SLNB) with additional methods such as methylene blue guided dissection, skin marking for clip on lymph node (CLN) localization, and wire guided with imaging excision of the CLN. TAD and ALND pathology results were evaluated and analyzed with patient and tumor characteristics. Results: 83 patients who met the eligibility criterias for the study were examined retrospectively. 21 of the patients underwent TAD alone, and 62 patients underwent ALND after TAD. CLN rate was 98.8% in patients underwent only TAD and this rate was increased to 100% in patients underwent ALND after TAD. FNR in SLN, CLN, and TAD were 28.6%, 10.7%, and 3.6%, respectively. Conclusion: TAD is a feasible and reliable surgical approach to detect axillary residual disease with a high success rate.
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2023.1332142
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Article: Retrospective Analysis of Parameters Affecting Metastatic Breast Cancer.

Burcu, Busra / Ertas, Ibrahim / Sener, Aziz / Demircioglu, Zeynep Gul / Cerekci, Esma / Kaya, Cemal

Sisli Etfal Hastanesi tip bulteni

2023 Volume 57, Issue 4, Page(s) 479–484

Abstract: Objectives: While metastatic breast cancer (MBC), which is the most common cause of death in women, has been seen as an incurable surgical problem in the past decade, as the heterogeneous nature of breast cancer becomes clear with increasing molecular ... ...

Abstract	Objectives: While metastatic breast cancer (MBC), which is the most common cause of death in women, has been seen as an incurable surgical problem in the past decade, as the heterogeneous nature of breast cancer becomes clear with increasing molecular studies and advances in oncological protocols, life expectancy is increasing. In this study, we aimed to examine the clinicopathological features of the patients we followed up with MBC. Methods: Patients who were operated on with the diagnosis of breast cancer in our hospital between 2018 and 2023 and who were later found to have metastases were retrospectively analyzed from the database. The age of the patients, the histological and molecular type, stage and grade of the tumor, the time from diagnosis to metastasis, the location of metastasis, the duration of treatment and follow-up were investigated. Patients who were operated on in other centers and/or were out of follow-up were excluded from the study. For the statistical analysis of the findings, number cruncher statistical system (NCSS) 2020 statistical software (NCSS LLC, Kaysville, Utah, USA) was used at a significance level of 0.05. Results: Metastasis was detected in 77.1% (n=37) of a total of 48 female patients, and recurrence was found in 22.9% (n=11). The mean age of the patients was 57 years. There was no statistically significant difference between the patients in terms of demographics. When evaluated according to the TNM stage, 24.3% (n=9) of the patients were in the early stage and 75.7% (n=28) were in the locally advanced stage; the number of locally advanced patients was found to be higher than the early stage. In histology examination, 27.1% (n=13) of the patients were luminal A, 31.3% (n=15) luminal B, 16.7% (n=8) HER2 positive, and 25% (n=12) triple negative. Ki67 was higher than 14% in 64.6% (n=31) patients. Breast conserving surgery was performed in 41.6% (n=20) of the patients, and mastectomy was performed in 58.3% (n=28) patients. Metastasis in 34.2% (n=13) of the cases within 1-2 years, in 42.1% (n=16) within 2-5 years, and in 23.7% (n=9) after 5 years took place. Sites of metastasis were bone (37.7%, n=28), liver (28.9%, n=11), brain (10.5%, n=4), and lung (7.9%, n=3). More than one metastasis site was observed in 21.05% (n=8) of patients with metastases. There was no statistically significant difference between luminal A, luminal B, HER 2 groups and triple-negative breast cancer in terms of metastasis time and location (p>0.05). Adjuvant hormone therapy was more common in the luminal A group, whereas neoadjuvant therapy was more common in the HER2+ group. A total of 20 deaths were observed in 48 patients (41.7%). The median disease-free survival was 64 months. Conclusion: Despite all the developments in metastatic breast cancer, the 5-year survival rate is 27%. Targeted personalized therapies may be promising when the mechanism of metastasis and specific pathways in breast cancer emerge.
Language	English
Publishing date	2023-12-29
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3026862-X
ISSN	1308-5123 ; 1302-7123
ISSN (online)	1308-5123
ISSN	1302-7123
DOI	10.14744/SEMB.2023.94803
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Article ; Online: A data directory to facilitate investigations on worldwide wildlife trafficking

Meredith L. Gore / Rowan Hilend / Jonathan O. Prell / Emily Griffin / John R. Macdonald / Burcu B. Keskin / Aaron Ferber / Bistra Dilkina

Big Earth Data, Vol 7, Iss 2, Pp 338-

2023 Volume 348

Abstract: ABSTRACTWildlife trafficking is a global phenomenon posing many negative impacts on socio-environmental systems. Scientific exploration of wildlife trafficking trends and the impact of interventions is significantly encumbered by a suite of data reuse ... ...

Abstract	ABSTRACTWildlife trafficking is a global phenomenon posing many negative impacts on socio-environmental systems. Scientific exploration of wildlife trafficking trends and the impact of interventions is significantly encumbered by a suite of data reuse challenges. We describe a novel, open-access data directory on wildlife trafficking and a corresponding visualization tool that can be used to identify data for multiple purposes, such as exploring wildlife trafficking hotspots and convergence points with other crime, discovering key drivers or deterrents of wildlife trafficking, and uncovering structural patterns. Keyword searches, expert elicitation, and peer-reviewed publications were used to search for extant sources used by industry and non-profit organizations, as well as those leveraged to publish academic research articles. The open-access data directory is designed to be a living document and searchable according to multiple measures. The directory can be instrumental in the data-driven analysis of unsustainable illegal wildlife trade, supply chain structure via link prediction models, the value of demand and supply reduction initiatives via multi-item knapsack problems, or trafficking behavior and transportation choices via network interdiction problems.
Keywords	Illegal wildlife trade ; supply chain ; operations management ; interdiction ; conservation ; Geography. Anthropology. Recreation ; G ; Geology ; QE1-996.5
Subject code	306
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Advancing interdisciplinary science for disrupting wildlife trafficking networks.

Gore, Meredith L / Griffin, Emily / Dilkina, Bistra / Ferber, Aaron / Griffis, Stanley E / Keskin, Burcu B / Macdonald, John

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 10, Page(s) e2208268120

Abstract: Wildlife trafficking, whether local or transnational in scope, undermines sustainable development efforts, degrades cultural resources, endangers species, erodes the local and global economy, and facilitates the spread of zoonotic diseases. Wildlife ... ...

Abstract	Wildlife trafficking, whether local or transnational in scope, undermines sustainable development efforts, degrades cultural resources, endangers species, erodes the local and global economy, and facilitates the spread of zoonotic diseases. Wildlife trafficking networks (WTNs) occupy a unique gray space in supply chains-straddling licit and illicit networks, supporting legitimate and criminal workforces, and often demonstrating high resilience in their sourcing flexibility and adaptability. Authorities in different sectors desire, but frequently lack knowledge about how to allocate resources to disrupt illicit wildlife supply networks and prevent negative collateral impacts. Novel conceptualizations and a deeper scientific understanding of WTN structures are needed to help unravel the dynamics of interaction between disruption and resilience while accommodating socioenvironmental context. We use the case of ploughshare tortoise trafficking to help illustrate the potential of key advancements in interdisciplinary thinking. Insights herein suggest a significant need and opportunity for scientists to generate new science-based recommendations for WTN-related data collection and analysis for supply chain visibility, shifts in illicit supply chain dominance, network resilience, or limits of the supplier base.
MeSH term(s)	Animals ; Humans ; Animals, Wild ; Wildlife Trade ; Concept Formation ; Criminals ; Data Collection
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2208268120
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Article: Impact of body weight-based dosing of palonosetron and ondansetron on postoperative nausea and vomiting following laparoscopic sleeve gastrectomy: a randomized, double-blind study.

Burcu, Büşra / Hacım, Nadir Adnan / Caliskan, Ozan / Demirgan, Serdar / Vartanoglu Aktokmakyan, Talar / Meric, Serhat / Duymaz, Tomris / Karabay, Onder / Solmaz, Ali

Acta chirurgica Belgica

2023 Volume 124, Issue 1, Page(s) 41–49

Abstract: Background: Postoperative nausea and vomiting (PONV) is a frequent adverse effect following laparoscopic sleeve gastrectomy. Palonosetron with a standard dosing (75 μg) schedule has been questioned due to its low efficiency in obese patients. This study ...

Abstract	Background: Postoperative nausea and vomiting (PONV) is a frequent adverse effect following laparoscopic sleeve gastrectomy. Palonosetron with a standard dosing (75 μg) schedule has been questioned due to its low efficiency in obese patients. This study aimed to investigate the effectiveness and safety of the body weight-based dosing of palonosetron in managing PONV following laparoscopic sleeve gastrectomy. Methods: A single-center, prospective, double-blinded randomized study was conducted between August 2021 and December 2021. Patients who underwent laparoscopic sleeve gastrectomy were prospectively recruited in the study. One hundred patients were randomly divided into palonosetron (Group P) and ondansetron (Group O). The demographic and clinical variables were recorded. The primary outcome of the study was the incidence of PONV between the two groups during the hospitalization. The secondary outcomes were the number of rescue anti-emetic and analgesic medications and the Functional Living Index-Emesis scores. Results: There were 50 patients in each group (Group P and Group O). There were significant differences in the scores of POVN, nausea, and vomiting favoring Group P. In Group P, the rate of patients using rescue anti-emetics was significantly lower. The incidence of complete response and proportion of patients with higher Functional Living Index-Emesis scores were significantly higher in patients using palonosetron. Conclusions: The use of palonosetron significantly reduced the incidence of PONV following laparoscopic sleeve gastrectomy. There was a significant improvement in the scores of Functional Living Index-Emesis in patients using palonosetron.
MeSH term(s)	Humans ; Palonosetron/therapeutic use ; Ondansetron/therapeutic use ; Postoperative Nausea and Vomiting/chemically induced ; Postoperative Nausea and Vomiting/drug therapy ; Double-Blind Method ; Prospective Studies ; Isoquinolines/adverse effects ; Quinuclidines/adverse effects ; Antiemetics/adverse effects ; Body Weight ; Gastrectomy ; Laparoscopy
Chemical Substances	Palonosetron (5D06587D6R) ; Ondansetron (4AF302ESOS) ; Isoquinolines ; Quinuclidines ; Antiemetics
Language	English
Publishing date	2023-03-13
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	210274-2
ISSN	0001-5458
ISSN	0001-5458
DOI	10.1080/00015458.2023.2184939
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Article: An Atherosclerosis Indicator Hyaluronic Acid: Can Plasma Hyaluronic Acid Be Useful in Diagnosing Alzheimer's Disease?

Ceylan, Serdar / Guner, Merve / Okyar-Bas, Arzu / Kahyaoglu, Zeynep / Koc, Neriman S / Koksal, Gamze N / Kiran, Yasin / Sagir, Aykut / Balci, Cafer / Halil, Meltem G / Cankurtaran, Mustafa / Yildirim, Tolga / Lay, Incilay / Dogu, Burcu B

Clinical laboratory

2024 Volume 70, Issue 3

Abstract: Background: The aim is to compare the plasma levels of hyaluronic acid (HA) which is closely related to inflam-mation and vascular changes and arterial stiffness (AS) related values in patients with Alzheimer's disease (AD), amnestic type mild cognitive ...

Abstract	Background: The aim is to compare the plasma levels of hyaluronic acid (HA) which is closely related to inflam-mation and vascular changes and arterial stiffness (AS) related values in patients with Alzheimer's disease (AD), amnestic type mild cognitive impairment (aMCI), and normal cognitive functions (NCF). Methods: Ninety participants were categorized into three groups, patients with AD, MCI, and NCF. Arterial stiffness measurement in the nephrology outpatient clinic, and storage and analysis of plasma samples in the biochemistry laboratory. Results: Of the 90 patients, 32 had NCF, 32 had aMCI, and 26 had AD. Between groups, there was no difference in HA, pulse wave velocity, and augmentation index. The HA level had no statistically significant correlation with any of the other variables. Conclusions: Plasma HA levels will not be useful in the diagnosis of AD. More comprehensive studies with larger number of patients are needed.
MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Hyaluronic Acid ; Pulse Wave Analysis ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/psychology ; Atherosclerosis/diagnosis
Chemical Substances	Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230734
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Article ; Online: Effect of Resection Distance from Pylorus on Weight Loss Outcomes in Laparoscopic Sleeve Gastrectomy.

Avlanmis, Omer / Isil, Riza Gurhan / Burcu, Busra

Obesity surgery

2019 Volume 29, Issue 9, Page(s) 2731–2738

Abstract: Background: Despite the established efficacy and safety of laparoscopic sleeve gastrectomy (LSG), controversy still exists on optimal operative technique, the resection distance from pylorus (DP) being among the most controversial issues. This study ... ...

Abstract	Background: Despite the established efficacy and safety of laparoscopic sleeve gastrectomy (LSG), controversy still exists on optimal operative technique, the resection distance from pylorus (DP) being among the most controversial issues. This study aimed to examine the effect of resection distance from pylorus on % excess weight loss (EWL) during postoperative period, in patients who underwent LSG for morbid obesity. Methods: A total of 390 patients who underwent laparoscopic sleeve gastrectomy for morbid obesity were included in this retrospective study. Patients were allocated into one of the two groups based on the distance between antrum resection margin and pylorus: group A, ≤ 3 cm and group B, > 3 cm. Follow-up data for %EWS and nausea/vomiting as well as demographical and perioperative data were retrospectively reviewed and logistic regression analysis was done. Results: Follow-up data up to 12 months were available for all patients, whereas 199 patients had follow-up data at 24 months. Shorter distance from pylorus was associated with higher %EWL throughout the treatment period (p < 0.001), evident from the first postoperative month (p = 0.013 for the first month, p < 0.001 for all other time points). The benefit extended up to 24 months in ≤ 3 cm group. However, nausea/vomiting was more frequent in the ≤ 3 cm group only at 1-month visit (15% vs. 4%, p < 0.001). In multivariate evaluations, while %EWL variable was taken as a dependent variable, time variable with DP × time interaction was statistically significant in the model. Conclusions: Our findings indicate that a short distance between resection margin and pylorus is associated with better and sustained %EWL in LSG. However, these patients seem to be more prone to nausea and vomiting in the early postoperative period. Further prospective large studies would help to define an optimal resection distance.
MeSH term(s)	Bariatric Surgery/adverse effects ; Bariatric Surgery/methods ; Bariatric Surgery/statistics & numerical data ; Gastrectomy/adverse effects ; Gastrectomy/methods ; Gastrectomy/statistics & numerical data ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Laparoscopy/statistics & numerical data ; Obesity, Morbid/surgery ; Pylorus/surgery ; Retrospective Studies ; Treatment Outcome ; Weight Loss/physiology
Keywords	covid19
Language	English
Publishing date	2019-05-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1070827-3
ISSN	1708-0428 ; 0960-8923
ISSN (online)	1708-0428
ISSN	0960-8923
DOI	10.1007/s11695-019-03923-3
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Article ; Online: Response to "Comment on Comparison of the Accuracy of Short Cognitive Screens Among Adults With Cognitive Complaints in Turkey".

Varan, Hacer D / O'Caoimh, Rónán / Molloy, David W / Yavuz, Burcu B

Alzheimer disease and associated disorders

2021 Volume 35, Issue 2, Page(s) 188–189

MeSH term(s)	Adult ; Cognition ; Cognition Disorders ; Humans ; Neuropsychological Tests ; Turkey
Language	English
Publishing date	2021-05-14
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1002700-2
ISSN	1546-4156 ; 0893-0341
ISSN (online)	1546-4156
ISSN	0893-0341
DOI	10.1097/WAD.0000000000000449
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Article ; Online: Older adults with colon cancer are not different from younger ones, but treated differently: Retrospective analysis from single centre.

Oytun, Merve Güner / Bulut, Gülcan / Gökmen, Erhan / Doğu, Burcu B / Karabulut, Bülent

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2021 Volume 28, Issue 3, Page(s) 569–576

Abstract: Aim: Decision- making of the treatment of colon cancer for the older patients becomes more complicated in consequence of comorbidities and geriatric syndromes, most importantly frailty. In the present study, we aimed to investigate whether there is a ... ...

Abstract	Aim: Decision- making of the treatment of colon cancer for the older patients becomes more complicated in consequence of comorbidities and geriatric syndromes, most importantly frailty. In the present study, we aimed to investigate whether there is a difference between tumour characteristics, treatment choices, and outcomes between the younger and older adults. Method: The patients who were diagnosed with colorectal carcinoma in our centre between 2010 and 2015 included. Clinicopathological features of tumour, treatment choices and survivals of the patients were recorded. Patients were separated into two groups according to their chronological age. Results: The present study included 465 patients, there were 173 patients aged 65 years and older. Clinicopathological features were similar in both groups. Adjuvant chemotherapy was given in similar rates. Whereas combination chemotherapies were preferred in younger patients as first-line therapy, single agents were given to the older group(p-value < 0.001). No significant differences were observed between combination therapy and monotherapy as progression-free and overall survival in older adults(p value > 0.05). It was observed that 53.2% of the older patients was not treated with any biological treatment (p-value < 0.001). Discussion: Geriatric people are underrepresented in clinical trials,because of the presence of the limitations in the older patients. The results of our study revealed older patients with colon cancer patients underwent surgery less than the younger ones, they recieved monotherapy more frequently as first-line chemotherapy, and less frequently targeted therapy. Their mortality was higher. It was shown that decision-making of colon cancer therapy is influenced by age according to our results.
MeSH term(s)	Age Factors ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chemotherapy, Adjuvant ; Colonic Neoplasms/drug therapy ; Colorectal Neoplasms/drug therapy ; Combined Modality Therapy ; Humans ; Retrospective Studies
Language	English
Publishing date	2021-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/10781552211002912
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