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  1. Article ; Online: Reply to Banno et al and Padhi et al.

    Hernandez, Adrian V / Roman, Yuani M / Burela, Paula A / Pasupuleti, Vinay / Piscoya, Alejandro / Vidal, Jose E

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 74, Issue 6, Page(s) 1122–1123

    MeSH term(s) COVID-19 ; Humans ; Ivermectin ; Randomized Controlled Trials as Topic
    Chemical Substances Ivermectin (70288-86-7)
    Language English
    Publishing date 2022-05-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials

    Roman, Yuani M / Burela, Paula A / Pasupuleti, Vinay / Piscoya, Alejandro / Vidal, Jose E / Hernandez, Adrian V

    medRxiv

    Abstract: Background: We systematically assessed benefits and harms of the use of ivermectin (IVM) in COVID-19 patients. Methods: Published and preprint randomized controlled trials (RCTs) assessing IVM effects on COVID-19 adult patients were searched until March ... ...

    Abstract Background: We systematically assessed benefits and harms of the use of ivermectin (IVM) in COVID-19 patients. Methods: Published and preprint randomized controlled trials (RCTs) assessing IVM effects on COVID-19 adult patients were searched until March 15, 2021 in five engines. Primary outcomes were all-cause mortality, length of stay (LOS), and adverse events (AE). Secondary outcomes included viral clearance and severe AEs. We evaluated risk of bias (RoB) using the Cochrane RoB 2.0 tool. Inverse variance random effect meta-analyses were performed with quality of evidence (QoE) evaluated using GRADE methodology. Subgroup analyses by severity of disease and RoB, and sensitivity analyses by time of follow-up were conducted. Results: Ten RCTs (n=1173) were included. Controls were standard of care [SOC] in five RCTs and placebo in five RCTs. RCTs sample size ranged from 24 to 398 patients, mean age from 26 to 56 years-old, and severity of COVID-19 disease was mild in 8 RCTs, moderate in one RCT, and mild and moderate in one RCT. IVM did not reduce all-cause mortality vs. controls (RR 1.11, 95%CI 0.16-7.65, very low QoE). IVM did not reduce LOS vs. controls (MD 0.72 days, 95%CI -0.86 to 2.29, very low QoE). AEs, severe AE and viral clearance were similar between IVM and controls (low QoE for these three outcomes). Subgroup analyses by severity of COVID-19 disease or RoB were consistent with main analyses. Sensitivity analyses excluding RCTs with follow up <21 days showed no difference in all-cause mortality but diminished heterogeneity (I2=0%). Conclusions: In comparison to SOC or placebo, IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease. IVM did not have effect on AEs or SAEs. IVM is not a viable option to treat COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2021-05-25
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.05.21.21257595
    Database COVID19

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  3. Article ; Online: Peruvian National Survey of Mental Health and Service Utilization in the third year of the COVID-19 pandemic: Protocol for a nationally representative multistage survey

    Cruz, Victor / Pariamachi, Andres / Napanga, Joana / Pena, Brian / Gamboa, Lisette / Gonzales, Caroline / Delgado, Paula / Burela, Paula A / Villa-Palomino, Julio / Valentin, Liz / Zuniga, Delia / Quispe, Orlando / Lopez, Pedro / Alcantara, Jessica / Bonilla, Nella / Anton, Sandra / Gutierrez, Mirella / Diaz, Carlos / Claux, Juan /
    Gonzales, Alberto / Vivar, Roxana / Lobe, Gloria / Contreras, Erika / Mahr, Blanca / Pampamallco, Milagros / Salazar, Silvia / Santos, Merle / Valentin, Veronica / Arias, Jose P / Alvarez, Militza / Amaro, Cindy / Calderon, Karla / Canchis, Jose / Carbajal, Fanny / Chire, Jessica / Correa, Liany / Hermoza, Linnette / Moron, Giannina / Palomino, Candy / Ramirez, Rocio / Rojas, Edelmira / Arevalo, Mercedes / Arellano, Cesar / Herrera, Vanessa / Ricardi, Janet / Gupio, Gloria / Jaramillo, Onesimo / Clapes, Carmen / Cerna, Esther / Antunez, Mariluz / Luna, Fernando / Saavedra, Alfredo / Carbajal, Sara / Vega, Favio / Ruiz, Paulo / Saavedra, Javier / Luna, Elba / Campo, Javier del / Familiar-Lopez, Itziar / Ametaj, Amantia A / Copeland, William E / Anthony, Jim / Nishimura, Rafael / Tiemeier, Henning / Gelaye, Bizu

    medRxiv

    Abstract: Background: Peru is the worst affected country by the COVID-19 pandemic showing the world highest mortality rate, thus triggering an increased mental health burden. Nevertheless, there are few population-based epidemiologic surveys of mental disorders in ...

    Abstract Background: Peru is the worst affected country by the COVID-19 pandemic showing the world highest mortality rate, thus triggering an increased mental health burden. Nevertheless, there are few population-based epidemiologic surveys of mental disorders in Peru; Therefore, nationally representative research is needed to understand the underlying population-based mental health burden and identify unmet care needs. Objective: The present study aims to estimate the prevalence and patterns of psychiatric disorders, mental health service use, and unmet mental health care needs Methods: This cross-sectional study will collect information from a multistage random sample of 19,500 households. A child, an adolescent, an adult, and an older adult will be interviewed in the household. Trained staff will conduct face-to-face diagnostic interviews via the Preschool Age Psychiatric Assessment, the Child and Adolescent Psychiatric Assessment, the WHO9s Composite International Diagnostic Interview, and the Alzheimer Disease 8 Scale. In addition, descriptive and inferential analysis for complex sampling will be performed to estimate the prevalence and correlates. Ethics and dissemination: IRB will approve the research protocol before the commencement of the study. Only respondents who signed their informed consents or assents will participate in the study; The parent or guardian will sign the consent for the participation of preschool children. The research findings will be disseminated in peer-reviewed publications, scientific reports, and presentations at national, and international meetings. In addition, de-identified data and study results will be posted on the Peruvian National Institute of Mental Health (PNIMH) website to be freely available to policymakers, researchers, and the general public.
    Keywords covid19
    Language English
    Publishing date 2023-02-23
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.02.22.23286197
    Database COVID19

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