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  1. Article ; Online: Interpretative phenomenological analysis of the collaboration among healthcare professionals in the nursing home setting.

    Crunenberg, Robin / Charles, Camille / Lallemand, Alice / Buret, Laetitia / Philippe, Geneviève / Ethgen, Olivier

    Exploratory research in clinical and social pharmacy

    2024  Volume 13, Page(s) 100424

    Abstract: Background: The theory of planned behavior (TPB) postulates that behavioral performance is guided by the intention to perform that behavior, influenced by attitudes, subjective norms, and perceived behavioral control. This framework can be applied to ... ...

    Abstract Background: The theory of planned behavior (TPB) postulates that behavioral performance is guided by the intention to perform that behavior, influenced by attitudes, subjective norms, and perceived behavioral control. This framework can be applied to studying interprofessional collaboration among healthcare professionals to enhance patient safety and public health within nursing homes.
    Objectives: This study aimed to explore the roles of physicians, pharmacists, and nurses in the interprofessional collaboration process while identifying facilitators and barriers to effective collaboration among healthcare professionals.
    Methods: A qualitative interpretative phenomenological analysis (IPA) was carried out. Individual semi-structured interviews were conducted with 19 healthcare professionals. Qualitative data were then integrated and analyzed through the lens of the TPB.
    Findings: The IPA revealed the ten following themes, considered as both facilitators and barriers to interprofessional collaboration among healthcare professionals in the nursing home setting: communication, roles and responsibilities, willingness and recognition of collaboration's importance, mutual knowledge, trust, confidence, support from decision-makers, protocols, and technology were considered as facilitators while distance was considered as a barrier.
    Conclusion: Enhancing pharmacist-physician collaboration and refining pharmacist-nurse collaboration were essential goals. Intention for collaboration was influenced by attitudes (such as communication and mutual understanding), subjective norms (including support from decision-makers), and perceived behavioral control (such as confidence and adherence to protocols and technology). Addressing these factors could improve collaboration, enhancing residents' quality of life and professionals' sense of achievement.
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article
    ISSN 2667-2766
    ISSN (online) 2667-2766
    DOI 10.1016/j.rcsop.2024.100424
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  2. Article ; Online: Mapping the current knowledge in syndemic research applied to men who have sex with men: A scoping review.

    Ouafik, Maxence R / Buret, Laetitia / Scholtes, Beatrice

    Social science & medicine (1982)

    2022  Volume 306, Page(s) 115162

    Abstract: Men who have sex with Men (MSM) represent a population affected by numerous health conditions. Syndemic theory has been used as a framework to study the health of MSM for nearly 20 years. However, the literature is plagued by a lack of consensus ... ...

    Abstract Men who have sex with Men (MSM) represent a population affected by numerous health conditions. Syndemic theory has been used as a framework to study the health of MSM for nearly 20 years. However, the literature is plagued by a lack of consensus regarding what constitutes a synergy in a syndemic and recent reviews have shown that most of the papers published thus far have failed to demonstrate a synergy nor describe the bio-social interaction needed to account for a true syndemic. Moreover, to our knowledge, none of the existing reviews have focused specifically on MSM. This scoping review aims to fill this gap by mapping in detail how syndemic research on MSM has been conducted. A systematic database search was conducted between 2020 and 2021 and 115 studies were included. Our findings showed a lack of diversity regarding the location, design, subpopulation, and outcomes studied. In addition, the syndemic conditions, as well as their measurement, were not focused enough to ensure the robustness and reproducibility of the findings. Furthermore, our results support previous reviews showing a lack of empirical data to support disease interaction in syndemic research applied to MSM. Our review offers some important recommendations to help move the field forward in future work and describes some promising methodological advances.
    MeSH term(s) Depression/epidemiology ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Male ; Reproducibility of Results ; Sexual Behavior ; Sexual and Gender Minorities ; Syndemic ; Unsafe Sex
    Language English
    Publishing date 2022-06-26
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2022.115162
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  3. Article ; Online: The DAWN antivirals trial: process evaluation of a COVID-19 trial in general practice.

    Tare, Dajana / Coenen, Samuel / De Sutter, An / Heytens, Stefan / Devroey, Dirk / Buret, Laetitia / Schoenmakers, Birgitte / Delvaux, Nicolas / Verbakel, Jan Y / Bogaerts, Kris / van den Bruel, Ann

    BJGP open

    2024  

    Abstract: Background: The DAWN antivirals trial was a multicentric, randomised placebo-controlled trial evaluating antiviral medication for COVID-19 in general practice. The trial was prematurely terminated because of insufficient recruitment.: Aim: To explore ...

    Abstract Background: The DAWN antivirals trial was a multicentric, randomised placebo-controlled trial evaluating antiviral medication for COVID-19 in general practice. The trial was prematurely terminated because of insufficient recruitment.
    Aim: To explore which factors contributed to the premature termination.
    Design & setting: General practice in Belgium.
    Method: Patients were randomised to camostat or placebo (patients and physicians blinded) between June 2021 and July 2022; a third arm evaluating molnupiravir (open label) was opened in March 2022. The outcome assessor was blinded for all comparisons except for the patient reported outcomes in case of molnupiravir. The authors analysed available trial data and evaluated trial context, implementation, and mechanisms of impact based on semi-structured interviews with trial stakeholders.
    Results: The trial recruited 44 participants; 19 were allocated to camostat (median age 55 years), 8 to molnupiravir (median age 60 years), and 17 to placebo (median age 56 years). There were no serious adverse events in either group. Most difficulties were related to the pandemic context: disruption to routine clinical services; multiple changes to the service model for COVID-19 patients; overwhelmed clinical staff; delays of trial medication; and staff shortages in the sponsor and clinical team. In addition, regulatory approval processes were lengthy and led to additional study procedures. It was felt that the trial started too late, when vaccinations had already begun.
    Conclusion: The DAWN antivirals trial was stopped prematurely. Although many barriers were related to the pandemic itself, hurdles such as a small and inexperienced sponsor and clinical teams, delays in regulatory processes, and research capacity in routine settings could be overcome by established research infrastructure and standardisation of processes.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ISSN 2398-3795
    ISSN (online) 2398-3795
    DOI 10.3399/BJGPO.2023.0109
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  4. Article ; Online: Dealing with health literacy at the organisational level, French translation and adaptation of the Vienna health literate organisation self-assessment tool.

    Henrard, Gilles / Vanmeerbeek, Marc / Buret, Laetitia / Rademakers, Jany

    BMC health services research

    2019  Volume 19, Issue 1, Page(s) 146

    Abstract: Background: Efforts to address health literacy should favour a system-based approach with the dual aim both of fostering the material conditions and creating a work culture inside health care organisations that makes it easier for people to use ... ...

    Abstract Background: Efforts to address health literacy should favour a system-based approach with the dual aim both of fostering the material conditions and creating a work culture inside health care organisations that makes it easier for people to use information. The Vienna Health Literate Organisation (V-HLO) self-assessment tool is a German-speaking questionnaire for quality managers of health care organisations. Its objective is to provide a diagnostic of the strengths and weaknesses of the organisation in terms of health literacy. Our goal was to translate and culturally adapt this questionnaire for the French-speaking part of Belgium.
    Methods: We followed the Translation, Review, Adjudication, Pretesting, and Documentation (TRAPD) team model for cross-cultural translation of questionnaires. We used cognitive interviews with quality experts to pre-test the translation.
    Results: Cognitive interviews allowed us to improve the translation by removing certain ambiguities, providing contextual clarifications or rephrasing some items in such a way as to render them more culturally appropriate. Local experts generally judged the tool to be relevant and applicable to their context. The insight gained with regard to their cognitive process when completing the V-HLO allowed us to identify possible barriers to the adoption of the tool (such as difficulties in considering staff literacy as a relevant target for the tool, fear of overwhelming staff, a feeling that some items fell outside the scope of health literacy and lack of attention for integration of services with primary care) and could contribute to the future development of the tool.
    Conclusion: We translated and adapted the V-HLO self-assessment tool for French. The French version of the V-HLO will now be implemented in our local context to assess whether it can make it easier for people to deal with the complexities of health care organisations.
    MeSH term(s) Belgium ; Delivery of Health Care ; Female ; Health Literacy ; Humans ; Interviews as Topic ; Male ; Self-Assessment ; Surveys and Questionnaires ; Translating ; Translations
    Language English
    Publishing date 2019-03-04
    Publishing country England
    Document type Journal Article
    ISSN 1472-6963
    ISSN (online) 1472-6963
    DOI 10.1186/s12913-019-3955-y
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  5. Article ; Online: Involvement of brain-derived neurotrophic factor (BDNF) in the long-term memory effects of glucocorticoid stimulation during adolescence/young adulthood.

    van den Buuse, Maarten / Buret, Laetitia / Hill, Rachel

    Behavioural brain research

    2019  Volume 377, Page(s) 112223

    Abstract: Brain-derived neurotrophic factor (BDNF) has been implicated in cognition and the effects of chronic stress. We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory ... ...

    Abstract Brain-derived neurotrophic factor (BDNF) has been implicated in cognition and the effects of chronic stress. We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF
    MeSH term(s) Age Factors ; Animals ; Brain-Derived Neurotrophic Factor/deficiency ; Brain-Derived Neurotrophic Factor/physiology ; Corticosterone/administration & dosage ; Corticosterone/pharmacology ; Disease Models, Animal ; Female ; Gene-Environment Interaction ; Glucocorticoids/administration & dosage ; Glucocorticoids/pharmacology ; Male ; Memory Disorders/chemically induced ; Memory Disorders/metabolism ; Memory Disorders/physiopathology ; Memory, Long-Term/drug effects ; Memory, Long-Term/physiology ; Mice ; Mice, Knockout ; Receptors, N-Methyl-D-Aspartate/drug effects ; Receptors, N-Methyl-D-Aspartate/metabolism ; Sex Characteristics ; Spatial Memory/drug effects ; Spatial Memory/physiology ; Stress, Psychological/chemically induced ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology
    Chemical Substances Bdnf protein, mouse ; Brain-Derived Neurotrophic Factor ; Glucocorticoids ; NR2B NMDA receptor ; Receptors, N-Methyl-D-Aspartate ; Corticosterone (W980KJ009P)
    Language English
    Publishing date 2019-09-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2019.112223
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1599: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Mapping the current knowledge in syndemic research applied to men who have sex with men: a scoping review protocol.

    Ouafik, Maxence / Buret, Laetitia / Belche, Jean-Luc / Scholtes, Beatrice

    BMJ open

    2020  Volume 10, Issue 11, Page(s) e041238

    Abstract: Introduction: Men who have sex with men (MSM) are disproportionally affected by a number of health conditions that are associated with violence, stigma, discrimination, poverty, unemployment or poor healthcare access. In recent years, syndemic theory ... ...

    Abstract Introduction: Men who have sex with men (MSM) are disproportionally affected by a number of health conditions that are associated with violence, stigma, discrimination, poverty, unemployment or poor healthcare access. In recent years, syndemic theory provided a framework to explore the interactions of these health disparities on the biological and social levels. Research in this field has been increasing for the past 10 years, but methodologies have evolved and sometimes differed from the original concept. The aim of this paper is to provide an overview of the existing literature on syndemic theory applied to MSM in order to identify knowledge gaps, inform future investigations and expand our understanding of the complex interactions between avoidable health conditions in a vulnerable population.
    Methods and analysis: The proposed scoping review will follow the methodological framework developed by Arksey and O'Malley with subsequent enhancements by Levac
    Ethics and dissemination: This scoping review does not require ethical approval. Data and code will be made accessible after manuscript submission. Final results will be disseminated through publication in a peer-reviewed journal and collaboration with grassroots Lesbian, Gay, Bisexual, Transgender, Queer, Intersex and Asexual (LGBTQIA+) organisations.
    Registration: This protocol was registered on manuscript submission on the Open Science Framework at the following address: https://osf.io/jwxtd; DOI: 10.17605/OSF.IO/JWXTD.
    MeSH term(s) Female ; Homosexuality, Male ; Humans ; Male ; Peer Review ; Sexual and Gender Minorities ; Syndemic ; Vulnerable Populations
    Language English
    Publishing date 2020-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2020-041238
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  7. Article ; Online: Vaccine hesitancy for the COVID-19 vaccine booster dose among nursing home staff fully vaccinated with the primary vaccination course in Belgium.

    Digregorio, Marina / Van Ngoc, Pauline / Delogne, Simon / Meyers, Eline / Deschepper, Ellen / Dardenne, Nadia / Duysburgh, Els / De Rop, Liselore / De Burghgraeve, Tine / Coen, Anja / De Clercq, Nele / De Sutter, An / Verbakel, Jan Y / Cools, Piet / Heytens, Stefan / Buret, Laëtitia / Scholtes, Beatrice

    Vaccine: X

    2024  Volume 16, Page(s) 100453

    Abstract: In Belgium, nursing home (NH) staff (NHS) and residents were prioritised for the initial COVID-19 vaccination and successive booster doses. The vaccination campaign for the first booster started in September 2021 in Belgian NH. Our first study about ... ...

    Abstract In Belgium, nursing home (NH) staff (NHS) and residents were prioritised for the initial COVID-19 vaccination and successive booster doses. The vaccination campaign for the first booster started in September 2021 in Belgian NH. Our first study about vaccine hesitancy towards the COVID-19 vaccine in Belgian NHS already showed a degree of fear for the primary vaccination course (T1). This new study aims to evaluate vaccine hesitancy to get the first booster (T2) in a population of fully vaccinated (with two doses) NHS. A random stratified sample of NHS who received the primary vaccination course (
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ISSN 2590-1362
    ISSN (online) 2590-1362
    DOI 10.1016/j.jvacx.2024.100453
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  8. Article ; Online: Des dispositifs d’intégration clinique pour les situations complexes : aide fonctionnelle et défi normatif.

    Buret, Laetitia / Duchesnes, Christiane / Giet, Didier

    Presse medicale (Paris, France : 1983)

    2017  

    Title translation Clinical integration programs for complex situations: Functional support and normative challenge.
    Language French
    Publishing date 2017-09-14
    Publishing country France
    Document type Letter
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/j.lpm.2017.08.001
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 794: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Ua VI Zs.87: Show issues Location:
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  9. Article ; Online: Validation of a rapid SARS-CoV-2 antibody test in general practice.

    Domen, Julie / Verbakel, Jan Yvan Jos / Adriaenssens, Niels / Scholtes, Beatrice / Peeters, Bart / Bruyndonckx, Robin / De Sutter, An / Heytens, Stefan / Van den Bruel, Ann / Desombere, Isabelle / Van Damme, Pierre / Goossens, Herman / Buret, Laetitia / Duysburgh, Els / Coenen, Samuel

    BMJ open

    2023  Volume 13, Issue 5, Page(s) e069997

    Abstract: Objectives: To validate a rapid serological test (RST) for SARS-CoV-2 antibodies used in seroprevalence studies in healthcare providers, including primary healthcare providers (PHCPs) in Belgium.: Design: A phase III validation study of the RST ( ... ...

    Abstract Objectives: To validate a rapid serological test (RST) for SARS-CoV-2 antibodies used in seroprevalence studies in healthcare providers, including primary healthcare providers (PHCPs) in Belgium.
    Design: A phase III validation study of the RST (OrientGene) within a prospective cohort study.
    Setting: Primary care in Belgium.
    Participants: Any general practitioner (GP) working in primary care in Belgium and any other PHCP from the same GP practice who physically manages patients were eligible in the seroprevalence study. For the validation study, all participants who tested positive (376) on the RST at the first testing timepoint (T1) and a random sample of those who tested negative (790) and unclear (24) were included.
    Intervention: At T2, 4 weeks later, PHCPs performed the RST with fingerprick blood (index test) immediately after providing a serum sample to be analysed for the presence of SARS-CoV-2 immunoglobulin G antibodies using a two-out-of-three assay (reference test).
    Primary and secondary outcome measures: The RST accuracy was estimated using inverse probability weighting to correct for missing reference test data, and considering unclear RST results as negative for the sensitivity and positive for the specificity. Using these conservative estimates, the true seroprevalence was estimated both for T2 and RST-based prevalence values found in a cohort study with PHCPs in Belgium.
    Results: 1073 paired tests (403 positive on the reference test) were included. A sensitivity of 73% (a specificity of 92%) was found considering unclear RST results as negative (positive). For an RST-based prevalence at T1 (13.9), T2 (24.9) and T7 (70.21), the true prevalence was estimated to be 9.1%, 25.9% and 95.7%, respectively.
    Conclusion: The RST sensitivity (73%) and specificity (92%) make an RST-based seroprevalence below (above) 23% overestimate (underestimate) the true seroprevalence.
    Trial registration number: NCT04779424.
    MeSH term(s) Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; SARS-CoV-2 ; Cohort Studies ; Prospective Studies ; Seroepidemiologic Studies ; Antibodies, Viral ; General Practice ; COVID-19 Testing
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-069997
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  10. Article ; Online: Prevalence and incidence of antibodies against SARS-CoV-2 among primary healthcare providers in Belgium during 1 year of the COVID-19 epidemic: prospective cohort study protocol.

    Adriaenssens, Niels / Scholtes, Beatrice / Bruyndonckx, Robin / Verbakel, Jan Y / De Sutter, An / Heytens, Stefan / Van den Bruel, Ann / Desombere, Isabelle / Van Damme, Pierre / Goossens, Herman / Buret, Laëtitia / Duysburgh, Els / Coenen, Samuel

    BMJ open

    2022  Volume 12, Issue 1, Page(s) e054688

    Abstract: Introduction: National SARS-CoV-2 seroprevalence data provide essential information about population exposure to the virus and help predict the future course of the epidemic. Early cohort studies have suggested declines in levels of antibodies in ... ...

    Abstract Introduction: National SARS-CoV-2 seroprevalence data provide essential information about population exposure to the virus and help predict the future course of the epidemic. Early cohort studies have suggested declines in levels of antibodies in individuals associated with, for example, illness severity, age and comorbidities. This protocol focuses on the seroprevalence among primary healthcare providers (PHCPs) in Belgium. PHCPs manage the vast majority of (COVID-19) patients and therefore play an essential role in the efficient organisation of healthcare. Currently, evidence is lacking on (1) how many PHCPs get infected with SARS-CoV-2 in Belgium, (2) the rate at which this happens, (3) their clinical spectrum, (4) their risk factors, (5) the effectiveness of the measures to prevent infection and (6) the accuracy of the serology-based point-of-care test (POCT) in a primary care setting.
    Methods and analysis: This study will be set up as a prospective cohort study. General practitioners (GPs) and other PHCPs (working in a GP practice) will be recruited via professional networks and professional media outlets to register online to participate. Registered GPs and other PHCPs will be asked at each testing point (n=9) to perform a capillary blood sample antibody POCT targeting IgM and IgG against the receptor-binding domain of SARS-CoV-2 and complete an online questionnaire. The primary outcomes are the prevalence and incidence of antibodies against SARS-CoV-2 in PHCPs during a 12-month follow-up period. Secondary outcomes include the longevity of antibodies against SARS-CoV-2.
    Ethics and dissemination: Ethical approval has been granted by the ethics committee of the University Hospital of Antwerp/University of Antwerp (Belgian registration number: 3002020000237). Alongside journal publications, dissemination activities include the publication of monthly reports to be shared with the participants and the general population through the publicly available website of the Belgian health authorities (Sciensano).
    Trial registration number: NCT04779424.
    MeSH term(s) Belgium/epidemiology ; COVID-19 ; Cohort Studies ; Health Personnel ; Humans ; Incidence ; Prevalence ; Prospective Studies ; SARS-CoV-2 ; Seroepidemiologic Studies
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2021-054688
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