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  1. Article ; Online: Monomania of political strife by Géricault.

    Burgos, Javier S

    The Lancet. Neurology

    2023  Volume 22, Issue 6, Page(s) 468–469

    MeSH term(s) Humans ; Mental Disorders ; Politics
    Language English
    Publishing date 2023-05-18
    Publishing country England
    Document type Letter
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00159-X
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    Zs.A 5955: Show issues Location:
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  2. Article ; Online: Monomania of drunkenness by Géricault.

    Burgos, Javier S

    The Lancet. Neurology

    2022  Volume 21, Issue 9, Page(s) 774–775

    MeSH term(s) Alcoholic Intoxication ; Humans ; Risk Factors
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Letter
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00304-0
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  3. Article ; Online: A new portrait by Géricault.

    Burgos, Javier S

    The Lancet. Neurology

    2021  Volume 20, Issue 2, Page(s) 90–91

    MeSH term(s) Art/history ; Depressive Disorder/history ; Depressive Disorder/psychology ; France ; History, 19th Century ; Mania/history ; Mania/psychology ; Psychiatry/history
    Language English
    Publishing date 2021-01-20
    Publishing country England
    Document type Biography ; Historical Article ; Letter ; Portrait
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(20)30479-8
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  4. Article ; Online: System Dynamics Modeling Of Within-Host Viral Kinetics Of Coronavirus (SARS CoV-2)

    Burgos, Javier

    bioRxiv

    Abstract: Mathematical models are being used extensively in the study of SARS-CoV-2 transmission dynamics, becoming an essential tool for decision making concerning disease control. It is now required to understand the mechanisms involved in the interaction ... ...

    Abstract Mathematical models are being used extensively in the study of SARS-CoV-2 transmission dynamics, becoming an essential tool for decision making concerning disease control. It is now required to understand the mechanisms involved in the interaction between the virus and the immune response effector cells, both innate and adaptive, in order to support lines of research related to the use of drugs, production of protective antibodies and of course, vaccines against SARS-CoV-2. The present study, using a system dynamic approach, hypothesizes over the conditions that characterize the fraction of the population which get infected by SARS-CoV-2 as the asymptomatic patients, the mild symptomatic, acute symptomatic, and also super-spreaders, in terms of innate immune response, the initial virus load, the virus burden with shedding events, and the cytokine levels.
    Keywords covid19
    Publisher BioRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #129312
    DOI 10.1101/2020.06.02.129312
    Database COVID19

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  5. Article: Combined Ultrahypofractionated Whole-Breast Irradiation and IORT-Boost: A Safety and Feasibility Analysis.

    Burgos-Burgos, Javier / Vega, Víctor / Macias-Verde, David / Gómez, Virginia / Vicente, Elena / Murias, Carmen / Santana, Carlos / Lara, Pedro C

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background: The current standard of local treatment for patients with localized breast cancer (BC) includes whole breast irradiation (WBI) after breast-conserving surgery (BCS). Ultrahypofractionated WBI schemes (1-week treatment) were shown not to be ... ...

    Abstract Background: The current standard of local treatment for patients with localized breast cancer (BC) includes whole breast irradiation (WBI) after breast-conserving surgery (BCS). Ultrahypofractionated WBI schemes (1-week treatment) were shown not to be inferior to the standard WBI. Tumor bed boost using photon intraoperative radiotherapy (IORT) is safe and feasible in combination with standard WBI. The aim of the present study is to assess, for the first time, the feasibility and safety of combining photon IORT with ultrahypofractionated WBI.
    Methods: Patients diagnosed with low-risk early BC candidates for BCS were included in this prospective study. IORT was administered at a dose of 20 Gy to the surface's applicator, and WBI was administered 3-5 weeks after surgery at a total dose of 26 Gy in five consecutive days.
    Results: From July 2020 to December 2022, seventy-two patients diagnosed with low-risk early BC and treated in our institution were included in this prospective study. All patients completed the proposed treatment, and no severe acute or late grade 3 toxicity was observed 3 and 12 months after WBI, respectively.
    Conclusions: Our results confirm for the first time that the combination of ultrafractionation WBI and photon-IORT after BCS is a feasible and safe option in patients with early BC.
    Language English
    Publishing date 2024-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061105
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  6. Article ; Online: Clinical Characteristics of Bronchiectasis due to Transplant-Related Immunosuppression.

    Rodríguez-Plaza, David / Martínez-De Las Fuentes, Ane / Burgos, Javier / Sabé, Núria / Santos, Salud / Suárez-Cuartín, Guillermo

    Open respiratory archives

    2024  Volume 6, Issue 2, Page(s) 100319

    Language English
    Publishing date 2024-04-05
    Publishing country Spain
    Document type Case Reports
    ISSN 2659-6636
    ISSN (online) 2659-6636
    DOI 10.1016/j.opresp.2024.100319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Low dose lung radiotherapy for COVID-19 pneumonia. The rationale for a cost-effective anti-inflammatory treatment.

    Lara, Pedro C / Burgos, Javier / Macias, David

    Clinical and translational radiation oncology

    2020  Volume 23, Page(s) 27–29

    Abstract: The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered of a respiratory disease that will progress to an acute respiratory distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop a systemic inflammatory ... ...

    Abstract The COVID-19 pandemia is affecting people worldwide. Most of the patients suffered of a respiratory disease that will progress to an acute respiratory distress syndrome (ARDS). SARS-CoV-2 pneumonia severely ill patients, develop a systemic inflammatory response with a Cytokine Release Syndrome (CRS), that is characterized by a sudden increase in several pro-inflammatory cytokines, mainly IL-1, IL-6 and TNF-alfa by activated macrophages (M1 phenotype). Blocking IL-6 with tocilizumab and using respirator equipment seems to be a very important issue in this (SARS-CoV-2) pneumonia, but not all patients are referred to such treatments. Low dose radiotherapy (0,5 Gy), is an evidence-based anti-inflammatory treatment, that could modify the immune landscape in the lung affected of SARS-CoV-2 pneumonia, through macrophages polarization to alternatively activated Macrophages (M2 phenotype). Radiation-induced cancer risk could be assumed due to the very low dose used, the advanced age of the patients and the life-threatening condition of SARS-Cov2 pneumonia. LDRT is a cost-effective non-toxic treatment already available in most general hospitals. This fact allows that it would be used for the large number of patients that will suffer this disease, and that would not receive specific anti-IL-6 treatments in ICUs in low and middle income countries.
    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publishing country Ireland
    Document type Journal Article
    ISSN 2405-6308
    ISSN (online) 2405-6308
    DOI 10.1016/j.ctro.2020.04.006
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  8. Article: Age-induced NLRP3 Inflammasome Over-activation Increases Lethality of SARS-CoV-2 Pneumonia in Elderly Patients.

    Lara, Pedro C / Macías-Verde, David / Burgos-Burgos, Javier

    Aging and disease

    2020  Volume 11, Issue 4, Page(s) 756–762

    Abstract: Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2 infection. In multivariate analysis, advanced age was an independent risk factor for death. Recent studies suggest a role for the nucleotide-binding domain and ... ...

    Abstract Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2 infection. In multivariate analysis, advanced age was an independent risk factor for death. Recent studies suggest a role for the nucleotide-binding domain and leucine rich repeat containing family, pyrin domain containing 3 (NLRP3) inflammasome activation in lung inflammation and fibrosis in SARS-CoV and SARS-CoV-2 infections. Increased NLRP3/ apoptosis-associated speck-like protein (ASC) mRNA expression and increased caspase-1 activity, have been observed in aged lung, provoking increased and heightened expression levels of mature Interleukin (IL)-1β and IL-18 in aged individuals. Aged individuals have a basal predisposition to over-react to infection, displaying an increased hyper-inflammatory cascade, that seems not to be fully physiologically controlled. NLRP3 inflammasome is over-activated in aged individuals, through deficient mitochondrial functioning, increased mitochondrial Reactive Oxigen Species (mtROS) and/or mitochondrial (mt)DNA, leading to a hyper-response of classically activated macrophages and subsequent increases in IL-1 β. This NLRP3 over-activated status in elderly individuals, is also observed in telomere dysfunctional mice models. In our opinion, the NLRP3 inflammasome plays a central role in the increased lethality observed in elderly patients infected by COVID-19. Strategies blocking inflammasome would deserve to be studied.
    Keywords covid19
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article
    ISSN 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2020.0601
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  9. Article ; Online: Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality.

    Macias-Verde, David / Lara, Pedro C / Burgos-Burgos, Javier

    Medical hypotheses

    2020  Volume 146, Page(s) 110396

    Abstract: We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term ...

    Abstract We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.
    MeSH term(s) Aerosols ; Air Microbiology ; Air Pollution, Radioactive/adverse effects ; COVID-19/etiology ; COVID-19/mortality ; Causality ; Climate Change ; Humans ; Inflammasomes/metabolism ; Inflammasomes/radiation effects ; Inflammation/etiology ; Models, Biological ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nervous System Diseases/etiology ; Pandemics ; Particle Size ; Particulate Matter/adverse effects ; Pneumonia/etiology ; SARS-CoV-2/pathogenicity
    Chemical Substances Aerosols ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Particulate Matter
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110396
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    Zs.A 1132: Show issues Location:
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  10. Article: Is reluctance to right-sided laparoscopic living donor nephrectomy justified?

    Burgos, Javier

    European urology

    2007  Volume 51, Issue 5, Page(s) 1171–1172

    MeSH term(s) Humans ; Kidney Transplantation ; Laparoscopy/methods ; Living Donors ; Nephrectomy/methods ; Renal Veins/anatomy & histology ; Renal Veins/surgery ; Tissue and Organ Harvesting/methods
    Language English
    Publishing date 2007-05
    Publishing country Switzerland
    Document type Comment ; Editorial
    ZDB-ID 193790-x
    ISSN 1421-993X ; 0302-2838
    ISSN (online) 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2007.01.021
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    Zs.MO 294: Show issues

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