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  1. Article: Relapsed/Refractory Mantle Cell Lymphoma: Beyond BTK Inhibitors.

    Burkart, Madelyn / Karmali, Reem

    Journal of personalized medicine

    2022  Volume 12, Issue 3

    Abstract: Mantle cell lymphoma (MCL) is a rare mature B-cell non-Hodgkin lymphoma (B-NHL) with historically poor outcomes. Virtually all patients will eventually experience refractory or relapsed (R/R) disease, with a virulent course of resistance and serial ... ...

    Abstract Mantle cell lymphoma (MCL) is a rare mature B-cell non-Hodgkin lymphoma (B-NHL) with historically poor outcomes. Virtually all patients will eventually experience refractory or relapsed (R/R) disease, with a virulent course of resistance and serial relapses, making treatment challenging. The available therapies for R/R MCL are not curative with conventional therapy, their goal being to palliate and prolong survival. A variety of agents approved for R/R MCL, including Bruton's tyrosine kinase inhibitors (BTKi), changed the treatment landscape of R/R MCL. In the pre-BTKi era, the median progression-free survival (PFS) in R/R disease was 4-9 months. With the introduction of ibrutinib, the median PFS improved to 13-14.6 months. Despite these impressive results, the duration of response is limited, and resistance to BTKi inevitably develops in a subset of patients. Outcomes after progression on BTKi are extremely poor, with a median overall survival (OS) of 6 to 10 months. Certain therapies, such as chimeric antigen receptor (CAR) T cells, have shown promising results after BTKi failure. The preferred combination and sequencing of therapies beyond BTKi remain unestablished and are currently being investigated. In this review, we describe the current evidence for the available treatment of R/R MCL after progression on BTKi.
    Language English
    Publishing date 2022-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm12030376
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  2. Article: Long-term benefits of EPs

    Tisch, Matthias / Roháč, Lubomír / Reineke, Thorsten / Burkart, Martin / Kostev, Karel

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1358879

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1358879
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  3. Article ; Online: Using NMR Titration Experiments to Study E. coli FAS-II- and AcpP-Mediated Protein-Protein Interactions.

    Mellor, Desirae A / Sanlley, Javier O / Burkart, Michael

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2670, Page(s) 49–68

    Abstract: Acyl carrier proteins (ACPs) are central to many primary and secondary metabolic pathways. In E. coli fatty acid biosynthesis (FAB), the central ACP, AcpP, transports intermediates to a suite of partner proteins (PP) for iterative modification and ... ...

    Abstract Acyl carrier proteins (ACPs) are central to many primary and secondary metabolic pathways. In E. coli fatty acid biosynthesis (FAB), the central ACP, AcpP, transports intermediates to a suite of partner proteins (PP) for iterative modification and elongation. The regulatory protein-protein interactions that occur between AcpP and the PP in FAB are poorly understood due to the dynamic and transient nature of these interactions. Solution-state NMR spectroscopy can reveal information at the atomic level through experiments such as the 2D heteronuclear single quantum coherence (HSQC). The following protocol describes NMR HSQC titration experiments that can elucidate biomolecular recognition events.
    MeSH term(s) Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Magnetic Resonance Spectroscopy ; Magnetic Resonance Imaging
    Chemical Substances Escherichia coli Proteins
    Language English
    Publishing date 2023-05-15
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3214-7_3
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  4. Article ; Online: Einfluss medikamentöser BPS-Therapie auf die sexuelle Funktion.

    Bschleipfer, T / Burkart, M

    Der Urologe. Ausg. A

    2018  Volume 57, Issue 12, Page(s) 1464–1471

    Abstract: Background: Benign prostate syndrome is frequently associated with sexual dysfunction. The therapeutic options discussed in the S2e guideline may be able to improve existing sexual dysfunctions but can also worsen disorders or even trigger new ones.: ... ...

    Title translation Influence of medical BPS treatment on sexual function.
    Abstract Background: Benign prostate syndrome is frequently associated with sexual dysfunction. The therapeutic options discussed in the S2e guideline may be able to improve existing sexual dysfunctions but can also worsen disorders or even trigger new ones.
    Objectives: What are the effects of therapeutic options as described in the S2e guideline on sexual function?
    Methods: By selective literature search related to benign prostate syndrome and sexual dysfunction adverse effects of drugs mentioned in the S2e guideline have been evaluated.
    Results: Serenoa repens extracts do not have adverse effects on sexual function; this is also true for muscarine receptor antagonists. 5α-Reductase inhibitors frequently worsen erectile function, libido and ejaculation; selective α
    Conclusions: A suitable therapy for benign prostate syndrome should be chosen jointly by the patient and the treating physician and should be adapted to personal needs. Effects on sexual functions have to be taken into consideration when choosing a therapy.
    MeSH term(s) 5-alpha Reductase Inhibitors ; Adrenergic alpha-Antagonists ; Ejaculation ; Erectile Dysfunction ; Humans ; Male ; Prostatic Hyperplasia ; Sexual Dysfunction, Physiological
    Chemical Substances 5-alpha Reductase Inhibitors ; Adrenergic alpha-Antagonists
    Language German
    Publishing date 2018-07-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-018-0739-7
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  5. Book ; Thesis: Familiäre Belastung mit primär progressiver Demenz bei Patienten mit Demenz vom Alzheimer-Typ oder mit major depression

    Burkart, Martin

    1995  

    Author's details vorgelegt von Martin Burkart
    Language German
    Size VIII, 107 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Mainz, Univ., Diss., 1995
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT007438865
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1997 MB 221 order for loan Magazin

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  6. Article ; Online: Prüfplan für die monozentrische prospektive randomisierte placebokontrollierte doppelblinde Phase-II-Studie zur Exploration protektiver Effekte des Ginkgo-biloba-Spezialextrakts EGb 761® vor einer vorübergehenden Hörschädigung durch Lärm.

    Mühlmeier, G / Schweikert, A / Schramm, S / Burkart, M / Tisch, M

    HNO

    2020  Volume 68, Issue 4, Page(s) 272–277

    Abstract: Background: Hearing loss is frequently induced by occupational noise exposure and leads to rising hearing thresholds as well as reduced otoacoustic emissions (OAE), mostly caused by metabolic hair cell decompensation.: Objective: Primary endpoint is ... ...

    Title translation Study protocol of the monocentric prospective randomized placebo-controlled double-blind phase II study to explore the protective effects of the ginkgo biloba extract EGb 761® from temporary noise-induced hearing loss.
    Abstract Background: Hearing loss is frequently induced by occupational noise exposure and leads to rising hearing thresholds as well as reduced otoacoustic emissions (OAE), mostly caused by metabolic hair cell decompensation.
    Objective: Primary endpoint is the increase in average pure tone thresholds after noise exposure, secondary endpoints are loss of distortion product and click-evoked OAE as well as reduction of their contralateral suppression.
    Participants and methods: The present study design describes the verification of the anti-oxidant and neuroprotective properties of EGb 761® by evaluation of cochlear protection from noise impact as well as its safety and tolerance in 202 healthy male participants distributed equally to verum and placebo groups in a double-blind manner. Participants were assessed, medicated, exposed to noise, and then examined at timepoints up to 10 min and 4 weeks thereafter.
    Conclusion: This summary of the verification study protocol highlights the complexity of diligent and precise planning according to the European Medicines Agency criteria for controlled trials (EudraCT). Key points are the intervention rationale, definitions of in- and exclusion criteria, estimation of subject numbers, and examination method setting in terms of optimum endpoint description.
    MeSH term(s) Audiometry, Pure-Tone ; Auditory Threshold ; Cochlea ; Double-Blind Method ; Hearing Loss, Noise-Induced/therapy ; Humans ; Male ; Otoacoustic Emissions, Spontaneous ; Plant Extracts/therapeutic use ; Prospective Studies
    Chemical Substances Plant Extracts ; Ginkgo biloba extract (19FUJ2C58T)
    Language German
    Publishing date 2020-02-07
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    DOI 10.1007/s00106-019-00807-x
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  7. Article: Balance Training With Vibrotactile Neurofeedback and

    Decker, Lars / Basta, Dietmar / Burkart, Martin / Ernst, Arne

    Frontiers in neurology

    2021  Volume 12, Page(s) 691917

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.691917
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  8. Article ; Online: Klinische Arzneimittelforschung in der deutschen Urologie aus Sicht eines Sponsors.

    Burkart, M

    Der Urologe. Ausg. A

    2006  Volume 45 Suppl 4, Page(s) 45–47

    Title translation Clinical drug research in German urology from the viewpoint of a sponsor.
    MeSH term(s) Controlled Clinical Trials as Topic/trends ; Cooperative Behavior ; Drug Design ; Drug Industry/trends ; Forecasting ; Germany ; Humans ; Interprofessional Relations ; Urology/trends
    Language German
    Publishing date 2006-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 204041-4
    ISSN 1433-0563 ; 0340-2592 ; 0375-4685
    ISSN (online) 1433-0563
    ISSN 0340-2592 ; 0375-4685
    DOI 10.1007/s00120-006-1130-7
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  9. Article ; Conference proceedings: Bewertung natürlicher Präparate zur Behandlung innerer Unruhe aus Sicht der Anwender

    Anghelescu, IG / Burkart, M / Michel, MC

    Zeitschrift für Phytotherapie

    2019  Volume 40, Issue S 01

    Event/congress Phytotherapiekongress 2019, Münster, 2019-09-19
    Language German
    Publishing date 2019-09-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 604850-x
    ISSN 1438-9584 ; 0722-348X ; 0720-227X
    ISSN (online) 1438-9584
    ISSN 0722-348X ; 0720-227X
    DOI 10.1055/s-0039-1697297
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  10. Article ; Conference proceedings: Individualized vibrotactile neurofeedback training and Ginkgo biloba special extract in presbyvertigo – a multicentre, randomized, controlled, single-blind trial

    Decker, L / Dietmar, B / Burkart, M / Ernst, A

    Laryngo-Rhino-Otologie

    2019  Volume 98, Issue S 02

    Event/congress Abstract- und Posterband - 90. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn - Digitalisierung in der HNO-Heilkunde, Estrel Congress Center Berlin, 2019-05-29
    Language English
    Publishing date 2019-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0935-8943 ; 0340-1588
    ISSN (online) 1438-8685
    ISSN 0935-8943 ; 0340-1588
    DOI 10.1055/s-0039-1686359
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