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  1. Article ; Online: Elevated Amyloid-β PET Scan and Cognitive and Functional Decline in Mild Cognitive Impairment and Dementia of Uncertain Etiology.

    Plassman, Brenda L / Ford, Cassie B / Smith, Valerie A / DePasquale, Nicole / Burke, James R / Korthauer, Laura / Ott, Brian R / Belanger, Emmanuelle / Shepherd-Banigan, Megan E / Couch, Elyse / Jutkowitz, Eric / O'Brien, Emily C / Sorenson, Corinna / Wetle, Terrie T / Van Houtven, Courtney H

    Journal of Alzheimer's disease : JAD

    2024  Volume 97, Issue 3, Page(s) 1161–1171

    Abstract: Background: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment ( ... ...

    Abstract Background: Elevated amyloid-β (Aβ) on positron emission tomography (PET) scan is used to aid diagnosis of Alzheimer's disease (AD), but many prior studies have focused on patients with a typical AD phenotype such as amnestic mild cognitive impairment (MCI). Little is known about whether elevated Aβ on PET scan predicts rate of cognitive and functional decline among those with MCI or dementia that is clinically less typical of early AD, thus leading to etiologic uncertainty.
    Objective: We aimed to investigate whether elevated Aβ on PET scan predicts cognitive and functional decline over an 18-month period in those with MCI or dementia of uncertain etiology.
    Methods: In 1,028 individuals with MCI or dementia of uncertain etiology, we evaluated the association between elevated Aβ on PET scan and change on a telephone cognitive status measure administered to the participant and change in everyday function as reported by their care partner.
    Results: Individuals with either MCI or dementia and elevated Aβ (66.6% of the sample) showed greater cognitive decline compared to those without elevated Aβ on PET scan, whose cognition was relatively stable over 18 months. Those with either MCI or dementia and elevated Aβ were also reported to have greater functional decline compared to those without elevated Aβ, even though the latter group showed significant care partner-reported functional decline over time.
    Conclusions: Elevated Aβ on PET scan can be helpful in predicting rates of both cognitive and functional decline, even among cognitively impaired individuals with atypical presentations of AD.
    MeSH term(s) Humans ; Uncertainty ; Cognitive Dysfunction/psychology ; Amyloid beta-Peptides ; Alzheimer Disease/psychology ; Cognition ; Positron-Emission Tomography/methods
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2024-02-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230950
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  2. Article ; Online: Prevalence and incidence of depressive symptoms and diagnosis of depression as associated with elevated amyloid among Medicare beneficiaries with cognitive impairment.

    Bélanger, Emmanuelle / Jutkowitz, Eric / Shewmaker, Peter / Van Houtven, Courtney H / Burke, James R / Plassman, Brenda L / Shepherd-Banigan, Megan / Couch, Elyse / Mills, Caroline / Wetle, Terrie T

    Journal of affective disorders

    2023  Volume 334, Page(s) 293–296

    Abstract: Background: Depression and cognitive impairment commonly co-occur, and it has been hypothesized that the two share pathological processes. Our objective for this study was to determine the relationship between elevated β-amyloid level and the prevalence ...

    Abstract Background: Depression and cognitive impairment commonly co-occur, and it has been hypothesized that the two share pathological processes. Our objective for this study was to determine the relationship between elevated β-amyloid level and the prevalence and incidence of depressive symptoms and diagnosed depression over two years among fee-for-service Medicare beneficiaries with cognitive impairment.
    Methods: We utilized data from the CARE-IDEAS cohort study (N = 2078) including two measures of depressive symptoms (PHQ-2) and administrative claims data to identify pre-scan and incident depression diagnosis in subsample of fee-for-service Medicare beneficiaries (N = 1443). We used descriptive statistics and Poisson regression models with robust covariance.
    Results: Beneficiaries whose scan results indicated not-elevated β-amyloid were significantly more likely to have been diagnosed with depression pre-scan (46.4 % vs. 33.1 %). There was no significant association between elevated amyloid and the incidence of depressive symptoms or diagnosed depression.
    Limitations: The sample was limited to Medicare beneficiaries with cognitive impairment. Race/ethnic composition and education levels were not representative of the general population and there was substantial loss to follow-up. Mixed depressive / anxious episodes were captured as diagnoses of depression, potentially overestimating depression in this population.
    Conclusions: There was a high prevalence and incidence of diagnosed depression in this cohort of Medicare beneficiaries, but the incidence of depressive symptoms and diagnosed depression was not associated with elevated β-amyloid.
    MeSH term(s) Aged ; Humans ; United States/epidemiology ; Medicare ; Cohort Studies ; Prevalence ; Incidence ; Depression/diagnosis ; Depression/epidemiology ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Amyloid
    Chemical Substances Amyloid
    Language English
    Publishing date 2023-05-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2023.04.115
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  3. Article ; Online: Association between results of an amyloid PET scan and healthcare utilization in individuals with cognitive impairment.

    Jutkowitz, Eric / Shewmaker, Peter / Ford, Cassie B / Smith, Valerie A / O'Brien, Emily / Shepherd-Banigan, Megan / Belanger, Emmanuelle / Plassman, Brenda L / Burke, James R / Van Houtven, Courtney H / Wetle, Terrie

    Journal of the American Geriatrics Society

    2023  Volume 72, Issue 3, Page(s) 707–717

    Abstract: Background: The Imaging Dementia Evidence for Amyloid Scanning (IDEAS) study reports that amyloid PET scans help providers diagnose and manage Alzheimer's disease and related dementias (ADRD). Using CARE-IDEAS, an IDEAS supplemental study, we examined ... ...

    Abstract Background: The Imaging Dementia Evidence for Amyloid Scanning (IDEAS) study reports that amyloid PET scans help providers diagnose and manage Alzheimer's disease and related dementias (ADRD). Using CARE-IDEAS, an IDEAS supplemental study, we examined the association between amyloid PET scan result (elevated or non-elevated amyloid), patient characteristics, and participant healthcare utilization.
    Methods: We linked respondents in CARE-IDEAS study to their Medicare fee-for-service records (n = 1333). We examined participants' cognitive impairment-related, outpatient, emergency department (ED), and inpatient encounters in the year before compared with the 2 years after the amyloid PET scan.
    Results: Individuals with a non-elevated amyloid scan had more healthcare encounters throughout the overall study period than those with an elevated amyloid scan. Regardless of the amyloid scan result, cognitive impairment-related and outpatient encounters overall decreased, but ED and inpatient encounters increased in the 2 years after the scan compared with the year prior. There was minimal evidence of differences in healthcare utilization between participants with an elevated and non-elevated amyloid scan.
    Conclusions: There is no difference in change in healthcare utilization between people with scans showing elevated and non-elevated beta-amyloid.
    MeSH term(s) Humans ; Aged ; United States ; Medicare ; Cognitive Dysfunction/diagnostic imaging ; Alzheimer Disease/diagnostic imaging ; Amyloid ; Amyloid beta-Peptides ; Positron-Emission Tomography/methods ; Delivery of Health Care ; Patient Acceptance of Health Care
    Chemical Substances Amyloid ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18696
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  4. Article ; Online: Amyloid-β PET Scan Results Disclosure and Care-Partner Emotional Well-Being Over Time.

    Shepherd-Banigan, Megan E / Ford, Cassie B / Smith, Valerie A / Belanger, Emmanuelle / Wetle, Terrie T / Plassman, Brenda L / Burke, James R / DePasquale, Nicole / O'Brien, Emily C / Sorenson, Corinna / Van Houtven, Courtney H

    Journal of Alzheimer's disease : JAD

    2022  Volume 90, Issue 2, Page(s) 775–782

    Abstract: Background: Diagnostic tests, such as amyloid-β positron emission tomography (PET) scans, can increase appropriate therapeutic management for the underlying causes of cognitive decline. To evaluate the full utility of this diagnostic tool, information ... ...

    Abstract Background: Diagnostic tests, such as amyloid-β positron emission tomography (PET) scans, can increase appropriate therapeutic management for the underlying causes of cognitive decline. To evaluate the full utility of this diagnostic tool, information is needed on whether results from amyloid-β PET scans influence care-partner outcomes.
    Objective: This study examines the extent to which previous disclosure of elevated amyloid (suggestive of Alzheimer's disease (AD) etiology) versus not-elevated amyloid (not suggestive of AD etiology) is associated with changes in care-partner wellbeing.
    Methods: The study used data derived from a national longitudinal survey of Medicare beneficiaries (n = 921) with mild cognitive impairment (MCI) or dementia and their care-partners. Care-partner wellbeing outcomes included depressive symptoms (PHQ-8), subjective burden (4-item Zarit burden score), and a 3-item measure of loneliness. Change was measured between 4 (Time 1) and 18 (Time 2) months after receiving the scan results. Adjusted linear regression models regressed change (Time 2-Time 1) in each outcome on scan result.
    Results: Care-partners were primarily white, non-Hispanic, college-educated, and married to the care recipient. Elevated amyloid was not associated with statistically significant Time 1 differences in outcomes or with statistically significant changes in depressive symptoms 0.22 (-0.18, 0.61), subjective burden 0.36 (-0.01, 0.73), or loneliness 0.15 (-0.01, 0.32) for care-partners from one time point to another.
    Conclusion: Given advances in AD biomarker testing, future research in more diverse samples is needed to understand the influence of scan results on care-partner wellbeing across populations.
    MeSH term(s) Aged ; Humans ; United States ; Disclosure ; Medicare ; Amyloid beta-Peptides ; Positron-Emission Tomography/methods ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/psychology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/psychology ; Amyloid ; Amyloidosis
    Chemical Substances Amyloid beta-Peptides ; Amyloid
    Language English
    Publishing date 2022-10-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-220611
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  5. Article ; Online: Association of OCT Angiography Parameters With Age in Cognitively Healthy Older Adults.

    Polascik, Bryce W / Thompson, Atalie C / Yoon, Stephen P / Powers, James H / Burke, James R / Grewal, Dilraj S / Fekrat, Sharon

    Ophthalmic surgery, lasers & imaging retina

    2020  Volume 51, Issue 12, Page(s) 706–714

    Abstract: Background and objective: To evaluate the association of changes in retinal anatomy and microvasculature with age and sex in cognitively healthy older adults.: Patients and methods: Cross-sectional study of cognitively healthy subjects aged 50 years ... ...

    Abstract Background and objective: To evaluate the association of changes in retinal anatomy and microvasculature with age and sex in cognitively healthy older adults.
    Patients and methods: Cross-sectional study of cognitively healthy subjects aged 50 years and older who underwent optical coherence tomography angiography (OCTA) to estimate the association between age and sex with ganglion cell layer-inner plexiform layer (GC-IPL); central subfield thickness (CST); subfoveal choroidal thickness (CT); foveal avascular zone (FAZ) size; and superficial (SCP), deep (DCP), and whole capillary plexus (WCP) vessel density (VD) and perfusion density (PD) measured in the ETDRS 3-mm and 6-mm circle and rings.
    Results: Among 141 older adults (72.9% female; median age: 69 years), 282 eyes were imaged. Females had a greater CT, GC-IPL thickness, and FAZ size and a lower CST than males. After controlling for sex, both CT (P = .001) and GC-IPL thickness (P < .001) decreased with age, whereas FAZ size and CST did not. There was a reduction in VD and PD in SCP, DCP, and WCP with age in the 3-mm circle, 3-mm ring, and 6-mm circle (all P < .05).
    Conclusions: There is a significant reduction in both VD and PD, as well as decreased choroidal and GC-IPL thickness associated with aging, even beyond the fifth decade, in cognitively healthy adults. [Ophthalmic Surg Lasers Imaging Retina. 2020;51:706-714.].
    MeSH term(s) Age Factors ; Aged ; Cross-Sectional Studies ; Female ; Fluorescein Angiography ; Humans ; Macula Lutea ; Male ; Middle Aged ; Retinal Vessels/diagnostic imaging ; Tomography, Optical Coherence
    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20201202-05
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  6. Article: Targeting I kappa B kinase for the treatment of inflammatory and other disorders.

    Burke, James R

    Current opinion in drug discovery & development

    2003  Volume 6, Issue 5, Page(s) 720–728

    Abstract: The nuclear transcription factor NF kappa B plays a critical role in the pathogenesis of a number of human disorders, particularly those with an inflammatory component. Due to the fact that I kappa B kinase (IKK)-catalyzed phosphorylation of I kappa B ... ...

    Abstract The nuclear transcription factor NF kappa B plays a critical role in the pathogenesis of a number of human disorders, particularly those with an inflammatory component. Due to the fact that I kappa B kinase (IKK)-catalyzed phosphorylation of I kappa B proteins is an essential step in the signal-induced activation of NF kappa B, targeting this kinase represents a fascinating opportunity to develop novel therapeutics. In this review, the current understanding of the role of IKK/NF kappa B in disease processes will be discussed, along with evidence demonstrating that IKK inhibitors will be efficacious in disorders ranging from rheumatoid arthritis to cancer and diabetes. Potential mechanism-based toxicities will also be discussed.
    MeSH term(s) Animals ; Carrier Proteins/antagonists & inhibitors ; Carrier Proteins/physiology ; Enzyme Inhibitors/therapeutic use ; Graft Rejection/drug therapy ; Graft Rejection/immunology ; Heart Failure/diet therapy ; Heart Failure/physiopathology ; Humans ; I-kappa B Kinase ; Inflammation/drug therapy ; Inflammation/immunology ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/physiology ; Neoplasms/drug therapy ; Neoplasms/physiopathology ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/physiology ; Reperfusion Injury/drug therapy ; Reperfusion Injury/physiopathology ; Transcription, Genetic/physiology ; Virus Diseases/drug therapy ; Virus Diseases/physiopathology
    Chemical Substances Carrier Proteins ; Elp1 protein, human ; Enzyme Inhibitors ; NF-kappa B ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; CHUK protein, human (EC 2.7.11.10) ; I-kappa B Kinase (EC 2.7.11.10) ; IKBKB protein, human (EC 2.7.11.10) ; IKBKE protein, human (EC 2.7.11.10)
    Language English
    Publishing date 2003-10-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1461136-3
    ISSN 2040-3437 ; 1367-6733
    ISSN (online) 2040-3437
    ISSN 1367-6733
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  7. Article ; Online: The Preventing Alzheimer's with Cognitive Training (PACT) randomized clinical trial.

    Nicholson, Jody S / Hudak, Elizabeth M / Phillips, Christine B / Chanti-Ketterl, Marianne / O'Brien, Jennifer L / Ross, Lesley A / Lister, Jennifer J / Burke, James R / Potter, Guy / Plassman, Brenda L / Woods, Adam J / Krischer, Jeffrey / Edwards, Jerri D

    Contemporary clinical trials

    2022  Volume 123, Page(s) 106978

    Abstract: Background: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially ...

    Abstract Background: To address the rising prevalence of Alzheimer's disease and related dementias, effective interventions that can be widely disseminated are warranted. The Preventing Alzheimer's with Cognitive Training study (PACT) investigates a commercially available computerized cognitive training program targeting improved Useful Field of View Training (UFOVT) performance. The primary goal is to test the effectiveness of UFOVT to reduce incidence of clinically defined mild cognitive impairment (MCI) or dementia with a secondary objective to examine if effects are moderated by plasma β-amyloid level or apolipoprotein E e4 (APOE e4) allele status.
    Methods/design: This multisite study utilizes a randomized, controlled experimental design with blinded assessors and investigators. Individuals who are 65 years of age and older are recruited from the community. Eligible participants who demonstrate intact cognitive status (Montreal Cognitive Assessment score > 25) are randomized and asked to complete 45 sessions of either a commercially available computerized-cognitive training program (UFOVT) or computerized games across 2.5 years. After three years, participants are screened for cognitive decline. For those demonstrating decline or who are part of a random subsample, a comprehensive neuropsychological assessment is completed. Those who perform below a pre-specified level are asked to complete a clinical evaluation, including an MRI, to ascertain clinical diagnosis of normal cognition, MCI, or dementia. Participants are asked to provide blood samples for analyses of Alzheimer's disease related biomarkers.
    Discussion: The PACT study addresses the rapidly increasing prevalence of dementia. Computerized cognitive training may provide a non-pharmaceutical option for reducing incidence of MCI or dementia to improve public health.
    Registration: The PACT study is registered at http://Clinicaltrials.govNCT03848312.
    MeSH term(s) Humans ; Alzheimer Disease/prevention & control ; Cognition ; Cognition Disorders ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/prevention & control ; Neuropsychological Tests ; Cognitive Training
    Language English
    Publishing date 2022-10-28
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2022.106978
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  8. Article ; Online: Assessing the Retinal Microvasculature in Individuals With Early and Late-Onset Alzheimer's Disease.

    Robbins, Cason B / Grewal, Dilraj S / Stinnett, Sandra S / Soundararajan, Srinath / Yoon, Stephen P / Polascik, Bryce W / Liu, Andy J / Burke, James R / Fekrat, Sharon

    Ophthalmic surgery, lasers & imaging retina

    2021  Volume 52, Issue 6, Page(s) 336–344

    Abstract: Background and objective: To evaluate retinal microvascular changes in early and late-onset Alzheimer's disease (AD).: Patients and methods: Eighty-six eyes of 50 late-onset AD participants, 27 eyes of 15 early onset AD participants, and 111 eyes of ... ...

    Abstract Background and objective: To evaluate retinal microvascular changes in early and late-onset Alzheimer's disease (AD).
    Patients and methods: Eighty-six eyes of 50 late-onset AD participants, 27 eyes of 15 early onset AD participants, and 111 eyes of 57 cognitively normal controls were included. Optical coherence tomography angiography (OCTA) vessel density (VD) and perfusion density (PD) in Early Treatment Diabetic Retinopathy Study 3-mm and 6-mm circles and rings were assessed.
    Results: There was decreased PD in early onset AD 3-mm circle (
    Conclusions: AD eyes exhibited decreased retinal microvascular density compared to controls. Retinal parameters may not differ between early onset AD and late-onset AD after adjusting for age.
    MeSH term(s) Alzheimer Disease/diagnosis ; Diabetic Retinopathy ; Fluorescein Angiography ; Humans ; Microvessels ; Retina/diagnostic imaging ; Retinal Vessels ; Tomography, Optical Coherence
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20210528-06
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  9. Article ; Online: Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants.

    Yoon, Stephen P / Grewal, Dilraj S / Thompson, Atalie C / Polascik, Bryce W / Dunn, Cynthia / Burke, James R / Fekrat, Sharon

    Ophthalmology. Retina

    2019  Volume 3, Issue 6, Page(s) 489–499

    Abstract: Purpose: Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared.!# ...

    Abstract Purpose: Evaluate and compare the retinal microvasculature in the superficial capillary plexus (SCP) in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively intact controls using OCT angiography. OCT parameters were also compared.
    Design: Cross-sectional study.
    Participants: Seventy eyes from 39 AD participants, 72 eyes from 37 MCI participants, and 254 eyes from 133 control participants were enrolled.
    Methods: Participants were imaged using Zeiss Cirrus HD-5000 with AngioPlex (Carl Zeiss Meditec, Dublin, CA) and underwent cognitive evaluation with Mini-Mental State Examination.
    Main outcome measures: Vessel density (VD) and perfusion density (PD) in the SCP within the Early Treatment Diabetic Retinopathy Study 6-mm circle, 3-mm circle, and 3-mm ring were compared between groups. Foveal avascular zone (FAZ) area, central subfield thickness (CST), macular ganglion cell-inner plexiform layer (GC-IPL) thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness were also compared.
    Results: Alzheimer's participants showed significantly decreased SCP VD and PD in the 3-mm ring (P = 0.001 and P = 0.002, respectively) and 3-mm circle (P = 0.003 and P = 0.004, respectively) and decreased SCP VD in the 6-mm circle (P = 0.047) compared with MCI and significantly decreased SCP VD and PD in the 3-mm ring (P = 0.008 and P = 0.004, respectively) and 3-mm circle (P = 0.015 and P = 0.009, respectively) and SCP PD in the 6-mm circle (P = 0.033) when compared with cognitively intact controls. There was no difference in SCP VD or PD between MCI and controls (P > 0.05). FAZ area and CST did not differ significantly between groups (P > 0.05). Alzheimer's participants showed significantly decreased GC-IPL thickness over the inferior (P = 0.032) and inferonasal (P = 0.025) sectors compared with MCI and significantly decreased GC-IPL thickness over the entire (P = 0.012), superonasal (P = 0.041), inferior (P = 0.004), and inferonasal (P = 0.006) sectors compared to controls. MCI participants showed significantly decreased temporal RNFL thickness (P = 0.04) compared with controls.
    Conclusions: Alzheimer's participants showed significantly reduced macular VD, PD, and GC-IPL thickness compared with MCI and controls. Changes in the retinal microvasculature may mirror small vessel cerebrovascular changes in AD.
    MeSH term(s) Aged ; Alzheimer Disease/complications ; Alzheimer Disease/diagnosis ; Alzheimer Disease/physiopathology ; Cerebrovascular Circulation ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/physiopathology ; Cross-Sectional Studies ; Female ; Fluorescein Angiography/methods ; Fundus Oculi ; Humans ; Male ; Microvessels/pathology ; Nerve Fibers/pathology ; Neuroimaging/methods ; Retinal Degeneration/diagnosis ; Retinal Degeneration/etiology ; Retinal Ganglion Cells/pathology ; Retinal Vessels/pathology ; Tomography, Optical Coherence/methods ; Visual Acuity
    Language English
    Publishing date 2019-03-11
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2019.02.002
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  10. Article ; Online: Correlation of OCTA and Volumetric MRI in Mild Cognitive Impairment and Alzheimer's Disease.

    Yoon, Stephen P / Thompson, Atalie C / Polascik, Bryce W / Calixte, Christopher / Burke, James R / Petrella, Jeffrey R / Grewal, Dilraj S / Fekrat, Sharon

    Ophthalmic surgery, lasers & imaging retina

    2019  Volume 50, Issue 11, Page(s) 709–718

    Abstract: Backgroud and objective: To evaluate the relationship between retinal microvascular parameters on optical coherence tomography angiography (OCTA) and neurodegenerative changes assessed by measurement of brain volume on volumetric magnetic resonance ... ...

    Abstract Backgroud and objective: To evaluate the relationship between retinal microvascular parameters on optical coherence tomography angiography (OCTA) and neurodegenerative changes assessed by measurement of brain volume on volumetric magnetic resonance imaging (MRI) in Alzheimer's disease (AD) and mild cognitive impairment (MCI).
    Patients and methods: Sixteen subjects with AD and MCI underwent OCTA imaging (3 mm × 3 mm and 6 mm × 6 mm scans) and volumetric brain MRI imaging with automated volumetric segmentation and quantification. Spearman's correlation (ρ) was performed between forebrain parenchyma, cortical gray matter, inferolateral ventricle (ILV), lateral ventricle (LV), and hippocampus (HP) MRI volumes and vessel density (VD), along with perfusion density (PD) for the 6-mm circle, 6-mm ring, 3-mm circle, and 3-mm ring Early Treatment Diabetic Retinopathy Study regions of the superficial capillary plexus.
    Results: Thirty eyes of 16 patients (seven MCI and nine AD) with good-quality OCTA images were analyzed. ILV volume inversely correlated with the VD in the 6-mm circle (ρ = -0 .565, P = .028) and 3-mm ring (ρ = -0.569, P = .027) and PD in the 3-mm ring (ρ = -0.605, P = .0169). Forebrain, cortical gray matter, LV, and HP volumes did not significantly correlate with either VD or PD (P > .05).
    Conclusions: In this pilot investigation, the authors found a significant correlation between reduction in the superficial capillary plexus VD and PD on OCTA and expansion of the ILV in MCI and AD. This relationship between the retinal microvasculature and cerebral volumetric changes deserves further investigation. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:709-718.].
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/pathology ; Brain/pathology ; Cognitive Dysfunction/pathology ; Cross-Sectional Studies ; Female ; Fluorescein Angiography/methods ; Humans ; Magnetic Resonance Imaging ; Male ; Microvessels/pathology ; Middle Aged ; Pilot Projects ; Regional Blood Flow ; Retinal Vessels/pathology ; Tomography, Optical Coherence/methods
    Language English
    Publishing date 2019-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701167-7
    ISSN 2325-8179 ; 2325-8160
    ISSN (online) 2325-8179
    ISSN 2325-8160
    DOI 10.3928/23258160-20191031-06
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