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Article ; Online: Restricted Eating in Preschoolers with Autism: Mother Stressors and Solutions.

Burkett, Karen / Haggard, Marissa-Li / Van Rafelghem, Dawn / Harpster, Karen

Journal of autism and developmental disorders

2021 Volume 52, Issue 6, Page(s) 2589–2597

Abstract: Feeding interventions for children with Autism Spectrum Disorder (ASD) focus solely on the child, not the family milieu. This qualitative study aimed to understand mothers' perspectives on managing restricted eating among preschoolers with ASD. Focus ... ...

Abstract	Feeding interventions for children with Autism Spectrum Disorder (ASD) focus solely on the child, not the family milieu. This qualitative study aimed to understand mothers' perspectives on managing restricted eating among preschoolers with ASD. Focus groups were conducted with eleven mothers of preschoolers with ASD. Audio recordings were transcribed, and data analyzed for themes. Mothers experienced stressors balancing priorities of adequate nutrition with family mealtime demands and found solutions in support from other mothers, strategies from a wide array of sources, and resorting to trial and error to improve eating. Healthcare practitioners should explore and consider family stressors, competing demands, and coping skills when recommending mealtime interventions for optimal child and family well-being.
MeSH term(s)	Adaptation, Psychological ; Autism Spectrum Disorder ; Autistic Disorder ; Child ; Female ; Humans ; Meals ; Mothers
Language	English
Publishing date	2021-06-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	391999-7
ISSN	1573-3432 ; 0162-3257
ISSN (online)	1573-3432
ISSN	0162-3257
DOI	10.1007/s10803-021-05078-6
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Article ; Online: Disparities Affect Developmental Risk for Head Start Preschoolers.

Burkett, Karen / Pickler, Rita / Bowers, Katherine / Folker, Ann E

Journal of pediatric nursing

2020 Volume 54, Page(s) 86–92

Abstract: Purpose: This paper presents an analysis of Head Start (HStart) preschooler data by severity of developmental concern, while considering socio-demographic and other factors that highlight racial and ethnic disparities in the early identification of ... ...

Abstract	Purpose: This paper presents an analysis of Head Start (HStart) preschooler data by severity of developmental concern, while considering socio-demographic and other factors that highlight racial and ethnic disparities in the early identification of developmental delay or disability (DD). Design and methods: We conducted an analysis of 2014-2015 academic year data for preschool-aged children in HStart in both urban and suburban centers in a large Midwestern city. Descriptive statistics were used to determine the prevalence of developmental concerns and compare characteristics of children with mild-to-moderate versus severe developmental concerns; differences between groups were compared using t-tests and chi-square tests. Multivariate logistic regression was used to determine the independent effect of each predictor of concern severity. Results: Nearly one-third of HStart preschoolers were identified with developmental concern; 70% were mild-to-moderate risk for DD and the remaining severe risk. Neither group was routinely referred to healthcare for evaluation or treatment, and most of the severe risk group did not qualify nor receive treatment for DD with an Individualized Education Plan. Suburban and urban preschoolers with severe concern were less likely to be African American or Latinx, suggesting that racially and ethnically diverse preschoolers in HStart may be under-identified and under-treated. Conclusions: Lags in the educational diagnosis of DD may mirror the disparities in diagnosis and treatment of DD among minority groups. Primary care is the first line for detection and treatment of DD, and offers a unique opportunity to act for racially and ethnically diverse HStart preschoolers disproportionately at-risk for DD.
MeSH term(s)	African Americans ; Chi-Square Distribution ; Child ; Child, Preschool ; Developmental Disabilities/diagnosis ; Developmental Disabilities/epidemiology ; Educational Status ; Ethnic Groups ; Healthcare Disparities ; Humans ; Minority Groups
Language	English
Publishing date	2020-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632731-x
ISSN	1532-8449 ; 0882-5963
ISSN (online)	1532-8449
ISSN	0882-5963
DOI	10.1016/j.pedn.2020.06.010
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Article ; Online: Latino-to-Latino: Promotores' Beliefs on Engaging Latino Participants in Autism Research.

Burkett, Karen / Kamimura-Nishimura, Kelly I / Suarez-Cano, Gabriela / Ferreira-Corso, Lorena / Jacquez, Farrah / Vaughn, Lisa M

Journal of racial and ethnic health disparities

2021 Volume 9, Issue 4, Page(s) 1125–1134

Abstract: Background: In Latino(a) communities, promotores de salud (i.e., community health workers; promotores) are becoming critical participants in prevention, health promotion, and the delivery of health care. Although involving culturally diverse ... ...

Abstract	Background: In Latino(a) communities, promotores de salud (i.e., community health workers; promotores) are becoming critical participants in prevention, health promotion, and the delivery of health care. Although involving culturally diverse participants in research is a national priority, recruitment and retention of research participants from these groups is challenging. Therefore, there is an increased need to identify strategies for successful recruitment of participants from underrepresented minority backgrounds. Our overall study purpose was to gain promotores' perspectives on recruiting Latino(a) immigrant community members for an intervention study on autism spectrum disorders (ASD). The goal of this paper is to explore insider promotores' views on the barriers and facilitators to research participation in the Latino(a) community and learn strategies for recruiting Latino(a) participants in a nontraditional destination city. Methods: We conducted qualitative focus groups with an established group of promotores known as Latinos Unidos por la Salud (LU-Salud), who were members of a community-academic research team. Fifteen LU-Salud promotores participated in the focus groups. Focus group interviews were analyzed by using Leininger's data analysis enabler. These results will inform our partnerships with promotores and Latino(a) neighborhood agencies to increase recruitment for community-based research on promoting awareness of ASD among Latino(a) families. Results: Promotores were credible community members able to gain community trust and committed to improving the health and well-being of their Latino(a) community, including involving them in research. Latino(a) research involvement meant facilitating community members' engagement to overcome barriers of distrust around legal and health care systems. Challenges included legal uncertainties, language and literacy barriers, health knowledge, and economic hardship. Promotores also voiced the diversity of cultural practices (subcultures) within the Latino(a) culture that influenced: (1) research engagement, (2) guidance from promotores, (3) immersion in the Latino(a) community, and (4) health and well-being. Experienced promotores, who are living in a nontraditional migration area, believe the primary facilitator to increasing research involvement is Latino(a)-to-Latino(a) recruitment. Conclusions: These findings will aid in building partnerships to recruit participants for future studies that promote early recognition of ASD in the Latino(a) community.
MeSH term(s)	Autistic Disorder ; Community Health Workers ; Emigrants and Immigrants ; Health Promotion ; Hispanic or Latino ; Humans
Language	English
Publishing date	2021-06-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2760524-3
ISSN	2196-8837 ; 2197-3792
ISSN (online)	2196-8837
ISSN	2197-3792
DOI	10.1007/s40615-021-01053-0
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Article ; Online: A sequence of methodological changes due to sequencing.

Burkett, Kelly / Greenwood, Celia

Current opinion in allergy and clinical immunology

2013 Volume 13, Issue 5, Page(s) 470–477

Abstract: Purpose of review: During the past 2 years, next-generation sequencing studies have revolutionized the field of genetic association studies. We review the concomitant evolution of statistical methods.: Recent findings: As much of the genetic ... ...

Abstract	Purpose of review: During the past 2 years, next-generation sequencing studies have revolutionized the field of genetic association studies. We review the concomitant evolution of statistical methods. Recent findings: As much of the genetic variability identified with sequencing is extremely rare, many new methods have been developed for rare variant association studies. Sequencing data available as a result of large public projects are also being integrated with genome-wide association study (GWAS) chip data to improve genotype imputation. A further trend in recent methodological development has been the use of the linear mixed effect model (LMM). LMMs are used for rare variant association to handle effect heterogeneity. They are also used more generally in GWAS to account for population structure. Summary: Many rare variant association tests have been developed to analyze the genetic variation discovered with large-scale DNA sequencing; however, no single approach outperforms others under all disease models and power tends to be low. Sequencing data are also contributing to improved imputation of uncommon genetic variants, although imputation of rare variants remains a challenge. The appropriate correction for population structure in rare variant analyses remains unclear; specialized adjustment techniques may be necessary.
MeSH term(s)	Analysis of Variance ; Animals ; Genome-Wide Association Study ; Genotype ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Models, Statistical ; Polymorphism, Genetic ; Research Design
Language	English
Publishing date	2013-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0b013e3283648f68
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Article ; Online: Encouraging Our NICU to "Read-a-Latte": Leveraging a Read-a-Thon to Launch a Quality Improvement Initiative.

Latif, Marina / Duarte Ribeiro, Ana Paula / Blatz, Mary Ann / Burkett, Kathleen / Dragon, Mary Ann / Craver, Traci / Cogan, Stacie / Ricciardi, Sheri / Weber, Ashley

Advances in neonatal care : official journal of the National Association of Neonatal Nurses

2022 Volume 23, Issue 2, Page(s) 120–131

Abstract: Background: Preterm infants have known impairments in language development relative to infants born at full term, and the language-poor environment of the neonatal intensive care unit (NICU) is a contributing factor. Adapting outpatient literacy ... ...

Abstract	Background: Preterm infants have known impairments in language development relative to infants born at full term, and the language-poor environment of the neonatal intensive care unit (NICU) is a contributing factor. Adapting outpatient literacy programs for the NICU is a potential evidence-based intervention to encourage adult speech exposure to infants through reading sessions during NICU hospitalization. Purpose: To evaluate implementation of a 10-day NICU Read-a-Thon and potential barriers and facilitators of a year-round program aimed at increasing reading sessions for NICU patients. Methods: We established an implementation team to execute a Read-a-Thon and evaluated its impact utilizing quantitative and qualitative approaches. Quantitative methodology was used to report number of donated books and infant reading sessions. Qualitative methodology inclusive of interviews, surveys, and source document reviews was used to evaluate the Read-a-Thon. Results: We received approximately 1300 donated books and logged 663 reading sessions over the 10-day Read-a-Thon. Qualitative evaluation of the Read-a-Thon identified 6 main themes: motivation, emotional response to the program, benefits and outcomes, barriers, facilitators, and future of literacy promotion in our NICU. Our evaluation informed specific aims for improvement (eg, maintaining book accessibility) for a quality improvement initiative to sustain a year-round reading program. Implications for practice and research: Neonatal units can leverage Read-a-Thons as small tests of change to evaluate barriers, facilitators, and change processes needed to implement reading programs. Process maps of book inventory and conducting a 5 W's, 2 H's (who, what, when, where, why, how, how much) assessment can aid in program planning.
MeSH term(s)	Infant ; Adult ; Infant, Newborn ; Humans ; Intensive Care Units, Neonatal ; Infant, Premature ; Reading ; Quality Improvement ; Hospitalization
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171013-2
ISSN	1536-0911 ; 1536-0903
ISSN (online)	1536-0911
ISSN	1536-0903
DOI	10.1097/ANC.0000000000001038
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Article ; Online: Long-Term Outcomes in Macular Telangiectasia Type 2 With Subretinal Neovascularization.

Bottini, Alexander R / Blackorby, Barton L / Michaels, Madelyn / Burkett, Katherine / Dang, Sabin / Blinder, Kevin J / Shah, Gaurav K

Journal of vitreoretinal diseases

2020 Volume 4, Issue 5, Page(s) 386–392

Abstract: Purpose: This work reports long-term outcomes in macular telangiectasia type 2 (MacTel) with subretinal neovascularization (SRNV).: Methods: A retrospective, single-center review of medical records was performed on all patients with a diagnosis of ... ...

Abstract	Purpose: This work reports long-term outcomes in macular telangiectasia type 2 (MacTel) with subretinal neovascularization (SRNV). Methods: A retrospective, single-center review of medical records was performed on all patients with a diagnosis of MacTel presenting between May 2004 and October 2019. Medical and ocular history, best-corrected visual acuity (BCVA) at baseline and final visit, optical coherence tomography data, and treatment history of SRNV secondary to MacTel were recorded. Results: A total of 471 eyes were diagnosed with MacTel. SRNV was present in 44 eyes (9.3%), of which 38 eyes met inclusion criteria for SRNV. Average follow-up duration in the SRNV group was 78.4 months. All SRNV patients underwent antivascular endothelial growth factor (anti-VEGF) therapy. There was no significant change from mean baseline (0.59 ± 0.45) to final (0.70 ± 0.49) BCVA in the SRNV group as a whole ( Conclusions: Visual acuity is maintained, not improved, in long-term follow-up of MacTel with SRNV treated with anti-VEGF. Patients presenting with SRNV have a worse prognosis than those who develop SRNV during follow-up.
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Journal Article
ISSN	2474-1272
ISSN (online)	2474-1272
DOI	10.1177/2474126420927149
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Article ; Online: Biochemometric Analysis of Fatty Acid Amide Hydrolase Inhibition by Echinacea Root Extracts.

Liu, Rui / Burkett, Kelly / Rapinski, Michel / Arnason, John T / Johnson, Franklin / Hintz, Phil / Baker, John / Harris, Cory S

Planta medica

2020 Volume 87, Issue 4, Page(s) 294–304

Abstract: Recent research demonstrates that Echinacea possesses cannabimimetic activity with potential applications beyond common contemporary uses for relief of cold and flu symptoms. In this study, we investigated ... ...

Abstract	Recent research demonstrates that Echinacea possesses cannabimimetic activity with potential applications beyond common contemporary uses for relief of cold and flu symptoms. In this study, we investigated the
MeSH term(s)	Amidohydrolases/genetics ; Chromatography, High Pressure Liquid ; Echinacea ; Plant Extracts/pharmacology
Chemical Substances	Plant Extracts ; Amidohydrolases (EC 3.5.-) ; fatty-acid amide hydrolase (EC 3.5.1.-)
Language	English
Publishing date	2020-12-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123545-x
ISSN	1439-0221 ; 0032-0943
ISSN (online)	1439-0221
ISSN	0032-0943
DOI	10.1055/a-1289-9569
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Article ; Online: Translating Research to Practice for Children With Autism Spectrum Disorder: Part I: Definition, Associated Behaviors, Prevalence, Diagnostic Process, and Interventions.

Johnson, Norah L / Burkett, Karen / Reinhold, Judy / Bultas, Margaret W

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2016 Volume 30, Issue 1, Page(s) 15–26

Abstract: Introduction: The number of children with autism spectrum disorder (ASD) is rising, along with the potential for challenging behaviors during health care encounters.: Method: We present an overview of the emerging science related to ASD diagnosis and ...

Abstract	Introduction: The number of children with autism spectrum disorder (ASD) is rising, along with the potential for challenging behaviors during health care encounters. Method: We present an overview of the emerging science related to ASD diagnosis and interventions for children with ASD. Results: Emerging science on ASD reveals common associated challenging behaviors, increasing prevalence, emphasis on early diagnosis at 18 to 24 months of age, changes in the diagnostic process with criteria from the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, and interventions with medication, education, and behavior management. Discussion: Family and health care provider preparation strategies facilitate care of children with ASD and their families. Early diagnosis at 18 to 24 months of age and evidence-based interventions contribute to best outcomes for children and families. Health care providers must be aware of the state of the science for diagnosis and best practices to provide family-centered care for this growing population.
MeSH term(s)	Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/therapy ; Child ; Child, Preschool ; Humans ; Prevalence ; Translational Medical Research
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036356-7
ISSN	1532-656X ; 0891-5245
ISSN (online)	1532-656X
ISSN	0891-5245
DOI	10.1016/j.pedhc.2015.09.008
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Article ; Online: Translating Research to Practice for Children With Autism Spectrum Disorder: Part 2: Behavior Management in Home and Health Care Settings.

Bultas, Margaret W / Johnson, Norah L / Burkett, Karen / Reinhold, Judy

Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners

2016 Volume 30, Issue 1, Page(s) 27–37

Abstract: Introduction: Managing home and health care for children with autism spectrum disorder can be challenging because of the range of symptoms and behaviors exhibited.: Method: This article presents an overview of the emerging science related to the ... ...

Abstract	Introduction: Managing home and health care for children with autism spectrum disorder can be challenging because of the range of symptoms and behaviors exhibited. Method: This article presents an overview of the emerging science related to the methods to foster family self-management of common concerns regarding activities of daily living and behaviors, as well as for the health care provider in primary and acute health care settings. Results: Recommendations are provided to enhance the overall delivery of services, including understanding and managing a child's challenging behaviors, and supporting family management of common activities of daily living and behaviors. Discussion: Health care providers' knowledge of evidence-based recommendations for providing care, supporting family self-management of common concerns, and referral heighten the likelihood of better outcomes for children with autism spectrum disorder.
MeSH term(s)	Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/epidemiology ; Autism Spectrum Disorder/therapy ; Child ; Child, Preschool ; Home Care Services/organization & administration ; Humans ; Mental Health Services/organization & administration ; Prevalence ; Translational Medical Research
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036356-7
ISSN	1532-656X ; 0891-5245
ISSN (online)	1532-656X
ISSN	0891-5245
DOI	10.1016/j.pedhc.2015.09.009
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Article ; Online: Type I Hypersensitivity in Ferrets Following Exposure to SARS-CoV-2 Inoculum: Lessons Learned.

Layton, Daniel / Burkett, Kathie / Marsh, Glenn A / Singanallur, Nagendrakumar B / Barr, Jennifer / Layton, Rachel / Riddell, Sarah-Jane / Brown, Sheree / Trinidad, Lee / Au, Gough G / McAuley, Alexander J / Lowther, Suzanne / Watson, James / Vasan, Seshadri S

ILAR journal

2021 Volume 62, Issue 1-2, Page(s) 232–237

Abstract: This case report discusses Type I hypersensitivity in ferrets following exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculum, observed during a study investigating the efficacy of candidate COVID-19 vaccines. Following a ... ...

Abstract	This case report discusses Type I hypersensitivity in ferrets following exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculum, observed during a study investigating the efficacy of candidate COVID-19 vaccines. Following a comprehensive internal root-cause investigation, it was hypothesized that prior prime-boost immunization of ferrets with a commercial canine C3 vaccine to protect against the canine distemper virus had resulted in primary immune response to fetal bovine serum (FBS) in the C3 preparation. Upon intranasal exposure to SARS-CoV-2 virus cultured in medium containing FBS, an allergic airway response occurred in 6 out of 56 of the ferrets. The 6 impacted ferrets were randomly dispersed across study groups, including different COVID-19 vaccine candidates, routes of vaccine candidate administration, and controls (placebo). The root-cause investigation and subsequent analysis determined that the allergic reaction was unrelated to the COVID-19 vaccine candidates under evaluation. Histological assessment suggested that the allergic response was characterized by eosinophilic airway disease; increased serum immunoglobulin levels reactive to FBS further suggested this response was caused by immune priming to FBS present in the C3 vaccine. This was further supported by in vivo studies demonstrating ferrets administered diluted FBS also presented clinical signs consistent with a hyperallergic response, while clinical signs were absent in ferrets that received a serum-free SARS-CoV-2 inoculum. It is therefore recommended that vaccine studies in higher order animals should consider the impact of welfare vaccination and use serum-free inoculum whenever possible.
MeSH term(s)	Animals ; COVID-19 ; COVID-19 Vaccines ; Dogs ; Ferrets ; Hypersensitivity, Immediate ; SARS-CoV-2 ; Viral Vaccines
Chemical Substances	COVID-19 Vaccines ; Viral Vaccines
Language	English
Publishing date	2021-05-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2192062-X
ISSN	1930-6180 ; 1084-2020
ISSN (online)	1930-6180
ISSN	1084-2020
DOI	10.1093/ilar/ilab019
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