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  1. Article ; Online: Psychedelic-like Activity of Norpsilocin Analogues.

    Sherwood, Alexander M / Burkhartzmeyer, Elise K / Williamson, Samuel E / Baumann, Michael H / Glatfelter, Grant C

    ACS chemical neuroscience

    2024  Volume 15, Issue 2, Page(s) 315–327

    Abstract: Primary metabolites of mushroom tryptamines, psilocybin and baeocystin (i.e., psilocin and norpsilocin), exhibit potent agonist activity at the serotonin 2A receptor (5- ... ...

    Abstract Primary metabolites of mushroom tryptamines, psilocybin and baeocystin (i.e., psilocin and norpsilocin), exhibit potent agonist activity at the serotonin 2A receptor (5-HT
    MeSH term(s) Mice ; Animals ; Hallucinogens/chemistry ; Serotonin/metabolism ; Receptors, Serotonin/metabolism ; Brain/metabolism ; Receptor, Serotonin, 5-HT2A/metabolism
    Chemical Substances Hallucinogens ; omega-N-methyl-4-hydroxytryptamine ; Serotonin (333DO1RDJY) ; Receptors, Serotonin ; Receptor, Serotonin, 5-HT2A
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.3c00610
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Swim in the Chiral Pool: MDMA and MDA Enantiomers from Alanine-Derived Precursors.

    Sherwood, Alexander M / Burkhartzmeyer, Elise K / Williamson, Samuel E / Faley, Michael T

    ACS omega

    2023  Volume 8, Issue 24, Page(s) 22132–22137

    Abstract: A divergent two-step process has provided access to optically pure enantiomers of MDMA and MDA, clinically relevant phenylisopropylamine entactogens. Target compounds were synthesized from commercially available alanine-derived aziridines. Critical ... ...

    Abstract A divergent two-step process has provided access to optically pure enantiomers of MDMA and MDA, clinically relevant phenylisopropylamine entactogens. Target compounds were synthesized from commercially available alanine-derived aziridines. Critical process parameters were identified, and the reactions were optimized to avoid chromatographic purifications toward gram-scale isolations, providing (
    Language English
    Publishing date 2023-06-06
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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