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Article ; Online: An Unusual Presentation of Choriocarcinoma in a Postmenopausal Woman: A case report.

Zribi, Aref / Mazroui, Reem Al / Sayani, Raza / Burney, Ikram A

Sultan Qaboos University medical journal

2024 Volume 24, Issue 1, Page(s) 135–138

Abstract: Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasise to distant organs. Limited case of gestational CC develops after a long latent period. We report a 52-year-old postmenopausal woman who developed ... ...

Abstract	Choriocarcinoma (CC) is a malignant neoplasm of the trophoblastic tissue, with a potential to metastasise to distant organs. Limited case of gestational CC develops after a long latent period. We report a 52-year-old postmenopausal woman who developed metastatic choriocarcinoma presumably of gestational origin, 8 years after the last pregnancy and 2 years after the last menstrual period. The patient was brought to the emergency room of a tertiary care centre in Muscat, Oman, in 2022 and was diagnosed with CC metastatic to the brain, spleen, lung and the kidney. The β-human chorionic gonadotrophin level was found to be raised (1,292,867 mIU/mL). The International Federation of Gynecologic Oncology risk score was calculated to be 14 (very high risk). The patient was initially treated with whole-brain radiotherapy and splenic artery embolisation because of a hemoperitoneum. Afterwards the patient received systemic treatment using the standard EMA/CO regimen till complete serological remission.
MeSH term(s)	Pregnancy ; Humans ; Female ; Middle Aged ; Postmenopause ; Choriocarcinoma/diagnosis ; Embolization, Therapeutic ; Emergency Service, Hospital ; Hemoperitoneum
Language	English
Publishing date	2024-02-28
Publishing country	Oman
Document type	Case Reports
ZDB-ID	2650196-X
ISSN	2075-0528 ; 2075-0528
ISSN (online)	2075-0528
ISSN	2075-0528
DOI	10.18295/squmj.5.2023.036
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Immunotherapy in Cancer: Incremental Gain or a Quantum Leap?

Burney, Ikram A

Oman medical journal

2016 Volume 32, Issue 1, Page(s) 1–2

Language	English
Publishing date	2016-12-09
Publishing country	Oman
Document type	Editorial
ZDB-ID	2571431-4
ISSN	2070-5204 ; 1999-768X
ISSN (online)	2070-5204
ISSN	1999-768X
DOI	10.5001/omj.2017.01
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Article ; Online: Successful Treatment of a Case of Crescentic Glomerulonephritis in a Patient with Primary Peritoneal Carcinoma: A case report.

Zribi, Aref / Nagy, Amro / Riyami, Marwa Al / Burney, Ikram A

Sultan Qaboos University medical journal

2022 Volume 24, Issue 1, Page(s) 119–122

Abstract: Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to ...

Abstract	Crescentic glomerulonephritis has been associated with several solid tumour malignancies. Only a few cases of nephropathy have been reported in association with tubo-ovarian/peritoneal malignancies. We report a 55-year-old female patient who presented to a tertiary care centre, Muscat, Oman, in 2022. She developed combined immune complex-mediated glomerulonephritis and pauci-immune necrotising crescentic vasculitis simultaneously with the diagnosis of tubo-ovarian/peritoneal cancer. The baseline estimated glomerular filtration rate (eGFR) was 13 mL/min. The patient received two doses of rituximab and three doses of pulse corticosteroids, leading to significant improvement in renal function and the disappearance of her proteinuria. The eGFR improved to >60mL/min; her proteinuria gradually resolved after 10 weeks of treatment. She was then given a combination chemotherapy treatment for tubo-ovarian/peritoneal cancer leading to a normalisation of her CA-125 after three months of therapy.
MeSH term(s)	Female ; Humans ; Middle Aged ; Patients ; Glomerulonephritis/drug therapy ; CA-125 Antigen ; Proteinuria ; Carcinoma
Chemical Substances	CA-125 Antigen
Language	English
Publishing date	2022-09-11
Publishing country	Oman
Document type	Case Reports
ZDB-ID	2650196-X
ISSN	2075-0528 ; 2075-0528
ISSN (online)	2075-0528
ISSN	2075-0528
DOI	10.18295/squmj.1.2023.013
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Article: Evolution of the Management of Brain Metastases: A Bibliometric Analysis.

Burney, Ikram A / Aal Hamad, Aya H / Hashmi, Syed F A / Ahmad, Nisar / Pervez, Nadeem

Cancers

2023 Volume 15, Issue 23

Abstract: A systematic review of the published literature was conducted to analyze the management evolution of brain metastases from different cancers. Using the keywords "brain metastasis", "brain metastases", "CNS metastasis", "CNS metastases", "phase III" AND/ ... ...

Abstract	A systematic review of the published literature was conducted to analyze the management evolution of brain metastases from different cancers. Using the keywords "brain metastasis", "brain metastases", "CNS metastasis", "CNS metastases", "phase III" AND/OR "Randomized Controlled Trial" (RCT), relevant articles were searched for on the SCOPUS database. A total of 1986 articles were retrieved, published over a 45-year period (1977-2022). Relevant articles were defined as clinical studies describing the treatment or prevention of brain metastases from any cancer. Articles on imaging, quality of life, cognitive impairment after treatment, or primary brain tumors were excluded. After a secondary analysis, reviewing the abstracts and/or full texts, 724 articles were found to be relevant. Publications significantly increased in the last 10 years. A total of 252 articles (34.8%) were published in 12 core journals, receiving 50% of the citations. The number of publications in Frontiers in Oncology, BMC Cancer, and Radiotherapy and Oncology have increased considerably over the last few years. There were 111 randomized controlled trials, 128 review articles, and 63 meta-analyses. Most randomized trials reported on brain metastases management from unselected tumors (49), lung cancer (47), or breast cancer (11). In the last 5 years (2017 to 2022), management of brain metastasis has moved on from WBRT, the use of chemotherapy, and radio-sensitization to three directions. First, Radiosurgery or Radiotherapy (SRS/SRT), or hippocampal-sparing WBRT is employed to reduce radiation toxicity. Second, it has moved to the use of novel agents, such as tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICI) and third, to the use of molecularly directed therapy such as TKIs, in asymptomatic low volume metastasis, obviating the need for WBRT.
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15235570
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Article: Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma.

Othman, Anjum / Kumar, Shiyam / Qureshi, Asim / Jawa, Zabah M / Burney, Ikram A

Case reports in oncology

2023 Volume 16, Issue 1, Page(s) 234–242

Abstract: Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with metastatic tubulocystic RCC whose disease progressed ... ...

Abstract	Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with metastatic tubulocystic RCC whose disease progressed through standard of care treatment for nonclear RCC. However, genetic analysis revealed a germline pathogenic variant of fumarate hydratase (FH) gene, and the patient had a sustained and durable response to pazopanib.
Language	English
Publishing date	2023-04-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2458961-5
ISSN	1662-6575
ISSN	1662-6575
DOI	10.1159/000528697
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Article ; Online: Complete Response to Sorafenib in Locally Recurrent Unresectable Aggressive Fibromatosis.

Burney, Ikram A / Kakaria, Anupam K / Al-Jahdhami, Suad

Sultan Qaboos University medical journal

2021 Volume 21, Issue 2, Page(s) e327–e328

MeSH term(s)	Fibromatosis, Aggressive/drug therapy ; Humans ; Neoplasm Recurrence, Local ; Sorafenib/pharmacology ; Sorafenib/therapeutic use
Chemical Substances	Sorafenib (9ZOQ3TZI87)
Language	English
Publishing date	2021-06-21
Publishing country	Oman
Document type	Journal Article
ZDB-ID	2650196-X
ISSN	2075-0528 ; 2075-0528
ISSN (online)	2075-0528
ISSN	2075-0528
DOI	10.18295/squmj.2021.21.02.027
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Article: Clinicopathological Features, Treatment, and Outcome of Omani Patients with Metastatic Prostate Cancer.

Kumar, Shiyam / Burney, Ikram A / Kunju, Joseph / Al-Marhoon, Mohammed Salim / Siddiqui, Khurrum Mutahir

Oman medical journal

2022 Volume 37, Issue 1, Page(s) e333

Abstract: Objectives: Prostate cancer (PCa) is the third most common cancer worldwide, with its incidence rising in the Middle East. There is a paucity of data about the clinicopathological features and outcomes of metastatic prostate cancer (mPCa) from the ... ...

Abstract	Objectives: Prostate cancer (PCa) is the third most common cancer worldwide, with its incidence rising in the Middle East. There is a paucity of data about the clinicopathological features and outcomes of metastatic prostate cancer (mPCa) from the Middle East. We report the outcomes of mPCa from Oman. Methods: We recruited consecutive men diagnosed with mPCa and treated at Sultan Qaboos University Hospital in Oman between January 2006 and December 2017. Information about demographics, clinical, laboratory, pathological, and radiological features at presentation, treatment, and survival outcomes was collected. Data were gathered until April 2019 or until the patient's death for progression-free survival (PFS) and overall survival (OS), whichever came first. Survival rates were estimated using the Kaplan-Meier method. Univariate and multivariate analysis and Cox regression analyses were performed to study factors affecting the PFS and the OS. Results: Of the 239 men diagnosed with PCa over the study period, 62 were diagnosed with mPCa. The median age was 71 (range = 57-92) years. The majority of patients (61.3%) had a Gleason score ≥ 8. Median prostate-specific antigen (PSA) level was 100.0. Bone was the most common site of metastatic disease (90.3%). The majority of patients with the hormone-sensitive disease were treated with testosterone suppression only, while abiraterone, enzalutamide, and docetaxel were added for treating metastatic castration-resistant mPCa (mCRPC). After a median follow-up of 34.5 months, the median PFS was 17 months, while the median OS was 43 months. Median survival post mCRPC was 17 months. Conclusions: Omani patients with mPCa present with high PSA and Gleason score and with widespread metastatic disease burden. Treatments offered are according to internationally accepted standards and have comparable PFS and OS as reported elsewhere.
Language	English
Publishing date	2022-01-31
Publishing country	Oman
Document type	Journal Article
ZDB-ID	2571431-4
ISSN	2070-5204 ; 1999-768X
ISSN (online)	2070-5204
ISSN	1999-768X
DOI	10.5001/omj.2021.117
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Article: The Prevalence and Patterns of Toxicity With Immune Checkpoint Inhibitors in Solid Tumors: A Real-World Experience From a Tertiary Care Center in Oman.

Salman, Bushra / AlWard, Nameer M / Al-Hashami, Zamzam / Al-Sharqi, Hadil / Al-Sayegh, Hasan / Burney, Ikram A

Cureus

2023 Volume 15, Issue 10, Page(s) e47050

Abstract: Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the management of multiple cancers over the last decade. They work by employing the immune system and exhibiting activity over T cells resulting in immune upregulation. Despite their ... ...

Abstract	Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the management of multiple cancers over the last decade. They work by employing the immune system and exhibiting activity over T cells resulting in immune upregulation. Despite their widespread use, they produce side effects that can limit their use. The immune-related adverse events (irAEs) can be sometimes significant. The irAEs caused by ICIs may occur at any time during the treatment and can vary in grade (G). We sought to study the prevalence and toxicity patterns of ICIs in Oman. Methods One hundred forty-one adult patients (≥18 years) who received at least one dose of nivolumab, pembrolizumab, atezolizumab, or durvalumab between 2016 and 2022 were included. The data were analyzed retrospectively using univariable and multiple-variable logistic regressions. The Wilcoxon rank-sum test and Cochran-Armitage trend test were also used to summarize the continuous and ordinal data. Results Out of the 141 patients, 80 patients (56.7%) received pembrolizumab, and 48 (34%) received nivolumab. Common irAEs included endocrine abnormalities, pneumonitis, and colitis. Thirty patients (21.3%) experienced varying irAE grade toxicity. Out of the 30, 23 patients (82%) developed grade 2 and 3 irAEs. Discussion Predictive analysis showed that male sex and lower hemoglobin (Hb) and bilirubin levels were all significant predictors (p < 0.05) when associated with irAE occurrence. The prevalence of irAEs was similar compared to other reports, literature reviews, or meta-analyses. Female sex has been mentioned previously also to be a predictive factor for endocrine-related toxicities.
Language	English
Publishing date	2023-10-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47050
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Article ; Online: Direct and Moderating Effects of Work Environment and Structural Empowerment on Job Stress and Job Satisfaction Among Nurses in Oman.

AbuAlRub, Raeda / Al Sabei, Sulaiman D / Al-Rawajfah, Omar / Labrague, Leodoro J / Burney, Ikram A

Sultan Qaboos University medical journal

2023 Volume 23, Issue 4, Page(s) 485–492

Abstract: Objectives: This study aimed to explore the relationships between nurses' work environment, job stress and job satisfaction, along with the moderating effects of work environment and empowerment on the relationship between job stress and job ... ...

Abstract	Objectives: This study aimed to explore the relationships between nurses' work environment, job stress and job satisfaction, along with the moderating effects of work environment and empowerment on the relationship between job stress and job satisfaction. Methods: A descriptive correlational design was utilised for this study. The study encompassed a convenience sample of 1,796 hospital nurses from the 11 governorates in Oman. Moreover, a self-report questionnaire that included a set of instruments was used to collect the data. Results: Nurses who perceived higher levels of job stress reported lower levels of satisfaction and empowerment and perceived their work environment as less favourable and supportive. The findings only confirmed the direct effects of work environment and empowerment on satisfaction, whereas no support was found for indirect or moderating effects. Furthermore, the hierarchical regression model showed that 46.5% of the variation in the level of job satisfaction was explained by the study variables. Conclusion: The results of this study demonstrate the importance of implementing strategies that empower staff, provide a supportive and positive work environment and tackle job stress to enhance levels of job satisfaction.
MeSH term(s)	Humans ; Job Satisfaction ; Oman ; Cross-Sectional Studies ; Occupational Stress ; Working Conditions
Language	English
Publishing date	2023-11-30
Publishing country	Oman
Document type	Journal Article
ZDB-ID	2650196-X
ISSN	2075-0528 ; 2075-0528
ISSN (online)	2075-0528
ISSN	2075-0528
DOI	10.18295/squmj.5.2023.031
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Article ; Online: Determinants of Physicians' Job Satisfaction: A national multi-centre study from the Sultanate of Oman.

Burney, Ikram A / Al Sabei, Sulaiman D / Al-Rawajfah, Omar / Labrague, Leodoro J / AbuAlrub, Raeda

Sultan Qaboos University medical journal

2023 Volume 23, Issue 2, Page(s) 198–205

Abstract: Objectives: This study aimed to examine and assess job satisfaction of physicians across several factors, such as quality of care, ease of practice, relationship with leadership and inter-professional collaboration.: Methods: The data for this ... ...

Abstract	Objectives: This study aimed to examine and assess job satisfaction of physicians across several factors, such as quality of care, ease of practice, relationship with leadership and inter-professional collaboration. Methods: The data for this descriptive cross-sectional study were collected between July 2019 and January 2020. Participants provided demographic information and completed surveys related to physician job satisfaction and inter-professional collaboration. Multiple linear regressions were used to determine the relationship between overall job satisfaction and demographic features and inter-professional collaboration. Results: Out of the 396 physicians contacted, 354 responded (response rate: 89.4%). Results showed that out of the 354 physicians, 4.3% were not satisfied with their jobs, 36.5% expressed a moderate level of satisfaction and 59.2% were highly satisfied. There was no difference in the mean job satisfaction score among different groups of study participants, except for gender and the working grade ( Conclusion: Overall, the job satisfaction rate was high. There was no difference among different groups of study participants, except for the working grade. Having a clinical postgraduate degree, a senior level of responsibility and good inter-professional relationship were associated with higher job satisfaction rates. The overall job satisfaction rates were higher for the quality of care and for ease of practice and lower for relationship with the leadership. Relationship with leadership is a modifiable factor and efforts at enhancing the physician-leadership relationship may lead to even higher satisfaction rates.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Oman ; Physicians ; Surveys and Questionnaires ; Job Satisfaction
Language	English
Publishing date	2023-05-31
Publishing country	Oman
Document type	Multicenter Study ; Journal Article
ZDB-ID	2650196-X
ISSN	2075-0528 ; 2075-0528
ISSN (online)	2075-0528
ISSN	2075-0528
DOI	10.18295/squmj.8.2022.050
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