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  1. Article ; Online: La recherche cancérologique en communauté française de Belgique.

    Burny, Arsène

    Bulletin du cancer

    2008  Volume 95, Issue 3, Page(s) 269–270

    Abstract: The author examines the status of cancer research in the French speaking community in Belgium. ...

    Title translation Cancer research in the French speaking community in Belgium.
    Abstract The author examines the status of cancer research in the French speaking community in Belgium.
    MeSH term(s) Belgium ; Humans ; Immunotherapy ; Language ; Neoplasm Metastasis ; Neoplasms/blood supply ; Neoplasms/psychology ; Neoplasms/therapy ; Neovascularization, Pathologic ; Psychotherapy ; Radiotherapy ; Research ; Research Support as Topic ; Stem Cells
    Language French
    Publishing date 2008-03
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Mesenchymal Stem/Stromal Cells as a Therapeutic Tool in Cell-Based Therapy and Regenerative Medicine: An Introduction Expertise to the Topical Collection.

    Merimi, Makram / Fahmi, Hassan / De Kock, Joery / Beguin, Charline / Burny, Arsène / Moll, Guido / Poggi, Alessandro / Najar, Mehdi

    Cells

    2022  Volume 11, Issue 19

    Abstract: We are pleased to present this opening editorial, introducing our topical collection, "The New Era of Mesenchymal Stromal/Stem Cell Functional Application: State of the Art, Therapeutic Challenges and Future Directions" [ ... ]. ...

    Abstract We are pleased to present this opening editorial, introducing our topical collection, "The New Era of Mesenchymal Stromal/Stem Cell Functional Application: State of the Art, Therapeutic Challenges and Future Directions" [...].
    MeSH term(s) Cell- and Tissue-Based Therapy ; Mesenchymal Stem Cells/physiology ; Regenerative Medicine
    Language English
    Publishing date 2022-10-08
    Publishing country Switzerland
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11193158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: IFNα induces CCR5 in CD4

    Le Buanec, Hélène / Schiavon, Valérie / Merandet, Marine / How-Kit, Alexandre / Song, Hongshuo / Bergerat, David / Fombellida-Lopez, Céline / Bensussan, Armand / Bouaziz, Jean-David / Burny, Arsène / Darcis, Gilles / Sajadi, Mohammad M / Kottilil, Shyamasundaran / Zagury, Daniel / Gallo, Robert C

    Communications medicine

    2024  Volume 4, Issue 1, Page(s) 52

    Abstract: Background: Among people living with HIV, elite controllers (ECs) maintain an undetectable viral load, even without receiving anti-HIV therapy. In non-EC patients, this therapy leads to marked improvement, including in immune parameters, but unlike ECs, ...

    Abstract Background: Among people living with HIV, elite controllers (ECs) maintain an undetectable viral load, even without receiving anti-HIV therapy. In non-EC patients, this therapy leads to marked improvement, including in immune parameters, but unlike ECs, non-EC patients still require ongoing treatment and experience co-morbidities. In-depth, comprehensive immune analyses comparing EC and treated non-EC patients may reveal subtle, consistent differences. This comparison could clarify whether elevated circulating interferon-alpha (IFNα) promotes widespread immune cell alterations and persists post-therapy, furthering understanding of why non-EC patients continue to need treatment.
    Methods: Levels of IFNα in HIV-infected EC and treated non-EC patients were compared, along with blood immune cell subset distribution and phenotype, and functional capacities in some cases. In addition, we assessed mechanisms potentially associated with IFNα overload.
    Results: Treatment of non-EC patients results in restoration of IFNα control, followed by marked improvement in distribution numbers, phenotypic profiles of blood immune cells, and functional capacity. These changes still do not lead to EC status, however, and IFNα can induce these changes in normal immune cell counterparts in vitro. Hypothesizing that persistent alterations could arise from inalterable effects of IFNα at infection onset, we verified an IFNα-related mechanism. The protein induces the HIV coreceptor CCR5, boosting HIV infection and reducing the effects of anti-HIV therapies. EC patients may avoid elevated IFNα following on infection with a lower inoculum of HIV or because of some unidentified genetic factor.
    Conclusions: Early control of IFNα is essential for better prognosis of HIV-infected patients.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-024-00453-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Early elevated IFNα is a key mediator of HIV pathogenesis.

    Buanec, Hélène Le / Schiavon, Valérie / Merandet, Marine / How-Kit, Alexandre / Bergerat, David / Fombellida-Lopez, Céline / Bensussan, Armand / Bouaziz, Jean-David / Burny, Arsène / Darcis, Gilles / Song, Hongshuo / Sajadi, Mohammad M / Kottilil, Shyamasundaran / Gallo, Robert C / Zagury, Daniel

    Communications medicine

    2024  Volume 4, Issue 1, Page(s) 53

    Abstract: Background: A complete understanding of the different steps of HIV replication and an effective drug combination have led to modern antiretroviral regimens that block HIV replication for decades, but these therapies are not curative and must be taken ... ...

    Abstract Background: A complete understanding of the different steps of HIV replication and an effective drug combination have led to modern antiretroviral regimens that block HIV replication for decades, but these therapies are not curative and must be taken for life. "Elite controllers" (ECs) is a term for the 0.5% of HIV-infected persons requiring no antiretroviral therapy, whose status may point the way toward a functional HIV cure. Defining the mechanisms of this control may be key to understanding how to replicate this functional cure in others.
    Methods: In ECs and untreated non-EC patients, we compared IFNα serum concentration, distribution of immune cell subsets, and frequency of cell markers associated with immune dysfunction. We also investigated the effect of an elevated dose of IFNα on distinct subsets within dendritic cells, natural killer cells, and CD4+ and CD8 + T cells.
    Results: Serum IFNα was undetectable in ECs, but all immune cell subsets from untreated non-EC patients were structurally and functionally impaired. We also show that the altered phenotype and function of these cell subsets in non-EC patients can be recapitulated when cells are stimulated in vitro with high-dose IFNα.
    Conclusions: Elevated IFNα is a key mediator of HIV pathogenesis.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-024-00454-6
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  5. Article: Early Elevated IFNα Identified as the Key Mediator of HIV Pathogenesis and its low level a Hallmark of Elite Controllers.

    Le Buanec, Hélène / Schiavon, Valérie / Merandet, Marine / How-Kit, Alexandre / Bergerat, David / Fombellida-Lopez, Céline / Bensussan, Armand / Bouaziz, Jean-David / Burny, Arsène / Darcis, Gilles / Song, Hongshuo / Sajadi, Mohammad M / Kottilil, Shyamasundaran / Gallo, Robert C / Zagury, Daniel

    Research square

    2023  

    Abstract: Advances in HIV therapy came from understanding its replication. Further progress toward "functional cure" -no therapy needed as found in Elite Controllers (EC)- may come from insights in pathogenesis and avoidance by EC. Here we show that all immune ... ...

    Abstract Advances in HIV therapy came from understanding its replication. Further progress toward "functional cure" -no therapy needed as found in Elite Controllers (EC)- may come from insights in pathogenesis and avoidance by EC. Here we show that all immune cells from HIV-infected persons are impaired in non-EC, but not in EC. Since HIV infects few cell types, these results suggest an additional mediator of pathogenesis. We identify that mediator as elevated pathogenic IFNα, controlled by EC likely by their preserved potent NK-cells and later by other killer cells. Since the earliest days of infection predict outcome genetic or chance events must be key to EC, and since we found no unique immune parameter at the onset, we suggest a chance infection with a lower HIV inoculum. These results offer an additional approach toward functional cure: a judicious targeting of IFNα for all non-EC patients.
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2813601/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: IFNα induces CCR5 in CD4

    Le Buanec, Hélène / Schiavon, Valérie / Merandet, Marine / How-Kit, Alexandre / Song, Hongshuo / Bergerat, David / Fombellida-Lopez, Céline / Bensussan, Armand / Bouaziz, Jean-David / Burny, Arsène / Darcis, Gilles / Sajadi, Mohammad M / Kottilil, Shyamasundaran / Zagury, Daniel / Gallo, Robert C

    Research square

    2023  

    Abstract: Like EC, we find that ART-treated patients control serum IFNα concentration and show few immune cell alterations enabling a healthy but fragile medical status. However, treatment interruption leads to elevated IFNα reflecting virus production indicating ... ...

    Abstract Like EC, we find that ART-treated patients control serum IFNα concentration and show few immune cell alterations enabling a healthy but fragile medical status. However, treatment interruption leads to elevated IFNα reflecting virus production indicating that like EC, ART does not achieve a virological cure. The immune system becomes overwhelmed by multiple immune cell abnormalities as found in untreated patients. These are chiefly mediated by elevated IFNα inducing signaling checkpoints abnormalities, including PD1, in cytotoxic immune cells. Importantly, during acute infection, elevated IFNα correlated with HIV load and we found that IFNα enhances CCR5, the HIV coreceptor in CD4
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2813616/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Mesenchymal Stem/Stromal Cells in Immunity and Disease: A Better Understanding for an Improved Use.

    Merimi, Makram / Lagneaux, Laurence / Moussa Agha, Douâa / Lewalle, Philippe / Meuleman, Nathalie / Burny, Arsène / Fahmi, Hassan / Najar, Mehdi

    Journal of clinical medicine

    2020  Volume 9, Issue 5

    Abstract: In this Special Issue, directed and supervised by Dr. Mehdi Najar, a collection of basic research articles and reviews, on the state of the art of Mesenchymal Stem/Stromal Cells (MSCs) immune biology, is presented. Among the major goals of this Special ... ...

    Abstract In this Special Issue, directed and supervised by Dr. Mehdi Najar, a collection of basic research articles and reviews, on the state of the art of Mesenchymal Stem/Stromal Cells (MSCs) immune biology, is presented. Among the major goals of this Special Issue is the presentation of an update about the immunomodulatory properties of MSCs and their capacity to respond to tissue microenvironment changes. MSCs hold great promise in the field of immunotherapy and regenerative medicine. Accordingly, a better understanding of MSC immune biology will improve their therapeutic value and use.
    Language English
    Publishing date 2020-05-18
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9051516
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  8. Article: Mesenchymal Stem/Stromal Cell Therapeutic Features: The Bridge between the Bench and the Clinic.

    Merimi, Makram / Lewalle, Philippe / Meuleman, Nathalie / Agha, Douâa Moussa / El-Kehdy, Hoda / Bouhtit, Fatima / Ayoub, Sara / Burny, Arsène / Fahmi, Hassan / Lagneaux, Laurence / Najar, Mehdi

    Journal of clinical medicine

    2021  Volume 10, Issue 5

    Abstract: Mesenchymal stem/stromal cells (MSCs) are considered a relevant therapeutic product for various clinical applications [ ... ]. ...

    Abstract Mesenchymal stem/stromal cells (MSCs) are considered a relevant therapeutic product for various clinical applications [...].
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10050905
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  9. Article ; Online: Role of the cellular factor CTCF in the regulation of bovine leukemia virus latency and three-dimensional chromatin organization.

    Bellefroid, Maxime / Rodari, Anthony / Galais, Mathilde / Krijger, Peter H L / Tjalsma, Sjoerd J D / Nestola, Lorena / Plant, Estelle / Vos, Erica S M / Cristinelli, Sara / Van Driessche, Benoit / Vanhulle, Caroline / Ait-Ammar, Amina / Burny, Arsène / Ciuffi, Angela / de Laat, Wouter / Van Lint, Carine

    Nucleic acids research

    2022  Volume 50, Issue 6, Page(s) 3190–3202

    Abstract: Bovine leukemia virus (BLV)-induced tumoral development is a multifactorial phenomenon that remains incompletely understood. Here, we highlight the critical role of the cellular CCCTC-binding factor (CTCF) both in the regulation of BLV transcriptional ... ...

    Abstract Bovine leukemia virus (BLV)-induced tumoral development is a multifactorial phenomenon that remains incompletely understood. Here, we highlight the critical role of the cellular CCCTC-binding factor (CTCF) both in the regulation of BLV transcriptional activities and in the deregulation of the three-dimensional (3D) chromatin architecture surrounding the BLV integration site. We demonstrated the in vivo recruitment of CTCF to three conserved CTCF binding motifs along the provirus. Next, we showed that CTCF localized to regions of transitions in the histone modifications profile along the BLV genome and that it is implicated in the repression of the 5'Long Terminal Repeat (LTR) promoter activity, thereby contributing to viral latency, while favoring the 3'LTR promoter activity. Finally, we demonstrated that BLV integration deregulated the host cellular 3D chromatin organization through the formation of viral/host chromatin loops. Altogether, our results highlight CTCF as a new critical effector of BLV transcriptional regulation and BLV-induced physiopathology.
    MeSH term(s) CCCTC-Binding Factor/metabolism ; Chromatin ; Leukemia Virus, Bovine/genetics ; Leukemia Virus, Bovine/metabolism ; Promoter Regions, Genetic ; Terminal Repeat Sequences/genetics ; Virus Latency
    Chemical Substances CCCTC-Binding Factor ; Chromatin
    Language English
    Publishing date 2022-02-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkac107
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1067: Show issues Location:
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  10. Article ; Online: Mesenchymal Stromal Cells and Natural Killer Cells: A Complex Story of Love and Hate.

    Najar, Mehdi / Fayyad-Kazan, Mohammad / Merimi, Makram / Burny, Arsène / Bron, Dominique / Fayyad-Kazan, Hussein / Meuleman, Nathalie / Lagneaux, Laurence

    Current stem cell research & therapy

    2018  Volume 14, Issue 1, Page(s) 14–21

    Abstract: Mesenchymal stromal cells (MSCs), characterized by both multidifferentiation potential and potent immunomodulatory capacity, represent a promising, safe and powerful cell based-therapy for repairing tissue damage and/or treating diseases associated with ... ...

    Abstract Mesenchymal stromal cells (MSCs), characterized by both multidifferentiation potential and potent immunomodulatory capacity, represent a promising, safe and powerful cell based-therapy for repairing tissue damage and/or treating diseases associated with aberrant immune responses. Natural killer (NK) cells are granular lymphocytes of the innate immune system that function alone or in combination with other immune cells to combat both tumors and virally infected cells. After their infusion, MSCs are guided by host inflammatory elements and can interact with different immune cells, particularly those of the innate immune system. Although some breakthroughs have been achieved in understanding these interactions, much remains to be determined. In this review, we discuss the complex interactions between NK cells and MSCs, particularly the importance of improving the therapeutic value of MSCs.
    MeSH term(s) Cell Communication ; Cell- and Tissue-Based Therapy ; Cytokine-Induced Killer Cells ; Cytokines/metabolism ; Humans ; Immunomodulation ; Killer Cells, Natural/physiology ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells/physiology ; Receptors, Immunologic/metabolism ; Serpins/biosynthesis ; Toll-Like Receptors/metabolism
    Chemical Substances Cytokines ; LAIR-2 receptor ; Receptors, Immunologic ; Serpins ; Toll-Like Receptors ; leukocyte-associated immunoglobulin-like receptor 1
    Language English
    Publishing date 2018-09-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2251937-3
    ISSN 2212-3946 ; 1574-888X
    ISSN (online) 2212-3946
    ISSN 1574-888X
    DOI 10.2174/1574888X13666180912125736
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