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  1. Article ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19-authors' reply to Kawada T.

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology

    2021  Volume 63, Issue 6, Page(s) 835–836

    MeSH term(s) COVID-19 ; Humans ; Intracranial Aneurysm/diagnostic imaging ; SARS-CoV-2 ; Subarachnoid Hemorrhage/diagnostic imaging ; Vasospasm, Intracranial
    Language English
    Publishing date 2021-04-17
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-021-02712-z
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  2. Article ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19.

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology

    2020  Volume 63, Issue 1, Page(s) 149–152

    Abstract: Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of ... ...

    Abstract Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of nonaneurysmal subarachnoid haemorrhage (SAH) in patients with severe COVID-19. Careful review of neuroimaging for haemorrhagic complications of COVID-19 should be undertaken, particularly for those patients receiving enhanced prophylaxis for venous thromboembolism. Although likely to be a marker of severe disease, non-aneurysmal SAH can be associated with favourable outcome.
    MeSH term(s) Aged ; COVID-19/complications ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Subarachnoid Hemorrhage/diagnostic imaging ; Subarachnoid Hemorrhage/etiology
    Keywords covid19
    Language English
    Publishing date 2020-08-28
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 123305-1
    ISSN 1432-1920 ; 0028-3940
    ISSN (online) 1432-1920
    ISSN 0028-3940
    DOI 10.1007/s00234-020-02535-4
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  3. Article: Non-aneurysmal subarachnoid haemorrhage in COVID-19

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology

    Abstract: Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of ... ...

    Abstract Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of nonaneurysmal subarachnoid haemorrhage (SAH) in patients with severe COVID-19. Careful review of neuroimaging for haemorrhagic complications of COVID-19 should be undertaken, particularly for those patients receiving enhanced prophylaxis for venous thromboembolism. Although likely to be a marker of severe disease, non-aneurysmal SAH can be associated with favourable outcome.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #734112
    Database COVID19

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  4. Article ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Harrogate , S , Mortimer , A , Burrows , L , Fiddes , B , Thomas , I & Rice , C M 2020 , ' Non-aneurysmal subarachnoid haemorrhage in COVID-19 ' , Neuroradiology . https://doi.org/10.1007/s00234-020-02535-4

    2020  

    Abstract: Coronavirus disease of 2019 (COVID-19) is associated with hyper-coagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage have also been reported. We present two cases of non- ... ...

    Abstract Coronavirus disease of 2019 (COVID-19) is associated with hyper-coagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage have also been reported. We present two cases of non-aneurysmal subarachnoid haemorrhage (SAH) in patients with severe COVID-19. Careful review of neuroimaging for haemorrhagic complications of COVID-19 should be undertaken, particularly for those patients receiving enhanced prophylaxis for venous thromboembolism. Although likely to be a marker of severe disease, non-aneurysmal SAH can be associated with favourable outcome.
    Keywords /dk/atira/pure/core/keywords/uob_covid19 ; Covid19 ; subarachnoid haemorrhage ; COVID-19 ; clinical neurology ; neuroradiology ; /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 ; Journal Article ; covid19
    Language English
    Publishing date 2020-08-28
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Non-aneurysmal subarachnoid haemorrhage in COVID-19

    Harrogate, Suzanne / Mortimer, Alex / Burrows, Lorna / Fiddes, Barnaby / Thomas, Ian / Rice, Claire M

    Neuroradiology ; ISSN 0028-3940 1432-1920

    2020  

    Keywords Radiology Nuclear Medicine and imaging ; Clinical Neurology ; Cardiology and Cardiovascular Medicine ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s00234-020-02535-4
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Public health engagement: detection of suspicious skin lesions, screening and referral behaviour of UK based chiropractors.

    Glithro, Sara / Newell, David / Burrows, Lorna / Hunnisett, Adrian / Cunliffe, Christina

    Chiropractic & manual therapies

    2015  Volume 23, Issue 1, Page(s) 5

    Abstract: Background: UK morbidity and mortality rates from skin cancer are increasing despite existing preventative strategies involving education and early detection. Manual therapists are ideally placed to support these goals as they see greater quantities of ... ...

    Abstract Background: UK morbidity and mortality rates from skin cancer are increasing despite existing preventative strategies involving education and early detection. Manual therapists are ideally placed to support these goals as they see greater quantities of exposed patient skin more often than most other healthcare professionals. The purpose of this study therefore was to ascertain the ability of manual therapists to detect, screen and refer suspicious skin lesions.
    Method: A web-based questionnaire and quiz was used in a sample of UK chiropractic student clinicians and registered chiropractors to gather data during 2011 concerning skin screening and referral behaviors for suspicious skin lesions.
    Results: A total of 120 questionnaires were included. Eighty one percent of participants agreed that screening for suspicious skin lesions was part of their clinical role, with nearly all (94%) assessing their patients for lesions during examination. Over 90% of the participants reported regularly having the opportunity for skin examination; with nearly all (98%) agreeing they would refer patients with suspicious skin lesions to a medical practitioner. A third of respondents had referred a total of 80 suspicious lesions within the last 12 months with 67% warranting further investigation.
    Conclusions: Nearly all respondents agreed that screening patients for suspicious skin lesions was part of their clinical role, with a significant number already referring patients with lesions.
    Language English
    Publishing date 2015
    Publishing country England
    Document type Journal Article
    ZDB-ID 2590836-4
    ISSN 2045-709X
    ISSN 2045-709X
    DOI 10.1186/s12998-014-0047-2
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  7. Article ; Online: Studies into the Mechanisms of Dermal Inflammation Using Cutaneous Microdialysis

    Church, Martin K. / Bewley, Anthony P. / Clough, Geraldine F. / Burrows, Lorna J. / Ferdinand, Sandra I. / Petersen, Lars J.

    International Archives of Allergy and Immunology

    1997  Volume 113, Issue 1-3, Page(s) 131–133

    Keywords Microdialysis ; Skin ; Histamine ; Bradykinin ; Cetirizine
    Language English
    Publisher S. Karger AG
    Publishing place Basel
    Publishing country Switzerland
    Document type Article ; Online
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000237526
    Database Karger publisher's database

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  8. Article ; Online: Adjuvant bevacizumab for melanoma patients at high risk of recurrence: survival analysis of the AVAST-M trial.

    Corrie, P G / Marshall, A / Nathan, P D / Lorigan, P / Gore, M / Tahir, S / Faust, G / Kelly, C G / Marples, M / Danson, S J / Marshall, E / Houston, S J / Board, R E / Waterston, A M / Nobes, J P / Harries, M / Kumar, S / Goodman, A / Dalgleish, A /
    Martin-Clavijo, A / Westwell, S / Casasola, R / Chao, D / Maraveyas, A / Patel, P M / Ottensmeier, C H / Farrugia, D / Humphreys, A / Eccles, B / Young, G / Barker, E O / Harman, C / Weiss, M / Myers, K A / Chhabra, A / Rodwell, S H / Dunn, J A / Middleton, M R / Nathan, Paul / Lorigan, Paul / Dziewulski, Peter / Holikova, Sonja / Panwar, Udaiveer / Tahir, Saad / Faust, Guy / Thomas, Anne / Corrie, Pippa / Sirohi, Bhawna / Kelly, Charles / Middleton, Mark / Marples, Maria / Danson, Sarah / Lester, James / Marshall, Ernest / Ajaz, Mazhar / Houston, Stephen / Board, Ruth / Eaton, David / Waterston, Ashita / Nobes, Jenny / Loo, Suat / Gray, Gill / Stubbings, Helen / Gore, Martin / Harries, Mark / Kumar, Satish / Goodman, Andrew / Dalgleish, Angus / Martin-Clavijo, Agustin / Marsden, Jerry / Westwell, Sarah / Casasola, Richard / Chao, David / Maraveyas, Anthony / Patel, Poulam / Ottensmeier, Christian / Farrugia, David / Humphreys, Alison / Eccles, Bryony / Dega, Renata / Herbert, Chris / Price, Christopher / Brunt, Murray / Scott-Brown, Martin / Hamilton, Joanna / Hayward, Richard Larry / Smyth, John / Woodings, Pamela / Nayak, Neena / Burrows, Lorna / Wolstenholme, Virginia / Wagstaff, John / Nicolson, Marianne / Wilson, Andrew / Barlow, Clare / Scrase, Christopher / Podd, Timothy / Gonzalez, Michael / Stewart, John / Highley, Martin / Grumett, Simon / Talbot, Toby / Nathan, Kannon / Coltart, Robert / Gee, Bruce

    Annals of oncology : official journal of the European Society for Medical Oncology

    2018  Volume 29, Issue 8, Page(s) 1843–1852

    Abstract: Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of ... ...

    Abstract Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of recurrence.
    Patients and methods: Patients with resected AJCC stage IIB, IIC and III cutaneous melanoma were randomised to receive either adjuvant bevacizumab (7.5 mg/kg i.v. 3 weekly for 1 year) or standard observation. The primary end point was detection of an 8% difference in 5-year overall survival (OS) rate; secondary end points included disease-free interval (DFI) and distant metastasis-free interval (DMFI). Tumour and blood were analysed for prognostic and predictive markers.
    Results: Patients (n=1343) recruited between 2007 and 2012 were predominantly stage III (73%), with median age 56 years (range 18-88 years). With 6.4-year median follow-up, 515 (38%) patients had died [254 (38%) bevacizumab; 261 (39%) observation]; 707 (53%) patients had disease recurrence [336 (50%) bevacizumab, 371 (55%) observation]. OS at 5 years was 64% for both groups [hazard ratio (HR) 0.98; 95% confidence interval (CI) 0.82-1.16, P = 0.78). At 5 years, 51% were disease free on bevacizumab versus 45% on observation (HR 0.85; 95% CI 0.74-0.99, P = 0.03), 58% were distant metastasis free on bevacizumab versus 54% on observation (HR 0.91; 95% CI 0.78-1.07, P = 0.25). Forty four percent of 682 melanomas assessed had a BRAFV600 mutation. In the observation arm, BRAF mutant patients had a trend towards poorer OS compared with BRAF wild-type patients (P = 0.06). BRAF mutation positivity trended towards better OS with bevacizumab (P = 0.21).
    Conclusions: Adjuvant bevacizumab after resection of high-risk melanoma improves DFI, but not OS. BRAF mutation status may predict for poorer OS untreated and potential benefit from bevacizumab.
    Clinical trial information: ISRCTN 81261306; EudraCT Number: 2006-005505-64.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Bevacizumab/administration & dosage ; Chemotherapy, Adjuvant/methods ; Dermatologic Surgical Procedures ; Disease-Free Survival ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Male ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/therapy ; Middle Aged ; Mutation ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Staging ; Proto-Oncogene Proteins B-raf/genetics ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Survival Analysis ; Time Factors ; Watchful Waiting ; Young Adult
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2018-11-01
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025984-3
    ISSN 1569-8041 ; 0923-7534
    ISSN (online) 1569-8041
    ISSN 0923-7534
    DOI 10.1093/annonc/mdy229
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