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Book: Management of difficult problems in hepatology

Burton, James R.

(Clinics in liver disease ; 10,2)

2006

Author's details	guest ed. James R. Burton
Series title	Clinics in liver disease ; 10,2
Collection
Language	English
Size	XV S., S. 207 - 443 : Ill., graph. Darst.
Publisher	Saunders
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT014893985
ISBN	1-4160-3908-2 ; 978-1-4160-3908-2
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
Se 1870 -10,2-	verfügbar in Königswinter	Königswinter

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Article: Herbal hepatitis due to use of alternative medicines for Lyme disease.

Perrillo, Robert P / Burton, James R / Westbrook, Lindsey M

Proceedings (Baylor University. Medical Center)

2021 Volume 35, Issue 1, Page(s) 104–105

Abstract: Lyme disease often leaves patients with chronic symptoms of fatigue, easy confusion, and even cardiac arrhythmias. We report a case in which Lyme disease was treated with an herbal mixture due to protracted symptoms despite intravenous antibiotics. This ... ...

Abstract	Lyme disease often leaves patients with chronic symptoms of fatigue, easy confusion, and even cardiac arrhythmias. We report a case in which Lyme disease was treated with an herbal mixture due to protracted symptoms despite intravenous antibiotics. This mixture was associated with hepatotoxicity. General providers should be aware of the fact that homeopathic remedies may be associated with hepatotoxicity, and herbalists need better understanding of the safety risks of the individual components in remedy mixtures.
Language	English
Publishing date	2021-10-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2703932-8
ISSN	1525-3252 ; 0899-8280
ISSN (online)	1525-3252
ISSN	0899-8280
DOI	10.1080/08998280.2021.1974272
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Article ; Online: Highlights From Controversies in Transplantation 2023 Conference.

Saben, Jessica L / Kaplan, Bruce / Burton, James R / Cooper, James E / Pomposelli, James J / Schold, Jesse D / Pomfret, Elizabeth A

Transplantation

2024 Volume 108, Issue 3, Page(s) 598–600

Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004699
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Article ; Online: Compartmental model describing the physiological basis for the HepQuant SHUNT test.

McRae, Michael P / Helmke, Steve M / Burton, James R / Everson, Gregory T

Translational research : the journal of laboratory and clinical medicine

2022 Volume 252, Page(s) 53–63

Abstract: The HepQuant SHUNT test quantifies hepatic functional impairment from the simultaneous clearance of cholate from the systemic and portal circulations for the purpose of monitoring treatment effects or for predicting risk for clinical outcome. ... ...

Abstract	The HepQuant SHUNT test quantifies hepatic functional impairment from the simultaneous clearance of cholate from the systemic and portal circulations for the purpose of monitoring treatment effects or for predicting risk for clinical outcome. Compartmental models are defined by distribution volumes and transfer rates between volumes to estimate parameters not defined by noncompartmental analyses. Previously, a noncompartmental analysis method, called the minimal model (MM), demonstrated reproducible and reliable measures of liver function (Translational Research 2021). The aim of this study was to compare the reproducibility and reliability of a new physiologically based compartmental model (CM) vs the MM. Data were analyzed from 16 control, 16 nonalcoholic steatohepatitis (NASH), and 16 hepatitis C virus (HCV) subjects, each with 3 replicate tests conducted on 3 separate days. The CM describes transfer of cholates between systemic, portal, and liver compartments with assumptions from measured or literature-derived values and unknown parameters estimated by nonlinear least-squares regression. The CM was compared to the MM for 6 key indices of hepatic disease in terms of intraclass correlation coefficient (ICC) with a lower acceptable limit of 0.7. The CM correlated well with the MM for disease severity index (DSI) with R
MeSH term(s)	Humans ; Epidemiological Models ; Reproducibility of Results ; Liver ; Non-alcoholic Fatty Liver Disease ; Liver Function Tests ; Cholates
Chemical Substances	Cholates
Language	English
Publishing date	2022-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2022.08.002
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Article ; Online: Choledochoduodenostomy is associated with fewer post-transplant biliary complications compared to Roux-en-Y in primary sclerosing cholangitis patients.

Jonica, Emily R / Han, Samuel / Burton, James R / Pomposelli, James J / Shah, Raj J

Clinical transplantation

2022 Volume 36, Issue 5, Page(s) e14597

Abstract: Background: For primary sclerosing cholangitis (PSC) patients undergoing liver transplantation (LT), a consensus regarding biliary reconstruction remains unresolved. Choledochoduodenostomy (CDD) represents an alternative to Roux-en-Y (RY) and duct-to- ... ...

Abstract	Background: For primary sclerosing cholangitis (PSC) patients undergoing liver transplantation (LT), a consensus regarding biliary reconstruction remains unresolved. Choledochoduodenostomy (CDD) represents an alternative to Roux-en-Y (RY) and duct-to-duct. We compared long-term post-transplant outcomes between CDD and RY. Methods: This was a retrospective review of patients transplanted for PSC who received CDD or RY, with minimum 12-months follow-up. The primary outcome was need for biliary intervention, with either percutaneous transhepatic cholangiography (PTC) or endoscopic retrograde cholangiopancreatography (ERCP). Secondary outcomes included biliary stricture(s) and cholangitis admission(s). Results: Ninety-three patients were transplanted between August 2004 and October 2019 (34 living donor [LDLT] and 59 deceased donor [DDLT]; 40 RY, 53 CDD). Need for either ERCP or PTC was similar (45.0% RY vs. 32.1% CDD, P = .203), though RY exhibited more anastomotic strictures (AS) (35.0% RY vs. 11.3% CDD, P = .006), which was also observed in LDLT subanalyses (50.0% LDLT/RY vs. 10.0% LDLT/CDD; P = .036). Cholangitis admissions were more frequent in RY versus CDD (37.5% vs. 15.1%, P = .013). Conclusions: CDD does not impart greater risk of biliary complications, and RY may have an incremental effect combined with LDLT status for predisposing to AS. CDD maintains standard endoscopic access without additional risk of biliary complications, thus should be considered when anatomically feasible.
MeSH term(s)	Anastomosis, Roux-en-Y ; Cholangiopancreatography, Endoscopic Retrograde ; Cholangitis ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/surgery ; Choledochostomy/adverse effects ; Humans ; Living Donors ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2022-01-27
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14597
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Article ; Online: The within-individual reproducibility of the disease severity index from the HepQuant SHUNT test of liver function and physiology.

Burton, James R / Helmke, Steven / Lauriski, Shannon / Kittelson, John / Everson, Gregory T

Translational research : the journal of laboratory and clinical medicine

2021 Volume 233, Page(s) 5–15

Abstract: The HepQuant SHUNT test quantifies liver function and blood flow using systemic and portal clearances of cholate. The test can identify the risk of well-compensated patients to develop complications of cirrhosis. To confirm the reliability of a single ... ...

Abstract	The HepQuant SHUNT test quantifies liver function and blood flow using systemic and portal clearances of cholate. The test can identify the risk of well-compensated patients to develop complications of cirrhosis. To confirm the reliability of a single HepQuant SHUNT test we defined its within-individual reproducibility. Healthy subjects (n = 16), 16 with nonalcoholic steatohepatitis (NASH), and 16 with chronic hepatitis C virus (HCV) underwent 3 HepQuant SHUNT tests on 3 separate days within 30 days. The test involves simultaneous administration of 20 mg 13C-cholate IV and 40 mg d4-cholate PO, and subsequent collection of 3 mL blood samples at 5, 20, 45, 60, and 90 minutes. Clearances are expressed as systemic and portal hepatic filtration rate. Portal-systemic shunting (SHUNT), a disease severity index (DSI), and an estimate of DSI (STAT) are calculated from the clearances. Reproducibility was determined by the intraclass correlation coefficient (ICC > 0.70) and Bland-Altman analysis. Equal numbers of NASH and HCV patients had either early (F0-F2) or advanced (F3/F4) stages of fibrosis. All F3/F4 subjects were clinically compensated. The intraclass correlation coefficient (ICC) for DSI was 0.94 (0.90-0.96 95% confidence interval) indicating excellent reproducibility. The other test parameters had ICCs ranging from 0.74 (SHUNT) to 0.90 (STAT). In Bland-Altman analysis, the mean of differences between measurements of DSI was 0.13 with standard deviation 2.12. The excellent reproducibility of the HepQuant SHUNT test, particularly DSI, supports the use this minimally invasive, blood-based test as a reliable test of liver function and physiology.
MeSH term(s)	Adult ; Carbon Isotopes ; Cholates/administration & dosage ; Cholates/blood ; Cholates/chemistry ; Deuterium ; Female ; Healthy Volunteers ; Hepatitis C, Chronic/physiopathology ; Humans ; Liver/blood supply ; Liver/physiology ; Liver Circulation/physiology ; Liver Function Tests/methods ; Liver Function Tests/statistics & numerical data ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease/physiopathology ; Reference Values ; Reproducibility of Results ; Severity of Illness Index ; Translational Medical Research ; Young Adult
Chemical Substances	Carbon Isotopes ; Cholates ; Deuterium (AR09D82C7G) ; Carbon-13 (FDJ0A8596D)
Language	English
Publishing date	2021-01-02
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2246684-8
ISSN	1878-1810 ; 1532-6543 ; 1931-5244
ISSN (online)	1878-1810 ; 1532-6543
ISSN	1931-5244
DOI	10.1016/j.trsl.2020.12.010
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Article ; Online: Pro: Steroids Can Be Withdrawn After Transplant in Recipients With Autoimmune Hepatitis.

Kalra, Avash / Burton, James R / Forman, Lisa M

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2018 Volume 24, Issue 8, Page(s) 1109–1112

Abstract: Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid-free options, resulting in most transplant centers weaning steroids after transplant ... ...

Abstract	Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid-free options, resulting in most transplant centers weaning steroids after transplant within days to months-an evidence-based management decision. Patients with autoimmune hepatitis (AIH), however, receive corticosteroids prior to transplant. This raises the question of whether these patients should also be weaned from corticosteroids. In this review, we discuss the benefits of avoiding steroid use in this population of patients-an approach that not only avoids the adverse effects of corticosteroids but does so without risking graft failure from recurrent AIH or from acute cellular rejection.
MeSH term(s)	Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Graft Rejection/epidemiology ; Graft Rejection/immunology ; Graft Rejection/prevention & control ; Hepatitis, Autoimmune/immunology ; Hepatitis, Autoimmune/surgery ; Humans ; Immunosuppression/adverse effects ; Immunosuppression/methods ; Immunosuppression/standards ; Liver Transplantation/adverse effects ; Liver Transplantation/standards ; Time Factors ; Treatment Outcome ; Withholding Treatment/standards
Chemical Substances	Glucocorticoids
Language	English
Publishing date	2018-07-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.25206
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Article ; Online: Differential in Kidney Graft Years on the Basis of Solitary Kidney, Simultaneous Liver-Kidney, and Kidney-after-Liver Transplants.

Schold, Jesse D / Mohan, Sumit / Jackson, Whitney E / Stites, Erik / Burton, James R / Bababekov, Yanik J / Saben, Jessica L / Pomposelli, James J / Pomfret, Elizabeth A / Kaplan, Bruce

Clinical journal of the American Society of Nephrology : CJASN

2023 Volume 19, Issue 3, Page(s) 364–373

Abstract: Background: The number of simultaneous liver-kidney (SLK) transplants has significantly increased in the United States. There has also been an increase in kidney-after-liver transplants associated with 2017 policy revisions aimed to fairly allocate ... ...

Abstract	Background: The number of simultaneous liver-kidney (SLK) transplants has significantly increased in the United States. There has also been an increase in kidney-after-liver transplants associated with 2017 policy revisions aimed to fairly allocate kidneys after livers. SLK and kidney-after-liver candidates are prioritized in allocation policy for kidney offers ahead of kidney-alone candidates. Methods: We compared kidney graft outcomes of kidney-alone transplant recipients with SLK and kidney-after-liver transplants using paired kidney models to mitigate differences among donor risk factors. We evaluated recipient characteristics between transplant types and calculated differential graft years using restricted mean survival estimates. Results: We evaluated 3053 paired donors to kidney-alone and SLK recipients and 516 paired donors to kidney-alone and kidney-after-liver recipients from August 2017 to August 2022. Kidney-alone recipients were younger, more likely on dialysis, and Black race. One-year and 3-year post-transplant kidney graft survival for kidney-alone recipients was 94% and 86% versus SLK recipients 89% and 80%, respectively, P < 0.001. One-year and 3-year kidney graft survival for kidney-alone recipients was 94% and 84% versus kidney-after-liver recipients 93% and 87%, respectively, P = 0.53. The additional kidney graft years for kidney-alone versus SLK transplants was 21 graft years/100 transplants (SEM=5.0) within 4 years post-transplantation, with no significant difference between kidney-after-liver and kidney-alone transplants. Conclusions: Over a 5-year period in the United States, SLK transplantation was associated with significantly lower kidney graft survival compared with paired kidney-alone transplants. Most differences in graft survival between SLK and kidney-alone transplants occurred within the first year post-transplantation. By contrast, kidney-after-liver transplants had comparable graft survival with paired kidney-alone transplants.
MeSH term(s)	Humans ; United States ; Liver Transplantation/adverse effects ; Solitary Kidney/etiology ; Kidney Transplantation/adverse effects ; Graft Survival ; Kidney/surgery ; Liver/surgery ; Tissue and Organ Procurement
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000353
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Article ; Online: Management of the transplant recipient with chronic hepatitis C.

Burton, James R / Everson, Gregory T

Clinics in liver disease

2013 Volume 17, Issue 1, Page(s) 73–91

Abstract: More than one-third of listed potential liver recipients in the US are infected with the hepatitis C virus (HCV). Recurrence of infection with HCV after liver transplantation is associated with accelerated graft loss and diminished patient survival. ... ...

Abstract	More than one-third of listed potential liver recipients in the US are infected with the hepatitis C virus (HCV). Recurrence of infection with HCV after liver transplantation is associated with accelerated graft loss and diminished patient survival. Current HCV treatments using peginterferon and ribavirin either alone or with first generation protease inhibitors (telaprevir, boceprevir) are limited by suboptimal viral response, drug-drug interaction, and side effects, some of which may be graft- or life-threatening. Rapid advances in new drug therapy for HCV promise to improve outcomes, reduce side effects and drug-drug interaction, shorten treatment duration, and simplify treatment regimens.
MeSH term(s)	Antiviral Agents/therapeutic use ; Drug Therapy, Combination/adverse effects ; Hepatitis C, Chronic/drug therapy ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/therapeutic use ; Interferons/therapeutic use ; Liver Transplantation ; Oligopeptides/therapeutic use ; Polyethylene Glycols/therapeutic use ; Postoperative Care ; Preoperative Care ; Proline/analogs & derivatives ; Proline/therapeutic use ; Ribavirin/therapeutic use ; Serine Proteinase Inhibitors/therapeutic use
Chemical Substances	Antiviral Agents ; Immunosuppressive Agents ; Oligopeptides ; Serine Proteinase Inhibitors ; Polyethylene Glycols (30IQX730WE) ; Ribavirin (49717AWG6K) ; telaprevir (655M5O3W0U) ; N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide (89BT58KELH) ; Interferons (9008-11-1) ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2013-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1472315-3
ISSN	1557-8224 ; 1089-3261
ISSN (online)	1557-8224
ISSN	1089-3261
DOI	10.1016/j.cld.2012.09.013
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Article ; Online: The vexing triad of obesity, alcohol, and coagulopathy predicts the need for multiple operations in liver transplantation.

Moore, Hunter B / Bababekov, Yanik J / Pomposelli, James J / Adams, Megan A / Crouch, Cara / Yoeli, Dor / Choudhury, Rashikh A / Ferrell, Tanner / Burton, James R / Pomfret, Elizabeth A / Nydam, Trevor L

American journal of surgery

2022 Volume 224, Issue 1 Pt A, Page(s) 69–74

Abstract: Introduction: One in four liver transplants (LT) require return to the operating room(R-OR) within 48 h of surgery. We hypothesize that donor, recipient, and intraoperative factors will predict R-OR.: Methods: LT recipients were enrolled in an ... ...

Abstract	Introduction: One in four liver transplants (LT) require return to the operating room(R-OR) within 48 h of surgery. We hypothesize that donor, recipient, and intraoperative factors will predict R-OR. Methods: LT recipients were enrolled in an observational study to measure coagulation with thrombelastography (TEG) were assessed with transplant recipient and donor variables for risk of R-OR. Results: 160 recipients with a median age of 55 years and a MELD-Na of 22 were analyzed. R-OR occurred in 22%. Recipient BMI (p = 0.006), donor heavy alcohol use (p = 0.017), TEG MA (p = 0.013) during the anhepatic phase of surgery, TEG MA at anhepatic and 30-min after reperfusion (p < 0.05), and red blood cell transfusions (p < 0.001) were associated with R-OR. Conclusion: The vexing triad of recipient obesity, heavy donor alcohol use, and low TEG MA were associated with a high rate of R-OR. Strategies to reduce this sub-optimal combination of risk factors could reduce the frequency of unplanned re-operations.
MeSH term(s)	Blood Coagulation ; Blood Coagulation Disorders/etiology ; Humans ; Liver Transplantation/adverse effects ; Middle Aged ; Obesity/complications ; Obesity/surgery ; Thrombelastography/adverse effects
Language	English
Publishing date	2022-02-19
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2022.02.053
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