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  1. AU="Burton, Jeffrey H"
  2. AU="Frederique Pitel"
  3. AU="Pierce, Aimee"
  4. AU="Luque-Ballesteros, Laura"
  5. AU="Dondi, Francesco"
  6. AU="McLachlan, Alex"
  7. AU="Krizova, Ludmila"
  8. AU="Balog, Attila"
  9. AU="Faerber, Karin"
  10. AU="Prettner, Klaus"
  11. AU="Ambrožová, I."
  12. AU="William, Doreen"
  13. AU="Gutiérrez-Sánchez, A M"
  14. AU="Bohan, Dana"
  15. AU="Spracklen, D."
  16. AU="Lobo, Brian C"
  17. AU=Zhuang Jianjian AU=Zhuang Jianjian
  18. AU=Pathanki Adithya M
  19. AU="Armando Vilchis-Ordoñez"
  20. AU="Zhongfu Lu"
  21. AU="Lo, Hong-Yip"
  22. AU="Ziman Xiong"
  23. AU="Oakes, Allison H"
  24. AU="Ma, Shaotong"
  25. AU="Zang, Lili"
  26. AU="Adams Brian D"
  27. AU="Maria Papaioannou"
  28. AU="Kollia, Georgia"
  29. AU="Auxiette, Catherine"
  30. AU="Guzmán, Luis"
  31. AU="Alipour, Elnaz"
  32. AU="Queiroz, Dayanna Joyce Marques"
  33. AU="Ramamurthy, Santosh"
  34. AU="Xueying Huang"
  35. AU="Cromwell, Howard C"
  36. AU="Spence, John C H"
  37. AU="Chapinal, Libertad"
  38. AU=Rohaim Mohammed A AU=Rohaim Mohammed A
  39. AU=Hempel Cornelius

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  1. Artikel: Racial Differences in Strength of Associations Between Colorectal Cancer Screening, Area Deprivation, Demographics, and Clinical Characteristics.

    Price-Haywood, Eboni G / Burton, Jeffrey H

    The Ochsner journal

    2023  Band 23, Heft 3, Seite(n) 194–205

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2023-08-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1524-5012
    ISSN 1524-5012
    DOI 10.31486/toj.23.0012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Comparison of proinsulin to C-peptide ratio in children with and without type 1 diabetes and its relation to age.

    Ellison, Benjamin R / Burton, Jeffrey H / Hsia, Daniel S

    Annals of pediatric endocrinology & metabolism

    2020  Band 25, Heft 1, Seite(n) 38–41

    Abstract: Purpose: This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio.: Methods: Nineteen participants (n=9 with type 1 ... ...

    Abstract Purpose: This study aimed to compare the proinsulin to C-peptide (PI:C) ratio in those with recent-onset type 1 diabetes versus those with no diabetes and to explore the effect of age on PI:C ratio.
    Methods: Nineteen participants (n=9 with type 1 diabetes and n=10 with no diabetes) between 10 and 19 years of age were enrolled in a single-visit cross-sectional study and underwent blood collection after 10 hours fasting to measure proinsulin and C-peptide levels as well as other glycemic parameters.
    Results: The median PI:C ratio was significantly different between type 1 diabetes and nondiabetes groups (6.24% vs. 1.46%, P<0.01). A significant negative correlation was seen between PI:C ratio and patient age after adjustment for duration of diabetes (r2=0.61, P=0.02) in the type 1 diabetes group.
    Conclusion: Even in this narrow age window, a higher degree of β-cell dysfunction indicated by a higher PI:C ratio was seen in younger children.
    Sprache Englisch
    Erscheinungsdatum 2020-03-31
    Erscheinungsland Korea (South)
    Dokumenttyp Journal Article
    ZDB-ID 2800460-7
    ISSN 2287-1292 ; 2287-1012
    ISSN (online) 2287-1292
    ISSN 2287-1012
    DOI 10.6065/apem.2020.25.1.38
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: An Analysis of the Timing for Closure of a Diverting Loop Ileostomy.

    Hussein, Nadia L / Stevenson, Autumn P / Lawton, Catherine F / Elmayan, Ardem / Hillis, Emma E / Burton, Jeffrey H / Fuhrman, George

    The American surgeon

    2023  Band 89, Heft 9, Seite(n) 3870–3872

    Abstract: A diverting loop ileostomy (DLI) is used to protect a distal gastrointestinal anastomosis at risk of leakage. While patients typically prefer early DLI closure, surgeons vary in opinion regarding optimal timing. This study evaluated whether the timing of ...

    Abstract A diverting loop ileostomy (DLI) is used to protect a distal gastrointestinal anastomosis at risk of leakage. While patients typically prefer early DLI closure, surgeons vary in opinion regarding optimal timing. This study evaluated whether the timing of DLI closure impacts outcomes.A retrospective review was performed on patients who underwent DLI creation within one health care system between 2012 and 2020. Patient characteristics and postoperative outcomes were compared across ileostomies closed in ≤2 months, 2-4 months, and >4 months. Outcomes examined included anastomotic leak, other complications, reintervention, and death within 30 days.A total of 500 DLIs were analyzed for the study, 455 of which were closed. The three closure groups were similar in patient characteristics and comorbidities. None of the outcome variables analyzed in this study demonstrated a statistically significant difference between groups, suggesting that in patients otherwise fit for surgery, DLI closure can be safely performed within 2 months of creation.
    Mesh-Begriff(e) Humans ; Ileostomy/adverse effects ; Anastomotic Leak/prevention & control ; Anastomotic Leak/etiology ; Anastomosis, Surgical/adverse effects ; Intestine, Small/surgery ; Retrospective Studies ; Postoperative Complications/etiology
    Sprache Englisch
    Erscheinungsdatum 2023-05-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    DOI 10.1177/00031348231173971
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Use of a New Standardized Unfractionated Heparin Protocol for Left-Sided Ablation Procedures Improves Time in the Therapeutic ACT Range.

    Ural, Kelly G / Moridzadeh, Sina S / Busch, Eric H / Masri, Omar El / Burton, Jeffrey H / Morin, Daniel P

    Journal of cardiothoracic and vascular anesthesia

    2023  Band 38, Heft 1, Seite(n) 67–72

    Abstract: Objectives: This study evaluated whether a novel standardized heparin dosing protocol used during atrial fibrillation catheter ablation resulted in a higher percentage of therapeutic activated clotting time (ACT) values compared to historic ... ...

    Abstract Objectives: This study evaluated whether a novel standardized heparin dosing protocol used during atrial fibrillation catheter ablation resulted in a higher percentage of therapeutic activated clotting time (ACT) values compared to historic nonstandardized procedures.
    Design: A retrospective cohort study SETTING: This study was conducted at Ochsner Medical Center, the largest tertiary-care teaching hospital in New Orleans, LA PARTICIPANTS: Patients undergoing catheter-based atrial fibrillation ablation INTERVENTIONS: The authors implemented a standardized heparin protocol, and enrolled 202 patients between November 2020 and March 2021. The historic controls consisted of 173 patients who underwent atrial fibrillation ablation between April 2020 and September 2020. Heparin administration in the control group was based on physician preference and was nonstandardized.
    Measurements and main results: The primary endpoint was the percentage of intraprocedural ACTs in therapeutic range (≥300 to <450 s). Secondary endpoints included first measured ACT at ≥300 s and percent of measured ACTs in the supratherapeutic range (>450 s). Comparisons were performed using chi-squared tests or Fisher exact tests. Patients in the intervention group had a higher mean percentage of ACTs in the therapeutic range compared to the control group (84.9% vs. 75.8%, p<0.001). More patients in the intervention group reached therapeutic ACT on the first measurement compared to the control group (70.3% vs. 31.2%, p<0.001).
    Conclusion: During catheter-based cardiac ablation procedures, a novel standardized unfractionated heparin dosing protocol resulted in a higher percentage of ACTs in the target range, and a higher proportion of initial ACTs in the therapeutic range compared with baseline nonstandardized heparin dosing.
    Mesh-Begriff(e) Humans ; Heparin ; Anticoagulants ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/surgery ; Retrospective Studies ; Treatment Outcome ; Catheter Ablation/methods
    Chemische Substanzen Heparin (9005-49-6) ; Anticoagulants
    Sprache Englisch
    Erscheinungsdatum 2023-11-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1067317-9
    ISSN 1532-8422 ; 1053-0770
    ISSN (online) 1532-8422
    ISSN 1053-0770
    DOI 10.1053/j.jvca.2023.11.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: A pediatric surgeon's dilemma: does cholecystectomy improve symptoms of biliary dyskinesia?

    Liebe, Heather L / Phillips, Ryan / Handley, Meghan / Gastanaduy, Mariella / Burton, Jeffrey H / Roybal, Jessica

    Pediatric surgery international

    2021  Band 37, Heft 9, Seite(n) 1251–1257

    Abstract: Background: Biliary dyskinesia (BD) is a well-established gallbladder pathology in adult patients and rates of cholecystectomy for BD continue to rise in the United States. Many pediatric patients with vague abdominal pain of variable duration are ... ...

    Abstract Background: Biliary dyskinesia (BD) is a well-established gallbladder pathology in adult patients and rates of cholecystectomy for BD continue to rise in the United States. Many pediatric patients with vague abdominal pain of variable duration are evaluated for biliary dyskinesia. It remains unknown which cohort of pediatric patients diagnosed with BD are most likely to have sustained improvement in symptoms following laparoscopic cholecystectomy. We aimed to determine whether cholecystectomy resulted in symptom relief and led to a reduction in the number of medical visits related to gastrointestinal (GI) symptoms after surgery.
    Methods: We performed a multi-institution retrospective review of all children < 18 years of age who underwent laparoscopic cholecystectomy for BD between January 2013 and April 2018 in our hospital system. GI symptoms and clinical visits related to a GI complaint were assessed preoperatively. Patients were followed for 2 years after surgery. At 6 months and 2 years postoperatively, symptoms and the rate of medical visits related to a GI complaint were quantified and compared to the preoperative values.
    Results: In total, 45 patients met our inclusion criteria. Of these, 82% of patients were female. The average age was 14 years old (± 2.6) and 56% of patients met the criteria for being overweight or obese. The mean gallbladder ejection fraction was 13% (± 10.8). All patients had abdominal pain, 82% (37/45) presented with nausea, and 51% (23/45) presented with post-prandial pain. Six months postoperatively, 58% of patients experienced resolution of their abdominal pain which decreased to 38% of patients after 2 years. Similarly, 59% had resolution of their nausea at 6 months compared to 43% at 2 years, and 100% had resolution of their post-prandial pain at 6 months compared to 91% at 2 years. The total number of clinical visits related to a GI complaint decreased from 2.6 (± 2.4) preoperatively to 1.0 (± 1.3) within 6 months postoperatively. When followed to 2 years postoperatively, the 6-month rate of clinical visits related to a GI complaint decreased from a mean of 2.6 preoperatively to 0.71 following surgery.
    Conclusions: Following cholecystectomy, we observed a high percentage of durable symptom resolution in those patients with BD who presented with post-prandial pain. Patients with non-food-related abdominal pain, with or without nausea and vomiting, had a lower rate of symptom resolution after surgery and the rate declined with time. For patients without post-prandial pain, evaluation and treatment of alternative sources of pain should be considered prior to surgery. Regardless of their presenting symptoms, patients who underwent surgery for BD had fewer clinical GI-related visits after surgery. However, no specific gallbladder ejection fraction or symptom alone was predictive of a lower rate of clinical visits postoperatively.
    Mesh-Begriff(e) Adolescent ; Adult ; Biliary Dyskinesia/complications ; Biliary Dyskinesia/surgery ; Child ; Cholecystectomy ; Cholecystectomy, Laparoscopic ; Female ; Humans ; Retrospective Studies ; Surgeons ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2021-05-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 632773-4
    ISSN 1437-9813 ; 0179-0358
    ISSN (online) 1437-9813
    ISSN 0179-0358
    DOI 10.1007/s00383-021-04922-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Racial Differences and Social Determinants of Health in Achieving Hypertension Control.

    Milani, Richard V / Price-Haywood, Eboni G / Burton, Jeffrey H / Wilt, Jonathan / Entwisle, Jonathan / Lavie, Carl J

    Mayo Clinic proceedings

    2022  Band 97, Heft 8, Seite(n) 1462–1471

    Abstract: Objective: To investigate whether specific social determinants of health could be a "health barrier" toward achieving blood pressure (BP) control and to further evaluate any differences between Black patients and White patients.: Patients and methods!# ...

    Abstract Objective: To investigate whether specific social determinants of health could be a "health barrier" toward achieving blood pressure (BP) control and to further evaluate any differences between Black patients and White patients.
    Patients and methods: We conducted a retrospective cohort study of 3305 patients with elevated BP who were enrolled in a hypertension digital medicine program for at least 60 days and followed up for up to 1 year. Patients were managed virtually by a dedicated hypertension team who provided guideline-based medication management and lifestyle support to achieve goal BP.
    Results: Compared with individuals without any health barriers, the addition of 1 barrier was associated with lower probability of control at 1 year from 0.73 to 0.60 and to 0.55 in those with 2 or more barriers. Health barriers were more prevalent in Black patients than in those who were White (44.6% [482 of 1081] vs 31.3% [674 of 2150]; P<.001). There was no difference at all in BP control between Black individuals and those who were White if 2 or more barriers were present.
    Conclusion: Patient-related health barriers are associated with BP control. Black patients with poorly controlled hypertension have a higher prevalence of health barriers than their White counterparts. When 2 or more health barriers were present, there was no differences in BP control between White and Black individuals.
    Mesh-Begriff(e) Blood Pressure ; Humans ; Hypertension/drug therapy ; Hypertension/therapy ; Race Factors ; Retrospective Studies ; Social Determinants of Health
    Sprache Englisch
    Erscheinungsdatum 2022-07-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2022.01.035
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Community versus individual risk of SARS-CoV-2 infection in two municipalities of Louisiana, USA: An assessment of Area Deprivation Index (ADI) paired with seroprevalence data over time.

    Feehan, Amy K / Denstel, Kara D / Katzmarzyk, Peter T / Velasco, Cruz / Burton, Jeffrey H / Price-Haywood, Eboni G / Seoane, Leonardo

    PloS one

    2021  Band 16, Heft 11, Seite(n) e0260164

    Abstract: Objective: Determine whether an individual is at greater risk of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) infection because of their community or their individual risk factors.: Study design and setting: 4,752 records ... ...

    Abstract Objective: Determine whether an individual is at greater risk of severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) infection because of their community or their individual risk factors.
    Study design and setting: 4,752 records from two large prevalence studies in New Orleans and Baton Rouge, Louisiana were used to assess whether zip code tabulation areas (ZCTA)-level area deprivation index (ADI) or individual factors accounted for risk of infection. Logistic regression models assessed associations of individual-level demographic and socioeconomic factors and the zip code-level ADI with SARS-CoV-2 infection.
    Results: In the unadjusted model, there were increased odds of infection among participants residing in high versus low ADI (both cities) and high versus mid-level ADI (Baton Rouge only) zip codes. When individual-level covariates were included, the odds of infection remained higher only among Baton Rouge participants who resided in high versus mid-level ADI ZCTAs. Several individual factors contributed to infection risk. After adjustment for ADI, race and age (Baton Rouge) and race, marital status, household size, and comorbidities (New Orleans) were significant.
    Conclusions: While higher ADI was associated with higher risk of SARS-CoV-2 infection, individual-level participant characteristics accounted for a significant proportion of this association. Additionally, stage of the pandemic may affect individual risk factors for infection.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/epidemiology ; COVID-19/virology ; Cities ; Female ; Humans ; Male ; Middle Aged ; New Orleans ; Probability ; Residence Characteristics ; Risk Factors ; SARS-CoV-2/physiology ; Seroepidemiologic Studies ; Social Deprivation ; Time Factors ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2021-11-30
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0260164
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Effect of Aerobic Exercise-induced Weight Loss on the Components of Daily Energy Expenditure.

    Broskey, Nicholas T / Martin, Corby K / Burton, Jeffrey H / Church, Timothy S / Ravussin, Eric / Redman, Leanne M

    Medicine and science in sports and exercise

    2021  Band 53, Heft 10, Seite(n) 2164–2172

    Abstract: Introduction: Exercise usually results in less weight loss than expected. This suggests increased energy intake and/or deceased expenditure counteract the energy deficit induced by exercise. The aim of this study was to evaluate changes in components of ...

    Abstract Introduction: Exercise usually results in less weight loss than expected. This suggests increased energy intake and/or deceased expenditure counteract the energy deficit induced by exercise. The aim of this study was to evaluate changes in components of daily energy expenditure (doubly labeled water and room calorimetry) after 24 wk of exercise training with two doses of aerobic exercise.
    Methods: This was an ancillary study in 42 (29 women, 13 men) sedentary, middle-age (47.8 ± 12.5 yr) individuals with obesity (35 ± 3.7 kg·m-2) enrolled in the Examination of Mechanisms of Exercise-induced Weight Compensation study. Subjects were randomized to three groups: healthy living control group (n = 13), aerobic exercise that expended 8 kcal·kg-1 of body weight per week (8 KKW, n = 14), or aerobic exercise that expended 20 kcal per kilogram of weight per week (20 KKW, n = 15). Total daily energy expenditure (TDEE) was measured in free-living condition by doubly labeled water and in sedentary conditions in a metabolic chamber over 24 h (24EE). Energy intake was calculated over 14 d from TDEE before and after the intervention using the intake-balance method.
    Results: Significant weight loss occurred with 20 KKW (-2.1 ± 0.7 kg, P = 0.04) but was only half of expected. In the 20 KKW group free-living TDEE increased by ~4% (P = 0.03), which is attributed to the increased exercise energy expenditure (P = 0.001), while 24EE in the chamber decreased by ~4% (P = 0.04). Aerobic exercise at 8 KKW did not induce weight change, and there was no significant change in any component of EE. There was no significant change in energy intake for any group (P = 0.53).
    Conclusions: Structured aerobic exercise at a dose of 20 KKW produced less weight loss than expected possibly due to behavioral adaptations leading to reduced 24EE in a metabolic chamber without any change in energy intake.
    Mesh-Begriff(e) Adaptation, Physiological ; Adult ; Body Fat Distribution ; Calorimetry, Indirect ; Energy Intake ; Energy Metabolism ; Exercise/physiology ; Exercise Therapy/methods ; Female ; Humans ; Male ; Middle Aged ; Obesity/therapy ; Weight Loss/physiology
    Sprache Englisch
    Erscheinungsdatum 2021-09-14
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000002689
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Solid Dose Form of Metformin with Ethyl Eicosapentaenoic Acid Does Not Improve Metformin Plasma Availability.

    Burton, Jeffrey H / Johnson, William D / Greenway, Frank L

    Pharmacology & pharmacy

    2016  Band 7, Heft 1, Seite(n) 29–35

    Abstract: Background: The purpose of the study was to investigate effects of ethyl eicosapentaenoic acid on pharmacokinetics of metformin. Pharmacokinetic profiles of metformin and ethyl eicosapentaenoic acid when delivered separately or together in solid dose ... ...

    Abstract Background: The purpose of the study was to investigate effects of ethyl eicosapentaenoic acid on pharmacokinetics of metformin. Pharmacokinetic profiles of metformin and ethyl eicosapentaenoic acid when delivered separately or together in solid dose form were investigated and compared to determine whether the solid dose resulted in an altered metforminpharmacokinetics when given with or without food.
    Methods: A single-center, open-label, repeated dose study investigated the pharmacokinetic (PK) profile of metformin when administered in solid dose form with ethyl eicosapentaenoic acid compared to co-administration with icosapent ethyl, an ester of eicosapentaenoic acid and ethyl alcohol used to treat severe hypertriglyceridemia with metformin hydrochloride. Non-compartmental PK methods were used to compare area under the plasma concentration curve (AUC) and maximum plasma concentration (C
    Results: Using these two PK parameters, results showed that metformin availability was higher under fasting conditions when delivered separately from icosapent ethyl. There were no group differences in the fed condition.
    Conclusions: The solid dose form of metformin and ethyl eicosapentaenoic acid did not improve the pharmacokinetics of metformin in terms of plasma availability, suggesting that little is to be gained over the separate administration of ethyl eicosapentaenoic acid and metformin hydrochloride.
    Sprache Englisch
    Erscheinungsdatum 2016-01-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2616892-3
    ISSN 2157-9431 ; 2157-9423
    ISSN (online) 2157-9431
    ISSN 2157-9423
    DOI 10.4236/pp.2016.71005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Evaluation of Spending Differences Between Beneficiaries in Medicare Advantage and the Medicare Shared Savings Program.

    Parikh, Ravi B / Emanuel, Ezekiel J / Brensinger, Colleen M / Boyle, Connor W / Price-Haywood, Eboni G / Burton, Jeffrey H / Heltz, Sabrina B / Navathe, Amol S

    JAMA network open

    2022  Band 5, Heft 8, Seite(n) e2228529

    Abstract: Importance: The 2 primary efforts of Medicare to advance value-based care are Medicare Advantage (MA) and the fee-for-service-based Medicare Shared Savings Program (MSSP). It is unknown how spending differs between the 2 programs after accounting for ... ...

    Abstract Importance: The 2 primary efforts of Medicare to advance value-based care are Medicare Advantage (MA) and the fee-for-service-based Medicare Shared Savings Program (MSSP). It is unknown how spending differs between the 2 programs after accounting for differences in patient clinical risk.
    Objective: To examine how spending and utilization differ between MA and MSSP beneficiaries after accounting for differences in clinical risk using data from administrative claims and electronic health records.
    Design, setting, and participants: This retrospective economic evaluation used data from 15 763 propensity score-matched beneficiaries who were continuously enrolled in MA or MSSP from January 1, 2014, to December 31, 2018, with diabetes, congestive heart failure (CHF), chronic kidney disease (CKD), or hypertension. Participants received care at a large nonprofit academic health system in the southern United States that bears risk for Medicare beneficiaries through both the MA and MSSP programs. Differences in beneficiary risk were mitigated by propensity score matching using validated clinical criteria based on data from administrative claims and electronic health records. Data were analyzed from January 2019 to May 2022.
    Exposures: Enrollment in MA or attribution to an accountable care organization in the MSSP program.
    Main outcomes and measures: Per-beneficiary annual total spending and subcomponents, including inpatient hospital, outpatient hospital, skilled nursing facility, emergency department, primary care, and specialist spending.
    Results: The sample of 15 763 participants included 12 720 (81%) MA and 3043 (19%) MSSP beneficiaries. MA beneficiaries, compared with MSSP beneficiaries, were more likely to be older (median [IQR] age, 75.0 [69.9-81.8] years vs 73.1 [68.3-79.8] years), male (5515 [43%] vs 1119 [37%]), and White (9644 [76%] vs 2046 [69%]) and less likely to live in low-income zip codes (2338 [19%] vs 750 [25%]). The mean unadjusted per-member per-year spending difference between MSSP and MA disease-specific subcohorts was $2159 in diabetes, $4074 in CHF, $2560 in CKD, and $2330 in hypertension. After matching on clinical risk and demographic factors, MSSP spending was higher for patients with diabetes (mean per-member per-year spending difference in 2015: $2454; 95% CI, $1431-$3574), CHF ($3699; 95% CI, $1235-$6523), CKD ($2478; 95% CI, $1172-$3920), and hypertension ($2258; 95% CI, $1616-2,939). Higher MSSP spending among matched beneficiaries was consistent over time. In the matched cohort in 2018, MSSP total spending ranged from 23% (CHF) to 30% (CKD) higher than MA. Adjusting for differential trends in coding intensity did not affect these results. Higher outpatient hospital spending among MSSP beneficiaries contributed most to spending differences between MSSP and MA, representing 49% to 62% of spending differences across disease cohorts.
    Conclusions and relevance: In this study, utilization and spending were consistently higher for MSSP than MA beneficiaries within the same health system even after adjusting for granular metrics of clinical risk. Nonclinical factors likely contribute to the large differences in MA vs MSSP spending, which may create challenges for health systems participating in MSSP relative to their participation in MA.
    Mesh-Begriff(e) Aged ; Diabetes Mellitus ; Humans ; Hypertension ; Male ; Medicare Part C ; Renal Insufficiency, Chronic ; Retrospective Studies ; United States
    Sprache Englisch
    Erscheinungsdatum 2022-08-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.28529
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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