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  1. Article ; Online: Ophthalmological Manifestations in Inflammatory Bowel Diseases: Keep an Eye on It.

    Migliorisi, Giulia / Vella, Giovanna / Dal Buono, Arianna / Gabbiadini, Roberto / Busacca, Anita / Loy, Laura / Bezzio, Cristina / Vinciguerra, Paolo / Armuzzi, Alessandro

    Cells

    2024  Volume 13, Issue 2

    Abstract: Background and aims: Inflammatory bowel diseases (IBD) are multifactorial chronic inflammatory disorders affecting the gastrointestinal tract. However, a broad spectrum of extraintestinal manifestations (EIMs) is associated with IBD, affecting several ... ...

    Abstract Background and aims: Inflammatory bowel diseases (IBD) are multifactorial chronic inflammatory disorders affecting the gastrointestinal tract. However, a broad spectrum of extraintestinal manifestations (EIMs) is associated with IBD, affecting several organs and systems, such as the skin, musculoskeletal and hepatobiliary systems, and, not least, the eye. Approximately 10% of IBD patients can develop ocular EIMs (O-EIMs) with a higher prevalence in Crohn's disease (CD). Eye-redness, photophobia, pain, and blurred vision are the common symptoms, with a wide rate of severity and clinical impact on the quality of life. This narrative review aims to summarize the prevalence, pathogenesis, and current evidence-based management of O-EIMs, underlying the importance of a holistic approach and specialties collaboration for a prompt diagnosis and treatment.
    Methods: PubMed was searched up to December 2023 to identify relevant studies investigating the pathogenesis, epidemiology, and treatment of O-EIMs in IBD patients.
    Results: The mechanisms underlying O-EIMs are partially unknown, encompassing immune dysregulation, shared antigens between the eye and the gut, genetic predisposition, and systemic inflammation driven by high levels of interleukins and cytokines in IBD patients. The complexity of O-EIMs' pathogenesis reflects in the management of these conditions, varying from topical and systemic steroids to immunomodulatory molecules and biologic therapy, such as anti-tumor necrosis factor (TNF)-alpha. A multidisciplinary approach is the backbone of the management of O-EIMs.
    MeSH term(s) Humans ; Quality of Life ; Eye ; Face ; Inflammatory Bowel Diseases ; Crohn Disease
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13020142
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  2. Article ; Online: The Course of COVID-19 in Inflammatory Bowel Disease: Protective Role of TNF Antagonists.

    Cappello, Maria / Busacca, Anita / Guida, Laura

    Gastroenterology

    2020  Volume 160, Issue 5, Page(s) 1885–1886

    MeSH term(s) Adrenal Cortex Hormones ; COVID-19 ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Registries ; SARS-CoV-2 ; Tumor Necrosis Factor Inhibitors
    Chemical Substances Adrenal Cortex Hormones ; Tumor Necrosis Factor Inhibitors
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.06.087
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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.44: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
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  3. Article ; Online: Small Bowel Imaging in Celiac Disease: Is there a role for Small Bowel Ultrasound?

    Rossi, Roberta Elisa / Busacca, Anita / Brandaleone, Luca / Masoni, Benedetta / Massironi, Sara / Fraquelli, Mirella / Repici, Alessandro

    Current gastroenterology reports

    2023  Volume 25, Issue 12, Page(s) 430–439

    Abstract: Purpose of review: The incidence of celiac disease (CD) has increased over the last decades in part due to better disease awareness. Small bowel ultrasound (sb US) enables dynamic assessment of the bowel; although this topic has been addressed, the use ... ...

    Abstract Purpose of review: The incidence of celiac disease (CD) has increased over the last decades in part due to better disease awareness. Small bowel ultrasound (sb US) enables dynamic assessment of the bowel; although this topic has been addressed, the use of sb US in the diagnosis and in the follow-up of CD patients is limited to a few specialized tertiary referral centers. Herein, we aimed at summarizing the available literature on this topic to better define the potential clinical implications of sb US in CD, also through a comparison with other available diagnostic techniques.
    Recent findings: According to available data, sb US can be of help in confirming or excluding CD in patients with clinical suspicion; specifically, the finding of increased gall bladder volume, free abdominal fluid and enlargement of mesenteric lymph nodes reliably and accurately predicts the diagnosis of CD, whereas the absence of bowel dilatation and increased peristalsis may exclude the diagnosis. However, the place of intestinal US in the diagnostic algorithm of CD is likely to vary depending on the probability of the disease in a given population. There are only a few studies on the role of sb US in complicated CD, even if recent reports suggest a possible clinical role. There is a lack of data on follow-up of CD patients, particularly with the aim of detecting a poor diet adherence. According to current data sb US parameters have been shown to be of value in confirming and excluding the diagnosis of CD. Prospective studies with large sample size are warranted to determine whether to include sb US in the available guidelines for CD diagnosis and monitoring.
    MeSH term(s) Humans ; Celiac Disease/diagnostic imaging ; Prospective Studies ; Intestine, Small/diagnostic imaging ; Ultrasonography ; Intestines
    Language English
    Publishing date 2023-11-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2041376-2
    ISSN 1534-312X ; 1522-8037
    ISSN (online) 1534-312X
    ISSN 1522-8037
    DOI 10.1007/s11894-023-00907-3
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5751: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Mental Illnesses in Inflammatory Bowel Diseases:

    Bartocci, Bianca / Dal Buono, Arianna / Gabbiadini, Roberto / Busacca, Anita / Quadarella, Alessandro / Repici, Alessandro / Mencaglia, Emanuela / Gasparini, Linda / Armuzzi, Alessandro

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 4

    Abstract: Background and ... ...

    Abstract Background and aims
    MeSH term(s) Male ; Humans ; Female ; Quality of Life/psychology ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/epidemiology ; Comorbidity ; Anxiety/epidemiology ; Cognition Disorders/epidemiology ; Depression/epidemiology
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59040682
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Article: Adalimumab Biosimilar in Pediatric Inflammatory Bowel Disease: A Retrospective Study from the Sicilian Network for Inflammatory Bowel Disease (SN-IBD).

    Dipasquale, Valeria / Pellegrino, Salvatore / Ventimiglia, Marco / Citrano, Michele / Graziano, Francesco / Cappello, Maria / Busacca, Anita / Orlando, Ambrogio / Accomando, Salvatore / Romano, Claudio / Sicilian Network For Inflammatory Bowel Disease

    Healthcare (Basel, Switzerland)

    2024  Volume 12, Issue 3

    Abstract: Background: The utilization of anti-tumor necrosis factor-α (anti-TNF-α) biosimilars in inflammatory bowel disease (IBD) is constantly increasing. However, pediatric data are limited. This study aimed to assess the effectiveness and safety of adalimumab ...

    Abstract Background: The utilization of anti-tumor necrosis factor-α (anti-TNF-α) biosimilars in inflammatory bowel disease (IBD) is constantly increasing. However, pediatric data are limited. This study aimed to assess the effectiveness and safety of adalimumab biosimilar (ADL-BioS) in pediatric IBD patients.
    Methods: All consecutive pediatric IBD patients from the Sicilian Network for Inflammatory Bowel Disease cohort treated with ADL-BioS from 2019 to 2021 were recruited. Remission at weeks 14 and 52, treatment persistence, and adverse events were the endpoints of this study. Factors associated with clinical remission and treatment persistence were examined.
    Results: There were 41 patients in total. Nine (22%) patients were switched from the reference product to ADL-BioS. Two patients had multiple switches. Eleven months was the median follow-up period. Clinical remission was attained by 70.7% and 72.0% of patients on weeks 14 and 52, respectively. Four (9.8%) adverse events occurred (10.1/100 person-year). Treatment persistence was 85.4% at 1 and 2 years. Patients with a longer duration of disease had a higher probability of stopping their treatment (
    Conclusions: This is the first real-world study that particularly addresses the use of ADL-BioS in pediatric IBD. With high rates of treatment persistence and a low frequency of non-serious side effects, ADL-BioS seems to be effective.
    Language English
    Publishing date 2024-02-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare12030404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Management of Post-Operative Crohn's Disease: Knowns and Unknowns.

    Spertino, Matteo / Gabbiadini, Roberto / Dal Buono, Arianna / Busacca, Anita / Franchellucci, Gianluca / Migliorisi, Giulia / Repici, Alessandro / Spinelli, Antonino / Bezzio, Cristina / Armuzzi, Alessandro

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by relapsing-remission phases. CD often requires surgical intervention during its course, mainly ileo-cecal/ileo-colonic resection. However, surgery in CD ...

    Abstract Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by relapsing-remission phases. CD often requires surgical intervention during its course, mainly ileo-cecal/ileo-colonic resection. However, surgery in CD is not curative and post-operative recurrence (POR) can happen. The management of CD after surgery presents challenges. Ensuring timely, effective, and safe therapy to prevent POR is essential but difficult, considering that approximately 20-30% of subjects may not experience endoscopic POR and that 40-50% will only exhibit intermediate lesions, which carry a low risk of mid- and long-term clinical and surgical POR. Currently, there are two accepted intervention strategies: early post-operative prophylactic therapy (systematically or based on the patient's risk of recurrence) or starting therapy after confirming endoscopic POR 6-12 months after surgery (endoscopy-driven prophylactic therapy). The risk of overtreatment lies in exposing patients to undesired adverse events, along with the costs associated with medications. Conversely, undertreatment may lead to missed opportunities to prevent bowel damage and the necessity for additional surgery. This article aims to perform a comprehensive review regarding the optimal strategy to reduce the risk of POR in CD patients and the current therapeutic options.
    Language English
    Publishing date 2024-04-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082300
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  7. Article: The course of Covid 19 in Inflammatory Bowel Disease: protective role of TNF antagonists Response to: Corticosteroids, but not TNF Antagonists, are Associated with Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results from an International Registry

    Cappello, Maria / Busacca, Anita / Guida, Laura

    Gastroenterology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #638728
    Database COVID19

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  8. Article ; Online: The course of Covid 19 in Inflammatory Bowel Disease

    Cappello, Maria / Busacca, Anita / Guida, Laura

    Gastroenterology ; ISSN 0016-5085

    protective role of TNF antagonists Response to: Corticosteroids, but not TNF Antagonists, are Associated with Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results from an International Registry

    2020  

    Keywords Gastroenterology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1053/j.gastro.2020.06.087
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Advancements in Endoscopic Resection for Colitis-Associated Colorectal Neoplasia in Inflammatory Bowel Disease: Turning Visible into Resectable.

    Maselli, Roberta / de Sire, Roberto / Massimi, Davide / Franchellucci, Gianluca / Busacca, Anita / Castiglione, Fabiana / Rispo, Antonio / Hassan, Cesare / Armuzzi, Alessandro / Repici, Alessandro

    Diagnostics (Basel, Switzerland)

    2023  Volume 14, Issue 1

    Abstract: Patients suffering from inflammatory bowel disease (IBD) face a two to three-fold higher risk of developing colorectal cancer (CRC) compared to the general population. In recent years, significant progress has been made in comprehending the natural ... ...

    Abstract Patients suffering from inflammatory bowel disease (IBD) face a two to three-fold higher risk of developing colorectal cancer (CRC) compared to the general population. In recent years, significant progress has been made in comprehending the natural history of IBD-associated CRC (IBD-CRC) and refining its treatment strategies. The decreased incidence of IBD-CRC can be attributed to improved therapeutic management of inflammation, advancements in endoscopy, and early detection of precancerous lesions via surveillance programs. Advanced imaging technologies have made previously undetectable dysplasia visible in most cases, allowing for a much more precise and detailed examination of the mucosa. Additionally, new tools have facilitated the endoscopic resection (ER) of visible lesions in IBD. Particularly, the key to effectively manage colitis-associated colorectal neoplasia (CAN) is to first identify it and subsequently guarantee a complete ER in order to avoid surgery and opt for continuing surveillance. Advanced ER techniques for CAN include endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), and hybrid ESD-EMR (h-ESD). This narrative review aims to consolidate the current literature on IBD-CRC, providing an overview of advanced techniques for ER of CAN in IBD, with a particular emphasis on the impact of ESD on the long-term outcomes of IBD patients.
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14010009
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  10. Article: Endoscopy Ultrasound-Guided Biliary Drainage Using Lumen Apposing Metal Stent in Malignant Biliary Obstruction.

    Fugazza, Alessandro / Andreozzi, Marta / De Marco, Alessandro / Da Rio, Leonardo / Colombo, Matteo / Spadaccini, Marco / Carrara, Silvia / Giacchetto, Marco / Sharma, Mrigya / Craviotto, Vincenzo / Busacca, Anita / Ferrari, Chiara / Repici, Alessandro

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 17

    Abstract: This narrative review provides an overview of the application of endoscopic ultrasound-guided biliary drainage (EUS-BD), including EUS-guided gallbladder drainage (EUS-GBD), for the treatment of malignant biliary obstruction. EUS-BD has demonstrated ... ...

    Abstract This narrative review provides an overview of the application of endoscopic ultrasound-guided biliary drainage (EUS-BD), including EUS-guided gallbladder drainage (EUS-GBD), for the treatment of malignant biliary obstruction. EUS-BD has demonstrated excellent technical and clinical success rates, with lower rates of adverse events when compared with percutaneous trans-hepatic biliary drainage (PTBD). EUS-BD is currently the preferred alternative technique for biliary drainage (BD) in patients with distal malignant biliary obstruction (DMBO) after failed endoscopic retrograde cholangiopancreatography (ERCP). Particularly, this review will focus on EUS-BD performed with the use of lumen apposing metal stent (LAMS). The introduction of these innovative devices, followed by the advent of electrocautery-enhanced LAMS (EC-LAMS), gave the procedure a great technical implementation and a widespread application.
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13172788
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