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  1. Book ; Online ; Thesis: Zur Entstehung einer Imbalance im limbo-präfrontalen System bei Meriones unguiculatus

    Busche, Andrea

    der Einfluss restriktiver Isolationsaufzucht und einer postnatalen Methamphetamin-Intoxikation auf die monoaminergen Transmitter Dopamin und Serotonin in limbischen Regionen ; eine Bewertung quantitativer Datenerhebungen

    2004  

    Author's details vorgelegt von Andrea Busche
    Keywords Metamfetamin ; Limbisches System ; Mongolische Rennmaus ; Serotonin ; Dopamin ; Aminerge Nervenzelle
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Bielefeld, 2004
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book ; Online ; Thesis: Zur Entstehung einer Imbalance im limbo-präfrontalen System bei Meriones unguiculatus

    Busche, Andrea

    der Einfluss restriktiver Isolationsaufzucht und einer postnatalen Methamphetamin-Intoxikation auf die monoaminergen Transmitter Dopamin und Serotonin in limbischen Regionen ; eine Bewertung quantitativer Datenerhebungen

    2004  

    Author's details vorgelegt von Andrea Busche
    Keywords Metamfetamin ; Limbisches System ; Mongolische Rennmaus ; Serotonin ; Dopamin ; Aminerge Nervenzelle
    Language German
    Size Online-Ressource
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss--Bielefeld, 2004
    Database Special collection on veterinary medicine and general parasitology

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  3. Book ; Online ; Thesis: Zur Entstehung einer Imbalance im limbo-präfrontalen System bei Meriones unguiculatus

    Busche, Andrea [Verfasser]

    der Einfluss restriktiver Isolationsaufzucht und einer postnatalen Methamphetamin-Intoxikation auf die monoaminergen Transmitter Dopamin und Serotonin in limbischen Regionen ; eine Bewertung quantitativer Datenerhebungen

    2004  

    Author's details vorgelegt von Andrea Busche
    Keywords Tiere (Zoologie) ; Animals (Zoology)
    Subject code sg590
    Language German
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  4. Article: Hemisphere-specific effects on serotonin but not dopamine innervation in the nucleus accumbens of gerbils caused by isolated rearing and a single early methamphetamine challenge.

    Lesting, Jörg / Neddens, Jörg / Busche, Andrea / Teuchert-Noodt, Gertraud

    Brain research

    2005  Volume 1035, Issue 2, Page(s) 168–176

    Abstract: The aim of this study was twofold: We examined whether serotonin (5-HT) and dopamine (DA) innervations of the nucleus accumbens are lateralised and whether the environment or the combination with an early pharmacological impact might interfere with the ... ...

    Abstract The aim of this study was twofold: We examined whether serotonin (5-HT) and dopamine (DA) innervations of the nucleus accumbens are lateralised and whether the environment or the combination with an early pharmacological impact might interfere with the postnatal maturation of the monoaminergic innervation. Male gerbils were assigned to either enriched rearing (ER) or isolated rearing (IR). Animals from both rearing conditions additionally received a single dose of either methamphetamine [MA (50 mg/kg ip)] or saline on postnatal day 14. DA and 5-HT fibres of the adult animals (postnatal day 90-110) were immunocytochemically stained and fibre densities were quantified in nucleus accumbens core and shell of both the left and right hemisphere. Our data demonstrate that the DA and 5-HT innervation is not lateralised in saline-treated animals of both rearing conditions. IR increases the DA fibre density in both hemispheres of saline controls, whereas an additional MA treatment reverses this effect. In both ER and IR groups, MA provokes an excessive 5-HT fibre in growth of only the right hemisphere. The combination of IR with MA induces right-side asymmetries of the 5-HT fibre density in both the core and shell. From the data obtained, we conclude that the maturation of the monoaminergic innervation of the nucleus accumbens is vulnerable to postnatal stimuli. The subtle "innervation imbalance" observed in our studies is consistent with previously reported effects in other brain regions of this animal model and may be causative for behavioural disturbances.
    MeSH term(s) Animals ; Dopamine/analysis ; Dopamine/metabolism ; Gerbillinae ; Male ; Methamphetamine/administration & dosage ; Nerve Fibers/chemistry ; Nerve Fibers/drug effects ; Nerve Fibers/metabolism ; Nucleus Accumbens/chemistry ; Nucleus Accumbens/drug effects ; Nucleus Accumbens/metabolism ; Serotonin/analysis ; Serotonin/metabolism ; Social Isolation ; Telencephalon/chemistry ; Telencephalon/drug effects ; Telencephalon/metabolism
    Chemical Substances Serotonin (333DO1RDJY) ; Methamphetamine (44RAL3456C) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2005-02-28
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2004.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Postnatal maturation of cortical serotonin lateral asymmetry in gerbils is vulnerable to both environmental and pharmacological epigenetic challenges.

    Neddens, Jörg / Dawirs, Ralph R / Bagorda, Francesco / Busche, Andrea / Horstmann, Sven / Teuchert-Noodt, Gertraud

    Brain research

    2004  Volume 1021, Issue 2, Page(s) 200–208

    Abstract: Long-term effects of postnatal differential rearing conditions and/or early methamphetamine (MA) application on serotonin (5-HT) fibre density were investigated in several cortical areas of both hemispheres of gerbils. The aim of this study was twofold: ( ...

    Abstract Long-term effects of postnatal differential rearing conditions and/or early methamphetamine (MA) application on serotonin (5-HT) fibre density were investigated in several cortical areas of both hemispheres of gerbils. The aim of this study was twofold: (1) Is the 5-HT fibre innervation of the cerebral cortex lateralised, and (2) if so, do postnatal environmental conditions and/or an early drug challenge interfere with development of 5-HT cerebral asymmetries? For that purpose, male gerbils were reared either under semi-natural or restricted environmental and social conditions, under both conditions once (on postnatal day 14) being treated with either a single dose of MA (50 mg/kg, i.p.) or saline. On postnatal day 110, 5-HT fibres were immunohistochemically stained and innervation densities quantified in prefrontal cortex, insular cortex, frontal cortex, parietal cortex, and entorhinal cortex. It was found that (1) 5-HT innervation in the cerebral cortex was clearly lateralised; (2) direction and extent of this asymmetry were not uniformly distributed over the different areas investigated; (3) both early methamphetamine challenge and rearing condition differentially interfered with adult 5-HT cerebral asymmetry; (4) combining MA challenge with subsequent restricted rearing tended to reverse the effects of MA on 5-HT cerebral asymmetry in some of the cortical areas investigated; and (5) significant responses in 5-HT cerebral asymmetry only occurred in prefrontal and entorhinal association cortices. The present findings suggest that the ontogenesis of cortical laterality is influenced by epigenetic factors and that disturbances of the postnatal maturation of lateralised functions may be associated with certain psychopathological behaviours.
    MeSH term(s) Adrenergic Agents/pharmacology ; Animals ; Cell Count ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiology ; Epigenesis, Genetic ; Functional Laterality/drug effects ; Gerbillinae ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Male ; Methamphetamine/pharmacology ; Nerve Fibers/drug effects ; Nerve Fibers/physiology ; Serotonin/metabolism ; Social Isolation
    Chemical Substances Adrenergic Agents ; Serotonin (333DO1RDJY) ; Methamphetamine (44RAL3456C)
    Language English
    Publishing date 2004-09-24
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2004.06.050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Administration of oral methylphenidate during adolescence prevents suppressive development of dopamine projections into prefrontal cortex and amygdala after an early pharmacological challenge in gerbils.

    Grund, Thorsten / Teuchert-Noodt, Gertraud / Busche, Andrea / Neddens, Jörg / Brummelte, Susanne / Moll, Gunther H / Dawirs, Ralph R

    Brain research

    2007  Volume 1176, Page(s) 124–132

    Abstract: The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil ... ...

    Abstract The enduring effects of postweaning subchronic methylphenidate (MP) treatment and/or previous early preweaning methamphetamine (MA) application on dopamine (DA) fiber density were investigated in multiple cortical and subcortical areas of the gerbil brain. The study aimed to explore three questions: (1) is the development of DA fiber innervation in control animals sensitive to a clinically relevant subchronic treatment with MP? (2) Is the development of DA fiber innervation in the forebrain altered by a single early MA challenge? (3) If so, might the subsequent institution of a therapeutically relevant MP application scheme interfere with such early induced alternative developmental trajectories for DA fiber innervation? For this purpose, gerbils pretreated both with saline and MA (50 mg/kg, i.p.) on day 14 received either H(2)O or MP (5 mg/kg) orally on days 30 to 60. On day 90, DA fibers were immunohistochemically detected and quantified. As a result, MP on its own did not have any significant influence on the postnatal development of the DA fiber systems, whereas it prevented a previously MA triggered suppressive development of DA fiber innervation in the prefrontal cortex and amygdala complex (30% less fiber innervation in both areas). Thus, MP prevented previously initiated miswiring of DA fibers from actually being implemented in the gerbil forebrain. During earlier studies, rather complex miswiring has been documented in response to an early preweaning MA challenge. This miswiring was associated with functional deficits resembling some of the symptoms of patients with ADHD. Therefore, morphogenetic properties of MP need further attention.
    MeSH term(s) Administration, Oral ; Aging/drug effects ; Aging/physiology ; Amygdala/drug effects ; Amygdala/growth & development ; Amygdala/metabolism ; Animals ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Central Nervous System Stimulants/pharmacology ; Gerbillinae ; Growth Cones/drug effects ; Growth Cones/metabolism ; Growth Cones/ultrastructure ; Male ; Methylphenidate/pharmacology ; Neural Pathways/drug effects ; Neural Pathways/growth & development ; Neural Pathways/metabolism ; Neurogenesis/drug effects ; Neurogenesis/physiology ; Prefrontal Cortex/drug effects ; Prefrontal Cortex/growth & development ; Prefrontal Cortex/metabolism ; Ventral Tegmental Area/drug effects ; Ventral Tegmental Area/growth & development ; Ventral Tegmental Area/metabolism
    Chemical Substances Central Nervous System Stimulants ; Methylphenidate (207ZZ9QZ49)
    Language English
    Publishing date 2007-10-24
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2007.06.107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Audio / Video: Lernen durch Lehren

    Universität Bielefeld, Audiovisuelles Zentrum (Bielefeld) / Bagorda, Francesco / Busche, Andrea / Grund, Thorsten / Horstmann, Sven / Lehmann, Konrad / Lesting, Jörg / Neddens, Jörg / Polascheck, Dierk / Schroeder, Ulrike / Teuchert-Noodt, Gertraud

    Physiologische Grundlagen des Lernens

    2003  

    Abstract: Lernen ist eine organische Leistung des Gehirns und beruht auf dem koordinierten Zusammenspiel von molekularen, zellulären und systemischen neuronalen Prozessen in den kooperierenden Subsystemen von Motorik, Sensorik und Assoziation. Zeitbefristet ... ...

    Title translation Learning by teaching: Physiological mechanisms of learning
    Abstract Lernen ist eine organische Leistung des Gehirns und beruht auf dem koordinierten Zusammenspiel von molekularen, zellulären und systemischen neuronalen Prozessen in den kooperierenden Subsystemen von Motorik, Sensorik und Assoziation. Zeitbefristet entfalten sich individuelle Dispositionen für selektive Fähigkeiten, welche die Motorik, stirnhirnrelevantes Denken in Raum- und Zeitkategorien, den lateralisierten Erwerb von Sprach- und Kunstfertigkeiten und limbisch induziertes motivations- und emotionsbedingtes Verhalten ganzheitlich einbeziehen. Dargestellt wird, dass (1) Lernen in kleinen und großen Regelkreisen stattfindet, die sich selektiv durch Struktur-Funktionskopplung stabilisieren; (2) Lernen den Regeln von aktivitätsbedingter Reorganisation folgt und immer nur aus individueller motivationaler und emotionaler Dynamik getragen ist und weder IQ noch EQ allein, sondern beide zusammen die Voraussetzung für einen Lernerfolg bilden; (3) vom Individuum sensomotorische und assoziative Regelkreise ganzheitlich und selbstverstärkend in den Lernprozess einbezogen werden, d. h. zwingend "Lernen durch Lehren".
    Keywords Fine Motor Skill Learning ; Gross Motor Skill Learning ; Learning ; Lernen ; Lernen feinmotorischer Fertigkeiten ; Lernen grobmotorischer Fertigkeiten ; Perceptual Motor Learning ; Physiologie ; Physiology ; Sensumotorisches Lernen
    Language German
    Size TIB AV-Portal: Dateigröße 1785 MB , 39,5 Minuten
    Publisher Institut für den Wissenschaftlichen Film
    Publishing place Göttingen
    Document type Audio / Video
    DOI 10.3203/IWF/C-12425
    Database PSYNDEX

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