LIVIVO - Search results -

Search results

Result 1 - 10 of total 12

Search options

Article ; Online: The Louis-Jeantet Prize 2013: Michael Stratton, Peter Hegemann and Georg Nagel.

Bushati, Natascha / Rossier, Bernard C

2013 Volume 5, Issue 2, Page(s) 167–168

MeSH term(s)	Awards and Prizes ; BRCA2 Protein/genetics ; BRCA2 Protein/metabolism ; Chlorophyta/genetics ; Chlorophyta/metabolism ; Germany ; History, 20th Century ; History, 21st Century ; Neoplasms/genetics ; Neoplasms/history ; Neoplasms/metabolism ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Rhodopsin/genetics ; Rhodopsin/metabolism ; United Kingdom
Chemical Substances	BRCA2 Protein ; Rhodopsin (9009-81-8) ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2013-01-22
Publishing country	England
Document type	Biography ; Editorial ; Historical Article
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.1002/emmm.201202394
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6784: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: MicroRNAs in neurodegeneration.

Bushati, Natascha / Cohen, Stephen M

Current opinion in neurobiology

2008 Volume 18, Issue 3, Page(s) 292–296

Abstract: microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse cellular and developmental processes. Many miRNAs are expressed specifically in the central nervous system, where they have roles in differentiation, neuronal ... ...

Abstract	microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse cellular and developmental processes. Many miRNAs are expressed specifically in the central nervous system, where they have roles in differentiation, neuronal survival, and potentially also in plasticity and learning. The absence of miRNAs in a variety of specific postmitotic neurons can lead to progressive loss of these neurons and behavioral defects reminiscent of the phenotypes seen in the pathologies of neurodegenerative diseases. Here, we review recent studies which provide a link between miRNA function and neurodegeneration. We also discuss evidence which might suggest involvement of miRNAs in the emergence or progression of neurodegenerative diseases.
MeSH term(s)	Animals ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Nerve Degeneration/genetics ; Nerve Degeneration/metabolism
Chemical Substances	MicroRNAs
Language	English
Publishing date	2008-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1078046-4
ISSN	1873-6882 ; 0959-4388
ISSN (online)	1873-6882
ISSN	0959-4388
DOI	10.1016/j.conb.2008.07.001
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3260: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: microRNA functions.

Bushati, Natascha / Cohen, Stephen M

Annual review of cell and developmental biology

2007 Volume 23, Page(s) 175–205

Abstract: microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by translational inhibition and mRNA destabilization. Here, we review recent work in animal ... ...

Abstract	microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by translational inhibition and mRNA destabilization. Here, we review recent work in animal models that provide insight into the diverse roles of miRNAs in vivo.
MeSH term(s)	Animals ; Gene Expression Regulation ; Genetic Diseases, Inborn/genetics ; Humans ; MicroRNAs/chemistry ; MicroRNAs/metabolism ; MicroRNAs/physiology
Chemical Substances	MicroRNAs
Language	English
Publishing date	2007
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1293750-2
ISSN	1530-8995 ; 1081-0706
ISSN (online)	1530-8995
ISSN	1081-0706
DOI	10.1146/annurev.cellbio.23.090506.123406
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 1003: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: An intuitive graphical visualization technique for the interrogation of transcriptome data.

Bushati, Natascha / Smith, James / Briscoe, James / Watkins, Christopher

Nucleic acids research

2011 Volume 39, Issue 17, Page(s) 7380–7389

Abstract: The complexity of gene expression data generated from microarrays and high-throughput sequencing make their analysis challenging. One goal of these analyses is to define sets of co-regulated genes and identify patterns of gene expression. To date, ... ...

Abstract	The complexity of gene expression data generated from microarrays and high-throughput sequencing make their analysis challenging. One goal of these analyses is to define sets of co-regulated genes and identify patterns of gene expression. To date, however, there is a lack of easily implemented methods that allow an investigator to visualize and interact with the data in an intuitive and flexible manner. Here, we show that combining a nonlinear dimensionality reduction method, t-statistic Stochastic Neighbor Embedding (t-SNE), with a novel visualization technique provides a graphical mapping that allows the intuitive investigation of transcriptome data. This approach performs better than commonly used methods, offering insight into underlying patterns of gene expression at both global and local scales and identifying clusters of similarly expressed genes. A freely available MATLAB-implemented graphical user interface to perform t-SNE and nearest neighbour plots on genomic data sets is available at www.nimr.mrc.ac.uk/research/james-briscoe/visgenex.
MeSH term(s)	Algorithms ; Animals ; Chick Embryo ; Cluster Analysis ; Computer Graphics ; Humans ; Mice ; Neurons/metabolism ; Principal Component Analysis ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Transcriptome
Language	English
Publishing date	2011-06-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkr462
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1067: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis.

Hilgers, Valérie / Bushati, Natascha / Cohen, Stephen M

PLoS biology

2010 Volume 8, Issue 6, Page(s) e1000396

Abstract: miR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from ... ...

Abstract	miR-263a/b are members of a conserved family of microRNAs that are expressed in peripheral sense organs across the animal kingdom. Here we present evidence that miR-263a and miR-263b play a role in protecting Drosophila mechanosensory bristles from apoptosis by down-regulating the pro-apoptotic gene head involution defective. Both microRNAs are expressed in the bristle progenitors, and despite a difference in their seed sequence, they share this key common target. In miR-263a and miR-263b deletion mutants, loss of bristles appears to be sporadic, suggesting that the role of the microRNAs may be to ensure robustness of the patterning process by promoting survival of these functionally specified cells. In the context of the retina, this mechanism ensures that the interommatidial bristles are protected during the developmentally programmed wave of cell death that prunes excess cells in order to refine the pattern of the pupal retina.
MeSH term(s)	Animals ; Apoptosis/genetics ; Base Sequence ; DNA Primers ; Drosophila/genetics ; Immunohistochemistry ; MicroRNAs/genetics ; Microscopy, Electron, Scanning ; Mutation ; Sense Organs/cytology ; Transgenes
Chemical Substances	DNA Primers ; MicroRNAs
Language	English
Publishing date	2010-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.1000396
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6193: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: miR-124 controls male reproductive success in Drosophila.

Weng, Ruifen / Chin, Jacqueline S R / Yew, Joanne Y / Bushati, Natascha / Cohen, Stephen M

eLife

2013 Volume 2, Page(s) e00640

Abstract: Many aspects of social behavior are controlled by sex-specific pheromones. Gender-appropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males ... ...

Abstract	Many aspects of social behavior are controlled by sex-specific pheromones. Gender-appropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of gender-appropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. DOI:http://dx.doi.org/10.7554/eLife.00640.001.
MeSH term(s)	Animals ; Female ; Male ; MicroRNAs/genetics ; MicroRNAs/physiology ; Mutation ; Reproduction/genetics ; Reproduction/physiology ; Sex Attractants/biosynthesis ; Sexual Behavior, Animal
Chemical Substances	MIRN124 microRNA, Drosophila ; MicroRNAs ; Sex Attractants
Language	English
Publishing date	2013-06-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.00640
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila.

Bushati, Natascha / Stark, Alexander / Brennecke, Julius / Cohen, Stephen M

Current biology : CB

2008 Volume 18, Issue 7, Page(s) 501–506

Abstract: During oogenesis, female animals load their eggs with messenger RNAs (mRNAs) that will be translated to produce new proteins in the developing embryo. Some of these maternally provided mRNAs are stable and continue to contribute to development long after ...

Abstract	During oogenesis, female animals load their eggs with messenger RNAs (mRNAs) that will be translated to produce new proteins in the developing embryo. Some of these maternally provided mRNAs are stable and continue to contribute to development long after the onset of transcription of the embryonic (zygotic) genome. However, a subset of maternal mRNAs are degraded during the transition from purely maternal to mixed maternal-zygotic gene expression. In Drosophila, two independent RNA degradation pathways are used to promote turnover of maternal transcripts during the maternal-to-zygotic transition [1]. The first is driven by maternally encoded factors, including SMAUG [2], whereas the second is activated about 2 hr after fertilization, coinciding with the onset of zygotic transcription. Here, we report that a cluster of zygotically expressed microRNAs (miRNAs) targets maternal mRNAs for turnover, as part of the zygotic degradation pathway. miRNAs are small noncoding RNAs that silence gene expression by repressing translation of their target mRNAs and by promoting mRNA turnover. Intriguingly, use of miRNAs to promote mRNA turnover during the maternal-to-zygotic transition appears to be a conserved phenomenon because a comparable role was reported for miR-430 in zebrafish [3]. The finding that unrelated miRNAs regulate the maternal to zygotic transition in different animals suggests convergent evolution.
MeSH term(s)	Animals ; Down-Regulation ; Drosophila/embryology ; Drosophila/genetics ; Drosophila/metabolism ; Female ; Fertility/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Messenger, Stored/metabolism ; Sequence Deletion ; Time Factors ; Zygote/metabolism
Chemical Substances	MicroRNAs ; RNA, Messenger, Stored
Language	English
Publishing date	2008-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2008.02.081
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3208: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recombinase-mediated cassette exchange provides a versatile platform for gene targeting: knockout of miR-31b.

Weng, Ruifen / Chen, Ya-Wen / Bushati, Natascha / Cliffe, Adam / Cohen, Stephen M

Genetics

2009 Volume 183, Issue 1, Page(s) 399–402

Abstract: A series of vectors has been designed to enhance the versatility of targeted homologous recombination. Recombinase-mediated cassette exchange permits sequential targeting at any locus and improves flexibility in making user-defined mutations. Application ...

Abstract	A series of vectors has been designed to enhance the versatility of targeted homologous recombination. Recombinase-mediated cassette exchange permits sequential targeting at any locus and improves flexibility in making user-defined mutations. Application of RMCE to delete an intronic microRNA gene is described.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Drosophila melanogaster/genetics ; Gene Targeting/methods ; Gene Transfer Techniques ; Genetic Vectors/chemical synthesis ; Genetic Vectors/genetics ; MicroRNAs/genetics ; Models, Biological ; Mutagenesis, Insertional/methods ; Recombinases/physiology ; Recombination, Genetic
Chemical Substances	MicroRNAs ; Recombinases
Language	English
Publishing date	2009-06-29
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1534/genetics.109.105213
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 767: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.

Stark, Alexander / Brennecke, Julius / Bushati, Natascha / Russell, Robert B / Cohen, Stephen M

Cell

2005 Volume 123, Issue 6, Page(s) 1133–1146

Abstract: MicroRNAs are small noncoding RNAs that serve as posttranscriptional regulators of gene expression in higher eukaryotes. Their widespread and important role in animals is highlighted by recent estimates that 20%-30% of all genes are microRNA targets. ... ...

Abstract	MicroRNAs are small noncoding RNAs that serve as posttranscriptional regulators of gene expression in higher eukaryotes. Their widespread and important role in animals is highlighted by recent estimates that 20%-30% of all genes are microRNA targets. Here, we report that a large set of genes involved in basic cellular processes avoid microRNA regulation due to short 3'UTRs that are specifically depleted of microRNA binding sites. For individual microRNAs, we find that coexpressed genes avoid microRNA sites, whereas target genes and microRNAs are preferentially expressed in neighboring tissues. This mutually exclusive expression argues that microRNAs confer accuracy to developmental gene-expression programs, thus ensuring tissue identity and supporting cell-lineage decisions.
MeSH term(s)	3' Untranslated Regions/genetics ; Animals ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Line ; Drosophila/embryology ; Drosophila/genetics ; Drosophila Proteins/genetics ; Embryo, Nonmammalian/metabolism ; Evolution, Molecular ; Gene Expression Regulation, Developmental/genetics ; Homeodomain Proteins/genetics ; In Situ Hybridization ; Membrane Proteins/genetics ; MicroRNAs/genetics ; MicroRNAs/physiology ; Molecular Sequence Data ; Muscles/embryology ; Muscles/metabolism ; Nerve Tissue Proteins/genetics ; Nervous System/embryology ; Nervous System/metabolism ; Nuclear Proteins/genetics ; RNA, Messenger/genetics ; Sequence Homology, Nucleic Acid ; Tropomyosin/genetics ; Vacuolar Proton-Translocating ATPases/genetics
Chemical Substances	3' Untranslated Regions ; Basic Helix-Loop-Helix Transcription Factors ; Drosophila Proteins ; Homeodomain Proteins ; Membrane Proteins ; MicroRNAs ; Nerve Tissue Proteins ; Nuclear Proteins ; RNA, Messenger ; Tm1 protein, Drosophila ; Tropomyosin ; cpo protein, Drosophila ; gliotactin ; l(1)sc protein, Drosophila ; repo protein, Drosophila ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-)
Language	English
Publishing date	2005-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2005.11.023
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands.

Stark, Alexander / Bushati, Natascha / Jan, Calvin H / Kheradpour, Pouya / Hodges, Emily / Brennecke, Julius / Bartel, David P / Cohen, Stephen M / Kellis, Manolis

Genes & development

2008 Volume 22, Issue 1, Page(s) 8–13

Abstract: MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of protein-coding genes to direct post-transcriptional repression. Here, we report that the miRNA iab-4 locus ... ...

Abstract	MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of protein-coding genes to direct post-transcriptional repression. Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from both DNA strands, giving rise to two distinct functional miRNAs. Both sense and antisense miRNA products target neighboring Hox genes via highly conserved sites, leading to homeotic transformations when ectopically expressed. We also report sense/antisense miRNAs in mouse and find antisense transcripts close to many miRNAs in both flies and mammals, suggesting that additional sense/antisense pairs exist.
MeSH term(s)	Animals ; Base Sequence ; Body Patterning ; DNA/chemistry ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila/metabolism ; Gene Expression Regulation, Developmental ; Genes, Homeobox ; Genes, Insect ; Genome ; Humans ; Mice ; MicroRNAs/biosynthesis ; MicroRNAs/genetics ; Models, Genetic ; Molecular Sequence Data ; Nucleic Acid Conformation ; RNA, Antisense/metabolism
Chemical Substances	MicroRNAs ; RNA, Antisense ; DNA (9007-49-2)
Language	English
Publishing date	2008-01-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	806684-x
ISSN	1549-5477 ; 0890-9369
ISSN (online)	1549-5477
ISSN	0890-9369
DOI	10.1101/gad.1613108
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 2292: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 54: Show issues

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito