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  1. Book: Malignancies of the Nasal Vestibule

    Bussu, Francesco

    A New Perspective on Classification, Staging, and Treatment

    2023  

    Author's details Francesco Bussu is currently a Professor and Chairman in Otolaryngology, as well as the Head of the ENT Division at the University Hospital of Sassari (Italy). He reactivated the Sassari Speech Therapy School in 2020. He is a member of the Italian commission for National Scientific Qualification to Professorship and the treasurer of the Italian Society of Otorhinolaryngology (SIO). He performed about 10,000 surgical procedures as first operator in all the subspecialties of otolaryngology, and in particular head and neck oncology. He introduced the lengthening temporalis myoplasty (Labbè operation) in Italy for long-term facial paralysis rehabilitation, and he has performed over 100 brachytherapy implants for head and neck malignancies, more than 50 for nasal vestibule primaries. He has contributed to clarifying the oncogenic role of HPV in non-oropharyngeal head and neck malignancies, and the clinical limits of the currently employed p16 IHC in the definition of HPV related carcinog
    Keywords interstitialHDRbrachytherapy ; Nasalcavity ; nosetip ; nasalcartilages ; alarcartilages ; InterventionalRadiotherapy ; Wangstaging ; rhinoseptoplasty ; subperichondralplanes ; squamouscellcarcinoma ; basalcellcarcinoma ; melanoma ; skincancer ; AJCC/UICCTNM ; Neckdissection ; interstitial HDR brachytherapy ; nasal cavity ; nose tip ; nasal cartilages ; alar cartilages ; Interventional radiotherapy ; neck dissection ; Wang staging ; subperichondral planes ; squamous cell carcinoma ; basal cell carcinoma ; Melanoma ; Skin cancer ; AJCC ; UICC TNM
    Language English
    Size 220 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_23
    Format 160 x 241 x 17
    ISBN 9783031328497 ; 3031328493
    Database PDA

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  2. Article ; Online: Function Preservation in Head and Neck Cancers.

    Budrukkar, A / Guinot, J L / Tagliaferri, L / Bussu, F / García-Consuegra, A / Kovacs, G

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2023  Volume 35, Issue 8, Page(s) 497–506

    Abstract: The treatment of head and neck cancers can have a significant impact on function and appearance, which results in impairment of quality of life. Various long-term sequelae of treatment include speech and swallowing difficulty, oral incompetence, trismus, ...

    Abstract The treatment of head and neck cancers can have a significant impact on function and appearance, which results in impairment of quality of life. Various long-term sequelae of treatment include speech and swallowing difficulty, oral incompetence, trismus, xerostomia, dental caries and osteoradionecrosis. Management has evolved from single modality treatment of either surgery or radiation to multimodality treatment to attain acceptable functional outcomes. Brachytherapy, also known as interventional radiotherapy, with its ability to deliver high doses centrally to the target, has been shown to improve local control rates. Due to the rapid fall-off of the dose of brachytherapy there is better organ at risk sparing as compared with that of external beam radiotherapy. In the head and neck region, brachytherapy has been practiced in various sites, including the oral cavity, oropharynx, nasopharynx, nasal vestibule and paranasal sinuses. Additionally, brachytherapy has also been considered for reirradiation as a salvage. Brachytherapy can also be considered as a perioperative technique together with surgery. Close multidisciplinary cooperation is required for a successful brachytherapy programme. In oral cavity cancers, depending on the location of the tumour, brachytherapy has been shown to preserve oral competence, maintain tongue mobility, maintain speech, swallowing and the hard palate. Brachytherapy in oropharyngeal cancers has been shown to reduce xerostomia and also reduce dysphagia and aspiration post-radiation therapy. For the nasopharynx, paranasal sinus and nasal vestibule, brachytherapy preserves the respiratory function of the mucosa. Despite such an incomparable impact on function and organ preservation, brachytherapy is an underutilised technique for head and neck cancers. There is a strong need to improve brachytherapy utilisation in head and neck cancers.
    MeSH term(s) Humans ; Dental Caries ; Quality of Life ; Carcinoma, Squamous Cell/pathology ; Head and Neck Neoplasms/radiotherapy ; Brachytherapy/methods ; Xerostomia ; Radiotherapy Dosage
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2023.01.022
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  3. Article: p16 Expression in Laryngeal Squamous Cell Carcinoma: A Surrogate or Independent Prognostic Marker?

    Gallus, Roberto / Rizzo, Davide / Rossi, Giorgia / Mureddu, Luca / Galli, Jacopo / Artuso, Alberto / Bussu, Francesco

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 2

    Abstract: Laryngeal squamous cell carcinoma (LSCC) is a common malignancy that, despite scientific advancements, has not seen an improvement in its prognosis in the last decades. Few promising predictive markers have been found and none are relevant in clinical ... ...

    Abstract Laryngeal squamous cell carcinoma (LSCC) is a common malignancy that, despite scientific advancements, has not seen an improvement in its prognosis in the last decades. Few promising predictive markers have been found and none are relevant in clinical practice. p16
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13020100
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  4. Article ; Online: Opportunities and obstacles of electronic health records in Italy: towards enhanced surgical care.

    Corbisiero, Michaele Francesco / Rizzo, Davide / Gallus, Roberto / Loreti, Pierpaolo / Bracciale, Lorenzo / Bussu, Francesco

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2024  Volume 44, Issue 2, Page(s) 140–142

    MeSH term(s) Italy ; Electronic Health Records ; Humans ; Surgical Procedures, Operative
    Language English
    Publishing date 2024-04-23
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-N2727
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  5. Article ; Online: Beware of the dangers along the path towards the diagnosis of HPV-driven oropharyngeal squamous cell carcinoma.

    Boscolo-Rizzo, P / Bussu, F

    Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

    2017  Volume 37, Issue 1, Page(s) 63–64

    Title translation Attenzione alle insidie riservate dalla diagnosi del carcinoma squamocellulare orofaringeo HPV-relato.
    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/virology ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/virology ; Humans ; Molecular Diagnostic Techniques ; Oropharyngeal Neoplasms/diagnosis ; Oropharyngeal Neoplasms/virology ; Papillomaviridae/isolation & purification ; Papillomavirus Infections/diagnosis ; Papillomavirus Infections/virology ; Squamous Cell Carcinoma of Head and Neck
    Language English
    Publishing date 2017-04-04
    Publishing country Italy
    Document type Letter
    ZDB-ID 604898-5
    ISSN 1827-675X ; 0392-100X
    ISSN (online) 1827-675X
    ISSN 0392-100X
    DOI 10.14639/0392-100X-1323
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  6. Article ; Online: Response to "Commentary on Periprosthetic Leakage in Tracheoesophageal Prosthesis: Proposal of a Standardized Therapeutic Algorithm".

    Parrilla, Claudio / Longobardi, Ylenia / Bussu, Francesco / Scarano, Emanuele / Galli, Jacopo

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2022  Volume 167, Issue 4, Page(s) 801–802

    MeSH term(s) Algorithms ; Humans ; Larynx, Artificial ; Prosthesis Failure
    Language English
    Publishing date 2022-09-19
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1177/01945998211073063
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  7. Article: Parapharyngeal Space Tumors: Our Experience.

    Galli, Jacopo / Rolesi, Rolando / Gallus, Roberto / Seccia, Annalisa / Pedicelli, Alessandro / Bussu, Francesco / Scarano, Emanuele

    Journal of personalized medicine

    2023  Volume 13, Issue 2

    Abstract: Para-pharyngeal space (PPS) tumors include an heterogeneous group of neoplasms, accounting for approximatively 0.5-1.5% of all head and neck tumors. Management of these neoplasms requires a careful diagnostic workout and an appropriate surgical approach ... ...

    Abstract Para-pharyngeal space (PPS) tumors include an heterogeneous group of neoplasms, accounting for approximatively 0.5-1.5% of all head and neck tumors. Management of these neoplasms requires a careful diagnostic workout and an appropriate surgical approach to obtain good outcomes associated with minimal aesthetic drawbacks. In this study we investigated clinical onset, histologic features, surgical treatment outcomes, peri operative complications and follow up of 98 patients treated for PPS tumors in our Centre between 2002 and 2021. Furthermore, we reviewed our preliminary experience of preoperative embolization of hyper vascular PPS tumors trough SQUID12, an ethylene vinyl alcohol copolymers (EVOH) which exhibits many advantages over other embolic agents, due to its better devascularization rate and lower risk of systemic complications. Our data support the hypothesis that transoral surgery scenario should be significantly revised, as it could represent a valid treatment for tumors located in lower and prestyloyd portion of PPS. Moreover, SQUID12, a novel embolization agent, may be a very promising choice for PPS hyper vascularized tumors, ensuring higher devascularization rate, safer procedures and lower risk of systemic dispersion compared to traditional Contour treatment.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13020283
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  8. Article: Salvage Strategies for Local Recurrences of Squamous Cell Carcinoma of the Nasal Vestibule: A Single-Center Experience of 22 Years.

    Rubino, Corrado / Trignano, Emilio / Bussu, Francesco / Serra, Pietro Luciano / Rodio, Manuela / Tettamanzi, Matilde / Rampazzo, Silvia

    Journal of clinical medicine

    2024  Volume 13, Issue 2

    Abstract: Squamous cell carcinomas of the nasal vestibule are an extremely rare neoplastic disease. Although brachytherapy is gaining popularity for primary treatment, surgery remains the best option in case of recurrences. The aim of this paper is to outline our ... ...

    Abstract Squamous cell carcinomas of the nasal vestibule are an extremely rare neoplastic disease. Although brachytherapy is gaining popularity for primary treatment, surgery remains the best option in case of recurrences. The aim of this paper is to outline our treatment experience of local recurrence of SCCNVs over the past 22 years. We retrospectively reviewed the clinical data of the patients who underwent surgical treatment for local recurrence of SCCNV: data regarding age, sex, primary tumor treatment, recurrence location and time of appearance, surgical resection, type of reconstruction, postoperative complication, surgical revision, and re-recurrence rate were analyzed. Twenty patients were included in the study. The median period for recurrence appearance was 17 months, and the prevalent location of recurrence was the nasal alae. Prevalent reconstructive procedures were the nasolabial flap and paramedian forehead flap. No postoperative complications were observed, and one case of re-recurrence was detected at 12-months of follow-up. Based on our experience, salvage surgical procedures for SCCNV recurrences must be individualized and carefully planned, taking into account the peculiar pattern of tumor spread and the presence of scar and heavily radiotherapy damaged tissue from previous treatment; delayed reconstruction should be considered for all the cases with skeletal involvement.
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13020541
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  9. Article ; Online: Vocal Fold Paralysis After Spinal and Epidural Anesthesia: A Case Report and Scoping Review.

    Contu, Nicolò / Gallus, Roberto / Profice, Paolo / Lucchetti, Dario / Degni, Emilia / Rizzo, Davide / Artuso, Alberto / Bussu, Francesco

    The Laryngoscope

    2024  

    Abstract: Objectives: Cranial nerve paralysis is a rare complication of spinal and epidural anesthesia, and some cases of vocal fold paralysis (VFP) have been reported. The aim of this article is to report a case, identify evidence supporting the possibility of ... ...

    Abstract Objectives: Cranial nerve paralysis is a rare complication of spinal and epidural anesthesia, and some cases of vocal fold paralysis (VFP) have been reported. The aim of this article is to report a case, identify evidence supporting the possibility of VFP being a complication of spinal and epidural anesthesia and to investigate the frequency, the characteristics, and the possible mechanisms of such a complication.
    Data sources: CINAHL Complete, Google Scholar, Cochrane Library, Pubmed, and EMBASE.
    Methods: Case report according to CARE guidelines; scoping review according to PRISMA-ScR criteria. All types of studies that reported on patients of any age and sex, all types of spinal/epidural anesthesia regardless of the location and of drugs used were included. A data extraction sheet was completed for each study selected for inclusion based on the full-text screenings. Extracted data included: study characteristics, participant characteristics, intervention characteristics, outcome measures, clinical investigations. The study did not receive external funding.
    Results: Eight studies met inclusion criteria and a total of 13 events (in 12 patients, including ours) were reported to date. Although there are some hypotheses in regard to the mechanism underlying the phenomena, including mechanical and inflammatory ones, the exact cause is still unclear.
    Conclusions: Only few cases of VFP after spinal or epidural anesthesia have been reported to date; however, it seems possible that VFP might be a potential underreported complication of such procedures. We believe that more research on the topic is warranted, especially considering the wide population potentially at risk.
    Level of evidence: NA Laryngoscope, 2024.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.31316
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  10. Article ; Online: Submandibular gland degloving: A minimally invasive function-preserving surgical approach for benign diseases.

    Piras, Antonio / Rizzo, Davide / Gallus, Roberto / Artuso, Alberto / Bussu, Francesco

    Head & neck

    2021  Volume 43, Issue 8, Page(s) 2560–2563

    Abstract: In the Video S1, a modified technique for submandibular gland resection in benign disease is shown. The main plane of dissection is below the fascia and immediately superficial to the fibrous capsule of the gland. The video shows the surgical steps and ... ...

    Abstract In the Video S1, a modified technique for submandibular gland resection in benign disease is shown. The main plane of dissection is below the fascia and immediately superficial to the fibrous capsule of the gland. The video shows the surgical steps and the structures that become evident along the procedure and illustrates some tips and tricks. Facial vessels are dissected, easily spared, and not ligated as it occurs in the classical technique. This technical variant is minimally invasive, respectful of anatomy, and through preservation of the fascial layer investing the gland aims at reducing the risk of injury to the marginalis mandibulae branch of the facial nerve, which lies within the fascia itself.
    MeSH term(s) Dissection ; Facial Nerve ; Humans ; Submandibular Gland/surgery
    Language English
    Publishing date 2021-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.26728
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