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Article ; Online: Optic cup morphogenesis across species and related inborn human eye defects.

Cardozo, Marcos J / Sánchez-Bustamante, Elena / Bovolenta, Paola

2023 Volume 150, Issue 2

Abstract: The vertebrate eye is shaped as a cup, a conformation that optimizes vision and is acquired early in development through a process known as optic cup morphogenesis. Imaging living, transparent teleost embryos and mammalian stem cell-derived organoids has ...

Abstract	The vertebrate eye is shaped as a cup, a conformation that optimizes vision and is acquired early in development through a process known as optic cup morphogenesis. Imaging living, transparent teleost embryos and mammalian stem cell-derived organoids has provided insights into the rearrangements that eye progenitors undergo to adopt such a shape. Molecular and pharmacological interference with these rearrangements has further identified the underlying molecular machineries and the physical forces involved in this morphogenetic process. In this Review, we summarize the resulting scenarios and proposed models that include common and species-specific events. We further discuss how these studies and those in environmentally adapted blind species may shed light on human inborn eye malformations that result from failures in optic cup morphogenesis, including microphthalmia, anophthalmia and coloboma.
MeSH term(s)	Animals ; Humans ; Eye ; Embryonic Development ; Coloboma ; Organogenesis ; Morphogenesis/genetics ; Retina ; Mammals
Language	English
Publishing date	2023-01-30
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.200399
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Article: Maternal

Camacho-Macorra, Carlos / Tabanera, Noemí / Sánchez-Bustamante, Elena / Bovolenta, Paola / Cardozo, Marcos J

Frontiers in cell and developmental biology

2024 Volume 12, Page(s) 1362695

Abstract: Gastrulation in zebrafish embryos commences with the morphogenetic rearrangement of blastodermal cells, which undergo a coordinated spreading from the animal pole to wrap around the egg at the vegetal pole. This rearrangement, known as epiboly, relies on ...

Abstract	Gastrulation in zebrafish embryos commences with the morphogenetic rearrangement of blastodermal cells, which undergo a coordinated spreading from the animal pole to wrap around the egg at the vegetal pole. This rearrangement, known as epiboly, relies on the orchestrated activity of maternal transcripts present in the egg, compensating for the gradual activation of the zygotic genome. Epiboly involves the mechano-transducer activity of yap1 but what are the regulators of yap1 activity and whether these are maternally or zygotically derived remain elusive. Our study reveals the crucial role of maternal vgll4a, a proposed Yap1 competitor, during zebrafish epiboly. In embryos lacking maternal/zygotic
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2024.1362695
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Article: Post-Austronesian migrational wave of West Polynesians to Micronesia

Palencia-Madrid, Leire / Baeta, Miriam / Kleinbielen, Tamara / Toro-Delgado, Nerea / Villaescusa, Patricia / Sanchez-Bustamante, Elena / de Pancorbo, Marian M. / Luis, Javier Rodriguez / Ware, Kathryn E. / Somarelli, Jason A. / Garcia-Bertrand, Ralph / Herrera, Rene J.

Gene. 2022 May 20, v. 823

2022

Abstract: This study examines Y-chromosome and mtDNA markers in the population of the island of Kiritimati in the context of geographically targeted reference populations from the Pacific. Kiritimati derives its population from the atoll islands of the Gilbert ... ...

Abstract	This study examines Y-chromosome and mtDNA markers in the population of the island of Kiritimati in the context of geographically targeted reference populations from the Pacific. Kiritimati derives its population from the atoll islands of the Gilbert Archipelago and representsa geographicaltransitional region between Micronesia, Polynesia and Melanesia that likely played a critical role during theAustronesian expansion. The large presence(84.1%)of individuals withO-M175, O2a-M324 and O2a2b-P164 sub-haplogroups, 69.9% being O2a2b-P164, the Y-STR homogeneity within O2a2b-P164 and the very recent age of the sub-haplogroup(363–548 years ago)inKiritimati suggestthe arrival ofa genetically homogenous population to the Gilberteses followed by a population expassion.The close Y-STR haplotype affinities with profiles from the Samoa and Tonga Archipelagos point to an unprecedented massive post-Austronesian expansionexodus from West Polynesia.Contrasting the abundance of AustronesianO2a2b-P164 sub-haplogroup, the most abundantMelanesian/Papuansub-haplogroup,C-M130is present at a frequency of 13.5%. Thenetwork topology suggests that C-M130 arrived to theKiribati Archipelago from West Polynesia, specifically from West Samoa, Tonga and/or Tutuila subsequent to the Austronesian expansion about 832–1408 years ago. The haplotype affinities withinO2a2b-P164 argue for anoriginal source in Taiwan and its dispersal to West Polynesia and then to Southeast Micronesia. The present investigation provides an understanding of the genetic composition and complex migration history of an understudied region of the Pacific and provides evidence for recent dispersals towards Micronesia from West Polynesia subsequent to the initial Austronesian expansion.
Keywords	Y chromosome ; atolls ; genes ; haplotypes ; topology ; Melanesia ; Micronesia ; Polynesia ; Samoa ; Taiwan ; Tonga
Language	English
Dates of publication	2022-0520
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146357
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Article: Multidecadal to centennial surface wintertime wind variability over Northeastern North America via statistical downscaling

Lucio-Eceiza, Etor E / Beltrami, Hugo / García-Bustamante, Elena / González-Rouco, J. Fidel / Navarro, Jorge

Climate dynamics. 2019 July, v. 53, no. 1-2

2019

Abstract: The variability of the surface wind field over Northeastern North America was analysed through a statistical downscaling (SD) approach, using the relationships among the main large-scale and observed wind circulation modes. The large-scale variables were ...

Abstract	The variability of the surface wind field over Northeastern North America was analysed through a statistical downscaling (SD) approach, using the relationships among the main large-scale and observed wind circulation modes. The large-scale variables were provided by 12 global reanalyses. The observed zonal and meridional wind components come from a database of 525 sites spanning over 1953–2010. A large percentage of the regional variability was explained in terms of three major large- and regional/local-scale coupled circulation patterns, accounting for 55.3% (59.3%) of the large (regional/local) scale variability. The method delivered robust results regardless of the SD model configuration, albeit with sensitivity to the number of retained circulation modes and the large-scale window size, but not to the reanalysis chosen for the large-scale variables. The methodological uncertainty was larger for sites/wind components with larger variability. A parameter configuration chosen for yielding the best possible SD estimations showed high correlation values between these estimations and the observations for the majority of the sites (0.6–0.9, significant at [Formula: see text]), and a realistic wind variance (standard deviation ratios between 0.6 and 1.0), with similar results regardless of the reanalysis. The reanalysis direct wind outputs showed higher correlations than the SD estimates (0.7–0.97, also significant). The skill in reproducing observational variance differed considerably from model to model (ratios between 0.5 and 3). The regional wind climatology was reconstructed back to 1850 with the help of century long reanalyses and two additional SLP gridded datasets allowing to estimate the variability at decadal and multidecadal timescales. Recent trends in the wind components are not unusual in the context of century-long reconstructed variability. Extreme values in both components tend to appear associated with high values in the first two modes of variability.
Keywords	atmospheric circulation ; climate ; climatology ; data collection ; databases ; models ; standard deviation ; uncertainty ; variance ; wind ; winter ; North America
Language	English
Dates of publication	2019-07
Size	p. 41-66.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-018-4569-5
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Article ; Online: Post-Austronesian migrational wave of West Polynesians to Micronesia.

Palencia-Madrid, Leire / Baeta, Miriam / Kleinbielen, Tamara / Toro-Delgado, Nerea / Villaescusa, Patricia / Sanchez-Bustamante, Elena / de Pancorbo, Marian M / Luis, Javier Rodriguez / Ware, Kathryn E / Somarelli, Jason A / Garcia-Bertrand, Ralph / Herrera, Rene J

Gene

2022 Volume 823, Page(s) 146357

Abstract	This study examines Y-chromosome and mtDNA markers in the population of the island of Kiritimati in the context of geographically targeted reference populations from the Pacific. Kiritimati derives its population from the atoll islands of the Gilbert Archipelago and representsa geographicaltransitional region between Micronesia, Polynesia and Melanesia that likely played a critical role during theAustronesian expansion. The large presence(84.1%)of individuals withO-M175, O2a-M324 and O2a2b-P164 sub-haplogroups, 69.9% being O2a2b-P164, the Y-STR homogeneity within O2a2b-P164 and the very recent age of the sub-haplogroup(363-548 years ago)inKiritimati suggestthe arrival ofa genetically homogenous population to the Gilberteses followed by a population expassion.The close Y-STR haplotype affinities with profiles from the Samoa and Tonga Archipelagos point to an unprecedented massive post-Austronesian expansionexodus from West Polynesia.Contrasting the abundance of AustronesianO2a2b-P164 sub-haplogroup, the most abundantMelanesian/Papuansub-haplogroup,C-M130is present at a frequency of 13.5%. Thenetwork topology suggests that C-M130 arrived to theKiribati Archipelago from West Polynesia, specifically from West Samoa, Tonga and/or Tutuila subsequent to the Austronesian expansion about 832-1408 years ago. The haplotype affinities withinO2a2b-P164 argue for anoriginal source in Taiwan and its dispersal to West Polynesia and then to Southeast Micronesia. The present investigation provides an understanding of the genetic composition and complex migration history of an understudied region of the Pacific and provides evidence for recent dispersals towards Micronesia from West Polynesia subsequent to the initial Austronesian expansion.
MeSH term(s)	Chromosomes, Human, Y/genetics ; DNA, Mitochondrial/genetics ; Genetics, Population/methods ; Haplotypes ; Human Migration ; Humans ; Micronesia/ethnology ; Phylogeny ; Polynesia/ethnology ; Sequence Analysis, DNA
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2022-02-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2022.146357
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Book ; Online: Land Surface Model influence on the simulated climatologies of temperature and precipitation extremes in the WRF v.3.9 model over North America

García-García, Almudena / Cuesta-Valero, Francisco José / Beltrami, Hugo / González-Rouco, J. Fidel / García-Bustamante, Elena / Finnis, Joel

eISSN: 1991-9603

2020

Abstract: The representation and projection of extreme temperature and precipitation events in regional and global climate models are of major importance for the study of climate change impacts. However, state-of-the-art global and regional climate model ... ...

Abstract	The representation and projection of extreme temperature and precipitation events in regional and global climate models are of major importance for the study of climate change impacts. However, state-of-the-art global and regional climate model simulations yield a broad inter-model range of intensity, duration and frequency of these extremes. Here, we present a modeling experiment using the Weather Research and Forecasting (WRF) model to determine the influence of the land surface model (LSM) component on uncertainties associated with extreme events. First, we evaluate land-atmosphere interactions within four simulations performed by the WRF model using three different LSMs from 1980 to 2012 over North America. Results show LSM-dependent differences at regional scales in the frequency of occurrence of events when surface conditions are altered by atmospheric forcing or land processes. The inter-model range of extreme statistics across the WRF simulations is large, particularly for indices related to the intensity and duration of temperature and precipitation extremes. Areas showing large uncertainty in WRF simulated extreme events are also identified in a model ensemble from three different Regional Climate Model (RCM) simulations participating in the Coordinated Regional Climate Downscaling Experiment (CORDEX) project, revealing the implications of these results for other model ensembles. This study illustrates the importance of the LSM choice in climate simulations, supporting the development of new modeling studies using different LSM components to understand inter-model differences in simulating temperature and precipitation extreme events, which in turn will help to reduce uncertainties in climate model projections.
Subject code	550 ; 910
Language	English
Publishing date	2020-04-20
Publishing country	de
Document type	Book ; Online
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Book ; Online: Land surface model influence on the simulated climatologies of temperature and precipitation extremes in the WRF v3.9 model over North America

García-García, Almudena / Cuesta-Valero, Francisco José / Beltrami, Hugo / González-Rouco, Fidel / García-Bustamante, Elena / Finnis, Joel

eISSN: 1991-9603

2020

Abstract	The representation and projection of extreme temperature and precipitation events in regional and global climate models are of major importance for the study of climate change impacts. However, state-of-the-art global and regional climate model simulations yield a broad inter-model range of intensity, duration and frequency of these extremes. Here, we present a modeling experiment using the Weather Research and Forecasting (WRF) model to determine the influence of the land surface model (LSM) component on uncertainties associated with extreme events. First, we analyze land–atmosphere interactions within four simulations performed by the WRF model from 1980 to 2012 over North America, using three different LSMs. Results show LSM-dependent differences at regional scales in the frequency of occurrence of events when surface conditions are altered by atmospheric forcing or land processes. The inter-model range of extreme statistics across the WRF simulations is large, particularly for indices related to the intensity and duration of temperature and precipitation extremes. Our results show that the WRF simulation of the climatology of heat extremes can be 5 ∘ C warmer and 6 d longer depending on the employed LSM component, and similarly for cold extremes and heavy precipitation events. Areas showing large uncertainty in WRF-simulated extreme events are also identified in a model ensemble from three different regional climate model (RCM) simulations participating in the Coordinated Regional Climate Downscaling Experiment (CORDEX) project, revealing the implications of these results for other model ensembles. Thus, studies based on multi-model ensembles and reanalyses should include a variety of LSM configurations to account for the uncertainty arising from this model component or to test the performance of the selected LSM component before running the whole simulation. This study illustrates the importance of the LSM choice in climate simulations, supporting the development of new modeling studies using different LSM components to understand inter-model differences in simulating extreme temperature and precipitation events, which in turn will help to reduce uncertainties in climate model projections.
Subject code	550 ; 910
Language	English
Publishing date	2020-11-05
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Making of the New European Wind Atlas. Pt.1

Hahmann, Andrea N. / Sile, Tija / Witha, Björn / Davis, Neil N. / Dörenkämper, Martin / Ezber, Yasemin / Garcia-Bustamante, Elena / Gonzales-Rouco, J. Fidel / Navarro, Jorge / Olsen, Bjarke T. / Söderberg, Stefan

Model Sensitivity

2020

Abstract: S.5053-5078 ... This is the first of two papers that document the creation of the New European Wind Atlas (NEWA). It describes the sensitivity analysis and evaluation procedures that formed the basis for choosing the final setup of the mesoscale model ... ...

Abstract	S.5053-5078 This is the first of two papers that document the creation of the New European Wind Atlas (NEWA). It describes the sensitivity analysis and evaluation procedures that formed the basis for choosing the final setup of the mesoscale model simulations of the wind atlas. The suitable combination of model setup and parameterizations, bound by practical constraints, was found for simulating the climatology of the wind field at turbine-relevant heights with the Weather Research and Forecasting (WRF) model. Initial WRF model sensitivity experiments compared the wind climate generated by using two commonly used planetary boundary layer schemes and were carried out over several regions in Europe. They confirmed that the most significant differences in annual mean wind speed at 100 m a.g.l. (above ground level) mostly coincide with areas of high surface roughness length and not with the location of the domains or maximum wind speed. Then an ensemble of more than 50 simulations with different setups for a single year was carried out for one domain covering northern Europe for which tall mast observations were available. We varied many different parameters across the simulations, e.g. model version, forcing data, various physical parameterizations, and the size of the model domain. These simulations showed that although virtually every parameter change affects the results in some way, significant changes in the wind climate in the boundary layer are mostly due to using different physical parameterizations, especially the planetary boundary layer scheme, the representation of the land surface, and the prescribed surface roughness length. Also, the setup of the simulations, such as the integration length and the domain size, can considerably influence the results. We assessed the degree of similarity between winds simulated by the WRF ensemble members and the observations using a suite of metrics, including the Earth Mover's Distance (EMD), a statistic that measures the distance between two probability ...
Subject code	551
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Insuficiencia renal crónica oculta en el anciano con cardiopatía isquémica.

Bustamante, Juan / Gómez-Martínez, M Loreto / Bustamante, Elena / Tamayo, Eduardo

Medicina clinica

2009 Volume 133, Issue 13, Page(s) 524; author reply 526

Title translation	Occult chronic kidney disease in the ederly with coronary heart disease.
MeSH term(s)	Aged ; Coronary Disease/complications ; Humans ; Kidney Failure, Chronic/complications
Language	Spanish
Publishing date	2009-10-10
Publishing country	Spain
Document type	Letter
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2009.01.014
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Article: Efficacy of Lime, Biosolids, and Mycorrhiza for the Phytostabilization of Sulfidic Copper Tailings in Chile: A Greenhouse Experiment

Verdugo, Cesar / Sanchez, Pablo / Santibanez, Claudia / Urrestarazu, Paola / Bustamante, Elena / Silva, Yasna / Gourdon, Denis / Ginocchio, Rosanna

International journal of phytoremediation. 2011, v. 13, no. 1-5

2011

Abstract: Inadequate abandonment of copper mine tailings under semiarid Mediterranean climate type conditions has posed important environmental risks in Chile due to wind and rain erosion. There are cost-effective technologies for tailings stabilization such as ... ...

Abstract	Inadequate abandonment of copper mine tailings under semiarid Mediterranean climate type conditions has posed important environmental risks in Chile due to wind and rain erosion. There are cost-effective technologies for tailings stabilization such as phytostabilization. However, this technology has not been used in Chile yet. This study evaluated in a greenhouse assay the efficacy of biosolids, lime, and a commercial mycorrhiza to improve adverse conditions of oxidized Cu mine tailings for adequate establishment and grow of Lolium perenne L. var nui. Chemical characterization of experimental substrates and pore water samples were performed; plant density, biomass production, chlorophyll content, and metal content in shoots was evaluated in rye grass plants after an eight-week growth period. Results showed that neutralization of tailings and superficial application of biosolids increased both aerial biomass production and chlorophyll content of rye grass. Increased Cu solubilization and translocation to shoots occurred after biosolids application (mixed), particularly on unlimed tailings, due to formation of soluble organometallic complexes with dissolved organic carbon (DOC) which can be readily absorbed by plant roots. Positive effects of mycorrhizal inoculation on rye grass growth were restricted to treatments with superficial application of biosolids, probably due to Cu toxicity effects on commercial mycorrhiza used (Glomulus intraradices).
Keywords	Lolium perenne ; Mediterranean climate ; aboveground biomass ; biomass production ; biosolids ; chlorophyll ; copper ; cost effectiveness ; dissolved organic carbon ; grasses ; greenhouse experimentation ; greenhouses ; mine tailings ; mycorrhizae ; neutralization ; phytoremediation ; plant density ; rain ; risk ; roots ; rye ; shoots ; solubilization ; toxicity ; Chile
Language	English
Size	p. 107-125.
Publishing place	CRC Lewis Publishers
Document type	Article
ZDB-ID	2055357-2
ISSN	1549-7879 ; 1522-6514
ISSN (online)	1549-7879
ISSN	1522-6514
DOI	10.1080/15226510903535056
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