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Article ; Online: Is

Garcia-Bustos, Victor

2024 Volume 15, Issue 4, Page(s) e0014624

Abstract: The emergence and evolutionary path ... ...

Abstract	The emergence and evolutionary path of
MeSH term(s)	Dogs ; Humans ; Animals ; Candida/genetics ; Candida/isolation & purification ; Candidiasis/veterinary ; Candidiasis/microbiology ; Candida auris ; Kansas ; Climate Change ; Fungi ; Zoonoses ; Mouth
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00146-24
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Importance and Impact of Francisella-like Endosymbionts in Hyalomma Ticks in the Era of Climate Change

Sesmero-García, Celia / Cabanero-Navalon, Marta Dafne / Garcia-Bustos, Victor

Diversity. 2023 Apr. 17, v. 15, no. 4

2023

Abstract: Ticks are obligatory hematophagous parasites that serve as vectors for a large amount of important human and livestock pathogens around the world, and their distribution and incidence of tick-associated diseases are currently increasing because of ... ...

Abstract	Ticks are obligatory hematophagous parasites that serve as vectors for a large amount of important human and livestock pathogens around the world, and their distribution and incidence of tick-associated diseases are currently increasing because of environmental biomass being modified by both climate change and other human activities. Hyalomma species are of major concern for public health, due to their important role as vectors of several diseases such as the Crimea–Congo hemorrhagic fever (CCHF) virus in humans or theileriosis in cattle. Characterizing the Hyalomma-associated microbiota and delving into the complex interactions between ticks and their bacterial endosymbionts for host survival, development, and pathogen transmission are fundamental, as it may provide new insights and spawn new paradigms to control tick-borne diseases. Francisella-like endosymbionts (FLEs) have recently gained importance, not only as a consequence of the public health concerns of the highly transmissible Francisella tularensis, but for the essential role of FLEs in tick homeostasis. In this comprehensive review, we discuss the growing importance of ticks associated with the genus Hyalomma, their associated tick-borne human and animal diseases in the era of climate change, as well as the role of the microbiome and the FLE in their ecology. We compile current evidence from around the world on FLEs in Hyalomma species and examine the impact of new molecular techniques in the study of tick microbiomes (both in research and in clinical practice). Lastly, we also discuss different endosymbiont-directed strategies for the control of tick populations and tick-borne diseases, providing insights into new evidence-based opportunities for the future.
Keywords	Francisella tularensis ; Hyalomma ; biomass ; cattle ; climate change ; disease transmission ; endosymbionts ; fever ; homeostasis ; humans ; microbiome ; microsymbionts ; public health ; theileriosis ; ticks ; viruses
Language	English
Dates of publication	2023-0417
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2518137-3
ISSN	1424-2818
ISSN	1424-2818
DOI	10.3390/d15040562
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The Ecology of Non-

Garcia-Bustos, Victor / Acosta-Hernández, Begoña / Cabañero-Navalón, Marta Dafne / Pemán, Javier / Ruiz-Gaitán, Alba Cecilia / Rosario Medina, Inmaculada

Journal of fungi (Basel, Switzerland)

2024 Volume 10, Issue 2

Abstract: Cetaceans, which are integral to marine ecosystems, face escalating anthropogenic threats, including climate change and pollution, positioning them as critical sentinel species for ocean and human health. This review explores the neglected realm of non- ...

Abstract	Cetaceans, which are integral to marine ecosystems, face escalating anthropogenic threats, including climate change and pollution, positioning them as critical sentinel species for ocean and human health. This review explores the neglected realm of non-
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof10020111
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Article: Potential Fungal Zoonotic Pathogens in Cetaceans: An Emerging Concern.

Garcia-Bustos, Victor / Acosta-Hernández, Begoña / Cabañero-Navalón, Marta Dafne / Ruiz-Gaitán, Alba Cecilia / Pemán, Javier / Rosario Medina, Inmaculada

Microorganisms

2024 Volume 12, Issue 3

Abstract: Over 60% of emerging infectious diseases in humans are zoonotic, often originating from wild animals. This long-standing ecological phenomenon has accelerated due to human-induced environmental changes. Recent data show a significant increase in fungal ... ...

Abstract	Over 60% of emerging infectious diseases in humans are zoonotic, often originating from wild animals. This long-standing ecological phenomenon has accelerated due to human-induced environmental changes. Recent data show a significant increase in fungal infections, with 6.5 million cases annually leading to 3.7 million deaths, indicating their growing impact on global health. Despite the vast diversity of fungal species, only a few are known to infect humans and marine mammals. Fungal zoonoses, especially those involving marine mammals like cetaceans, are of global public health concern. Increased human-cetacean interactions, in both professional and recreational settings, pose risks for zoonotic disease transmission. This review focuses on the epidemiology, clinical manifestations, and zoonotic potential of major fungal pathogens shared in humans and cetaceans, highlighting their interspecies transmission capability and the challenges posed by antifungal resistance and environmental changes. It underscores the need for enhanced awareness and preventative measures in high-risk settings to protect public health and marine ecosystems.
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12030554
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Article: Ten-year Spanish cohort of diving-related injuries in a non-hyperbaric tertiary hospital on the Spanish Mediterranean coast.

Garcia-Bustos, Victor / Cabañero-Navalón, Marta Dafne

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

2021 Volume 48, Issue 4, Page(s) 382–390

Abstract: Introduction: Global evidence on the epidemiology of prevalent diving-related injuries (DRI) different from decompression sickness (DCS) and other fatalities is lacking. This study aimed to perform a comprehensive review of DRIs in the year-period ... ...

Abstract	Introduction: Global evidence on the epidemiology of prevalent diving-related injuries (DRI) different from decompression sickness (DCS) and other fatalities is lacking. This study aimed to perform a comprehensive review of DRIs in the year-period between 2010-2020 in a non-hyperbaric tertiary hospital in the Spanish Mediterranean coast, in addition to identifying patient risk factors for severe middle ear barotrauma. Methods: The study was conducted via a retrospective review of medical records during a 10-year period (2010-2020) at the University and Polytechnic Hospital La Fe (UPHLF) of Valencia. We performed a case-control study recruiting controls through an online survey to identify independent predictors for severe middle ear barotrauma. Results: A total of 68 patients with DRI attended the emergency department of our tertiary referral hospital. Barotrauma accounted for more than 80% of DRI, followed by unrecognized DCS and animal-related injuries. Most patients required neither hospital admission nor surgery; appropriate treatment could be carried out largely on an outpatient basis. The presence of subsequent sequelae was minimal. Previous presence of significant ear, nose and throat (ENT) comorbidities (OR 3.05 - CI 95% 1.11 - 8.35), and older age (OR of younger age 0.94 - CI 95% 0.91 - 0.98) were identified as independent risk factors for severe middle ear barotrauma, with an acceptable discrimination capacity (AUC 0.793, 95% CI 0.71 - 0.87). Conclusion: The incidence of DRI may be higher than previously thought, and the need to know their epidemiology, their associated morbidity, and the deficiencies of the diving management system is becoming steadily important in order to develop prevention, diagnostic and therapeutic protocols in non-hyperbaric hospitals of these regions.
MeSH term(s)	Aged ; Barotrauma/epidemiology ; Barotrauma/etiology ; Case-Control Studies ; Decompression Sickness/epidemiology ; Decompression Sickness/etiology ; Diving/adverse effects ; Humans ; Infant ; Retrospective Studies ; Tertiary Care Centers
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1154414-4
ISSN	1066-2936
ISSN	1066-2936
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Article ; Online: Amyloidogenic and anti-amyloidogenic properties of presenilin 1.

Bustos, Victor / Pulina, Maria V / Ledo, Jose

Advances in pharmacology (San Diego, Calif.)

2020 Volume 90, Page(s) 239–251

Abstract: Presenilin 1 (PS1) is an intramembrane protease, the active subunit of the γ-secretase complex. Its well-studied function is the amyloidogenic cleavage of the C-terminal fragment of the amyloid precursor protein, also known as C99, to produce the Abeta ... ...

Abstract	Presenilin 1 (PS1) is an intramembrane protease, the active subunit of the γ-secretase complex. Its well-studied function is the amyloidogenic cleavage of the C-terminal fragment of the amyloid precursor protein, also known as C99, to produce the Abeta peptide. Recent findings from the Greengard laboratory suggest that PS1 also have anti-amyloidogenic activities, which reduce Abeta levels. First, it redirects APP-C99 toward autophagic degradation, lowering the amount that can be converted into Abeta. The protein kinase CK1γ2 phosphorylates PS1 at Ser367. Phosphorylated PS1 at this position interacts with Annexin A2, which, in turn, interacts with the lysosomal N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) Vamp8. Annexin A2 facilitates the binding of Vamp8 to the autophagosomal SNARE Syntaxin 17 to modulate the fusion of autophagosomes with lysosomes. Thus, PS1 phosphorylated at Ser367 has an anti-amyloidogenic function, promoting autophagosome-lysosome fusion and increasing C99 degradation. Second, it enhances the ability of microglia to phagocyte and degrade extracellular Abeta oligomer, through regulating the expression of the lysosomal master regulator TFEB. Thus, PS1 has a role in both the production and the clearance of Abeta. Drugs designed to activate CK1γ2 and increase the level of PS1 phosphorylated at Ser367 should be useful in the treatment of Alzheimer's disease.
MeSH term(s)	Amyloid/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/metabolism ; Animals ; Autophagy ; Humans ; Nerve Degeneration/pathology ; Presenilin-1/metabolism
Chemical Substances	Amyloid ; Amyloid beta-Peptides ; Presenilin-1 ; Amyloid Precursor Protein Secretases (EC 3.4.-)
Language	English
Publishing date	2020-10-24
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1557-8925
ISSN (online)	1557-8925
DOI	10.1016/bs.apha.2020.09.010
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Article: Good Ol' Fat: Links between Lipid Signaling and Longevity.

Bustos, Victor / Partridge, Linda

Trends in biochemical sciences

2017 Volume 42, Issue 10, Page(s) 812–823

Abstract: Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect ... ...

Abstract	Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling. In this review we summarize accumulating evidence that points to changes in lipid metabolism, and in particular lipid signaling, as an underlying mechanism for healthy aging.
MeSH term(s)	Animals ; Humans ; Lipid Metabolism ; Lipids ; Longevity ; Signal Transduction
Chemical Substances	Lipids
Language	English
Publishing date	2017-08-09
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2017.07.001
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Article ; Online: Climate change, animals, and Candida auris: insights into the ecological niche of a new species from a One Health approach.

Garcia-Bustos, Victor / Cabañero-Navalon, Marta Dafne / Ruiz-Gaitán, Alba / Salavert, Miguel / Tormo-Mas, María Ángeles / Pemán, Javier

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

2023 Volume 29, Issue 7, Page(s) 858–862

Abstract: Background: One of the most puzzling traits of Candida auris is the recent simultaneous and independent emergence of five genetically distinct clades on three continents. Global warming has been proposed as a contributing factor for this emergence owing ...

Abstract	Background: One of the most puzzling traits of Candida auris is the recent simultaneous and independent emergence of five genetically distinct clades on three continents. Global warming has been proposed as a contributing factor for this emergence owing to high thermotolerance of C. auris compared with phylogenetically close Candida species. This hypothesis postulates that climate change induced an environmental ancestor to become pathogenic through thermal adaptation and was then globally disseminated by an intermediate host. Objectives: The aim of this review is to compile the current knowledge on the emergence and ecological environmental niches of C. auris and highlight the potential role of animals in transmission. Sources: A literature search was conducted using PubMed, MEDLINE, Google Scholar, and Web of Science from May 2022 to January 2023. Content: We discuss the up-to-date data on the ecological niches of this fungus and its mechanisms of emergence, transmission cycle in nature, and worldwide dissemination. We highlight the possibility of an originally intermediate host possibly related to marine or freshwater ecosystems on the basis of recent molecular and microbiological evidence from a One Health perspective. The consequences of harmful human impact on the environment in the rise of new fungal pathogenic species, such as C. auris, are also analysed and compared with other animal precedents. Implications: The present knowledge can prompt the generation of new evidence on the ecological reservoirs of C. auris and its original mechanisms of environmental or interspecies transmission. Further research on the highlighted gaps will help understand the importance of the relationships between human, animal, and ecosystem health as factors involved in the rise and spread of emerging fungal pathogenic species.
MeSH term(s)	Animals ; Humans ; Candidiasis/epidemiology ; Candidiasis/microbiology ; Candida auris ; Ecosystem ; Climate Change ; One Health
Language	English
Publishing date	2023-03-18
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1328418-6
ISSN	1469-0691 ; 1470-9465 ; 1198-743X
ISSN (online)	1469-0691
ISSN	1470-9465 ; 1198-743X
DOI	10.1016/j.cmi.2023.03.016
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Zs.MO 284: Show issues

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Article: Good Ol’ Fat: Links between Lipid Signaling and Longevity

Bustos, Victor / Linda Partridge

Trends in biochemical sciences. 2017 Oct., v. 42, no. 10

2017

Abstract	Aging is the single greatest risk factor for the development of disease. Understanding the biological molecules and mechanisms that modulate aging is therefore critical for the development of health-maximizing interventions for older people. The effect of fats on longevity has traditionally been disregarded as purely detrimental. However, new studies are starting to uncover the possible beneficial effects of lipids working as signaling molecules on health and longevity. These studies highlight the complex links between aging and lipid signaling. In this review we summarize accumulating evidence that points to changes in lipid metabolism, and in particular lipid signaling, as an underlying mechanism for healthy aging.
Keywords	elderly ; lipid metabolism ; lipids ; longevity ; risk factors
Language	English
Dates of publication	2017-10
Size	p. 812-823.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	194220-7
ISSN	0968-0004 ; 0376-5067
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2017.07.001
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New Additions to the CRISPR Toolbox: CRISPR-

Shola, Dorjee T N / Yang, Chingwen / Kewaldar, Vhy-Shelta / Kar, Pradip / Bustos, Victor

The CRISPR journal

2020 Volume 3, Issue 2, Page(s) 109–122

Abstract: CRISPR-Cas has proven to be the most versatile genetic tinkering system of our time, predominantly as a precision genome editing tool. Here, we demonstrate two additions to the repertoire of CRISPR's application for constructing donor DNA templates: ... ...

Abstract	CRISPR-Cas has proven to be the most versatile genetic tinkering system of our time, predominantly as a precision genome editing tool. Here, we demonstrate two additions to the repertoire of CRISPR's application for constructing donor DNA templates: CRISPR-
Language	English
Publishing date	2020-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3017891-5
ISSN	2573-1602 ; 2573-1599
ISSN (online)	2573-1602
ISSN	2573-1599
DOI	10.1089/crispr.2019.0062
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Zs.MG 119: Show issues

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