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  1. Article ; Online: Control of regulatory T cell homeostasis.

    Buszko, Maja / Shevach, Ethan M

    Current opinion in immunology

    2020  Volume 67, Page(s) 18–26

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Animals ; Cytokines/immunology ; Homeostasis/immunology ; Humans ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Cytokines ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2020-08-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.07.001
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  2. Article ; Online: T Follicular Regulatory Cell Suppression of T Follicular Helper Cell Function Is Context-Dependent

    Lopez-Ocasio, Maria / Buszko, Maja / Blain, Melissa / Wang, Ke / Shevach, Ethan M

    Frontiers in immunology

    2020  Volume 11, Page(s) 637

    Abstract: The production of antibody-secreting plasma cells and memory B cells requires the interaction of T follicular helper (Tfh) cells with B cells in the follicle and is modulated by T follicular regulatory (Tfr) cells. We compare the effects of Tfr cells in ... ...

    Abstract The production of antibody-secreting plasma cells and memory B cells requires the interaction of T follicular helper (Tfh) cells with B cells in the follicle and is modulated by T follicular regulatory (Tfr) cells. We compare the effects of Tfr cells in an
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; CD40 Antigens/genetics ; CD40 Antigens/metabolism ; Cell Communication ; Cells, Cultured ; Germinal Center/immunology ; Interleukin-4/metabolism ; Interleukins/metabolism ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances CD40 Antigens ; Interleukins ; Interleukin-4 (207137-56-2) ; interleukin-21 (MKM3CA6LT1)
    Language English
    Publishing date 2020-04-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00637
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  3. Article ; Online: Elevated sodium leads to the increased expression of HSP60 and induces apoptosis in HUVECs.

    Jakic, Bojana / Buszko, Maja / Cappellano, Giuseppe / Wick, Georg

    PloS one

    2017  Volume 12, Issue 6, Page(s) e0179383

    Abstract: Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and ... ...

    Abstract Atherosclerosis is the leading cause of death in the world. We have previously shown that expression of heat shock protein 60 (HSP60) on the surface of endothelial cells is the main cause of initiating the disease as it acts as a T cell auto-antigen and can be triggered by classical atherosclerosis risk factors, such as infection (e.g. Chlamydia pneumoniae), chemical stress (smoking, oxygen radicals, drugs), physical insult (heat, shear blood flow) and inflammation (inflammatory cytokines, lipopolysaccharide, oxidized low density lipoprotein, advanced glycation end products). In the present study, we show that increasing levels of sodium chloride can also induce an increase in intracellular and surface expression of HSP60 protein in human umbilical vein endothelial cells. In addition, we found that elevated sodium induces apoptosis.
    MeSH term(s) Apoptosis/drug effects ; Apoptosis/genetics ; Biomarkers ; Chaperonin 60/genetics ; Chaperonin 60/metabolism ; Gene Expression Regulation/drug effects ; Human Umbilical Vein Endothelial Cells/drug effects ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Immunophenotyping ; Protein Transport ; Sodium/metabolism ; Sodium/pharmacology
    Chemical Substances Biomarkers ; Chaperonin 60 ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0179383
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  4. Article ; Online: The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge.

    Buszko, Maja / Park, Jung-Hyun / Verthelyi, Daniela / Sen, Ranjan / Young, Howard A / Rosenberg, Amy S

    Nature immunology

    2020  Volume 21, Issue 10, Page(s) 1146–1151

    MeSH term(s) Angioedema/blood ; Angioedema/immunology ; Angioedema/pathology ; Angioedema/virology ; Angiotensin-Converting Enzyme 2 ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus/immunology ; Biomarkers/blood ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Congresses as Topic ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Cytokines/antagonists & inhibitors ; Cytokines/blood ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Internet ; Kallikrein-Kinin System/drug effects ; Kallikrein-Kinin System/immunology ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pulmonary Alveoli/immunology ; Pulmonary Alveoli/pathology ; SARS-CoV-2 ; Severity of Illness Index ; Signal Transduction/drug effects ; Signal Transduction/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Spike Glycoprotein, Coronavirus/metabolism ; Time Factors ; Time-to-Treatment
    Chemical Substances Anti-Inflammatory Agents ; Antiviral Agents ; Biomarkers ; Cytokines ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-0779-1
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    Zs.MG 42: Show issues

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  5. Article ; Online: Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease.

    Morina, Lyra / Jones, Madalyn E / Oguz, Cihan / Kaplan, Mariana J / Gangaplara, Arunakumar / Fitzhugh, Courtney D / Kanakry, Christopher G / Shevach, Ethan M / Buszko, Maja

    Frontiers in immunology

    2023  Volume 14, Page(s) 1114780

    Abstract: Foxp3 is regarded as the major transcription factor for T regulatory ( ... ...

    Abstract Foxp3 is regarded as the major transcription factor for T regulatory (T
    MeSH term(s) Mice ; Animals ; Humans ; T-Lymphocytes, Regulatory/metabolism ; COVID-19/metabolism ; Transcription Factors/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Graft vs Host Disease/metabolism ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/metabolism
    Chemical Substances Transcription Factors ; Receptors, Antigen, T-Cell ; Foxp3 protein, mouse ; Forkhead Transcription Factors
    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1114780
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  6. Article ; Online: Lessons learned: new insights on the role of cytokines in COVID-19.

    Buszko, Maja / Nita-Lazar, Aleksandra / Park, Jung-Hyun / Schwartzberg, Pamela L / Verthelyi, Daniela / Young, Howard A / Rosenberg, Amy S

    Nature immunology

    2021  Volume 22, Issue 4, Page(s) 404–411

    MeSH term(s) Age Factors ; Animals ; Autoimmunity ; Biomedical Research ; COVID-19/immunology ; COVID-19/metabolism ; COVID-19/therapy ; COVID-19/virology ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/metabolism ; Cytokine Release Syndrome/virology ; Cytokines/immunology ; Cytokines/metabolism ; Host-Pathogen Interactions ; Humans ; Immune System/immunology ; Immune System/metabolism ; Immune System/virology ; Prognosis ; Risk Factors ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/metabolism ; Systemic Inflammatory Response Syndrome/therapy ; Systemic Inflammatory Response Syndrome/virology
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-03-17
    Publishing country United States
    Document type Congress ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-021-00901-9
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    Zs.A 5294: Show issues Location:
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    Zs.MG 42: Show issues

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  7. Article ; Online: Cutting Edge: Inhibition of the Interaction of NK Inhibitory Receptors with MHC Class I Augments Antiviral and Antitumor Immunity.

    Panda, Abir K / Gangaplara, Arunakumar / Buszko, Maja / Natarajan, Kannan / Boyd, Lisa F / Sharma, Suveena / Margulies, David H / Shevach, Ethan M

    Journal of immunology (Baltimore, Md. : 1950)

    2020  Volume 205, Issue 3, Page(s) 567–572

    Abstract: NK cells recognize MHC class I (MHC-I) Ags via stochastically expressed MHC-I-specific inhibitory receptors that prevent NK cell activation via cytoplasmic ITIM. We have identified a pan anti-MHC-I mAb that blocks NK cell inhibitory receptor binding at a ...

    Abstract NK cells recognize MHC class I (MHC-I) Ags via stochastically expressed MHC-I-specific inhibitory receptors that prevent NK cell activation via cytoplasmic ITIM. We have identified a pan anti-MHC-I mAb that blocks NK cell inhibitory receptor binding at a site distinct from the TCR binding site. Treatment of unmanipulated mice with this mAb disrupted immune homeostasis, markedly activated NK and memory phenotype T cells, enhanced immune responses against transplanted tumors, and augmented responses to acute and chronic viral infection. mAbs of this type represent novel checkpoint inhibitors in tumor immunity, potent tools for the eradication of chronic infection, and may function as adjuvants for the augmentation of the immune response to weak vaccines.
    MeSH term(s) Animals ; Female ; Histocompatibility Antigens Class I/immunology ; Immunologic Memory ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/pathology ; Rats ; Receptors, Natural Killer Cell/immunology ; Virus Diseases/immunology ; Virus Diseases/pathology
    Chemical Substances Histocompatibility Antigens Class I ; Receptors, Natural Killer Cell
    Language English
    Publishing date 2020-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000412
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  8. Article: The dynamic changes in cytokine responses in COVID-19: a snapshot of the current state of knowledge

    Buszko, Maja / Park, Jung-Hyun / Verthelyi, Daniela / Sen, Ranjan / Young, Howard A / Rosenberg, Amy S

    Nat Immunol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #733513
    Database COVID19

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  9. Article ; Online: The dynamic changes in cytokine responses in COVID-19

    Buszko, Maja / Park, Jung-Hyun / Verthelyi, Daniela / Sen, Ranjan / Young, Howard A. / Rosenberg, Amy S.

    Nature Immunology

    a snapshot of the current state of knowledge

    2020  Volume 21, Issue 10, Page(s) 1146–1151

    Keywords Immunology ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-020-0779-1
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  10. Article ; Online: In vitro immunoregulatory effects of thymoglobulin on human immune cell subpopulations.

    Buszko, Maja / Jakic, Bojana / Ploner, Christian / Hoertnagl, Paul / Mayerl, Christina / Wick, Georg / Cappellano, Giuseppe

    Immunology letters

    2017  Volume 186, Page(s) 1–8

    Abstract: Thymoglobulin (ATG) is a polyclonal rabbit antibody against human thymocytes used as a T cell-depleting agent in organ transplantation. Its polyclonal character suggests that its effect may go far beyond just T cell depletion. The aim of this study was ... ...

    Abstract Thymoglobulin (ATG) is a polyclonal rabbit antibody against human thymocytes used as a T cell-depleting agent in organ transplantation. Its polyclonal character suggests that its effect may go far beyond just T cell depletion. The aim of this study was to further elucidate possible mechanisms underlying the suppressive activity of ATG. For in vitro studies, human peripheral blood mononuclear cells (PBMC) were incubated with ATG or control Ig for various time points. Foxp3
    Language English
    Publishing date 2017-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 445150-8
    ISSN 1879-0542 ; 0165-2478
    ISSN (online) 1879-0542
    ISSN 0165-2478
    DOI 10.1016/j.imlet.2017.04.002
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