Article ; Online: A therapeutic antibody targeting annexin-A1 inhibits cancer cell growth in vitro and in vivo.
2024 Volume 43, Issue 8, Page(s) 608–614
Abstract: In this study we conducted the first investigation to assess the efficacy of a novel therapeutic antibody developed to target annexin-A1 (ANXA1). ANXA1 is an immunomodulatory protein which has been shown to be overexpressed in, and promote the ... ...
| Abstract | In this study we conducted the first investigation to assess the efficacy of a novel therapeutic antibody developed to target annexin-A1 (ANXA1). ANXA1 is an immunomodulatory protein which has been shown to be overexpressed in, and promote the development and progression of, several cancer types. In particular, high ANXA1 expression levels correlate with poorer overall survival in pancreatic and triple-negative breast cancers, two cancers with considerable unmet clinical need. MDX-124 is a humanised IgG1 monoclonal antibody which specifically binds to ANXA1 disrupting its interaction with formyl peptide receptors 1 and 2 (FPR1/2). Here we show that MDX-124 significantly reduced proliferation (p < 0.013) in a dose-dependent manner across a panel of human cancer cell lines expressing ANXA1. The anti-proliferative effect of MDX-124 is instigated by arresting cell cycle progression with cancer cells accumulating in the G |
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| MeSH term(s) | Animals ; Humans ; Mice ; Annexin A1/antagonists & inhibitors ; Annexin A1/metabolism ; Cell Line ; Neoplasms | |||||
| Chemical Substances | Annexin A1 | |||||
| Language | English | |||||
| Publishing date | 2024-01-10 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 639046-8 | |||||
| ISSN | 1476-5594 ; 0950-9232 | |||||
| ISSN (online) | 1476-5594 | |||||
| ISSN | 0950-9232 | |||||
| DOI | 10.1038/s41388-023-02919-9 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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