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  1. Article ; Online: Social media to monitor prevalent diseases: Hay fever and Twitter activity in Germany.

    Sitaru, Sebastian / Wecker, Hannah / Buters, Jeroen / Biedermann, Tilo / Zink, Alexander

    Allergy

    2023  Volume 78, Issue 10, Page(s) 2777–2780

    MeSH term(s) Humans ; Rhinitis, Allergic, Seasonal ; Social Media ; Germany/epidemiology ; Surveys and Questionnaires
    Language English
    Publishing date 2023-06-14
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15787
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Dosing intact birch pollen grains at the air-liquid interface (ALI) to the immortalized human bronchial epithelial cell line BEAS-2B.

    Candeias, Joana / Schmidt-Weber, Carsten B / Buters, Jeroen

    PloS one

    2021  Volume 16, Issue 11, Page(s) e0259914

    Abstract: In real life, humans are exposed to whole pollen grains at the air epithelial barrier. We developed a system for in vitro dosing of whole pollen grains at the Air-Liquid Interface (ALI) and studied their effect on the immortalized human bronchial ... ...

    Abstract In real life, humans are exposed to whole pollen grains at the air epithelial barrier. We developed a system for in vitro dosing of whole pollen grains at the Air-Liquid Interface (ALI) and studied their effect on the immortalized human bronchial epithelial cell line BEAS-2B. Pollen are sticky and large particles. Dosing pollen needs resuspension of single particles rather than clusters, and subsequent transportation to the cells with little loss to the walls of the instrumentation i.e. in a straight line. To avoid high speed impacting insults to cells we chose sedimentation by gravity as a delivery step. Pollen was resuspended into single particles by pressured air. A pollen dispersion unit including PTFE coating of the walls and reduced air pressure limited impaction loss to the walls. The loss of pollen to the system was still about 40%. A linear dose effect curve resulted in 327-2834 pollen/cm2 (± 6.1%), the latter concentration being calculated as the amount deposited on epithelial cells on high pollen days. After whole pollen exposure, the largest differential gene expression at the transcriptomic level was late, about 7 hours after exposure. Inflammatory and response to stimulus related genes were up-regulated. We developed a whole pollen exposure air-liquid interface system (Pollen-ALI), in which cells can be gently and reliably dosed.
    MeSH term(s) Betula/chemistry ; Bronchi/chemistry ; Bronchi/cytology ; Bronchi/drug effects ; Cell Line ; Cytokines/genetics ; Epithelial Cells/chemistry ; Epithelial Cells/cytology ; Epithelial Cells/drug effects ; Fractionation, Field Flow ; Gene Expression Profiling/methods ; Gene Expression Regulation ; Humans ; Interleukin-17/genetics ; Interleukin-33/genetics ; Pollen/adverse effects ; Pollen/immunology
    Chemical Substances Cytokines ; IL25 protein, human ; IL33 protein, human ; Interleukin-17 ; Interleukin-33 ; TSLP protein, human
    Language English
    Publishing date 2021-11-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0259914
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  3. Article: Assessing the national burden of allergic asthma by web-search data, pollen counts, and drug prescriptions in Germany and Sweden.

    Sitaru, Sebastian / Tizek, Linda / Buters, Jeroen / Ekebom, Agneta / Wallin, Jan-Erik / Zink, Alexander

    The World Allergy Organization journal

    2023  Volume 16, Issue 2, Page(s) 100752

    Abstract: Background: Asthma and its main phenotype allergic asthma are prevalent, chronic, and complex diseases affecting 4% of the population. One main trigger for allergic asthma exacerbations is pollen. Online health information search behavior by people is ... ...

    Abstract Background: Asthma and its main phenotype allergic asthma are prevalent, chronic, and complex diseases affecting 4% of the population. One main trigger for allergic asthma exacerbations is pollen. Online health information search behavior by people is increasing, and analysis of web-search data can provide valuable insight into disease burden and risk factors of a population.
    Objectives: We sought to perform a web-search data analysis and correlation to climate factors and pollen in 2 European countries.
    Methods: We analyzed the national web-search volume for allergic asthma-related keywords in Germany and Sweden from 2018 to 2021 and correlated it to local pollen counts, climatic factors, and drug prescription rates.
    Results: Per capita, more searches were conducted in Sweden than in Germany. A complex geographic stratification within the countries was observed. Search results were seasonal with a peak in spring and correlated with pollen counts in both countries. However, anti-asthmatic drug prescription rates in Sweden, as well as temperature and precipitation in both countries, did not correlate with search volume.
    Conclusion: Our analysis offers population-level insights about this complex disease by reporting its needs and establishing the correlation to pollen counts, which enables a targeted approach in the public health management of allergic asthma. Local pollen counts, as opposed to temperature or precipitation, might be good predictors of allergic asthma disease burden.
    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2023.100752
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  4. Book ; Online ; Thesis: Effect of whole birch pollen grains on human bronchial epithelial at the air-liquid interface, with or without pre-exposure to fresh combustion aerosol

    Gürth Candeias, Joana Rita Verfasser] / [Buters, Jeroen T. M. [Akademischer Betreuer] / Durner, Jörg Gutachter] / [Buters, Jeroen T. M. [Gutachter]

    2022  

    Author's details Joana Rita Gürth Candeias ; Gutachter: Jörg Durner, Jeroen Buters ; Betreuer: Jeroen Buters
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article: Allergie im Fokus: Umwelt, Klimawandel, Exposition - Einfluss auf allergische Erkrankungen

    Raulf, Monika / Buters, Jeroen / Lob-Corzilius, Thomas

    Allergologie

    2022  Volume 45, Issue 3, Page(s) 211

    Language German
    Document type Article
    ZDB-ID 547065-1
    ISSN 0344-5062
    Database Current Contents Medicine

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    In stock of ZB MED Cologne/Königswinter

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  6. Article: [No title information]

    Buters, Jeroen / Oteros, Jose / Gebauer, Robert / Heigl, Katharina

    Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung

    2020  Volume 29, Issue 3, Page(s) 14–16

    Title translation Automatisches Pollenmonitoring in Deutschland: Eine Arbeit der Sektion Umwelt- und Arbeitsmedizin der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI).
    Keywords covid19
    Language German
    Publishing date 2020-05-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1136943-7
    ISSN 0941-8849
    ISSN 0941-8849
    DOI 10.1007/s15007-020-2527-0
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  7. Article: Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort.

    Fieten, Karin B / Maya-Manzano, José M / Rückert, Beate / Candeias, Joana / Pusch, Gudrun / Buters, Jeroen / Akdis, Cezmi A / Traidl-Hoffmann, Claudia

    The World Allergy Organization journal

    2023  Volume 16, Issue 12, Page(s) 100847

    Abstract: Background: The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We ... ...

    Abstract Background: The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We conducted a cross-sectional study to investigate local environmental exposure and concomitant prevalence of allergic sensitization among local school children born and raised in an alpine environment.
    Methods: Clinical and demographic data were collected with a questionnaire. Allergen content was assessed in residential settled dust samples, lifetime exposure to pollen and air pollution was calculated using data from national pollen and air pollution monitoring stations, and the allergic sensitization profile was determined with component resolved diagnostics (ISAC®). Univariate and multivariate regression models were used to estimate the relation between exposure and sensitization.
    Results: In a cohort of children born and raised in an alpine environment, sensitization to aeroallergens is quite common (38%), especially to grass (33%) and cat (16%). House dust mite allergen was detected in up to 38% of residential dust samples, but sensitization to HDM was low (2.5%). Pollutant levels were low, but an increasing trend was observed in the amount of ozone and PM
    Conclusion: In a healthy alpine environment, pollution might still be an important factor contributing to allergic sensitization.
    Language English
    Publishing date 2023-12-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1016/j.waojou.2023.100847
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  8. Article ; Online: Chromium(VI) Contact Dermatitis: Getting Closer to Understanding the Underlying Mechanisms of Toxicity and Sensitization!

    Buters, Jeroen / Biedermann, Tilo

    The Journal of investigative dermatology

    2017  Volume 137, Issue 2, Page(s) 274–277

    Abstract: Various haptens trigger innate immune pathways and/or induce cytotoxicity as a part of sensitization. Adam et al. decipher in vitro the mechanisms by which chromium(VI) induces inflammation, the likely prerequisites for toxicity, sensitization, and ... ...

    Abstract Various haptens trigger innate immune pathways and/or induce cytotoxicity as a part of sensitization. Adam et al. decipher in vitro the mechanisms by which chromium(VI) induces inflammation, the likely prerequisites for toxicity, sensitization, and allergic contact dermatitis against chromium(VI). Importantly, and in line with other observations, chromium(VI), but not chromium(III) (or Ni(II)), induces mitochondrial reactive oxygen species accumulation. Mitochondrial reactive oxygen species in turn activate the NLRP3 inflammasome, allowing increased IL-1β processing and secretion, which likely underlies both chromium(VI)-induced cutaneous toxicity and sensitization. Interrupting this mechanism, perhaps with reducing agents or inhibitors of the NLRP3/IL-1 axis, may be a new option to prevent occupational chromium toxicity and allergy.
    MeSH term(s) Dermatitis, Allergic Contact/immunology ; Inflammasomes/immunology ; Interleukin-1beta ; Mitochondria ; Reactive Oxygen Species
    Chemical Substances Inflammasomes ; Interleukin-1beta ; Reactive Oxygen Species
    Language English
    Publishing date 2017-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2016.11.015
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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.124: Show issues Location:
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  9. Article ; Online: Predicting the main pollen season of Broussonetia Papyrifera (paper mulberry) tree.

    Kakakhail, Ahmad / Rextin, Aimal / Buters, Jeroen / Lin, Chun / Maya-Manzano, José M / Nasim, Mehwish / Oteros, Jose / Picornell, Antonio / Pinnock, Hillary / Schwarze, Jurgen / Yusuf, Osman

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0296878

    Abstract: Paper mulberry pollen, declared a pest in several countries including Pakistan, can trigger severe allergies and cause asthma attacks. We aimed to develop an algorithm that could accurately predict high pollen days to underpin an alert system that would ... ...

    Abstract Paper mulberry pollen, declared a pest in several countries including Pakistan, can trigger severe allergies and cause asthma attacks. We aimed to develop an algorithm that could accurately predict high pollen days to underpin an alert system that would allow patients to take timely precautionary measures. We developed and validated two prediction models that take historical pollen and weather data as their input to predict the start date and peak date of the pollen season in Islamabad, the capital city of Pakistan. The first model is based on linear regression and the second one is based on phenological modelling. We tested our models on an original and comprehensive dataset from Islamabad. The mean absolute errors (MAEs) for the start day are 2.3 and 3.7 days for the linear and phenological models, respectively, while for the peak day, the MAEs are 3.3 and 4.0 days, respectively. These encouraging results could be used in a website or app to notify patients and healthcare providers to start preparing for the paper mulberry pollen season. Timely action could reduce the burden of symptoms, mitigate the risk of acute attacks and potentially prevent deaths due to acute pollen-induced allergy.
    MeSH term(s) Humans ; Trees ; Broussonetia ; Morus ; Seasons ; Pollen ; Hypersensitivity ; Rhinitis, Allergic, Seasonal ; Allergens
    Chemical Substances Allergens
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296878
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  10. Article: Drivers of the release of the allergens Bet v 1 and Phl p 5 from birch and grass pollen

    Maya-Manzano, José M. / Oteros, Jose / Rojo, Jesús / Traidl-Hoffmann, Claudia / Schmidt-Weber, Carsten / Buters, Jeroen

    Environmental research. 2022 Nov., v. 214

    2022  

    Abstract: The drivers affecting the Pollen Allergen Potency (PAP, amount of allergen released per pollen) are sparsely known. Betula and Poaceae airborne pollen are the two main allergenic pollen in the World. Airborne pollen and their allergens Bet v 1 and Phl p ... ...

    Abstract The drivers affecting the Pollen Allergen Potency (PAP, amount of allergen released per pollen) are sparsely known. Betula and Poaceae airborne pollen are the two main allergenic pollen in the World. Airborne pollen and their allergens Bet v 1 and Phl p 5 were simultaneously measured from 2010 to 2015 in Davos (Switzerland) and Munich (Germany) by using volumetric traps and ChemVol cascade impactors. Daily variations in PAP were analysed in PM>₁₀ and PM₂.₅₋₁₀ air fractions and generalized additive models were created to explain which factors determine PAP, including meteorological parameters and inorganic pollutants. 87.1 ± 13.9% of Bet v 1 and 88.8 ± 15.5% of Phl p 5 was detected in the fraction PM>₁₀ where most pollen grains were collected. Significantly higher PAP for grasses (3.5 ± 1.9 pg Phl p 5/pollen grain) were observed in Munich than in Davos (2.4 ± 1.5 pg/pollen grain, p < 0.001), but not for Betula (2.5 ± 1.6 pg Bet v 1/pollen grain in Munich and 2.3 ± 1.7 in Davos, N.S.). PAP varied between days, years and location, and increased along the pollen season for Poaceae, but remaining constant for Betula. Free allergens (allergens observed in the fraction with limited pollen, PM₂.₅₋ ₁₀) were recorded mostly at the beginning or at the end of the pollen season, being linked to higher humidity and rainy days. Also, PAP was higher when the airborne pollen concentrations increased rapidly after one day of low/moderate levels. Our findings show that pollen exposure explains allergen exposure only to a limited extend, and that day in the season, geographic location and some weather conditions need to be considered also to explain symptoms of allergic individuals.
    Keywords Betula ; Poaceae ; air ; allergenicity ; allergens ; grasses ; humidity ; pollen ; pollen season ; research ; Germany ; Switzerland
    Language English
    Dates of publication 2022-11
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.113987
    Database NAL-Catalogue (AGRICOLA)

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