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Article ; Online: Breast exam use during the protracted COVID-19 pandemic, by age, race, and geography.

Butler, Eboneé N / Benefield, Thad / Henderson, Louise / Kuzmiak, Cherie / Pritchard, Michael / Nyante, Sarah

JNCI cancer spectrum

2023 Volume 7, Issue 2

Abstract: In this study we analyzed data collected from the onset of the COVID-19 pandemic through March 31, 2022, to identify temporal shifts in breast exam volume. Screening mammography volume stabilized toward the end of the study period, and diagnostic exam ... ...

Abstract	In this study we analyzed data collected from the onset of the COVID-19 pandemic through March 31, 2022, to identify temporal shifts in breast exam volume. Screening mammography volume stabilized toward the end of the study period, and diagnostic exam volume varied over time and by age. Older women experienced a decline in diagnostic exam volume between August 2020 and April 2021 that was not observed among women aged younger than 50 years (50-69 years: monthly percentage change [MPC] = -6.5%; and 70 years and older: MPC = -15.7%). With respect to breast biopsy volume, women aged younger than 70 years had increased exam volume beginning in April 2020 and June 2020, whereas a corresponding increase among older women was delayed until April 2021 (70 years and older: MPC = 9.3%). Findings from our study suggest a temporal shift in the use of breast exams that could result in differential detection of breast cancer by age.
MeSH term(s)	Female ; Humans ; Aged ; Mammography ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/epidemiology ; Pandemics ; Early Detection of Cancer ; COVID-19/epidemiology ; Geography
Language	English
Publishing date	2023-03-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2515-5091
ISSN (online)	2515-5091
DOI	10.1093/jncics/pkad025
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Article ; Online: Understanding mechanisms of racial disparities in breast cancer: an assessment of screening and regular care in the Carolina Breast Cancer Study.

Dunn, Matthew R / Metwally, Eman M / Vohra, Sanah / Hyslop, Terry / Henderson, Louise M / Reeder-Hayes, Katherine / Thompson, Caroline A / Lafata, Jennifer Elston / Troester, Melissa A / Butler, Eboneé N

Cancer causes & control : CCC

2024 Volume 35, Issue 5, Page(s) 825–837

Abstract: Purpose: Screening history influences stage at detection, but regular preventive care may also influence breast tumor diagnostic characteristics. Few studies have evaluated healthcare utilization (both screening and primary care) in racially diverse ... ...

Abstract	Purpose: Screening history influences stage at detection, but regular preventive care may also influence breast tumor diagnostic characteristics. Few studies have evaluated healthcare utilization (both screening and primary care) in racially diverse screening-eligible populations. Methods: This analysis included 2,058 women age 45-74 (49% Black) from the Carolina Breast Cancer Study, a population-based cohort of women diagnosed with invasive breast cancer between 2008 and 2013. Screening history (threshold 0.5 mammograms per year) and pre-diagnostic healthcare utilization (i.e. regular care, based on responses to "During the past ten years, who did you usually see when you were sick or needed advice about your health?") were assessed as binary exposures. The relationship between healthcare utilization and tumor characteristics were evaluated overall and race-stratified. Results: Among those lacking screening, Black participants had larger tumors (5 + cm) (frequency 19.6% vs 11.5%, relative frequency difference (RFD) = 8.1%, 95% CI 2.8-13.5), but race differences were attenuated among screening-adherent participants (10.2% vs 7.0%, RFD = 3.2%, 0.2-6.2). Similar trends were observed for tumor stage and mode of detection (mammogram vs lump). Among all participants, those lacking both screening and regular care had larger tumors (21% vs 8%, RR = 2.51, 1.76-3.56) and advanced (3B +) stage (19% vs 6%, RR = 3.15, 2.15-4.63) compared to the referent category (screening-adherent and regular care). Under-use of regular care and screening was more prevalent in socioeconomically disadvantaged areas of North Carolina. Conclusions: Access to regular care is an important safeguard for earlier detection. Our data suggest that health equity interventions should prioritize both primary care and screening.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnosis ; Breast Neoplasms/ethnology ; Middle Aged ; Aged ; Early Detection of Cancer/statistics & numerical data ; Healthcare Disparities/statistics & numerical data ; Healthcare Disparities/ethnology ; North Carolina/epidemiology ; Mammography/statistics & numerical data ; Patient Acceptance of Health Care/statistics & numerical data ; Patient Acceptance of Health Care/ethnology ; Black or African American/statistics & numerical data ; Cohort Studies ; White People/statistics & numerical data ; Mass Screening/statistics & numerical data ; Mass Screening/methods
Language	English
Publishing date	2024-01-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-023-01833-5
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Article ; Online: Cigarette smoking and prostate cancer aggressiveness among African and European American men.

Ellis, Edgar T / Fairman, Brian J / Stahr, Shelbie D / Bensen, Jeannette T / Mohler, James L / Song, Lixin / Butler, Eboneé N / Su, L Joseph / Hsu, Ping-Ching

Cancer causes & control : CCC

2024

Abstract: Purpose: Smoking is a modifiable lifestyle factor that has not been established as a prostate cancer risk factor, nor emphasized in prostate cancer prevention. Studies have shown that African American (AA) smokers have a poorer cancer prognosis than ... ...

Abstract	Purpose: Smoking is a modifiable lifestyle factor that has not been established as a prostate cancer risk factor, nor emphasized in prostate cancer prevention. Studies have shown that African American (AA) smokers have a poorer cancer prognosis than European Americans (EAs), while having a lower prevalence of heavy smoking. We examined the relationship between cigarette smoking and prostate cancer aggressiveness and assessed racial differences in smoking habits on the probability of high-aggressive prostate cancer. Methods: Using data from the North Carolina-Louisiana Prostate Cancer Project (n = 1,279), prostate cancer aggressiveness was defined as high or low based on Gleason scores, serum prostate-specific antigen levels, and tumor stage. Cigarette smoking was categorized as current, former, or never smokers. Multivariable logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI). Results: Self-reported current (OR = 1.99; 95% CI 1.30-3.06) smoking was associated with high-aggressive prostate cancer relative to never smokers. When stratified by self-reported race, the odds of having high-aggressive cancer increased among AA current (OR = 3.58; 95% CI 2.04-6.28) and former smokers (OR = 2.21; 95% CI 1.38-3.53) compared to AA never smokers, but the odds were diminished among the EA stratum (P Conclusion: Cigarette smoking is associated with prostate cancer aggressiveness, a relationship modulated by self-reported race. Future research is needed to investigate types of cigarettes smoked and metabolic differences that may be contributing to the racial disparities observed.
Language	English
Publishing date	2024-05-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1064022-8
ISSN	1573-7225 ; 0957-5243
ISSN (online)	1573-7225
ISSN	0957-5243
DOI	10.1007/s10552-024-01883-3
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Article ; Online: An Up-to-date Assessment of US Prostate Cancer Incidence Rates by Stage and Race: A Novel Approach Combining Multiple Imputation with Age and Delay Adjustment.

Cook, Michael B / Hurwitz, Lauren M / Geczik, Ashley M / Butler, Eboneé N

European urology

2020 Volume 79, Issue 1, Page(s) 33–41

Abstract: Background: In the USA, it is unknown whether metastatic prostate cancer incidence has continued to increase and whether racial differences have persisted.: Objective: Combining multiple imputation with age and delay adjustment, we provide an up-to- ... ...

Abstract	Background: In the USA, it is unknown whether metastatic prostate cancer incidence has continued to increase and whether racial differences have persisted. Objective: Combining multiple imputation with age and delay adjustment, we provide an up-to-date, comprehensive assessment of US prostate cancer incidence trends by stage and race. Design, setting, and participants: From Surveillance Epidemiology and End Results (SEER)-18, 774 240 prostate cancer cases were diagnosed during 2004-2017. Outcome measurements and statistical analysis: Multiple imputation assigned prostate cancer stage to the 4.7% of cases with missing stage, which varied by year and race-ethnicity. SEER delay factors adjusted case counts to anticipated future data corrections. Twenty datasets were imputed, and Rubin's rules were used for summary estimation. Overall and stage-specific rates were estimated and stratified by race and age group. Joinpoint software identified significant temporal changes and estimated annual percentage changes. We compared these estimates without multiple imputation and delay adjustment. Results and limitations: Metastatic prostate cancer incidence increased during 2011-2017, with an annual percentage change of 5.5. This was followed by increases in localized and regional disease since 2014. Non-Hispanic black men continued to have the highest incidence, especially for metastatic disease. The increasing rate of metastatic prostate cancer in non-Hispanic white men aged 50-74 yr accelerated recently, and the incidence was 56% higher in 2017 than in 2004. Rates without multiple imputation and delay adjustment were quantitatively and qualitatively different. This observational study is unable to assign causes to observed changes in prostate cancer incidence. Conclusions: Multiple imputation and delay adjustment are essential for portraying accurately stage- and race-specific prostate cancer incidence as clinical practice evolves. Patient summary: In the USA, diagnosis of prostate cancer that has spread to distant sites (metastatic disease) continues to increase. Black men continue to have higher risks of being diagnosed with metastatic prostate cancer than other race-ethnicities.
MeSH term(s)	Age Distribution ; Humans ; Incidence ; Male ; Neoplasm Staging ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/pathology ; Racial Groups/statistics & numerical data ; Time Factors ; United States/epidemiology
Language	English
Publishing date	2020-10-20
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article ; Observational Study ; Research Support, N.I.H., Intramural
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2020.09.041
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Redefining precision cancer prevention to promote health equity.

Butler, Eboneé N / Umar, Asad / Heckman-Stoddard, Brandy M / Kundrod, Kathryn A / Signorello, Lisa B / Castle, Philip E

Trends in cancer

2022 Volume 8, Issue 4, Page(s) 295–302

Abstract: Precision cancer prevention as it is currently envisioned is a targeted, molecular-based approach to intercept carcinogenesis before cancer develops or before it becomes untreatable. Unfortunately, due to systemic biases, current precision cancer ... ...

Abstract	Precision cancer prevention as it is currently envisioned is a targeted, molecular-based approach to intercept carcinogenesis before cancer develops or before it becomes untreatable. Unfortunately, due to systemic biases, current precision cancer prevention interventions might not be effective in all populations, especially in minoritized communities. In addition, not all cancer risk is attributable to genetic or even biological factors, but includes social determinants of health (SDH). Here, we propose a broader framework for precision cancer prevention, anchored in optimizing the benefits to harms for all people. We propose that precision cancer prevention considers not only what is being delivered, but also for whom, where, and how, with a goal of achieving cancer prevention health equity.
MeSH term(s)	Health Equity ; Health Promotion ; Health Status Disparities ; Humans ; Neoplasms/genetics ; Neoplasms/prevention & control ; Social Determinants of Health
Language	English
Publishing date	2022-02-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2852626-0
ISSN	2405-8025 ; 2405-8033 ; 2405-8033
ISSN (online)	2405-8025 ; 2405-8033
ISSN	2405-8033
DOI	10.1016/j.trecan.2022.01.009
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Article ; Online: Testosterone therapy and cancer risks among men in the SEER-Medicare linked database.

Butler, Eboneé N / Zhou, Cindy Ke / Curry, Michael / McMenamin, Úna / Cardwell, Christopher / Bradley, Marie C / Graubard, Barry I / Cook, Michael B

British journal of cancer

2022 Volume 128, Issue 1, Page(s) 48–56

Abstract: Background: We examined associations between two forms of testosterone therapy (TT) and risks of seven cancers among men.: Methods: SEER-Medicare combines cancer registry data from the Surveillance, Epidemiology, and End Results programme with ... ...

Abstract	Background: We examined associations between two forms of testosterone therapy (TT) and risks of seven cancers among men. Methods: SEER-Medicare combines cancer registry data from the Surveillance, Epidemiology, and End Results programme with Medicare claims. Our population-based case-control study included incident cancer cases diagnosed between 1992-2015: prostate (n = 130,713), lung (n = 105,466), colorectal (n = 56,433), bladder (n = 38,873), non-Hodgkin lymphoma (n = 17,854), melanoma (n = 14,241), and oesophageal (n = 9116). We selected 100,000 controls from a 5% random sample of Medicare beneficiaries and used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: TT was associated with lower risk of distant-stage prostate cancer (injection/implantation OR = 0.72, 95% CI: 0.60-0.86; topical OR = 0.50, 95% CI: 0.24-1.03). We also observed inverse associations for distant-stage colorectal cancer (injection/implantation OR = 0.75, 95% CI: 0.62-0.90; topical OR = 0.11, 95% CI: 0.05-0.24). Risks of distant-stage colorectal and prostate cancers decreased with time after initiating TT by injection/implantation. By contrast, TT was positively associated with distant-stage melanoma (injection/implantation OR = 1.70, 95% CI: 1.37-2.11). TT was not associated with bladder cancer, oesophageal cancer, lung cancer or non-Hodgkin lymphoma. Conclusion: TT was inversely associated with distant-stage prostate and colorectal cancers but was positively associated with distant-stage melanoma. These observations may suggest an aetiologic role for TT or the presence of residual confounding.
MeSH term(s)	Male ; Humans ; Aged ; United States/epidemiology ; Case-Control Studies ; Testosterone/adverse effects ; Medicare ; SEER Program ; Prostatic Neoplasms/epidemiology ; Lymphoma, Non-Hodgkin/epidemiology ; Logistic Models ; Melanoma ; Colorectal Neoplasms
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2022-10-28
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-022-02019-7
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Article: Prevalence of physical activity and sedentary behavior among stroke survivors in the United States.

Butler, Eboneé N / Evenson, Kelly R

Topics in stroke rehabilitation

2014 Volume 21, Issue 3, Page(s) 246–255

Abstract: Background: The risk of stroke is greatest among adults who have experienced a previous stroke, transient ischemic attack, or myocardial infarction. Physical activity may reduce the secondary risk of stroke through mediating effects on blood pressure, ... ...

Abstract	Background: The risk of stroke is greatest among adults who have experienced a previous stroke, transient ischemic attack, or myocardial infarction. Physical activity may reduce the secondary risk of stroke through mediating effects on blood pressure, vasoconstriction, and circulating lipid concentrations; however, little is known about the prevalence of physical activity and sedentary behavior among stroke survivors in the United States. Methods: Using data from the National Health and Nutrition Examination Survey (NHANES), we describe self-reported and objectively measured physical activity and sedentary behavior among adults with a self-reported history of stroke. We also contrast physical activity among stroke survivors with that of adults without stroke (unexposed) to illustrate expected behavior in the absence of disease. Results: Fewer participants with stroke met weekly physical activity guidelines as outlined in the 2008 Physical Activity Guidelines for Americans when compared with unexposed participants (17.9% vs 25.0%) according to self-reported data. In addition, participants with stroke reported less moderate (46.1% vs 54.7%) and vigorous (9.1% vs 19.6%) leisure activity compared with unexposed participants. As measured by accelerometer, time since diagnosis was inversely associated with physical activity engagement, and participants with stroke recorded more daily hours of sedentary behavior compared with unexposed participants (10.1 hours vs 8.9 hours). Conclusion: Findings from this study provide a basis for future work seeking to measure the impact of physical activity on the secondary prevention of stroke by characterizing the prevalence of physical activity and sedentary behavior among stroke survivors in the United States.
MeSH term(s)	Accelerometry ; Adult ; Aged ; Aged, 80 and over ; Female ; Guidelines as Topic ; Humans ; Male ; Middle Aged ; Motor Activity/physiology ; Prevalence ; Sedentary Behavior ; Stroke/epidemiology ; Survivors/statistics & numerical data ; Time Factors ; United States/epidemiology
Language	English
Publishing date	2014-06-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1213112-x
ISSN	1074-9357
ISSN	1074-9357
DOI	10.1310/tsr2103-246
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Zs.A 4139: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 454: Show issues

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Article ; Online: Fatal prostate cancer incidence trends in the United States and England by race, stage, and treatment.

Butler, Eboneé N / Kelly, Scott P / Coupland, Victoria H / Rosenberg, Philip S / Cook, Michael B

British journal of cancer

2020 Volume 123, Issue 3, Page(s) 487–494

Abstract: Background: Differential uptake of prostate-specific antigen testing in the US and UK has been linked to between-country differences for prostate cancer incidence. We examined stage-specific fatal prostate cancer incidence trends in the US and England, ... ...

Abstract	Background: Differential uptake of prostate-specific antigen testing in the US and UK has been linked to between-country differences for prostate cancer incidence. We examined stage-specific fatal prostate cancer incidence trends in the US and England, by treatment and race/ethnicity. Methods: Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program and Public Health England's National Cancer Registration and Analysis Service, we identified prostate cancer patients diagnosed between 1995 and 2005, aged 45-84 years. Fatal prostate cancer was defined as death attributed to the disease within 10 years of diagnosis. We used age-period-cohort models to assess trends in fatal prostate cancer incidence. Results: Fatal prostate cancer incidence declined in the US by -7.5% each year and increased in England by 7.7% annually. These trends were primarily driven by locoregional disease in the US and distant disease in England. Black men in both countries had twofold to threefold higher fatal prostate cancer incidence rates, when compared with their white counterparts; however, receipt of radical prostatectomy lessened this disparity. Conclusions: We report a significant increasing rate of fatal prostate cancer incidence among English men. The black-white racial disparity appears pervasive but is attenuated among those who received radical prostatectomy in the US.
MeSH term(s)	African Continental Ancestry Group/statistics & numerical data ; Age Distribution ; Aged ; Aged, 80 and over ; England/epidemiology ; England/ethnology ; European Continental Ancestry Group/statistics & numerical data ; Humans ; Incidence ; Male ; Middle Aged ; Prostatectomy/statistics & numerical data ; Prostatic Neoplasms/ethnology ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/surgery ; Registries ; United States/epidemiology ; United States/ethnology
Language	English
Publishing date	2020-05-20
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-020-0859-x
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Article ; Online: Oncologist-Reported Reasons for Not Ordering Multimarker Tumor Panels: Results From a Nationally Representative Survey.

Roberts, Megan C / Spees, Lisa P / Freedman, Andrew N / Klein, William M P / Prabhu Das, Irene / Butler, Eboneé N / de Moor, Janet S

JCO precision oncology

2021 Volume 5

Abstract: This study examines oncologist-reported reasons for not using multimarker tumor panel testing and the association between these reasons and oncologist-level, facility-level, and patient-mix characteristics.: Methods: We used data collected from a ... ...

Abstract	This study examines oncologist-reported reasons for not using multimarker tumor panel testing and the association between these reasons and oncologist-level, facility-level, and patient-mix characteristics. Methods: We used data collected from a nationally representative sample (N = 1,281) of medical oncologists participating in the National Cancer Institute's Results: In addition to Conclusion: Modifiable, organizational factors were associated with ordering multimarker tumor panels. Receipt of genomics training and organizational policies related to the use of genomics were associated with lower reporting of barriers to ordering multimarker tumor panels, pointing to potential targets for future studies aimed at increasing appropriate multimarker tumor panel testing in cancer treatment management.
MeSH term(s)	Genetic Testing/statistics & numerical data ; Health Care Surveys ; Humans ; Medical Oncology ; Neoplasms/diagnosis ; Neoplasms/genetics ; Practice Patterns, Physicians' ; United States
Language	English
Publishing date	2021-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.20.00431
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Article ; Online: Linking African ancestral substructure to prostate cancer health disparities.

Gheybi, Kazzem / Mmekwa, Naledi / Lebelo, Maphuti Tebogo / Patrick, Sean M / Campbell, Raymond / Nenzhelele, Mukudeni / Soh, Pamela X Y / Obida, Muvhulawa / Loda, Massimo / Shirindi, Joyce / Butler, Eboneé N / Mutambirwa, Shingai B A / Bornman, M S Riana / Hayes, Vanessa M

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20909

Abstract: Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such exclude for ... ...

Abstract	Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking within the continent and as such exclude for significant ancestral diversity. Here, we investigate a series of epidemiological demographic and lifestyle risk factors for 1387 men recruited as part of the multi-ethnic Southern African Prostate Cancer Study (SAPCS). We found poverty to be a decisive factor for disease grade and age at diagnosis, with other notably significant PCa associated risk factors including sexually transmitted diseases, erectile dysfunction, gynaecomastia, and vertex or complete pattern balding. Aligned with African American data, Black ethnicity showed significant risk for PCa diagnosis (OR = 1.44, 95% CI 1.05-2.00), and aggressive disease presentation (ISUP ≥ 4: OR = 2.25, 95% CI 1.49-3.40). New to this study, we demonstrate African ancestral population substructure associated PCa disparity, observing increased risk for advanced disease for the southern African Tsonga people (ISUP ≥ 4: OR = 3.43, 95% CI 1.62-7.27). Conversely, South African Coloured were less likely to be diagnosed with aggressive disease overall (ISUP ≥ 3: OR = 0.38, 95% 0.17-0.85). Understanding the basis for PCa health disparities calls for African inclusion, however, lack of available data has limited the power to begin discussions. Here, focusing on arguably the largest study of its kind for the African continent, we draw attention to the contribution of within African ancestral diversity as a contributing factor to PCa health disparities within the genetically diverse region of southern Africa.
MeSH term(s)	Humans ; Male ; Black People ; Prostate ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/ethnology ; Prostatic Neoplasms/genetics ; Risk Factors ; South Africa
Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47993-x
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