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  1. Article ; Online: T

    Meyran, Deborah / Zhu, Joe Jiang / Butler, Jeanne / Tantalo, Daniela / MacDonald, Sean / Nguyen, Thu Ngoc / Wang, Minyu / Thio, Niko / D'Souza, Criselle / Qin, Vicky Mengfei / Slaney, Clare / Harrison, Aaron / Sek, Kevin / Petrone, Pasquale / Thia, Kevin / Giuffrida, Lauren / Scott, Andrew M / Terry, Rachael L / Tran, Ben /
    Desai, Jayesh / Prince, H Miles / Harrison, Simon J / Beavis, Paul A / Kershaw, Michael H / Solomon, Ben / Ekert, Paul G / Trapani, Joseph A / Darcy, Phillip K / Neeson, Paul J

    Science translational medicine

    2023  Volume 15, Issue 690, Page(s) eabk1900

    Abstract: Patients who receive chimeric antigen receptor (CAR)-T cells that are enriched in memory T cells exhibit better disease control as a result of increased expansion and persistence of the CAR-T cells. Human memory T cells include stem-like ... ...

    Abstract Patients who receive chimeric antigen receptor (CAR)-T cells that are enriched in memory T cells exhibit better disease control as a result of increased expansion and persistence of the CAR-T cells. Human memory T cells include stem-like CD8
    MeSH term(s) Humans ; Immunotherapy, Adoptive/methods ; Neoplasms ; T-Lymphocytes ; Cytokines/metabolism ; Stem Cells/metabolism ; Receptors, Antigen, T-Cell/metabolism
    Chemical Substances Cytokines ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2023-04-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.abk1900
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes.

    Fourlanos, Spiros / Perry, Christine / Gellert, Shane A / Martinuzzi, Emanuela / Mallone, Roberto / Butler, Jeanne / Colman, Peter G / Harrison, Leonard C

    Diabetes

    2011  Volume 60, Issue 4, Page(s) 1237–1245

    Abstract: Objective: Insulin in pancreatic β-cells is a target of autoimmunity in type 1 diabetes. In the NOD mouse model of type 1 diabetes, oral or nasal administration of insulin induces immune tolerance to insulin and protects against autoimmune diabetes. ... ...

    Abstract Objective: Insulin in pancreatic β-cells is a target of autoimmunity in type 1 diabetes. In the NOD mouse model of type 1 diabetes, oral or nasal administration of insulin induces immune tolerance to insulin and protects against autoimmune diabetes. Evidence for tolerance to mucosally administered insulin or other autoantigens is poorly documented in humans. Adults with recent-onset type 1 diabetes in whom the disease process is subacute afford an opportunity to determine whether mucosal insulin induces tolerance to insulin subsequently injected for treatment.
    Research design and methods: We randomized 52 adults with recent-onset, noninsulin-requiring type 1 diabetes to nasal insulin or placebo for 12 months. Fasting blood glucose and serum C-peptide, glucagon-stimulated serum C-peptide, and serum antibodies to islet antigens were monitored three times monthly for 24 months. An enhanced ELISpot assay was used to measure the T-cell response to human proinsulin.
    Results: β-Cell function declined by 35% overall, and 23 of 52 participants (44%) progressed to insulin treatment. Metabolic parameters remained similar between nasal insulin and placebo groups, but the insulin antibody response to injected insulin was significantly blunted in a sustained manner in those who had received nasal insulin. In a small cohort, the interferon-γ response of blood T-cells to proinsulin was suppressed after nasal insulin.
    Conclusions: Although nasal insulin did not retard loss of residual β-cell function in adults with established type 1 diabetes, evidence that it induced immune tolerance to insulin provides a rationale for its application to prevent diabetes in at-risk individuals.
    MeSH term(s) Administration, Intranasal ; Adult ; Aged ; Blood Glucose/metabolism ; C-Peptide/blood ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/prevention & control ; Double-Blind Method ; Fasting/blood ; Female ; Humans ; Hypoglycemic Agents/administration & dosage ; Hypoglycemic Agents/pharmacology ; Immune Tolerance/drug effects ; Insulin/administration & dosage ; Insulin/pharmacology ; Insulin Antibodies/blood ; Male ; Middle Aged ; Placebos ; T-Lymphocytes/immunology
    Chemical Substances Blood Glucose ; C-Peptide ; Hypoglycemic Agents ; Insulin ; Insulin Antibodies ; Placebos
    Language English
    Publishing date 2011-02-09
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db10-1360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.175: Show issues Location:
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