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Article ; Online: Positive selection of IgG

Sundling, Christopher / Lau, Angelica W Y / Bourne, Katherine / Young, Clara / Laurianto, Candy / Hermes, Jana R / Menzies, Rosemary J / Butt, Danyal / Kräutler, Nike J / Zahra, David / Suan, Dan / Brink, Robert

Immunity

2021 Volume 54, Issue 5, Page(s) 988–1001.e5

Abstract: Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity maturation of antibody responses. Here, we examined the mechanism underlying the parallel transition from immunoglobulin M (IgM) to IgG. Early GCs contained mostly ... ...

Abstract	Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity maturation of antibody responses. Here, we examined the mechanism underlying the parallel transition from immunoglobulin M (IgM) to IgG. Early GCs contained mostly unswitched IgM
MeSH term(s)	Animals ; Antibody Formation/immunology ; Antigens/immunology ; B-Lymphocytes/immunology ; Female ; Germinal Center/immunology ; Immunoglobulin Class Switching/immunology ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Immunoglobulin Variable Region/immunology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Sheep/immunology ; Somatic Hypermutation, Immunoglobulin/immunology
Chemical Substances	Antigens ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin Variable Region
Language	English
Publishing date	2021-04-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2021.03.013
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.

Tan, Yunhao / Mosallanejad, Kenta / Zhang, Qingxiu / O'Brien, Stephen / Clements, Meghan / Perper, Stuart / Wilson, Sarah / Chaulagain, Sudiksha / Wang, Jing / Abdalla, Mary / Al-Saidi, Helen / Butt, Danyal / Clabbers, Anca / Ofori, Kwasi / Dillon, Beth / Harvey, Bohdan / Memmott, John / Negron, Christopher / Winarta, David /

Tan, Catherine / Biswas, Amlan / Dong, Feng / Morales-Tirado, Vanessa / Lu, Xiaoqing / Singh, Gurminder / White, Michael / Ashley, Shanna / Knight, Heather / Westmoreland, Susan / Phillips, Lucy / Carr, Tracy / Reinke-Breen, Lauren / Singh, Rajeeva / Xu, Jianwen / Wu, Kan / Rinaldi, Lisa / Stoll, Brian / He, Yupeng David / Hazelwood, Lisa / Karman, Jozsef / McCluskey, Andrew / Stine, William / Correia, Ivan / Gauld, Stephen / Levesque, Marc C / Veldman, Geertruida / Hubeau, Cedric / Radstake, Timothy / Sadhukhan, Ramkrishna / Fiebiger, Edda

Frontiers in immunology

2024 Volume 15, Page(s) 1293883

Abstract: Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell ... ...

Abstract	Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell activation has been identified as a central mechanism for promoting fibrosis downstream of TGFβ. IL11 signaling has recently been reported to promote fibroblast-to-myofibroblast transition, thus leading to various pro-fibrotic phenotypic changes. We confirmed increased mRNA expression of IL11 and IL11Rα in fibrotic diseases by OMICs approaches and
MeSH term(s)	Humans ; Transforming Growth Factor beta/metabolism ; Interleukin-11 ; Signal Transduction ; Fibrosis ; Myofibroblasts/metabolism
Chemical Substances	Transforming Growth Factor beta ; Interleukin-11
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1293883
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Article ; Online: An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease.

Clarke, Adam W / Poulton, Lynn / Shim, Doris / Mabon, David / Butt, Danyal / Pollard, Matthew / Pande, Vanya / Husten, Jean / Lyons, Jacquelyn / Tian, Chen / Doyle, Anthony G

mAbs

2018 Volume 10, Issue 4, Page(s) 664–677

Abstract: TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blockade of the TL1A pathway has been shown to reduce inflammatory responses while leaving baseline immunity ... ...

Abstract	TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blockade of the TL1A pathway has been shown to reduce inflammatory responses while leaving baseline immunity intact, and to be beneficial in animal models of colitis and asthma. Given the therapeutic potential of blocking this pathway in IBD and asthma, we developed C03V, a human antibody that binds with high affinity to soluble and membrane-bound TL1A. In an assay measuring apoptosis induced by exogenous TL1A, C03V was 43-fold more potent than the next most potent anti-TL1A antibody analyzed. C03V also potently inhibited endogenous TL1A activity in a primary cell-based assay. This potency was linked to the C03V-binding epitope on TL1A, encompassing the residue R32. This residue is critical for the binding of TL1A to its signaling receptor DR3 but not to its decoy receptor DcR3, and explains why C03V inhibited TL1A-DR3 binding to a much greater extent than TL1A-DcR3 binding. This characteristic may be advantageous to preserve some of the homeostatic functions of DcR3, such as TL1A antagonism. In colitis models, C03V significantly ameliorated microscopic, macroscopic and clinical aspects of disease pathology, and in an asthma model it significantly reduced airways inflammation. Notable in both types of disease model was the reduction in fibrosis observed after C03V treatment. C03V has the potential to address unmet medical needs in asthma and IBD.
MeSH term(s)	Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/pharmacology ; Asthma/immunology ; Humans ; Inflammatory Bowel Diseases/immunology ; Tumor Necrosis Factor Ligand Superfamily Member 15/antagonists & inhibitors
Chemical Substances	Antibodies, Monoclonal ; TNFSF15 protein, human ; Tumor Necrosis Factor Ligand Superfamily Member 15
Language	English
Publishing date	2018-03-05
Publishing country	United States
Document type	Journal Article
ISSN	1942-0870
ISSN (online)	1942-0870
DOI	10.1080/19420862.2018.1440164
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Article ; Online: CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

Suan, Dan / Kräutler, Nike J / Maag, Jesper L V / Butt, Danyal / Bourne, Katherine / Hermes, Jana R / Avery, Danielle T / Young, Clara / Statham, Aaron / Elliott, Michael / Dinger, Marcel E / Basten, Antony / Tangye, Stuart G / Brink, Robert

Immunity

2017 Volume 47, Issue 6, Page(s) 1142–1153.e4

Abstract: Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC ...

Abstract	Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to the MBC lineage. Here, we report that the chemokine receptor CCR6 uniquely marks MBC precursors in both mouse and human GCs. CCR6
MeSH term(s)	Animals ; B7-2 Antigen/genetics ; B7-2 Antigen/immunology ; Cell Differentiation ; Cell Lineage/immunology ; Gene Expression Profiling ; Gene Expression Regulation ; Germinal Center/cytology ; Germinal Center/immunology ; Humans ; Immunity, Humoral ; Immunologic Memory ; Immunophenotyping ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Phenotype ; Plasma Cells/cytology ; Plasma Cells/immunology ; Positive Regulatory Domain I-Binding Factor 1/genetics ; Positive Regulatory Domain I-Binding Factor 1/immunology ; Precursor Cells, B-Lymphoid/cytology ; Precursor Cells, B-Lymphoid/immunology ; Receptors, CCR6/genetics ; Receptors, CCR6/immunology ; Receptors, CXCR4/genetics ; Receptors, CXCR4/immunology ; Signal Transduction
Chemical Substances	B7-2 Antigen ; CCR6 protein, mouse ; CXCR4 protein, mouse ; Cd86 protein, mouse ; Prdm1 protein, mouse ; Receptors, CCR6 ; Receptors, CXCR4 ; Positive Regulatory Domain I-Binding Factor 1 (EC 2.1.1.-)
Language	English
Publishing date	2017--19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2017.11.022
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.

Kräutler, Nike J / Suan, Dan / Butt, Danyal / Bourne, Katherine / Hermes, Jana R / Chan, Tyani D / Sundling, Christopher / Kaplan, Warren / Schofield, Peter / Jackson, Jennifer / Basten, Antony / Christ, Daniel / Brink, Robert

The Journal of experimental medicine

2017 Volume 214, Issue 5, Page(s) 1259–1267

Abstract: Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying ... ...

Abstract	Plasma cells (PCs) derived from germinal centers (GCs) secrete the high-affinity antibodies required for long-term serological immunity. Nevertheless, the process whereby GC B cells differentiate into PCs is uncharacterized, and the mechanism underlying the selective PC differentiation of only high-affinity GC B cells remains unknown. In this study, we show that differentiation into PCs is induced among a discrete subset of high-affinity B cells residing within the light zone of the GC. Initiation of differentiation required signals delivered upon engagement with intact antigen. Signals delivered by T follicular helper cells were not required to initiate differentiation but were essential to complete the differentiation process and drive migration of maturing PCs through the dark zone and out of the GC. This bipartite or two-signal mechanism has likely evolved to both sustain protective immunity and avoid autoantibody production.
MeSH term(s)	Animals ; Antigens, Differentiation, B-Lymphocyte/physiology ; B-Lymphocytes/physiology ; Cell Differentiation/physiology ; Germinal Center/physiology ; Mice ; Mice, Inbred C57BL ; Plasma Cells/physiology ; T-Lymphocytes, Helper-Inducer/physiology
Chemical Substances	Antigens, Differentiation, B-Lymphocyte
Language	English
Publishing date	2017-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20161533
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Ua VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

Chan, Tyani D / Wood, Katherine / Hermes, Jana R / Butt, Danyal / Jolly, Christopher J / Basten, Antony / Brink, Robert

Immunity

2012 Volume 37, Issue 5, Page(s) 893–904

Abstract: Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to ... ...

Abstract	Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B cells has long been recognized, it has not previously been possible to identify such cells and study their fate. In the current study, self-reactive B cells generated de novo in the GC failed to survive when their target self-antigen was either expressed ubiquitously or specifically in cells proximal to the GC microenvironment. By contrast, GC B cells that recognized rare or tissue-specific self-antigens were not eliminated, and could instead undergo positive selection by cross-reactive foreign antigen and produce plasma cells secreting high-affinity autoantibodies. These findings demonstrate the incomplete nature of GC self-tolerance and may explain the frequent association of cross-reactive, organ-specific autoantibodies with postinfectious autoimmune disease.
MeSH term(s)	Animals ; Antibody Affinity/genetics ; Antibody Affinity/immunology ; Autoantigens/genetics ; Autoantigens/immunology ; Autoantigens/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CHO Cells ; Cell Line ; Cellular Microenvironment/genetics ; Cellular Microenvironment/immunology ; Cricetinae ; Cross Reactions ; Genes, Immunoglobulin ; Germinal Center/immunology ; Germinal Center/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mutation ; Plasma Cells/immunology ; Plasma Cells/metabolism ; Somatic Hypermutation, Immunoglobulin/genetics ; Somatic Hypermutation, Immunoglobulin/immunology
Chemical Substances	Autoantigens
Language	English
Publishing date	2012-11-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2012.07.017
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes.

Nature communications

2018 Volume 9, Issue 1, Page(s) 3372

Abstract: Vaccine-induced immunity depends on the generation of memory B cells (MBC). However, where and how MBCs are reactivated to make neutralising antibodies remain unknown. Here we show that MBCs are prepositioned in a subcapsular niche in lymph nodes where, ... ...

Abstract	Vaccine-induced immunity depends on the generation of memory B cells (MBC). However, where and how MBCs are reactivated to make neutralising antibodies remain unknown. Here we show that MBCs are prepositioned in a subcapsular niche in lymph nodes where, upon reactivation by antigen, they rapidly proliferate and differentiate into antibody-secreting plasma cells in the subcapsular proliferative foci (SPF). This novel structure is enriched for signals provided by T follicular helper cells and antigen-presenting subcapsular sinus macrophages. Compared with contemporaneous secondary germinal centres, SPF have distinct single-cell molecular signature, cell migration pattern and plasma cell output. Moreover, SPF are found both in human and mouse lymph nodes, suggesting that they are conserved throughout mammalian evolution. Our data thus reveal that SPF is a seat of immunological memory that may be exploited to rapidly mobilise secondary antibody responses and improve vaccine efficacy.
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/metabolism ; Cell Movement/drug effects ; Cells, Cultured ; Flow Cytometry ; Humans ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Mice ; Mice, Inbred C57BL ; Models, Theoretical ; Pyrazoles/pharmacology ; Pyrimidines/pharmacology ; Tamoxifen/pharmacology
Chemical Substances	Pyrazoles ; Pyrimidines ; Tamoxifen (094ZI81Y45) ; ibrutinib (1X70OSD4VX)
Language	English
Publishing date	2018-08-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-018-05772-7
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Article ; Online: FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

Butt, Danyal / Chan, Tyani D / Bourne, Katherine / Hermes, Jana R / Nguyen, Akira / Statham, Aaron / O'Reilly, Lorraine A / Strasser, Andreas / Price, Susan / Schofield, Peter / Christ, Daniel / Basten, Antony / Ma, Cindy S / Tangye, Stuart G / Phan, Tri Giang / Rao, V Koneti / Brink, Robert

Immunity

2015 Volume 42, Issue 5, Page(s) 890–902

Abstract: The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise ... ...

Abstract	The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal center (GC) B cells. Here we show that FAS is in fact not required for this process. Instead, FAS inactivation led to accumulation of a population of unconventional GC B cells that underwent somatic hypermutation, survived despite losing antigen reactivity, and differentiated into a large population of plasma cells that included autoantibody-secreting clones. IgE(+) plasma cell numbers, in particular, increased after FAS inactivation and a major cohort of ALPS-affected patients were found to have hyper-IgE. We propose that these previously unidentified cells, designated "rogue GC B cells," are a major driver of autoantibody production and provide a mechanistic explanation for the linked production of IgE and autoantibodies in autoimmune disease.
MeSH term(s)	Animals ; Autoantibodies/biosynthesis ; Autoantibodies/immunology ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Fluorescent Antibody Technique ; Germinal Center/cytology ; Germinal Center/immunology ; Humans ; Immunoglobulin E/biosynthesis ; Immunoglobulin E/immunology ; Mice ; Polymerase Chain Reaction ; fas Receptor/deficiency ; fas Receptor/immunology ; fas Receptor/metabolism
Chemical Substances	Autoantibodies ; fas Receptor ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2015-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2015.04.010
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

McDonald, Michelle M / Khoo, Weng Hua / Ng, Pei Ying / Xiao, Ya / Zamerli, Jad / Thatcher, Peter / Kyaw, Wunna / Pathmanandavel, Karrnan / Grootveld, Abigail K / Moran, Imogen / Butt, Danyal / Nguyen, Akira / Corr, Alexander / Warren, Sean / Biro, Maté / Butterfield, Natalie C / Guilfoyle, Siobhan E / Komla-Ebri, Davide / Dack, Michael R G /

Dewhurst, Hannah F / Logan, John G / Li, Yongxiao / Mohanty, Sindhu T / Byrne, Niall / Terry, Rachael L / Simic, Marija K / Chai, Ryan / Quinn, Julian M W / Youlten, Scott E / Pettitt, Jessica A / Abi-Hanna, David / Jain, Rohit / Weninger, Wolfgang / Lundberg, Mischa / Sun, Shuting / Ebetino, Frank H / Timpson, Paul / Lee, Woei Ming / Baldock, Paul A / Rogers, Michael J / Brink, Robert / Williams, Graham R / Bassett, J H Duncan / Kemp, John P / Pavlos, Nathan J / Croucher, Peter I / Phan, Tri Giang

Cell

2021 Volume 184, Issue 5, Page(s) 1330–1347.e13

Abstract: Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that RANKL-stimulated ... ...

Abstract	Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that RANKL-stimulated osteoclasts have an alternative cell fate in which they fission into daughter cells called osteomorphs. Inhibiting RANKL blocked this cellular recycling and resulted in osteomorph accumulation. Single-cell RNA sequencing showed that osteomorphs are transcriptionally distinct from osteoclasts and macrophages and express a number of non-canonical osteoclast genes that are associated with structural and functional bone phenotypes when deleted in mice. Furthermore, genetic variation in human orthologs of osteomorph genes causes monogenic skeletal disorders and associates with bone mineral density, a polygenetic skeletal trait. Thus, osteoclasts recycle via osteomorphs, a cell type involved in the regulation of bone resorption that may be targeted for the treatment of skeletal diseases.
MeSH term(s)	Animals ; Apoptosis ; Bone Resorption/metabolism ; Bone Resorption/pathology ; Cell Fusion ; Cells, Cultured ; Humans ; Macrophages/cytology ; Mice ; Osteochondrodysplasias/drug therapy ; Osteochondrodysplasias/genetics ; Osteochondrodysplasias/metabolism ; Osteochondrodysplasias/pathology ; Osteoclasts/metabolism ; Osteoclasts/pathology ; RANK Ligand/metabolism ; Signal Transduction
Chemical Substances	RANK Ligand ; Tnfsf11 protein, mouse
Language	English
Publishing date	2021-02-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.02.002
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Article ; Online: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption.

Cell

2021 Volume 184, Issue 7, Page(s) 1940

Language	English
Publishing date	2021-03-08
Publishing country	United States
Document type	Published Erratum
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2021.03.010
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