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Article ; Online: Consistent responses to moisture stress despite diverse growth forms within mountain fynbos communities.

Skelton, Robert P / West, Adam G / Buttner, Daniel / Dawson, Todd E

2023 Volume 201, Issue 2, Page(s) 323–339

Abstract: Understanding climate change impacts on the Cape Floristic Region requires improved knowledge of plant physiological responses to the environment. Studies examining physiological responses of mountain fynbos have consisted of campaign-based measurements, ...

Abstract	Understanding climate change impacts on the Cape Floristic Region requires improved knowledge of plant physiological responses to the environment. Studies examining physiological responses of mountain fynbos have consisted of campaign-based measurements, capturing snapshots of plant water relations and photosynthesis. We examine conclusions drawn from prior studies by tracking in situ physiological responses of three species, representing dominant growth forms (proteoid, ericoid, restioid), over 2 years using miniature continuous sap flow technology, long-term observations of leaf/culm water potential and gas exchange, and xylem vulnerability to embolism. We observed considerable inter-specific variation in the timing and extent of seasonal declines in productivity. Shallow-rooted Erica monsoniana exhibited steep within-season declines in sap flow and water potentials, and pronounced inter-annual variability in total daily sap flux (J
MeSH term(s)	Plant Physiological Phenomena ; Water/physiology ; Plant Leaves/physiology ; Photosynthesis ; Seasons ; Droughts ; Trees/physiology
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-01-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123369-5
ISSN	1432-1939 ; 0029-8549
ISSN (online)	1432-1939
ISSN	0029-8549
DOI	10.1007/s00442-023-05326-9
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Article ; Online: Consistent responses to moisture stress despite diverse growth forms within mountain fynbos communities

Skelton, Robert P. / West, Adam G. / Büttner, Daniel / Dawson, Todd E.

Oecologia. 2023 Feb., v. 201, no. 2 p.323-339

2023

Abstract	Understanding climate change impacts on the Cape Floristic Region requires improved knowledge of plant physiological responses to the environment. Studies examining physiological responses of mountain fynbos have consisted of campaign-based measurements, capturing snapshots of plant water relations and photosynthesis. We examine conclusions drawn from prior studies by tracking in situ physiological responses of three species, representing dominant growth forms (proteoid, ericoid, restioid), over 2 years using miniature continuous sap flow technology, long-term observations of leaf/culm water potential and gas exchange, and xylem vulnerability to embolism. We observed considerable inter-specific variation in the timing and extent of seasonal declines in productivity. Shallow-rooted Erica monsoniana exhibited steep within-season declines in sap flow and water potentials, and pronounced inter-annual variability in total daily sap flux (Jₛ). Protea repens showed steady reductions in Jₛ across both years, despite deeper roots and less negative water potentials. Cannomois congesta—a shallow-rooted restioid—was least negatively impacted. Following rehydrating rain at the end of summer, gas exchange recovery was lower in the drier year compared with the normal year, but did not differ between species. Loss of function in the drier year was partially accounted for by loss of xylem transport capacity in Erica and Cannomois, but not Protea. Hitherto unseen water use patterns, including inter-annual variability of gas exchange associated with contrasting water uptake properties, reveal that species use different mechanisms to cope with summer dry periods. Revealing physiological responses of key growth forms enhances predictions of plant function within mountain fynbos under future conditions.
Keywords	Erica ; Protea repens ; climate change ; culms ; embolism ; fynbos ; gas exchange ; leaves ; photosynthesis ; rain ; sap flow ; summer ; water potential ; water uptake ; xylem
Language	English
Dates of publication	2023-02
Size	p. 323-339.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	123369-5
ISSN	1432-1939 ; 0029-8549
ISSN (online)	1432-1939
ISSN	0029-8549
DOI	10.1007/s00442-023-05326-9
Database	NAL-Catalogue (AGRICOLA)

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Article: An in vitro assessment of the potential antidiabetic activity and cytotoxic effects of ethanolic and aqueous extracts from three invasive Australian acacias

Buttner, Daniel H / Reddy, Shanika / Koekemoer, Trevor / Venter, Maryna van de

SAAB South African journal of botany. 2021 Sept., v. 141

2021

Abstract: Acacia cyclops, Acacia saligna and Acacia mearnsii are characterized as prolific invasive alien plants (IAPs) presenting a substantial ecological and economic burden on South Africa. While conventionally these species are perceived as weeds having little ...

Abstract	Acacia cyclops, Acacia saligna and Acacia mearnsii are characterized as prolific invasive alien plants (IAPs) presenting a substantial ecological and economic burden on South Africa. While conventionally these species are perceived as weeds having little value, this study attempts to demonstrate their respective potential as a phytomedicinal resource in the treatment of type 2 diabetes – thereby incentivizing their eradication. Moreover, this study aimed to assess the antidiabetic and cytotoxic effects of extracts from these three invasive Australian acacias in vitro. The α-glucosidase and ɑ-amylase activities of ethanolic and aqueous extracts derived from aerial tissues of A. cyclops, A. saligna, and A. mearnsii were investigated, followed by a cytotoxicity assessment using Hoechst 33342-Propidium Iodide (PI) dual staining and quantitative fluorescence microscopy on the human colon (Caco-2) cell line. Of the extracts screened, A. saligna ethanolic bark demonstrated the highest inhibitory activity against α-amylase and α-glucosidase with an IC₅₀ of 10.45 ± 3.79 μg/ml and 2.35 ± 0.61 μg/ml followed by leaf extract depicting strong α-glucosidase (IC₅₀ of 3.64 ± 1.59 μg/ml) and moderate α-amylase (IC₅₀ of 17.67 ± 3.84 μg/ml) inhibition. The IC₅₀ values of all extracts were significantly (p < 0.05) lower than Acarbose (IC₅₀ of 330.71 ± 28.36 μg/ml) and Epigallocatechin gallate (IC₅₀ of 68.2 ± 8.34 μg/ml). All extracts were found to be nontoxic at test concentrations on Caco-2 cells as confirmed by Hoescht 33342-PI dual staining. Overall, the findings presented in this study provide the first concurrent account of three invasive Acacias in South Africa reporting on their potential as an alternative therapeutic option for the treatment of type 2 diabetes.
Keywords	Acacia cyclops ; Acacia mearnsii ; Acacia saligna ; acarbose ; alpha-amylase ; bark ; colon ; cytotoxicity ; epigallocatechin gallate ; fluorescence microscopy ; glycemic effect ; humans ; invasive species ; iodides ; leaf extracts ; noninsulin-dependent diabetes mellitus ; therapeutics ; South Africa
Language	English
Dates of publication	2021-09
Size	p. 1-11.
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2126918-X
ISSN	0254-6299
ISSN	0254-6299
DOI	10.1016/j.sajb.2021.04.021
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Profile of the multicenter cohort of the German Cancer Consortium's Clinical Communication Platform.

Maier, Daniel / Vehreschild, Jörg Janne / Uhl, Barbara / Meyer, Sandra / Berger-Thürmel, Karin / Boerries, Melanie / Braren, Rickmer / Grünwald, Viktor / Hadaschik, Boris / Palm, Stefan / Singer, Susanne / Stuschke, Martin / Juárez, David / Delpy, Pierre / Lambarki, Mohamed / Hummel, Michael / Engels, Cäcilia / Andreas, Stefanie / Gökbuget, Nicola /

Ihrig, Kristina / Burock, Susen / Keune, Dietmar / Eggert, Angelika / Keilholz, Ulrich / Schulz, Hagen / Büttner, Daniel / Löck, Steffen / Krause, Mechthild / Esins, Mirko / Ressing, Frank / Schuler, Martin / Brandts, Christian / Brucker, Daniel P / Husmann, Gabriele / Oellerich, Thomas / Metzger, Patrick / Voigt, Frederik / Illert, Anna L / Theobald, Matthias / Kindler, Thomas / Sudhof, Ursula / Reckmann, Achim / Schwinghammer, Felix / Nasseh, Daniel / Weichert, Wilko / von Bergwelt-Baildon, Michael / Bitzer, Michael / Malek, Nisar / Öner, Öznur / Schulze-Osthoff, Klaus / Bartels, Stefan / Haier, Jörg / Ammann, Raimund / Schmidt, Anja Franziska / Guenther, Bernd / Janning, Melanie / Kasper, Bernd / Loges, Sonja / Stilgenbauer, Stephan / Kuhn, Peter / Tausch, Eugen / Runow, Silvana / Kerscher, Alexander / Neumann, Michael / Breu, Martin / Lablans, Martin / Serve, Hubert

European journal of epidemiology

2023 Volume 38, Issue 5, Page(s) 573–586

Abstract: Treatment concepts in oncology are becoming increasingly personalized and diverse. Successively, changes in standards of care mandate continuous monitoring of patient pathways and clinical outcomes based on large, representative real-world data. The ... ...

Abstract	Treatment concepts in oncology are becoming increasingly personalized and diverse. Successively, changes in standards of care mandate continuous monitoring of patient pathways and clinical outcomes based on large, representative real-world data. The German Cancer Consortium's (DKTK) Clinical Communication Platform (CCP) provides such opportunity. Connecting fourteen university hospital-based cancer centers, the CCP relies on a federated IT-infrastructure sourcing data from facility-based cancer registry units and biobanks. Federated analyses resulted in a cohort of 600,915 patients, out of which 232,991 were incident since 2013 and for which a comprehensive documentation is available. Next to demographic data (i.e., age at diagnosis: 2.0% 0-20 years, 8.3% 21-40 years, 30.9% 41-60 years, 50.1% 61-80 years, 8.8% 81+ years; and gender: 45.2% female, 54.7% male, 0.1% other) and diagnoses (five most frequent tumor origins: 22,523 prostate, 18,409 breast, 15,575 lung, 13,964 skin/malignant melanoma, 9005 brain), the cohort dataset contains information about therapeutic interventions and response assessments and is connected to 287,883 liquid and tissue biosamples. Focusing on diagnoses and therapy-sequences, showcase analyses of diagnosis-specific sub-cohorts (pancreas, larynx, kidney, thyroid gland) demonstrate the analytical opportunities offered by the cohort's data. Due to its data granularity and size, the cohort is a potential catalyst for translational cancer research. It provides rapid access to comprehensive patient groups and may improve the understanding of the clinical course of various (even rare) malignancies. Therefore, the cohort may serve as a decisions-making tool for clinical trial design and contributes to the evaluation of scientific findings under real-world conditions.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Young Adult ; Neoplasms/diagnosis ; Neoplasms/epidemiology ; Neoplasms/therapy ; Middle Aged ; Aged ; Aged, 80 and over ; Cohort Studies
Language	English
Publishing date	2023-04-05
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article
ZDB-ID	632614-6
ISSN	1573-7284 ; 0393-2990
ISSN (online)	1573-7284
ISSN	0393-2990
DOI	10.1007/s10654-023-00990-w
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Article ; Online: Genehmigungsverfahren klinischer Studien im Bereich der Radioonkologie.

Simon, Monique / Habeck, Matthias / Büttner, Daniel / Habeck, Uta / Nölling, Torsten / Krause, Mechthild / Brix, Gunnar / Willich, Normann / Wenz, Frederik / Schmidberger, Heinz / Debus, Jürgen / Baumann, Michael

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

2015 Volume 191, Issue 12, Page(s) 909–920

Abstract: Background and purpose: Application of ionizing radiation for the purpose of medical research in Germany needs to be approved by the national authority for radiation protection (Bundesamt für Strahlenschutz, BfS). For studies in the field of radiation ... ...

Title translation	Approval procedures for clinical trials in the field of radiation oncology.
Abstract	Background and purpose: Application of ionizing radiation for the purpose of medical research in Germany needs to be approved by the national authority for radiation protection (Bundesamt für Strahlenschutz, BfS). For studies in the field of radiation oncology, differentiation between use of radiation for "medical care (Heilkunde)" versus "medical research" frequently leads to contradictions. The aim of this article is to provide principle investigators, individuals, and institutions involved in the process, as well as institutional review or ethics committees, with the necessary information for this assessment. Information on the legal frame and the approval procedures are also provided. Methods: A workshop was co-organized by the German Society for Radiation Oncology (DEGRO), the Working Party for Radiation Oncology (ARO) of the German Cancer Society (DKG), the German Society for Medical Physics (DGMP), and the German Cancer Consortium (DKTK) in October 2013. This paper summarizes the results of the workshop and the follow-up discussions between the organizers and the BfS. Results: Differentiating between "Heilkunde" which does not need to be approved by the BfS and "medical research" is whether the specific application of radiation (beam quality, dose, schedule, target volume, etc.) is a clinically established and recognized procedure. This must be answered by the qualified physician(s) ("fachkundiger Arzt" according to German radiation protection law) in charge of the study and the treatments of the patients within the study, taking into consideration of the best available evidence from clinical studies, guidelines and consensus papers. Among the important parameters for assessment are indication, total dose, and fractionation. Radiation treatments applied outside clinical trials do not require approval by the BfS, even if they are applied within a randomized or nonrandomized clinical trial. The decision-making by the "fachkundigem Arzt" may be supported on request by an opinion given by the DEGRO Expert Committee for clinical trials. Conclusion: An important aim for promoting clinical research and patient care in radiation oncology is to further professionalize planning and implementation of clinical trials in this field. Correct assessment, at an early stage, whether a trial needs to be approved by the BfS may reduce unnecessary costs and reduce the time needed for the approval procedure for those trials which need to be assessed by the BfS.
MeSH term(s)	Clinical Protocols ; Clinical Trials as Topic/legislation & jurisprudence ; Education ; Education, Medical, Continuing/legislation & jurisprudence ; Germany ; Government Regulation ; Humans ; National Health Programs/legislation & jurisprudence ; Radiation Oncology/education ; Radiation Oncology/legislation & jurisprudence ; Radiation Protection/legislation & jurisprudence ; Societies, Medical
Language	German
Publishing date	2015-12
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	84983-2
ISSN	1439-099X ; 0179-7158 ; 0039-2073
ISSN (online)	1439-099X
ISSN	0179-7158 ; 0039-2073
DOI	10.1007/s00066-015-0914-3
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Article ; Online: Creating a data exchange strategy for radiotherapy research: towards federated databases and anonymised public datasets.

Skripcak, Tomas / Belka, Claus / Bosch, Walter / Brink, Carsten / Brunner, Thomas / Budach, Volker / Büttner, Daniel / Debus, Jürgen / Dekker, Andre / Grau, Cai / Gulliford, Sarah / Hurkmans, Coen / Just, Uwe / Krause, Mechthild / Lambin, Philippe / Langendijk, Johannes A / Lewensohn, Rolf / Lühr, Armin / Maingon, Philippe /

Masucci, Michele / Niyazi, Maximilian / Poortmans, Philip / Simon, Monique / Schmidberger, Heinz / Spezi, Emiliano / Stuschke, Martin / Valentini, Vincenzo / Verheij, Marcel / Whitfield, Gillian / Zackrisson, Björn / Zips, Daniel / Baumann, Michael

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2014 Volume 113, Issue 3, Page(s) 303–309

Abstract: Disconnected cancer research data management and lack of information exchange about planned and ongoing research are complicating the utilisation of internationally collected medical information for improving cancer patient care. Rapidly collecting/ ... ...

Abstract	Disconnected cancer research data management and lack of information exchange about planned and ongoing research are complicating the utilisation of internationally collected medical information for improving cancer patient care. Rapidly collecting/pooling data can accelerate translational research in radiation therapy and oncology. The exchange of study data is one of the fundamental principles behind data aggregation and data mining. The possibilities of reproducing the original study results, performing further analyses on existing research data to generate new hypotheses or developing computational models to support medical decisions (e.g. risk/benefit analysis of treatment options) represent just a fraction of the potential benefits of medical data-pooling. Distributed machine learning and knowledge exchange from federated databases can be considered as one beyond other attractive approaches for knowledge generation within "Big Data". Data interoperability between research institutions should be the major concern behind a wider collaboration. Information captured in electronic patient records (EPRs) and study case report forms (eCRFs), linked together with medical imaging and treatment planning data, are deemed to be fundamental elements for large multi-centre studies in the field of radiation therapy and oncology. To fully utilise the captured medical information, the study data have to be more than just an electronic version of a traditional (un-modifiable) paper CRF. Challenges that have to be addressed are data interoperability, utilisation of standards, data quality and privacy concerns, data ownership, rights to publish, data pooling architecture and storage. This paper discusses a framework for conceptual packages of ideas focused on a strategic development for international research data exchange in the field of radiation therapy and oncology.
MeSH term(s)	Biomedical Research/methods ; Biomedical Research/organization & administration ; Data Collection/methods ; Data Mining/methods ; Databases, Factual ; Electronic Health Records/organization & administration ; Humans ; Information Dissemination/methods ; International Cooperation ; Neoplasms/radiotherapy ; Research Design
Language	English
Publishing date	2014-10-28
Publishing country	Ireland
Document type	Journal Article ; Review
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2014.10.001
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Book ; Online: Auspicium Novi Anni M.DC.XCVI. Omnibus Hamburgi Civibus Et Inquilinis Summis, Medioxumis, Infimis Felix, Faustum, Fortunatumque Apprecatur Daniel Büttnerus I.U. Licentiatus Et Professor Publicus

Büttner, Daniel

1696

Language	Latin
Size	Online-Ressource, 4°
Publisher	Niedersächsische Staats- und Universitätsbibliothek ; Neumann
Publishing place	Göttingen ; Hamburg ; Hamburgi
Document type	Book ; Online
Note	Erscheinungsjahr nach Jahreszahl auf dem Titelblatt
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Online: Fato Gentilium Exploso Primordia Novi Anni Reipublicae Hamburgensi Eiusque Civibus, Et Incolis Ad Unum Omnibus Felicia, Fausta Et Fortunata Esse Iubeat Summus Rerum Omnium Moderator ... Ex Voto Danielis Büttneri

Büttner, Daniel

1693

Title variant	rei publicae
Language	Latin
Size	Online-Ressource, 4°
Publisher	Niedersächsische Staats- und Universitätsbibliothek ; Neumann
Publishing place	Göttingen ; Hamburg ; Hamburgi
Document type	Book ; Online
Database	Former special subject collection: coastal and deep sea fishing

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Book: Calendas Ianuarias, rerum agendarum Auspices, Anni M.DC.XCI. Hamburgo, Eiusque Incolis, primis, medioxumis, infimis, Felices, Faustas, Fortunatasque apprecatur

Büttner, Daniel

1691

Author's details	Daniel Büttnerus, Iur. Utr. Licent. quondam eiusd. Facult in Univers. ... Professor Publicus
Language	Latin
Size	[4] Bl, 4°
Publisher	Typis Viduae Rebenlinianae
Publishing place	Hamburg
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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Book: Auroram Purpurantem, Serenitatis praesagitionem, sub auspicium Novi Anni M.DC.XC. Auspice Christo, Bonorum omnium Satore & Datore, Hamburgo, Omnibusq[ue] eius Civibus & Incolis, piovotorum desiderio precatur Daniel Büttnerus, I.U. Licent. quondam eiusd. Facultatis in Elector. Acad. Hier. iam vero in illustri Hamburg. Athen. Professor Publicus

Büttner, Daniel

1690

Language	Latin
Size	[4] Bl, 4°
Publisher	Typis Viduae Rebenlinianae
Publishing place	Hamburg ; Hamburgi
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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