Article: Retroperitoneal fibrosis as a postoperative complication following renal transplantation in cats
Journal of feline medicine and surgery. 2022 Apr., v. 24, no. 4
2022
Abstract: The aim of this report was to describe the clinical signs, diagnostic imaging findings, surgical management, histopathological findings, outcome and possible risk factors for cats that developed retroperitoneal fibrosis (RPF) following renal ... ...
| Abstract | The aim of this report was to describe the clinical signs, diagnostic imaging findings, surgical management, histopathological findings, outcome and possible risk factors for cats that developed retroperitoneal fibrosis (RPF) following renal transplantation. Medical records of cats that underwent renal transplantation and developed clinically significant RPF between 1995 and 2019 were reviewed. Eighty-one cats underwent 83 renal transplantations. Of these 81 cats, six developed clinically significant RPF. For all six cats, renal transplantation was performed using cold organ preservation solution and ureteral papilla implantation. Immunosuppression protocol included ciclosporin and prednisolone. All cats had at least one subtherapeutic trough ciclosporin level (<250 ng/ml) in the postoperative period. Cats presented with moderate-to-severe azotemia 39–210 days following renal transplantation. Abdominal ultrasonography and contrast pyelography revealed various degrees of hydroureter and hydronephrosis of the transplanted kidney. Surgical examination revealed a layer of dense fibrous tissue surrounding the transplanted kidney, ureter and bladder resulting in ureteral obstruction. Ureteral obstruction was managed by reimplantation of the proximal ureter or renal pelvis to the bladder. Histopathologic examination of the fibrous tissue and affected portion of the distal ureter revealed fibrous connective tissue with lymphoplasmacytic infiltration and perivascular inflammation suggestive of an autoimmune type reaction. Of the six cats, two died within 5 days after revision surgery, two developed signs consistent with recurrent partial ureteral obstruction (40 and 41 days after revision), one was euthanized 6 years later for an unrelated disease and one was lost to follow-up. The incidence of RPF in this population of cats was relatively low (7%), but still represents a significant cause of morbidity and mortality. The cause of RPF remains unknown, although investigation into suboptimal immunosuppression as a potential cause for local rejection reaction is warranted. |
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| Keywords | bladder ; cats ; cold ; cyclosporine ; fibrosis ; histopathology ; immunosuppression ; inflammation ; kidney transplant ; kidneys ; medicine ; morbidity ; mortality ; pelvis ; prednisolone ; protocols ; ultrasonography ; uremia ; ureter |
| Language | English |
| Dates of publication | 2022-04 |
| Size | p. 304-310. |
| Publishing place | SAGE Publications |
| Document type | Article |
| ZDB-ID | 2049047-1 |
| ISSN | 1532-2750 ; 1098-612X |
| ISSN (online) | 1532-2750 |
| ISSN | 1098-612X |
| DOI | 10.1177/1098612X211018976 |
| Database | NAL-Catalogue (AGRICOLA) |
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