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  1. Article ; Online: Combining safety and trainee education in surgical oncology: we all win.

    Byrd, David R

    Annals of surgical oncology

    2013  Volume 20, Issue 12, Page(s) 3705–3706

    MeSH term(s) Clinical Competence ; Female ; General Surgery/education ; Humans ; Internship and Residency ; Male ; Neoplasms/surgery ; Outcome and Process Assessment (Health Care) ; Patient Safety ; Postoperative Complications
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-013-3081-8
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  2. Article ; Online: The Eighth Edition of TNM: Implications for the Surgical Oncologist.

    Byrd, David R / Greene, Frederick L

    Annals of surgical oncology

    2017  Volume 25, Issue 1, Page(s) 10–12

    MeSH term(s) Humans ; Neoplasm Staging/methods ; Neoplasms/pathology ; Surgical Oncology
    Language English
    Publishing date 2017-08-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-017-6027-8
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  3. Article: The persistent anchor of lymph node removal in patients with melanoma.

    Byrd, David R

    Cancer

    2010  Volume 116, Issue 5, Page(s) 1150–1152

    MeSH term(s) Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/surgery ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
    Language English
    Publishing date 2010-03-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.24869
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  4. Article ; Online: Current and future cancer staging after neoadjuvant treatment for solid tumors.

    Byrd, David R / Brierley, James D / Baker, Thomas P / Sullivan, Daniel C / Gress, Donna M

    CA: a cancer journal for clinicians

    2020  Volume 71, Issue 2, Page(s) 140–148

    Abstract: Until recently, cancer registries have only collected cancer clinical stage at diagnosis, before any therapy, and pathological stage after surgical resection, provided no treatment has been given before the surgery, but they have not collected stage data ...

    Abstract Until recently, cancer registries have only collected cancer clinical stage at diagnosis, before any therapy, and pathological stage after surgical resection, provided no treatment has been given before the surgery, but they have not collected stage data after neoadjuvant therapy (NAT). Because NAT is increasingly being used to treat a variety of tumors, it has become important to make the distinction between both the clinical and the pathological assessment without NAT and the assessment after NAT to avoid any misunderstanding of the significance of the clinical and pathological findings. It also is important that cancer registries collect data after NAT to assess response and effectiveness of this treatment approach on a population basis. The prefix y is used to denote stage after NAT. Currently, cancer registries of the American College of Surgeons' Commission on Cancer only partially collect y stage data, and data on the clinical response to NAT (yc or posttherapy clinical information) are not collected or recorded in a standardized fashion. In addition to NAT, nonoperative management after radiation and chemotherapy is being used with increasing frequency in rectal cancer and may be expanded to other treatment sites. Using examples from breast, rectal, and esophageal cancers, the pathological and imaging changes seen after NAT are reviewed to demonstrate appropriate staging.
    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Esophageal Neoplasms/diagnosis ; Esophageal Neoplasms/pathology ; Esophageal Neoplasms/therapy ; Female ; Humans ; Male ; Neoadjuvant Therapy ; Neoplasm Staging/methods ; Neoplasm Staging/statistics & numerical data ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/therapy ; Registries/statistics & numerical data ; Treatment Outcome ; United States
    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603553-x
    ISSN 1542-4863 ; 0007-9235
    ISSN (online) 1542-4863
    ISSN 0007-9235
    DOI 10.3322/caac.21640
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  5. Article ; Online: The American Joint Committee on Cancer turns 60.

    Greene, Frederick L / Byrd, David R / Brookland, Robert K / Amin, Mahul B / Gress, Donna M

    Cancer

    2019  Volume 125, Issue 15, Page(s) 2704–2705

    MeSH term(s) Humans ; Neoplasms/epidemiology ; Time Factors ; United States
    Language English
    Publishing date 2019-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1429-1
    ISSN 1097-0142 ; 0008-543X ; 1934-662X
    ISSN (online) 1097-0142
    ISSN 0008-543X ; 1934-662X
    DOI 10.1002/cncr.32159
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  6. Article ; Online: An In Vivo Model of Human Macrophages in Metastatic Melanoma.

    Voillet, Valentin / Berger, Trisha R / McKenna, Kelly M / Paulson, Kelly G / Tan, Wei Hong / Smythe, Kimberly S / Hunter, Daniel S / Valente, William J / Weaver, Stephanie / Campbell, Jean S / Kim, Teresa S / Byrd, David R / Bielas, Jason H / Pierce, Robert H / Chapuis, Aude G / Gottardo, Raphaël / Rongvaux, Anthony

    Journal of immunology (Baltimore, Md. : 1950)

    2022  Volume 209, Issue 3, Page(s) 606–620

    Abstract: Despite recent therapeutic progress, advanced melanoma remains lethal for many patients. The composition of the immune tumor microenvironment (TME) has decisive impacts on therapy response and disease outcome, and high-dimensional analyses of patient ... ...

    Abstract Despite recent therapeutic progress, advanced melanoma remains lethal for many patients. The composition of the immune tumor microenvironment (TME) has decisive impacts on therapy response and disease outcome, and high-dimensional analyses of patient samples reveal the heterogeneity of the immune TME. Macrophages infiltrate TMEs and generally associate with tumor progression, but the underlying mechanisms are incompletely understood. Because experimental systems are needed to elucidate the functional properties of these cells, we developed a humanized mouse model reconstituted with human immune cells and human melanoma. We used two strains of recipient mice, supporting or not supporting the development of human myeloid cells. We found that human myeloid cells favored metastatic spread of the primary tumor, thereby recapitulating the cancer-supportive role of macrophages. We next analyzed the transcriptome of human immune cells infiltrating tumors versus other tissues. This analysis identified a cluster of myeloid cells present in the TME, but not in other tissues, which do not correspond to canonical M2 cells. The transcriptome of these cells is characterized by high expression of glycolytic enzymes and multiple chemokines and by low expression of gene sets associated with inflammation and adaptive immunity. Compared with humanized mouse results, we found transcriptionally similar myeloid cells in patient-derived samples of melanoma and other cancer types. The humanized mouse model described here thus complements patient sample analyses, enabling further elucidation of fundamental principles in melanoma biology beyond M1/M2 macrophage polarization. The model can also support the development and evaluation of candidate antitumor therapies.
    MeSH term(s) Animals ; Cell Line, Tumor ; Disease Models, Animal ; Humans ; Macrophage Activation ; Macrophages ; Melanoma/pathology ; Mice ; Tumor Microenvironment
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2101109
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  7. Article ; Online: Narrow excision margins are appropriate for Merkel cell carcinoma when combined with adjuvant radiation: Analysis of 188 cases of localized disease and proposed management algorithm.

    Tarabadkar, Erica S / Fu, Teresa / Lachance, Kristina / Hippe, Daniel S / Pulliam, Thomas / Thomas, Hannah / Li, Janet Y / Lewis, Christopher W / Doolittle-Amieva, Coley / Byrd, David R / Kampp, Jeremy T / Parvathaneni, Upendra / Nghiem, Paul

    Journal of the American Academy of Dermatology

    2020  Volume 84, Issue 2, Page(s) 340–347

    Abstract: Background: Merkel cell carcinoma (MCC) management typically includes surgery with or without adjuvant radiation therapy (aRT). Major challenges include determining surgical margin size and whether aRT is indicated.: Objective: To assess the ... ...

    Abstract Background: Merkel cell carcinoma (MCC) management typically includes surgery with or without adjuvant radiation therapy (aRT). Major challenges include determining surgical margin size and whether aRT is indicated.
    Objective: To assess the association of aRT, surgical margin size, and MCC local recurrence.
    Methods: Analysis of 188 MCC cases presenting without clinical nodal involvement.
    Results: aRT-treated patients tended to have higher-risk tumors (larger diameter, positive microscopic margins, immunosuppression) yet had fewer local recurrences (LRs) than patients treated with surgery only (1% vs 15%; P = .001). For patients who underwent surgery alone, 7 of 35 (20%) treated with narrow margins (defined as ≤1.0 cm) developed LR, whereas 0 of 13 patients treated with surgical margins greater than 1.0 cm developed LR (P = .049). For aRT-treated patients, local control was excellent regardless of surgical margin size; only 1% experienced recurrence in each group (1 of 70 with narrow margins ≤1 cm and 1 of 70 with margins >1 cm; P = .56).
    Limitations: This was a retrospective study.
    Conclusions: Among patients treated with aRT, local control was superb even if significant risk factors were present and margins were narrow. We propose an algorithm for managing primary MCC that integrates risk factors and optimizes local control while minimizing morbidity.
    MeSH term(s) Aged ; Aged, 80 and over ; Carcinoma, Merkel Cell/diagnosis ; Carcinoma, Merkel Cell/mortality ; Carcinoma, Merkel Cell/pathology ; Carcinoma, Merkel Cell/therapy ; Critical Pathways/standards ; Dermatologic Surgical Procedures/methods ; Dermatologic Surgical Procedures/standards ; Dermatologic Surgical Procedures/statistics & numerical data ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Male ; Margins of Excision ; Middle Aged ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/prevention & control ; Neoplasm Staging ; Practice Guidelines as Topic ; Radiotherapy, Adjuvant/standards ; Radiotherapy, Adjuvant/statistics & numerical data ; Retrospective Studies ; Risk Assessment/methods ; Risk Factors ; Skin Neoplasms/diagnosis ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy ; Time-to-Treatment/standards ; Time-to-Treatment/statistics & numerical data
    Language English
    Publishing date 2020-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2020.07.079
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  8. Article ; Online: Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma.

    Paulson, Kelly G / Iyer, Jayasri G / Byrd, David R / Nghiem, Paul

    Journal of the American Academy of Dermatology

    2013  Volume 69, Issue 4, Page(s) 653–654

    MeSH term(s) Biopsy, Needle ; Carcinoma, Merkel Cell/epidemiology ; Carcinoma, Merkel Cell/pathology ; Carcinoma, Merkel Cell/secondary ; Databases, Factual ; Female ; Humans ; Immunohistochemistry ; Incidence ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Male ; Needs Assessment ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology
    Language English
    Publishing date 2013-09-14
    Publishing country United States
    Document type Comparative Study ; Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2013.06.002
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  9. Article ; Online: Neoantigen-specific CD4

    Veatch, Joshua R / Lee, Sylvia M / Shasha, Carolyn / Singhi, Naina / Szeto, Julia L / Moshiri, Ata S / Kim, Teresa S / Smythe, Kimberly / Kong, Paul / Fitzgibbon, Matthew / Jesernig, Brenda / Bhatia, Shailender / Tykodi, Scott S / Hall, Evan T / Byrd, David R / Thompson, John A / Pillarisetty, Venu G / Duhen, Thomas / McGarry Houghton, A /
    Newell, Evan / Gottardo, Raphael / Riddell, Stanley R

    Cancer cell

    2022  Volume 40, Issue 4, Page(s) 393–409.e9

    Abstract: ... ...

    Abstract CD4
    MeSH term(s) Animals ; Antigens, Neoplasm/genetics ; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Humans ; Macrophages ; Melanoma/genetics ; Mice ; Tumor Microenvironment
    Chemical Substances Antigens, Neoplasm
    Language English
    Publishing date 2022-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2022.03.006
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  10. Article ; Online: BRCA testing is important for our patients.

    Anderson, Benjamin O / Javid, Sara H / Calhoun, Kristine E / Byrd, David R

    Surgery

    2012  Volume 151, Issue 4, Page(s) 637–638

    MeSH term(s) BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Breast Neoplasms/diagnosis ; Carcinoma, Ductal, Breast/diagnosis ; Carcinoma, Intraductal, Noninfiltrating/diagnosis ; Female ; Genetic Testing/trends ; Humans
    Chemical Substances BRCA1 Protein ; BRCA2 Protein
    Language English
    Publishing date 2012-04
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2011.12.031
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