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  1. Book: Australia

    Byrne, Niall

    harvesting biotechnology

    (Nature ; 429, No. 6991, Suppl.)

    2004  

    Author's details [suppl. ed. Niall Byrne]
    Series title Nature ; 429, No. 6991, Suppl.
    Collection
    Keywords Australien ; Biotechnologie
    Subject Technische Biochemie ; Technische Biologie ; Biotechnik ; Biotech
    Language English
    Size A25 S. : Ill., graph. Darst.
    Publisher Nature Publ. Group
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014060844
    Database Catalogue ZB MED Medicine, Health

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    Zs A 26 -429,6991,Suppl.- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Hobson's choice: patient-centred or standardized care.

    Byrne, Niall

    Advances in health sciences education : theory and practice

    2020  Volume 26, Issue 1, Page(s) 335–338

    MeSH term(s) Clinical Protocols/standards ; Humans ; Patient Satisfaction ; Patient-Centered Care/standards
    Language English
    Publishing date 2020-01-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1352832-4
    ISSN 1573-1677 ; 1382-4996
    ISSN (online) 1573-1677
    ISSN 1382-4996
    DOI 10.1007/s10459-019-09951-z
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  3. Article ; Online: Urethane dimethacrylate-based photopolymerizable resins for stereolithography 3D printing: A physicochemical characterisation and biocompatibility evaluation.

    Pitzanti, Giulia / Mohylyuk, Valentyn / Corduas, Francesca / Byrne, Niall M / Coulter, Jonathan A / Lamprou, Dimitrios A

    Drug delivery and translational research

    2023  Volume 14, Issue 1, Page(s) 177–190

    Abstract: Vat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of biocompatible ... ...

    Abstract Vat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of biocompatible photocurable resins, its application in the healthcare sector is still limited. In this work, we formulate photocurable resins based on urethane dimethacrylate (UDMA) combined with three different difunctional methacrylic diluents named ethylene glycol dimethacrylate (EGDMA), di(ethylene glycol) dimethacrylate (DEGDMA) or tri(ethylene glycol) dimethacrylate (TEGDMA). The resins were tested for viscosity, thermal behaviour and printability. After printing, the 3D printed specimens were measured with a digital calliper in order to investigate their accuracy to the digital model and tested with FT-IR, TGA and DSC. Their mechanical properties, contact angle, water sorption and biocompatibility were also evaluated. The photopolymerizable formulations investigated in this work achieved promising properties so as to be suitable for tissue engineering and other biomedical applications.
    MeSH term(s) Stereolithography ; Composite Resins/chemistry ; Spectroscopy, Fourier Transform Infrared ; Printing, Three-Dimensional
    Chemical Substances urethane dimethacrylate luting resin (125523-74-2) ; Composite Resins
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2590155-2
    ISSN 2190-3948 ; 2190-393X
    ISSN (online) 2190-3948
    ISSN 2190-393X
    DOI 10.1007/s13346-023-01391-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Radiation Response in the Tumour Microenvironment: Predictive Biomarkers and Future Perspectives.

    Byrne, Niall M / Tambe, Prajakta / Coulter, Jonathan A

    Journal of personalized medicine

    2021  Volume 11, Issue 1

    Abstract: Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering potentially curative outcomes. Despite its success, ... ...

    Abstract Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering potentially curative outcomes. Despite its success, tumour
    Language English
    Publishing date 2021-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm11010053
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  5. Article: Exploiting Current Understanding of Hypoxia Mediated Tumour Progression for Nanotherapeutic Development.

    Feng, Jie / Byrne, Niall M / Al Jamal, Wafa / Coulter, Jonathan A

    Cancers

    2019  Volume 11, Issue 12

    Abstract: Hypoxia is one of the most common phenotypes of malignant tumours. Hypoxia leads to the increased activity of hypoxia-inducible factors (HIFs), which regulate the expression of genes controlling a raft of pro-tumour phenotypes. These include maintenance ... ...

    Abstract Hypoxia is one of the most common phenotypes of malignant tumours. Hypoxia leads to the increased activity of hypoxia-inducible factors (HIFs), which regulate the expression of genes controlling a raft of pro-tumour phenotypes. These include maintenance of the cancer stem cell compartment, epithelial-mesenchymal transition (EMT), angiogenesis, immunosuppression, and metabolic reprogramming. Hypoxia can also contribute to the tumour progression in a HIF-independent manner via the activation of a complex signalling network pathway, including JAK-STAT, RhoA/ROCK, NF-κB and PI3/AKT. Recent studies suggest that nanotherapeutics offer a unique opportunity to target the hypoxic microenvironment, enhancing the therapeutic window of conventional therapeutics. In this review, we summarise recent advances in understanding the impact of hypoxia on tumour progression, while outlining possible nanotherapeutic approaches for overcoming hypoxia-mediated resistance.
    Language English
    Publishing date 2019-12-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers11121989
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  6. Article ; Online: Tumor Cell Dormancy and Reactivation in Bone: Skeletal Biology and Therapeutic Opportunities.

    Byrne, Niall M / Summers, Matthew A / McDonald, Michelle M

    JBMR plus

    2019  Volume 3, Issue 3, Page(s) e10125

    Abstract: In the advanced stages of many cancers, tumor cells disseminate from the primary site and colonize distant locations such as the skeleton. These disseminated tumor cells colonizing bone can evade treatments and survive for prolonged periods in a dormant ... ...

    Abstract In the advanced stages of many cancers, tumor cells disseminate from the primary site and colonize distant locations such as the skeleton. These disseminated tumor cells colonizing bone can evade treatments and survive for prolonged periods in a dormant state before becoming reactivated to form overt metastases. The precise interactions between tumor cells and the bone microenvironment that promote survival, dormancy, and reactivation are currently unknown; as a result, bone metastases remain incurable. In this review we discuss the unique cellular and microenvironmental features of endosteal bone that tumor cells engage with to persist and survive, and ultimately reactivate and proliferate. Specifically, we provide a detailed summary of current perspectives on the processes of tumor cell colonization of the skeleton, and the endosteal bone cells as critical controllers of the dormant cancer cell phenotype, as well as relevant microenvironmental effects such as hypoxia. Evidence for the role of the osteoclast in controlling dormant cancer cell reactivation in bone is highlighted, preceding a discussion of therapeutics targeting the bone microenvironment, including anti-RANK ligand and bisphosphonate therapies and their potential utility in preventing tumor cell reactivation in addition to protecting bone from tumor-induced destruction. © 2018 The Authors.
    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1002/jbm4.10125
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  7. Article ; Online: Future outlook.

    Byrne, Niall

    Nature

    2004  Volume 429, Issue 6991 Suppl, Page(s) 25

    MeSH term(s) Australia ; Biodiversity ; Biomedical Research/economics ; Biomedical Research/manpower ; Biomedical Research/trends ; Biotechnology/economics ; Biotechnology/manpower ; Biotechnology/trends ; Humans ; Synchrotrons
    Language English
    Publishing date 2004-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/429a25a
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  8. Article ; Online: Comparison Between a Typical Undergraduate Psychiatry Program in China and Canada--an Approach to Inform Psychiatry Education Reform in China.

    Yu, Miaoyu / Law, Samuel / Dang, Kien / Byrne, Niall

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2016  Volume 40, Issue 2, Page(s) 229–234

    Abstract: Objective: Psychiatry as a field and undergraduate psychiatry education (UPE) specifically have historically been in the periphery of medicine in China, unlike the relatively central role they occupy in the West. During the current economic reform, ... ...

    Abstract Objective: Psychiatry as a field and undergraduate psychiatry education (UPE) specifically have historically been in the periphery of medicine in China, unlike the relatively central role they occupy in the West. During the current economic reform, Chinese undergraduate medical education (UME) is undergoing significant changes and standardization under the auspices of the national accreditation body. A comparative study, using Bereday's comparative education methodology and Feldmann's evaluative criteria as theoretical frameworks, to gain understanding of the differences and similarities between China and the West in terms of UPE can contribute to the UME reform, and specifically UPE development in China, and promote cross-cultural understanding.
    Method: The authors employed multi-sourced information to perform a comparative study of UPE, using the University of Toronto as a representative of the western model and Guangxi Medical University, a typical program in China, as the Chinese counterpart.
    Results: Key contrasts are numerous; highlights include the difference in age and level of education of the entrants to medical school, centrally vs. locally developed UPE curriculum, level of integration with the rest of medical education, visibility within the medical school, adequacy of teaching resources, amount of clinical learning experience, opportunity for supervision and mentoring, and methods of student assessment.
    Conclusions: Examination of the existing, multi-sourced information reveals some fundamental differences in the current UPE between the representative Chinese and western programs, reflecting historical, political, cultural, and socioeconomic circumstances of the respective settings. The current analyses show some areas worthy of further exploration to inform Chinese UPE reform. The current research is a practical beginning to the development of a deeper collaborative dialogue about psychiatry and its educational underpinnings between China and the West.
    MeSH term(s) Canada ; China ; Cooperative Behavior ; Cross-Cultural Comparison ; Curriculum ; Education, Medical, Undergraduate ; Humans ; Models, Educational ; Psychiatry/education ; Psychiatry/manpower ; Universities
    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-014-0179-7
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  9. Article ; Online: Do medical professionalism and medical education involve commitments to political advocacy?

    Banack, Jeannine Girard-Pearlman / Byrne, Niall

    Academic medicine : journal of the Association of American Medical Colleges

    2011  Volume 86, Issue 9, Page(s) 1064–5; author reply 1065

    MeSH term(s) Education, Medical/organization & administration ; Humans ; Patient Advocacy ; Physician's Role ; Politics ; Professional Competence ; Public Policy
    Language English
    Publishing date 2011-09
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0b013e318226765c
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    Zs.A 112: Show issues Location:
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  10. Article ; Online: Strategic Planning in Health Professions Education: Scholarship or Management?

    Byrne, Niall / Cole, Donald C / Woods, Nicole / Kulasegaram, Kulamakan / Martimianakis, Maria Athina / Richardson, Lisa / Whitehead, Cynthia R

    Academic medicine : journal of the Association of American Medical Colleges

    2019  Volume 94, Issue 10, Page(s) 1455–1460

    Abstract: Strategic planning, in its various forms, is an evaluation practice that is ubiquitous in academic medicine. However, published reports of strategic planning at academic health centers usually ignore theory. In a 2017 strategic planning exercise at the ... ...

    Abstract Strategic planning, in its various forms, is an evaluation practice that is ubiquitous in academic medicine. However, published reports of strategic planning at academic health centers usually ignore theory. In a 2017 strategic planning exercise at the Wilson Centre, a scholarly model evolved using a theoretical framework and a research approach rather than a conventional management model, which typically identifies outcomes and how to achieve them. After completing this exercise, the authors considered the larger questions of the assumptions underpinning different models of strategic planning and strategic planning's value to academic medicine. To elaborate on these questions, the authors examine relevant literature and set out the Wilson Centre's emergent scholarly model. They describe the main features of the scholarly model, including ways it differs from a management approach and from the typical approach to strategic planning in the authors' experience and in the field of health professions education research. The authors also share lessons learned as a means to encourage consideration by other academic organizations.
    MeSH term(s) Academic Medical Centers/organization & administration ; Health Occupations/education ; Humans ; Models, Organizational ; Strategic Planning
    Language English
    Publishing date 2019-07-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000002852
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