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  1. Article: The effect of omalizumab treatment on severe allergic asthma and allergic comorbidities: real-life experience from the Czech Anti-IgE Registry.

    Hutyrová, Beáta / Bystroň, Jaromír

    Postepy dermatologii i alergologii

    2018  Volume 35, Issue 5, Page(s) 510–515

    Abstract: Introduction: Omalizumab is indicated for the treatment of severe allergic asthma (SAA) and chronic spontaneous urticaria, although a number of studies have confirmed the effectiveness of this therapy also for other IgE-mediated diseases.: Aim: To ... ...

    Abstract Introduction: Omalizumab is indicated for the treatment of severe allergic asthma (SAA) and chronic spontaneous urticaria, although a number of studies have confirmed the effectiveness of this therapy also for other IgE-mediated diseases.
    Aim: To assess the impact of anti-IgE therapy on SAA and comorbid IgE-mediated allergic diseases in patients treated with omalizumab for SAA enrolled in the CAR (Czech Anti-IgE Registry).
    Material and methods: Three hundred and ten patients with SAA treated with omalizumab were enrolled in the CAR. Two hundred and twenty-nine individuals were evaluated after 12 months of omalizumab treatment for asthma control test (ACT), examination of fractional exhaled nitric oxide (FENO), forced expiratory volume in 1 s (FEV
    Results: After 12 months of treatment with omalizumab, patients experienced a significant improvement of ACT and FEV
    Conclusions: In the CAR registry, patients with SAA treated with omalizumab showed a significant positive effect of anti-IgE therapy not only on the asthma control, but also on allergic comorbidities.
    Language English
    Publishing date 2018-07-19
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2596142-1
    ISSN 1642-395X
    ISSN 1642-395X
    DOI 10.5114/ada.2018.77243
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Four seasons of Czech asthma study: asthma characteristics and management reality in the Czech Republic.

    Terl, Milan / Pohunek, Petr / Kuhn, Matyas / Bystron, Jaromir

    The Journal of asthma : official journal of the Association for the Care of Asthma

    2019  Volume 57, Issue 8, Page(s) 898–910

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Administration, Inhalation ; Adrenergic beta-2 Receptor Agonists/administration & dosage ; Adult ; Aged ; Allergy and Immunology/standards ; Allergy and Immunology/statistics & numerical data ; Allergy and Immunology/trends ; Anti-Asthmatic Agents/administration & dosage ; Asthma/diagnosis ; Asthma/drug therapy ; Budesonide/administration & dosage ; Cross-Sectional Studies ; Czech Republic ; Delayed Diagnosis/statistics & numerical data ; Drug Combinations ; Drug Prescriptions/statistics & numerical data ; Drug Therapy, Combination/methods ; Drug Therapy, Combination/statistics & numerical data ; Female ; Formoterol Fumarate ; Glucocorticoids/administration & dosage ; Guideline Adherence/statistics & numerical data ; Guideline Adherence/trends ; Humans ; Male ; Middle Aged ; Practice Guidelines as Topic ; Pulmonary Medicine/standards ; Pulmonary Medicine/statistics & numerical data ; Pulmonary Medicine/trends ; Societies, Medical/standards ; Young Adult
    Chemical Substances Adrenergic beta-2 Receptor Agonists ; Anti-Asthmatic Agents ; Drug Combinations ; Glucocorticoids ; Budesonide (51333-22-3) ; Formoterol Fumarate (W34SHF8J2K)
    Language English
    Publishing date 2019-05-30
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 603816-5
    ISSN 1532-4303 ; 0277-0903
    ISSN (online) 1532-4303
    ISSN 0277-0903
    DOI 10.1080/02770903.2019.1619082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 18: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article: Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.

    Kalus, Ulrich / Pruss, Axel / Bystron, Jaromir / Jurecka, Moric / Smekalova, Alice / Lichius, Johannes Josef / Kiesewetter, Holger

    Phytotherapy research : PTR

    2003  Volume 17, Issue 10, Page(s) 1209–1214

    Abstract: Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies. The plant's mechanism of action is still ... ...

    Abstract Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies. The plant's mechanism of action is still largely unknown. Due to the lack of study data on its efficacy in allergies, four studies on the clinical efficacy of Nigella sativa in allergic diseases are presented. In these studies, a total of 152 patients with allergic diseases (allergic rhinitis, bronchial asthma, atopic eczema) were treated with Nigella sativa oil, given in capsules at a dose of 40 to 80 mg/kg/day. The patients scored the subjective severity of target symptoms using a predefined scale. The following laboratory parameters were investigated: IgE, eosinophil count, endogenous cortisol in plasma and urine, ACTH, triglycerides, total cholesterol, LDL and HDL cholesterol and lymphocyte subpopulations. The score of subjective feeling decreased over the course of treatment with black seed oil in all four studies. A slight decrease in plasma triglycerides and a discrete increase in HDL cholesterol occurred while the lymphocyte subpopulations, endogenous cortisol levels and ACTH release remained unchanged. Black seed oil therefore proved to be an effective adjuvant for the treatment of allergic diseases.
    MeSH term(s) Administration, Oral ; Adolescent ; Adrenocorticotropic Hormone/blood ; Adrenocorticotropic Hormone/drug effects ; Adult ; Aged ; Anti-Allergic Agents/administration & dosage ; Anti-Allergic Agents/pharmacology ; Anti-Allergic Agents/therapeutic use ; Child ; Child, Preschool ; Cholesterol/blood ; Cholesterol, HDL/blood ; Cholesterol, LDL/blood ; Cross-Over Studies ; Double-Blind Method ; Eosinophils/drug effects ; Female ; Humans ; Hydrocortisone/blood ; Hydrocortisone/urine ; Immunoglobulin E/drug effects ; Lymphocyte Subsets/drug effects ; Male ; Middle Aged ; Nigella sativa ; Phytotherapy ; Plant Oils/administration & dosage ; Plant Oils/pharmacology ; Plant Oils/therapeutic use ; Respiratory Hypersensitivity/blood ; Respiratory Hypersensitivity/drug therapy ; Respiratory Hypersensitivity/psychology ; Seeds ; Triglycerides/blood
    Chemical Substances Anti-Allergic Agents ; Cholesterol, HDL ; Cholesterol, LDL ; Plant Oils ; Triglycerides ; Immunoglobulin E (37341-29-0) ; Adrenocorticotropic Hormone (9002-60-2) ; Cholesterol (97C5T2UQ7J) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2003-12
    Publishing country England
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 639136-9
    ISSN 1099-1573 ; 0951-418X
    ISSN (online) 1099-1573
    ISSN 0951-418X
    DOI 10.1002/ptr.1356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3092: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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