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  1. AU="Céline Chauleur"
  2. AU="Savic, Ivana"
  3. AU="Koçak, Emine Eren"
  4. AU="Azreen Hashim, Nurul"
  5. AU="Alvarez, Abel V. Jr" AU="Alvarez, Abel V. Jr"
  6. AU="Boboshko, Vladimir A"
  7. AU=Zweig Ann S AU=Zweig Ann S
  8. AU="Fortea, Jose Ignacio"
  9. AU="Graeme S. Cumming"
  10. AU="Field, Belinda G"
  11. AU="Erhart, Stephen"
  12. AU="Glenn Smith"
  13. AU="Shillingford, Shanelle R"
  14. AU="Ahn, Sung Soo"
  15. AU="Salih, Harith M"
  16. AU="Clayton, Philip A"
  17. AU="Soto, A. Garcia"
  18. AU="Jones, Daniel OB"
  19. AU="Chen, Maosheng"
  20. AU="Li, Zhengxi"
  21. AU="Toshiya Takahashi"
  22. AU=Hickey Chelsea L.
  23. AU="Badhrinarayanan, Shreya"
  24. AU="Milani, Liliana"
  25. AU="Reinhardt, Klaus"
  26. AU="Caudillo-Flores, Uriel"
  27. AU="Yin, Yizhen"
  28. AU=Kaushansky Kenneth
  29. AU="Golla, Jaya Prakash"
  30. AU="Penn, Marc S"
  31. AU="Montero, Vincent"
  32. AU="Etevenon, Pierre"
  33. AU="Hyseni, Agon"
  34. AU="Seitzman, Natalie"
  35. AU="Loukil, Abdelhalim"
  36. AU="Giammusso, Bruno"
  37. AU="Kaplan, Jonathan E"
  38. AU=Francolini Giulio
  39. AU="Yuhu Li"
  40. AU=Kim Moojung
  41. AU="Vise, Luciana M"
  42. AU="Marcinowska, Zuzanna"
  43. AU="Graff, Pablo"

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  1. Artikel ; Online: Endometrial biopsy performed before the first in vitro fertilization does not impact the early pregnancy rate

    Mathilde Cellier / Sophie Werlen / Mery Lionel / Anne Genod / Bertrand Felloni / Tiphaine Semay / Béatrice Trombert / Céline Chauleur / Tiphaine Raia-Barjat

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    2024  Band 10

    Abstract: Abstract Endometrial biopsy (EB) has been showed to increase the rate of clinical pregnancy in patients who underwent in vitro fertilization (IVF) failures. The purpose of this work was to assess the impact of an EB performed before the first in IVF on ... ...

    Abstract Abstract Endometrial biopsy (EB) has been showed to increase the rate of clinical pregnancy in patients who underwent in vitro fertilization (IVF) failures. The purpose of this work was to assess the impact of an EB performed before the first in IVF on the early pregnancy rate. Be One study is a prospective, single-centre, randomized, open-label study. In this parallel study, patients were evenly split into two groups. In one group, patients underwent an EB between days 17 and 22 of the menstrual cycle that precedes the ovarian stimulation. In the other group (control), no EB was performed. The hCG-positive rate (early pregnancy rate) was evaluated on day 14 after the ovarian puncture. In total, 157 patients were randomized in the EB group and 154 patients were in the control group. The early pregnancy rate was 33.1% (52/157) in the EB group and 29.9% (46/154) in the control group (p = 0.54). Other parameters, including perforation, endometritis, or pain level were reassuring. An EB performed during the luteal phase of the menstrual cycle preceding the stimulation of the first IVF did not increase early pregnancy rate.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Brain Metastases from Gynecologic Malignancies

    Georgia Karpathiou / Florian Camy / Céline Chauleur / Maroa Dridi / Pierre Dal Col / Michel Peoc’h

    Medicina, Vol 58, Iss 548, p

    2022  Band 548

    Abstract: Background and Objectives : To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. Materials and Methods : We retrospectively review 18 patients with histologically confirmed brain metastases ... ...

    Abstract Background and Objectives : To present a series of brain metastases from gynecologic primaries and provide a summary of the relevant literature. Materials and Methods : We retrospectively review 18 patients with histologically confirmed brain metastases from gynecologic primaries and summarize the largest series of relative reports. Results : Six brain metastases were of endometrial primary and 12 of ovarian primary. In 3 cases (16.7%), diagnosis of brain metastases was made at presentation of the gynecologic primary; in the others, median time to development of brain metastasis was 34 (range, 6–115) months. Median survival after brain metastasis diagnosis was 5 (range, 1–89) months. Favorable prognostic factors were better performance status ( p = 0.04) and, marginally, smaller metastasis size ( p = 0.06). No differences in brain metastases between endometrial and ovarian primaries were found, except for the time interval from primary to brain metastases diagnosis, which was shorter for endometrial tumors ( p = 0.05). A comprehensive summary of previous studies is provided. Conclusions : Performance status and smaller brain metastases size are good prognostic factors. Endometrial cancer brain metastases develop earlier than ovarian cancer brain metastases.
    Schlagwörter ovarian cancer ; endometrial cancer ; brain metastasis ; Medicine (General) ; R5-920
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2022-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Animal Models of Chorioamnionitis

    Tiphaine Raia-Barjat / Margaux Digonnet / Antoine Giraud / Taghreed Ayash / Seline Vancolen / Mohamed Benharouga / Céline Chauleur / Nadia Alfaidy / Guillaume Sébire

    Biomedicines, Vol 10, Iss 811, p

    Considerations for Translational Medicine

    2022  Band 811

    Abstract: Preterm birth is defined as any birth occurring before 37 completed weeks of gestation by the World Health Organization. Preterm birth is responsible for perinatal mortality and long-term neurological morbidity. Acute chorioamnionitis is observed in 70% ... ...

    Abstract Preterm birth is defined as any birth occurring before 37 completed weeks of gestation by the World Health Organization. Preterm birth is responsible for perinatal mortality and long-term neurological morbidity. Acute chorioamnionitis is observed in 70% of premature labor and is associated with a heavy burden of multiorgan morbidities in the offspring. Unfortunately, chorioamnionitis is still missing effective biomarkers and early placento- as well as feto-protective and curative treatments. This review summarizes recent advances in the understanding of the underlying mechanisms of chorioamnionitis and subsequent impacts on the pregnancy outcome, both during and beyond gestation. This review also describes relevant and current animal models of chorioamnionitis used to decipher associated mechanisms and develop much needed therapies. Improved knowledge of the pathophysiological mechanisms underpinning chorioamnionitis based on preclinical models is a mandatory step to identify early in utero diagnostic biomarkers and design novel anti-inflammatory interventions to improve both maternal and fetal outcomes.
    Schlagwörter animal models ; chorioamnionitis ; preterm birth ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2022-03-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Uterine transarterial embolization as nonsurgical management for uterine rupture following vaginal delivery

    Rémi Grange, MD / Laure-Elie Digonnet, MD / Alexandre Mayaud, MD / Céline Chauleur, MD, PhD / Claire Boutet, MD, PhD / Tiphaine Raia-Barjat, MD, PhD / Sylvain Grange, MD

    Radiology Case Reports, Vol 18, Iss 1, Pp 322-

    A report of two cases

    2023  Band 325

    Abstract: Uterine rupture (UR) is an unexpected, rare, and serious obstetrical condition, occurring in less than 0.1% of pregnancies. Complete UR is defined as a direct communication between the uterine cavity and the peritoneum due to a complete rupture of the ... ...

    Abstract Uterine rupture (UR) is an unexpected, rare, and serious obstetrical condition, occurring in less than 0.1% of pregnancies. Complete UR is defined as a direct communication between the uterine cavity and the peritoneum due to a complete rupture of the myometrium. Here, we present 2 cases of non-surgical management of UR following vaginal delivery, which were both treated by uterine transarterial embolization (UAE). A 26-year-old woman (G0P0) was referred to the emergency ward at 35 weeks of amenorrhea to treat the rupture of membranes, in the context of twin pregnancy. A vaginal delivery was performed and blood loss exceeded 2 liters. Gelatin sponge was injected in an attempt to occlude the right uterine artery. The injection was unsuccessful. After the medical team's discussion, it was decided to definitively occlude the right uterine artery. A 37-year-old woman (G3P3) was referred for a vaginal delivery for a medical termination at 38 weeks of amenorrhea. The ultrasound revealed a left latero-uterine pelvic hematoma, suggestive of UR. Four fibered coils were used to definitively occlude the left uterine artery. Computed tomography scan showed a progressive resorption of hematoma and satisfactory enhancement of the uterine wall in the 2 cases. Transarterial embolization may allow for bleeding to stop without resorting to exploratory laparotomy, with ad-integrum restitution of the uterine wall, and thus prevent a potential hysterectomy. The findings in these 2 cases suggest that UAE should be considered if pregnant women develop UR after delivery.
    Schlagwörter Embolization ; Hemorrhage ; Coils ; Uterine rupture ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Elsevier
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  5. Artikel ; Online: Vitamin D deficiency during late pregnancy mediates placenta-associated complications

    Tiphaine Raia-Barjat / Camille Sarkis / Florence Rancon / Lise Thibaudin / Jean-Christophe Gris / Nadia Alfaidy / Céline Chauleur

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Band 9

    Abstract: Abstract During pregnancy, maternal vitamin D insufficiency could increase the risk of preeclampsia. Aim of the study was to evaluate the relationship between vitamin D status and the occurrence of placenta-mediated complications (PMCs) in a population ... ...

    Abstract Abstract During pregnancy, maternal vitamin D insufficiency could increase the risk of preeclampsia. Aim of the study was to evaluate the relationship between vitamin D status and the occurrence of placenta-mediated complications (PMCs) in a population at high risk. A prospective multicenter cohort study of 200 pregnant patients was conducted. The vitamin D level of patients with placenta-mediated complications was lower at 32 weeks compared to uncomplicated pregnancies (P = 0.001). At 32 weeks, the risk of occurrence of PMCs was five times higher in patients with vitamin D deficiency (RR: 5.14 95% CI (1.50–17.55)) compared to patients with normal vitamin D levels. There was a strong, inverse relationship between serum 25(OH)D levels at 32 weeks and the subsequent risk of PMCs (P = 0.001). At 32 weeks, the vitamin D level of patients with late-onset PMCs was lower than the one of patients with early-onset PMCs and of patients without PMCs (P < 0.0001). These results suggest a role of vitamin D in the maintenance of placental performance and therefore in the prevention of the onset of late PMC.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag Nature Portfolio
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Randomized comparison between indocyanine green fluorescence plus 99mtechnetium and 99mtechnetium alone methods for sentinel lymph node biopsy in breast cancer

    Charlotte Vermersch / Tiphaine Raia-Barjat / Céline Chapelle / Suzanne Lima / Céline Chauleur

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Band 6

    Abstract: Abstract Use of both patent blue and a radioisotope to locate, and reduce the risk of sentinel lymph node (SLN) detection failure in breast cancer is recommended, but drawbacks commonly lead to using only a radioisotope. An alternative method would ... ...

    Abstract Abstract Use of both patent blue and a radioisotope to locate, and reduce the risk of sentinel lymph node (SLN) detection failure in breast cancer is recommended, but drawbacks commonly lead to using only a radioisotope. An alternative method would therefore be valuable. This randomized, controlled study in 99 patients compared SLN detection using 99mtechnetium (Tc) alone versus Tc combined with indocyanine green (ICG). The primary endpoint was the SLN identification rate. The primary outcome measure was the number of patients with <2 SLN detected. One SLN was detected in 44.0% of patients in the dual detection group and 40.8% in the 99mTc alone group (RR = 1.08 (95% CI 0.68; 1.72), p = 0.84). A mean (±SD) of 2.14 ± 1.23 SLN were identified in the dual detection group vs. 1.77 ± 0.85 using Tc alone (p = 0.09). Eight-five (78.7%) SLN were both ICG+ and TC+, 15 (13.9%) ICG+ and Tc−, and 7 (6.5%) ICG− and Tc+. SLN detected were ICG-positive in 92.6% of patients and 99mTc-positive in 85.2% with. No adverse event related to ICG injection was recorded. Dual detection of SLN using ICG and radioisotope is reliable and sensitive but was not superior to isotope alone in successfully locating SLN in our pilot randomized trial.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2019-05-01T00:00:00Z
    Verlag Nature Publishing Group
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  7. Artikel ; Online: Clinical, pathological, and comprehensive molecular analysis of the uterine clear cell carcinoma

    Elsa Nigon / Claudia Lefeuvre-Plesse / Alejandra Martinez / Céline Chauleur / Alain Lortholary / Laure Favier / Anne-Sophie Bats / Arnaud Guille / José AdélaÏde / Pascal Finetti / Victoire de Casteljac / Magali Provansal / Emilie Mamessier / François Bertucci / Isabelle Ray-Coquard / Renaud Sabatier

    Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-

    a retrospective national study from TMRG and GINECO network

    2023  Band 15

    Abstract: Abstract Background Uterine clear cell carcinomas (CCC) represent less than 5% of uterine cancers. Their biological characteristics and clinical management remain uncertain. A multicenter study to explore both clinical and molecular features of these ... ...

    Abstract Abstract Background Uterine clear cell carcinomas (CCC) represent less than 5% of uterine cancers. Their biological characteristics and clinical management remain uncertain. A multicenter study to explore both clinical and molecular features of these rare tumors was conducted. Methods This multicenter retrospective national study was performed within the French TMRG (Rare Gynecologic Malignant Tumors) network. Clinical data and, when available, FFPE blocks were collected. Clinical features, treatments, and outcome (progression-free survival (PFS) and overall survival (OS)) were analyzed and correlated to the protein (tissue micro-array), RNA (Nanostring nCounter® technology), and DNA (array-Comparative Genomic hybridization and target-next generation sequencing) levels using the tumor samples available. Results Sixty-eight patients with uterine CCC were enrolled, 61 from endometrial localization and 5 with cervix localization. Median age at diagnosis was 68.9 years old (range 19–89.7). Most tumors were diagnosed at an early stage (78% FIGO stage I–II). Hysterectomy (performed in 90%) and lymph node dissection (80%) were the most frequent surgical treatment. More than 70% of patients received external beam radiotherapy and 57% received brachytherapy. Nearly half (46%) of the patients received chemotherapy. After a median follow-up of 24.7 months, median PFS was 64.8 months (95 CI [5.3–124.4]) and median OS was 79.7 (IC95 [31.0–128.4]). Low hormone receptor expression (13% estrogen-receptor positive), frequent PI3K pathway alterations (58% PTEN loss, 50% PIK3CA mutations), and P53 abnormalities (41%) were observed. Mismatch repair deficiency was identified in 20%. P16 expression was associated with shorter PFS (HR = 5.88, 95 CI [1.56–25], p = 0.009). Transcriptomic analyzes revealed a specific transcriptomic profile notably with a high expression of immune response-associated genes in uterine CCC displaying a very good overall prognosis. Conclusions Uterine CCC reported to be potentially MSI high, hormone ...
    Schlagwörter Uterine cancer ; Clear cell carcinoma ; Tissue micro-array ; Genomics ; Gene expression profiling ; Medicine ; R
    Thema/Rubrik (Code) 616 ; 610
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag BMC
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    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Tissue factor pathway inhibitor for prediction of placenta-mediated adverse pregnancy outcomes in high-risk women

    Aurélie Di Bartolomeo / Céline Chauleur / Jean-Christophe Gris / Céline Chapelle / Edouard Noblot / Silvy Laporte / Tiphaine Raia-Barjat

    PLoS ONE, Vol 12, Iss 3, p e

    AngioPred study.

    2017  Band 0173596

    Abstract: OBJECTIVE:The study aimed to evaluate if the rate of tissue factor pathway inhibitor during pregnancy and following delivery could be a predictive factor for placenta-mediated adverse pregnancy outcomes in high-risk women. METHODS:This was a prospective ... ...

    Abstract OBJECTIVE:The study aimed to evaluate if the rate of tissue factor pathway inhibitor during pregnancy and following delivery could be a predictive factor for placenta-mediated adverse pregnancy outcomes in high-risk women. METHODS:This was a prospective multicentre cohort study of 200 patients at a high risk of occurrence or recurrence of placenta-mediated adverse pregnancy outcomes conducted between June 2008 and October 2010. Measurements of tissue factor pathway inhibitor resistance (normalized ratio) and tissue factor pathway inhibitor activity were performed for the last 72 patients at 20, 24, 28, 32, and 36 weeks of gestation and during the postpartum period. RESULTS:Overall, 15 patients presented a placenta-mediated adverse pregnancy outcome. There was no difference in normalized tissue factor pathway inhibitor ratios between patients with and without placenta-mediated adverse pregnancy outcomes during pregnancy and in the post-partum period. Patients with placenta-mediated adverse pregnancy outcomes had tissue factor pathway inhibitor activity rates that were significantly higher than those in patients without at as early as 24 weeks of gestation. The same results were observed following delivery. CONCLUSION:Among high-risk women, the tissue factor pathway inhibitor activity of patients with gestational vascular complications is higher than that in other patients. Hence, these markers could augment a screening strategy that includes an analysis of angiogenic factors as well as clinical and ultrasound imaging with Doppler measurement of the uterine arteries.
    Schlagwörter Medicine ; R ; Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2017-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Relationship between Plasma D-Dimer Concentration and Three-Dimensional Ultrasound Placental Volume in Women at Risk for Placental Vascular Diseases

    Cécile Fanget / Céline Chauleur / Amandine Stadler / Emilie Presles / Marie-Noëlle Varlet / Jean-Christophe Gris / Tiphaine Raia-Barjat

    PLoS ONE, Vol 11, Iss 6, p e

    A Monocentric Prospective Study.

    2016  Band 0156593

    Abstract: INTRODUCTION:The aim of this study was to correlate placental volumes deduced from three-dimensional ultrasound and virtual organ computer-aided analysis (VOCAL) software with systemic concentrations of D-dimer and soluble endothelial protein C receptor ( ...

    Abstract INTRODUCTION:The aim of this study was to correlate placental volumes deduced from three-dimensional ultrasound and virtual organ computer-aided analysis (VOCAL) software with systemic concentrations of D-dimer and soluble endothelial protein C receptor (sEPCR). METHODS:This was a monocentric experimental prospective study conducted from October 2008 to July 2009. Forty consecutive patients at risk of placental vascular pathology (PVP) recurrence or occurrence were included. Placental volumes were systematically measured three times (11-14, 16-18 and 20-22 weeks of gestation (WG)) by two independent sonographers. D-dimers and sEPCR plasma concentrations were measured using ELISA kits (Enzyme Linked ImmunoSorbent Assay). RESULTS:Eleven patients had a PVP. The plasma D-dimer level was positively correlated with placental volume (r = 0.45, p < 0.001). A smaller placental volume and placental quotient was evidenced in women who developed a PVP at the three gestational ages, and the difference was more pronounced during the third exam (20 WG). No obvious correlation could be demonstrated between the development of a PVP and the levels of D-dimer and sEPCR. There was no significant difference in the values of placental volumes measured by the two sonographers. CONCLUSION:The placenta growth could be a major determinant of the elevation of D-dimer during pregnancy. Consideration of placental volume could allow for modulation of the D-dimer concentrations for restoring their clinical interest.
    Schlagwörter Medicine ; R ; Science ; Q
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2016-01-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
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  10. Artikel ; Online: Cervical ripening in prolonged pregnancies by silicone double balloon catheter versus vaginal dinoprostone slow release system

    Caroline Diguisto / Amélie Le Gouge / Chloé Arthuis / Norbert Winer / Olivier Parant / Christophe Poncelet / Celine Chauleur / Jacob Hannigsberg / Guillaume Ducarme / Denis Gallot / Rene Gabriel / Raoul Desbriere / Gael Beucher / Cyrille Faraguet / Helene Isly / Patrick Rozenberg / Bruno Giraudeau / Franck Perrotin / Groupe de Recherche en Obstétrique et Gynécologie (GROG)

    PLoS Medicine, Vol 18, Iss 2, p e

    The MAGPOP randomised controlled trial.

    2021  Band 1003448

    Abstract: Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method ... ...

    Abstract Background Prolonged pregnancies are a frequent indication for induction of labour. When the cervix is unfavourable, cervical ripening before oxytocin administration is recommended to increase the likelihood of vaginal delivery, but no particular method is currently recommended for cervical ripening of prolonged pregnancies. This trial evaluates whether the use of mechanical cervical ripening with a silicone double balloon catheter for induction of labour in prolonged pregnancies reduces the cesarean section rate for nonreassuring fetal status compared with pharmacological cervical ripening by a vaginal pessary for the slow release of dinoprostone (prostaglandin E2). Methods and findings This is a multicentre, superiority, open-label, parallel-group, randomised controlled trial conducted in 15 French maternity units. Women with singleton pregnancies, a vertex presentation, ≥41+0 and ≤42+0 weeks' gestation, a Bishop score <6, intact membranes, and no history of cesarean delivery for whom induction of labour was decided were randomised to either mechanical cervical ripening with a Cook Cervical Ripening Balloon or pharmacological cervical ripening by a Propess vaginal pessary serving as a prostaglandin E2 slow-release system. The primary outcome was the rate of cesarean for nonreassuring fetal status, with an independent endpoint adjudication committee determining whether the fetal heart rate was nonreassuring. Secondary outcomes included delivery (time from cervical ripening to delivery, number of patients requiring analgesics), maternal and neonatal outcomes. Between January 2017 and December 2018, 1,220 women were randomised in a 1:1 ratio, 610 allocated to a silicone double balloon catheter, and 610 to the Propess vaginal pessary for the slow release of dinoprostone. The mean age of women was 31 years old, and 80% of them were of white ethnicity. The cesarean rates for nonreassuring fetal status were 5.8% (35/607) in the mechanical ripening group and 5.3% (32/609) in the pharmacological ripening group ...
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-02-01T00:00:00Z
    Verlag Public Library of Science (PLoS)
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