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  1. Article: Corrigendum: Follow-up of young adult monozygotic twins after simultaneous critical coronavirus disease 2019: a case report.

    de Castro, Mateus V / Silva, Monize V R / Soares, Flávia B / Cória, Vivian R / Naslavsky, Michel S / Scliar, Marilia O / Castelli, Erick C / de Oliveira, Jamile R / de Medeiros, Giuliana X / Sasahara, Greyce L / Santos, Keity S / Cunha-Neto, Edecio / Kalil, Jorge / Zatz, Mayana

    Frontiers in medicine

    2023  Volume 10, Page(s) 1185833

    Abstract: This corrects the article DOI: 10.3389/fmed.2022.1008585.]. ...

    Abstract [This corrects the article DOI: 10.3389/fmed.2022.1008585.].
    Language English
    Publishing date 2023-04-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1185833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Follow-up of young adult monozygotic twins after simultaneous critical coronavirus disease 2019: A case report.

    de Castro, Mateus V / Silva, Monize V R / Soares, Flávia B / Cória, Vivian R / Naslavsky, Michel S / Scliar, Marilia O / Castelli, Erick C / de Oliveira, Jamile R / Sasahara, Greyce L / Santos, Keity S / Cunha-Neto, Edecio / Kalil, Jorge / Zatz, Mayana

    Frontiers in medicine

    2022  Volume 9, Page(s) 1008585

    Abstract: Background: The influence of the host genome on coronavirus disease 2019 (COVID-19) susceptibility and severity is supported by reports on monozygotic (MZ) twins where both were infected simultaneously with similar disease outcomes, including several ... ...

    Abstract Background: The influence of the host genome on coronavirus disease 2019 (COVID-19) susceptibility and severity is supported by reports on monozygotic (MZ) twins where both were infected simultaneously with similar disease outcomes, including several who died due to the SARS-CoV-2 infection within days apart. However, successive exposures to pathogens throughout life along with other environmental factors make the immune response unique for each individual, even among MZ twins.
    Case presentation and methods: Here we report a case of a young adult monozygotic twin pair, who caught attention since both presented simultaneously severe COVID-19 with the need for oxygen support despite age and good health conditions. One of the twins, who spent more time hospitalized, reported symptoms of long-COVID even 7 months after infection. Immune cell profile and specific responses to SARS-CoV-2 were evaluated as well as whole exome sequencing.
    Conclusion: Although the MZ twin brothers shared the same genetic mutations which may be associated with their increased risk of developing severe COVID-19, their clinical progression was different, reinforcing the role of both immune response and genetics in the COVID-19 presentation and course. Besides, post-COVID syndrome was observed in one of them, corroborating an association between the duration of hospitalization and the occurrence of long-COVID symptoms.
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1008585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Recurrence of COVID-19 associated with reduced T-cell responses in a monozygotic twin pair.

    de Castro, Mateus V / Santos, Keity S / Apostolico, Juliana S / Fernandes, Edgar R / Almeida, Rafael R / Levin, Gabriel / Magawa, Jhosiene Y / Nunes, João Paulo S / Bruni, Mirian / Yamamoto, Marcio M / Lima, Ariane C / Silva, Monize V R / Matos, Larissa R B / Coria, Vivian R / Castelli, Erick C / Scliar, Marilia O / Kuramoto, Andreia / Bruno, Fernanda R / Jacintho, Lucas C /
    Nunes, Kelly / Wang, Jaqueline Y T / Coelho, Veronica P / Neto, Miguel Mitne / Maciel, Rui M B / Naslavsky, Michel S / Passos-Bueno, Maria Rita / Boscardin, Silvia B / Rosa, Daniela S / Kalil, Jorge / Zatz, Mayana / Cunha-Neto, Edecio

    Open biology

    2022  Volume 12, Issue 2, Page(s) 210240

    Abstract: Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind the recurrence have not been thoroughly investigated. The presence of neutralizing antibodies (nAbs) in recurrence/reinfection cases ... ...

    Abstract Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind the recurrence have not been thoroughly investigated. The presence of neutralizing antibodies (nAbs) in recurrence/reinfection cases suggests that other types of immune response are involved in protection against recurrence. Here, we investigated the innate type I/III interferon (IFN) response, binding and nAb assays and T-cell responses to severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) with IFN gamma (IFN
    MeSH term(s) Adolescent ; Adult ; COVID-19/immunology ; Epitopes, T-Lymphocyte/immunology ; Female ; Humans ; Immunity, Cellular ; Male ; Recurrence ; SARS-CoV-2/immunology ; T-Lymphocytes/immunology ; Twins, Monozygotic
    Chemical Substances Epitopes, T-Lymphocyte
    Language English
    Publishing date 2022-02-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Twin Study
    ZDB-ID 2630944-0
    ISSN 2046-2441 ; 2046-2441
    ISSN (online) 2046-2441
    ISSN 2046-2441
    DOI 10.1098/rsob.210240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MHC Variants Associated With Symptomatic

    Castelli, Erick C / de Castro, Mateus V / Naslavsky, Michel S / Scliar, Marilia O / Silva, Nayane S B / Andrade, Heloisa S / Souza, Andreia S / Pereira, Raphaela N / Castro, Camila F B / Mendes-Junior, Celso T / Meyer, Diogo / Nunes, Kelly / Matos, Larissa R B / Silva, Monize V R / Wang, Jaqueline Y T / Esposito, Joyce / Coria, Vivian R / Bortolin, Raul H / Hirata, Mario H /
    Magawa, Jhosiene Y / Cunha-Neto, Edecio / Coelho, Verônica / Santos, Keity S / Marin, Maria Lucia C / Kalil, Jorge / Mitne-Neto, Miguel / Maciel, Rui M B / Passos-Bueno, Maria Rita / Zatz, Mayana

    Frontiers in immunology

    2021  Volume 12, Page(s) 742881

    Abstract: Despite the high number of individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms worldwide, many exposed individuals remain asymptomatic and/or uninfected and ... ...

    Abstract Despite the high number of individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who develop coronavirus disease 2019 (COVID-19) symptoms worldwide, many exposed individuals remain asymptomatic and/or uninfected and seronegative. This could be explained by a combination of environmental (exposure), immunological (previous infection), epigenetic, and genetic factors. Aiming to identify genetic factors involved in immune response in symptomatic COVID-19 as compared to asymptomatic exposed individuals, we analyzed 83 Brazilian couples where one individual was infected and symptomatic while the partner remained asymptomatic and serum-negative for at least 6 months despite sharing the same bedroom during the infection. We refer to these as "discordant couples". We performed whole-exome sequencing followed by a state-of-the-art method to call genotypes and haplotypes across the highly polymorphic major histocompatibility complex (MHC) region. The discordant partners had comparable ages and genetic ancestry, but women were overrepresented (65%) in the asymptomatic group. In the antigen-presentation pathway, we observed an association between
    MeSH term(s) Adult ; Aged ; Asymptomatic Infections ; Brazil ; COVID-19/genetics ; COVID-19/immunology ; Female ; Genetic Predisposition to Disease ; Genotype ; Histocompatibility Antigens/genetics ; Histocompatibility Antigens/immunology ; Humans ; Major Histocompatibility Complex/genetics ; Major Histocompatibility Complex/immunology ; Male ; Middle Aged ; SARS-CoV-2 ; Exome Sequencing
    Chemical Substances Histocompatibility Antigens
    Language English
    Publishing date 2021-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.742881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil.

    Castelli, Erick C / de Castro, Mateus V / Naslavsky, Michel S / Scliar, Marilia O / Silva, Nayane S B / Pereira, Raphaela N / Ciriaco, Viviane A O / Castro, Camila F B / Mendes-Junior, Celso T / Silveira, Etiele de S / de Oliveira, Iuri M / Antonio, Eduardo C / Vieira, Gustavo F / Meyer, Diogo / Nunes, Kelly / Matos, Larissa R B / Silva, Monize V R / Wang, Jaqueline Y T / Esposito, Joyce /
    Cória, Vivian R / Magawa, Jhosiene Y / Santos, Keity S / Cunha-Neto, Edecio / Kalil, Jorge / Bortolin, Raul H / Hirata, Mário Hiroyuki / Dell'Aquila, Luiz P / Razuk-Filho, Alvaro / Batista-Júnior, Pedro B / Duarte-Neto, Amaro N / Dolhnikoff, Marisa / Saldiva, Paulo H N / Passos-Bueno, Maria Rita / Zatz, Mayana

    Frontiers in immunology

    2022  Volume 13, Page(s) 975918

    Abstract: Background: Although aging correlates with a worse prognosis for Covid-19, super elderly still unvaccinated individuals presenting mild or no symptoms have been reported worldwide. Most of the reported genetic variants responsible for increased disease ... ...

    Abstract Background: Although aging correlates with a worse prognosis for Covid-19, super elderly still unvaccinated individuals presenting mild or no symptoms have been reported worldwide. Most of the reported genetic variants responsible for increased disease susceptibility are associated with immune response, involving type I IFN immunity and modulation; HLA cluster genes; inflammasome activation; genes of interleukins; and chemokines receptors. On the other hand, little is known about the resistance mechanisms against SARS-CoV-2 infection. Here, we addressed polymorphisms in the MHC region associated with Covid-19 outcome in super elderly resilient patients as compared to younger patients with a severe outcome.
    Methods: SARS-CoV-2 infection was confirmed by RT-PCR test. Aiming to identify candidate genes associated with host resistance, we investigated 87 individuals older than 90 years who recovered from Covid-19 with mild symptoms or who remained asymptomatic following positive test for SARS-CoV-2 as compared to 55 individuals younger than 60 years who had a severe disease or died due to Covid-19, as well as to the general elderly population from the same city. Whole-exome sequencing and an in-depth analysis of the MHC region was performed. All samples were collected in early 2020 and before the local vaccination programs started.
    Results: We found that the resilient super elderly group displayed a higher frequency of some missense variants in the MUC22 gene (a member of the mucins' family) as one of the strongest signals in the MHC region as compared to the severe Covid-19 group and the general elderly control population. For example, the missense variant rs62399430 at MUC22 is two times more frequent among the resilient super elderly (p = 0.00002, OR = 2.24).
    Conclusion: Since the pro-inflammatory basal state in the elderly may enhance the susceptibility to severe Covid-19, we hypothesized that MUC22 might play an important protective role against severe Covid-19, by reducing overactive immune responses in the senior population.
    MeSH term(s) Aged ; Humans ; Brazil/epidemiology ; COVID-19/epidemiology ; COVID-19/genetics ; Genes, MHC Class II ; HLA-A Antigens ; SARS-CoV-2/genetics
    Chemical Substances HLA-A Antigens ; MUC22 protein, human
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.975918
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Monozygotic twins discordant for severe clinical recurrence of COVID-19 show drastically distinct T cell responses to SARS-Cov-2

    Castro, Mateus V. / Santos, Keity S. / Apostolico, Juliana S. / Fernandes, Edgar R. / Almeida, Rafael R. / Levin, Gabriel / Magawa, Jhosiene Y. / Nunes, Joao Paulo S. / Bruni, Mirian / Yamamoto, Marcio M. / Lima, Ariane C. / Silva, Monize V. R. / Matos, Larissa R. B. / Coria, Vivian R. / Castelli, Erick C. / Scliar, Marilia O. / Kuramoto, Andreia / Bruno, Fernanda R. / Jacintho, Lucas C. /
    Nunes, Kelly / Wang, Jaqueline Y. T. / Coelho, Veronica P. / Mitne Neto, Miguel / Maciel, Rui M. B. / Naslavsky, Michel S. / Passos-Bueno, Maria Rita / Boscardin, Silvia B. / Rosa, Daniela S. / Kalil, Jorge / Zatz, Mayana / Cunha-Neto, Edecio

    medRxiv

    Abstract: Background. Clinical recurrence of COVID-19 in convalescent patients has been reported, which immune mechanisms have not been thoroughly investigated. Presence of neutralizing antibodies suggests other types of immune response are involved. Methods. We ... ...

    Abstract Background. Clinical recurrence of COVID-19 in convalescent patients has been reported, which immune mechanisms have not been thoroughly investigated. Presence of neutralizing antibodies suggests other types of immune response are involved. Methods. We assessed the innate type I/III IFN response, T cell responses to SARS-CoV-2 with IFNγ ELISPOT, binding and neutralizing antibody assays, in two monozygotic twin pairs with one COVID-19 recurrence case. Results. In pair 1, four months after a first mild episode of infection for both siblings, one displayed severe clinical recurrence of COVID-19. Twin pair 2 of siblings underwent non-recurring asymptomatic infection. All fours individuals presented similar overall responses, except for remarkably difference found in specific cellular responses. Recurring sibling presented a reduced number of recognized T cell epitopes as compared to the other three including her non-recurring sibling. Conclusions. Our results suggest that an effective SARS-CoV-2-specific T cell immune response is key for complete viral control and avoidance of clinical recurrence of COVID-19. Besides, adaptive immunity can be distinct in MZ twins. Given the rising concern about SARS-CoV-2 variants that evade neutralizing antibodies elicited by vaccination or infection, our study stresses the importance of T cell responses in protection against recurrence/reinfection.
    Keywords covid19
    Language English
    Publishing date 2021-03-28
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.03.26.21253645
    Database COVID19

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