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  1. Article: Rare scrotal chylous effusion: A case report.

    Ducharme, Amy / Côté, Benoît

    SAGE open medical case reports

    2024  Volume 12, Page(s) 2050313X241231368

    Abstract: Klippel-Trenaunay syndrome is a rare congenital malformation predominantly affecting lower limb. In most cases, it is characterized by a classic triad of cutaneous capillary malformation (port-wine stain), lymphatic and venous abnormalities, in ... ...

    Abstract Klippel-Trenaunay syndrome is a rare congenital malformation predominantly affecting lower limb. In most cases, it is characterized by a classic triad of cutaneous capillary malformation (port-wine stain), lymphatic and venous abnormalities, in association with variable soft tissue and bone overgrowths. We describe a 48-year-old male presenting on the genitalia several whitish vesicles discharging a milky fluid compatible with chyle. Extensive radiology workup revealed pelvic megalymphatic malformations. Pelvic lymphatic ligations and bleomycin sclerotherapy only allowed a partial improvement. Given the high potential of recurrence, the patient will soon undergo a genetic evaluation for PIK3CA gene mutation and may need further systemic treatment with Sirolimus. As this scrotal chylous effusion in the setting of Klippel-Trenaunay syndrome is rare and highly affects the quality of life, we wanted to raise awareness of this entity and its management.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X241231368
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  2. Article ; Online: Modeling and Analysis of a Simple Flexible Wing-Thorax System in Flapping-Wing Insects.

    Cote, Braden / Weston, Samuel / Jankauski, Mark

    Biomimetics (Basel, Switzerland)

    2022  Volume 7, Issue 4

    Abstract: Small-scale flapping-wing micro air vehicles (FWMAVs) are an emerging robotic technology with many applications in areas including infrastructure monitoring and remote sensing. However, challenges such as inefficient energetics and decreased payload ... ...

    Abstract Small-scale flapping-wing micro air vehicles (FWMAVs) are an emerging robotic technology with many applications in areas including infrastructure monitoring and remote sensing. However, challenges such as inefficient energetics and decreased payload capacity preclude the useful implementation of FWMAVs. Insects serve as inspiration to FWMAV design owing to their energy efficiency, maneuverability, and capacity to hover. Still, the biomechanics of insects remain challenging to model, thereby limiting the translational design insights we can gather from their flight. In particular, it is not well-understood how wing flexibility impacts the energy requirements of flapping flight. In this work, we developed a simple model of an insect drive train consisting of a compliant thorax coupled to a flexible wing flapping with single-degree-of-freedom rotation in a fluid environment. We applied this model to quantify the energy required to actuate a flapping wing system with parameters based off a hawkmoth
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics7040207
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  3. Article: Consistency of thrombophilia testing in a reference center according to the current guidelines.

    Henry-Bonniot, G / Côté, B / Yannoutsos, A / Emmerich, J

    Journal de medecine vasculaire

    2020  Volume 45, Issue 3, Page(s) 125–129

    Abstract: Objective: The clinical relevance of hereditary thrombophilia (HT) testing in venous thromboembolic disease (VTE) is limited to specific guidelines. The present study aimed to evaluate the consistency of HT prescriptions in clinical practice according ... ...

    Abstract Objective: The clinical relevance of hereditary thrombophilia (HT) testing in venous thromboembolic disease (VTE) is limited to specific guidelines. The present study aimed to evaluate the consistency of HT prescriptions in clinical practice according to the current French guidelines.
    Methods: This study was conducted from April 2017 to February 2018 in a specialized haemostasis centre and included 58 consecutive patients referred by their clinicians for thrombophilia screening (56 patients following a personal VTE event and 2 asymptomatic relatives of a first-degree patient who had had VTE). One experienced clinician met every patient and assessed a pre-test prediction for the presence or absence of HT based on the clinical characteristics of VTE which was compared to the HT biological results.
    Results: Among the 58 patients referred to our specialized haemostasis centre, 60% were outside the scope of recommendations for thrombophilia screening. Eight patients were diagnosed with HT. Six out of 8 (75%) patients with diagnosed HT had a history of unprovoked VTE event. Familial history with VTE was a poor predictor for positive HT testing among relatives. The positive and negative predictive values of the clinical prediction were respectively of 19% and 89%.
    Conclusion: The present results underline that screening for HT remains too largely prescribed. Pre-test physician's feeling for the presence of HT was neither sensitive nor specific. Increasing physicians' awareness on this issue and current recommendations should limit prescriptions of HT tests while providing the best possible care for patients with VTE.
    MeSH term(s) Adolescent ; Adult ; Aged ; Blood Coagulation ; Blood Coagulation Tests/standards ; Clinical Decision-Making ; Female ; Guideline Adherence/standards ; Humans ; Male ; Middle Aged ; Molecular Diagnostic Techniques/standards ; Practice Guidelines as Topic/standards ; Predictive Value of Tests ; Referral and Consultation/standards ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Thrombophilia/blood ; Thrombophilia/diagnosis ; Thrombophilia/genetics ; Venous Thromboembolism/blood ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/genetics ; Young Adult
    Language English
    Publishing date 2020-04-09
    Publishing country France
    Document type Journal Article ; Observational Study
    ISSN 2542-4513
    ISSN 2542-4513
    DOI 10.1016/j.jdmv.2020.03.007
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  4. Article: Acute lower limb ischemia caused by vaccine-induced immune thrombotic thrombocytopenia: focus on perioperative considerations for 2 cases.

    Roberge, Guillaume / Côté, Benoit / Calabrino, Anthony / Gilbert, Nathalie / Gagnon, Nathalie

    Thrombosis journal

    2022  Volume 20, Issue 1, Page(s) 38

    Abstract: Background: ChAdOx1 nCoV-19 (AstraZeneca) and Ad26COV2.S (Johnson & Johnson/Janssen) adenoviral vector vaccines have been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT). Arterial thrombosis and acute limb ischemia have been ... ...

    Abstract Background: ChAdOx1 nCoV-19 (AstraZeneca) and Ad26COV2.S (Johnson & Johnson/Janssen) adenoviral vector vaccines have been associated with vaccine-induced immune thrombotic thrombocytopenia (VITT). Arterial thrombosis and acute limb ischemia have been described in a minority of patients with VITT. These patients usually need a revascularization, but they potentially are at a higher risk of complications. Optimal perioperative care of patients undergoing vascular surgery in acute VITT is unknown and important considerations in such context need to be described.
    Cases presentations: We report 2 cases of VITT presenting with acute limb ischemia who needed vascular surgery and we describe the multidisciplinary team decisions for specific treatment surrounding the interventions. Both patients' platelet counts initially increased after either intravenous immune globulin (IVIG) or therapeutic plasma exchange (TPE). None received platelet transfusion. They both received argatroban as an alternative to heparin for their surgery. Despite persistent positivity of anti-platelet factor 4 (PF4) antibodies and serotonin-release assay with added PF4 (PF4-SRA) in both patients, only one received a repeated dose of IVIG before the intervention. Per- and post-operative courses were both unremarkable.
    Conclusion: In spite of persistent anti-PF4 and PF4-SRA positivity in the setting of VITT, after platelet count improvement using either IVIG or TPE, vascular interventions using argatroban can show favorable courses. Use of repeated IVIG or TPE before such interventions still needs to be defined.
    Language English
    Publishing date 2022-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-022-00398-8
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  5. Article ; Online: Superiority of Rituximab Over Mycophenolate Mofetil in the Treatment of Pemphigus Vulgaris: A Step Further in Its Approval as a First-Line Treatment?

    Lemieux, Alexandre / Saber, Melissa / Côté, Benoit

    Journal of cutaneous medicine and surgery

    2021  Volume 26, Issue 1, Page(s) 103–104

    MeSH term(s) Humans ; Immunologic Factors/therapeutic use ; Mycophenolic Acid/therapeutic use ; Pemphigus/drug therapy ; Rituximab/therapeutic use
    Chemical Substances Immunologic Factors ; Rituximab (4F4X42SYQ6) ; Mycophenolic Acid (HU9DX48N0T)
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Letter
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754211035098
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Nanomedicine for Drug Delivery throughout the Alimentary Canal.

    Cote, Brianna / Rao, Deepa / Alani, Adam W G

    Molecular pharmaceutics

    2021  Volume 19, Issue 8, Page(s) 2690–2711

    Abstract: The field of nanomedicine continues to grow with new technologies and formulations in development for several disease states. Much research focuses on the use of injectable nanomedicines for treatment of neoplasms; however, there are several formulations ...

    Abstract The field of nanomedicine continues to grow with new technologies and formulations in development for several disease states. Much research focuses on the use of injectable nanomedicines for treatment of neoplasms; however, there are several formulations in development that use nanotechnology that can be administered enterally for noncancer indications. These nanomedicine treatments have been developed for systemic drug delivery or local drug delivery along the gastrointestinal tract. This Review gives a brief overview of the alimentary canal and highlights new research in nanomedicine in noncancer disease states delivered via enteral routes of administration. Relevant recent research is summarized on the basis of the targeted site of action or absorption, including the buccal, sublingual, stomach, small intestine, and large intestine areas of the alimentary canal. The benefits of nanodrug delivery are discussed as well as barriers and challenges for future development in the field.
    MeSH term(s) Drug Delivery Systems ; Gastrointestinal Tract ; Humans ; Nanomedicine ; Nanotechnology ; Neoplasms
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.0c00694
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  7. Article ; Online: The Engaged Learners Program: Effects on Student Engagement During Small Group Reading Instruction.

    Roberts, Garrett J / Lindström, Esther R / Watts, Gavin W / Coté, Brooke / Ghosh, Ekta

    Behavior modification

    2023  Volume 48, Issue 2, Page(s) 150–181

    Abstract: In this study we tested the usability, feasibility, social validity, and effectiveness ... ...

    Abstract In this study we tested the usability, feasibility, social validity, and effectiveness of
    MeSH term(s) Humans ; Reading ; Students ; Cognition ; Mentoring
    Language English
    Publishing date 2023-12-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 432229-0
    ISSN 1552-4167 ; 0145-4455
    ISSN (online) 1552-4167
    ISSN 0145-4455
    DOI 10.1177/01454455231213980
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  8. Article: A case of durvalumab-induced lichenoid eruption evolving to bullous eruption after phototherapy: A case report.

    Manko, Svitlana / Côté, Benoît / Provost, Nathalie

    SAGE open medical case reports

    2021  Volume 9, Page(s) 2050313X21993279

    Abstract: Immune checkpoint inhibitor therapy nowadays became a treatment for a wide range of cancers, and may be responsible for various dermatologic adverse effects, including bullous eruptions. In our report, we present a case of late-onset immunotherapy- ... ...

    Abstract Immune checkpoint inhibitor therapy nowadays became a treatment for a wide range of cancers, and may be responsible for various dermatologic adverse effects, including bullous eruptions. In our report, we present a case of late-onset immunotherapy-induced eruption in a 62-year-old woman treated with anti-programmed cell death-L1 agent durvalumab for metastatic squamous cell carcinoma. Diagnosed as lichenoid dermatitis upon initial presentation, this eruption evolved into necrotic bullous dermatitis after several weeks of phototherapy, with histology and direct immunofluorescence study favoring lichen planus pemphigoides. Thus, this case may be regarded as durvalumab-induced lichenoid dermatitis with phototherapy-triggered progression to necrotic lichen planus pemphigoides-like eruption. The patient's eruption responded to oral prednisone and immunotherapy interruption. Interestingly, durvalumab reintroduction in this patient led to recurrent lichenoid dermatitis without bullous component. This case of immunotherapy skin toxicity is rather distinctive by its clinical and histopathologic features, with phototherapy as an additional triggering factor.
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X21993279
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  9. Article: Treatment of moderate to severe psoriasis with apremilast over 2 years in the context of long-term treated HIV infection: A case report.

    Zarbafian, Misha / Cote, Benoit / Richer, Vincent

    SAGE open medical case reports

    2019  Volume 7, Page(s) 2050313X19845193

    Abstract: Treatment of moderate-to-severe psoriasis in patients with HIV infection is a clinical challenge. We present the case of a patient with a longstanding history of well-controlled HIV. He had failed topical management, and his hypertriglyceridemia made use ...

    Abstract Treatment of moderate-to-severe psoriasis in patients with HIV infection is a clinical challenge. We present the case of a patient with a longstanding history of well-controlled HIV. He had failed topical management, and his hypertriglyceridemia made use of acitretin potentially unsafe. He was unable to regularly attend a phototherapy unit. Physical examination revealed 12% total body surface area involvement with a Psoriasis Area Severity Index (PASI) of 10.2. His Dermatology Quality of Life Index (DLQI) was 20. After 3 months of apremilast treatment, his PASI decreased to 4.1. After 7 months, his PASI decreased to 2.7 and his DLQI to 1. Two years later, his PASI score was 2.4, with a stable CD4 count of 1200 cells/mm
    Language English
    Publishing date 2019-05-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2736953-5
    ISSN 2050-313X
    ISSN 2050-313X
    DOI 10.1177/2050313X19845193
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  10. Article: Cost of Practice Transformation in Primary Care: Joining an Accountable Care Organization.

    Hofler, Richard / Ortiz, Judith / Coté, Brian

    Journal of health care finance

    2019  Volume 44, Issue 3

    Abstract: The purpose of this study is to examine the costs related to practice transformation from the perspective of primary care organizations transitioning to become participants in Accountable Care Organizations (ACOs). We pose two research questions: 1) Will ...

    Abstract The purpose of this study is to examine the costs related to practice transformation from the perspective of primary care organizations transitioning to become participants in Accountable Care Organizations (ACOs). We pose two research questions: 1) Will a Rural Health Clinic that participates in an Accountable Care Organization see higher or lower cost per visit, and 2) If the cost per visit is higher or lower, how large will that difference be? We analyze administrative data from a panel of over 800 Rural Health Clinics for the period 2007 - 2013 using a treatment effects approach, where a clinic's participation in an ACO is viewed as a "treatment." Since the first year that an RHC could join an ACO was 2012 and our most recent year of complete data is 2013, we restricted our analysis of the impact of participation in an ACO to include only 2012 and 2013 data. The estimates of the average treatment effect on the treated (ATET) pertain to only those RHCs that joined ACOs. The results show that those 20 sample ACO RHCs experienced an average from $15.00 to $18.61 higher cost per visit than the matching non-ACO RHCs. At this very early stage of ACO development, our results must be considered very preliminary at best. Whatever conclusions we draw from these results are intended to merely suggest what might be found once many more RHCs join ACOs. The conclusions we draw from this early analysis can lay a foundation for more analysis after data are available when more RHCs join ACOs.
    MeSH term(s) Accountable Care Organizations/economics ; Costs and Cost Analysis ; Health Care Costs ; Primary Health Care ; Rural Health Services ; United States
    Language English
    Publishing date 2019-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1226981-5
    ISSN 1078-6767
    ISSN 1078-6767
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