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  1. Article ; Online: A Personal Remembrance of Charles A. Engh Sr MD (1938-2022).

    Engh, C Anderson

    Clinical orthopaedics and related research

    2022  Volume 480, Issue 12, Page(s) 2472–2474

    Language English
    Publishing date 2022-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80301-7
    ISSN 1528-1132 ; 0009-921X
    ISSN (online) 1528-1132
    ISSN 0009-921X
    DOI 10.1097/CORR.0000000000002419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.188: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Eye and head movements while encoding and recognizing panoramic scenes in virtual reality.

    Walter F Bischof / Nicola C Anderson / Alan Kingstone

    PLoS ONE, Vol 18, Iss 2, p e

    2023  Volume 0282030

    Abstract: One approach to studying the recognition of scenes and objects relies on the comparison of eye movement patterns during encoding and recognition. Past studies typically analyzed the perception of flat stimuli of limited extent presented on a computer ... ...

    Abstract One approach to studying the recognition of scenes and objects relies on the comparison of eye movement patterns during encoding and recognition. Past studies typically analyzed the perception of flat stimuli of limited extent presented on a computer monitor that did not require head movements. In contrast, participants in the present study saw omnidirectional panoramic scenes through an immersive 3D virtual reality viewer, and they could move their head freely to inspect different parts of the visual scenes. This allowed us to examine how unconstrained observers use their head and eyes to encode and recognize visual scenes. By studying head and eye movement within a fully immersive environment, and applying cross-recurrence analysis, we found that eye movements are strongly influenced by the content of the visual environment, as are head movements-though to a much lesser degree. Moreover, we found that the head and eyes are linked, with the head supporting, and by and large mirroring the movements of the eyes, consistent with the notion that the head operates to support the acquisition of visual information by the eyes.
    Keywords Medicine ; R ; Science ; Q
    Subject code 700 ; 290
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Editorial: The 2021 Hip Society Members Meeting and 2022 Awards.

    Macaulay, William / Engh, C Anderson

    The Journal of arthroplasty

    2022  Volume 37, Issue 7S, Page(s) S384–S385

    MeSH term(s) Awards and Prizes ; Humans ; Societies, Medical
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Editorial
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2022.02.082
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    Zs.A 2134: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Tumors recycle glucocorticoids to drive Treg-mediated immunosuppression

    Julian Swatler / Young-Jun Ju / Ana C. Anderson / Enrico Lugli

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 18

    Abstract: Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals, can ...

    Abstract Suppression of antitumor immunity is a prominent feature of the tumor microenvironment. In this issue of the JCI, Taves, Otsuka, and authors show that glucocorticoids (GCs), which are potent immunosuppressive hormones mainly produced by the adrenals, can be reconverted from their inactive form to active metabolites via the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme expressed by murine tumor cell lines. In the tumor microenvironment, GCs acted on CD4+ regulatory T cells to enhance their immunosuppressive function and promote tumor growth. The findings suggest that targeting GC recycling as a strategy for modulating tumor immunosuppression has the potential to improve therapeutic efficacy of immune checkpoint blockade.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Loss of thymic function promotes EAE relapse in anti-CD52-treated mice

    Adeolu O. Adegoke / Jiaxin Lin / Colin C. Anderson

    Current Research in Immunology, Vol 3, Iss , Pp 37-

    2022  Volume 41

    Abstract: Anti-CD52 treatment creates a long-lasting CD4 T cell lymphopenia and reduces multiple sclerosis (MS) relapses in humans. In contrast, anti-CD52 therapy at disease onset more fully suppresses experimental autoimmune encephalomyelitis (EAE) in mice, and T ...

    Abstract Anti-CD52 treatment creates a long-lasting CD4 T cell lymphopenia and reduces multiple sclerosis (MS) relapses in humans. In contrast, anti-CD52 therapy at disease onset more fully suppresses experimental autoimmune encephalomyelitis (EAE) in mice, and T cell repopulation is rapid. To test whether prolonged T cell lymphopenia promotes relapses, we thymectomized mice prior to EAE induction and anti-CD52 treatment. Thymectomy greatly reduced the number of recent thymic emigrant T cells and was associated with a prolonged reduction in CD4 T cells in peripheral blood. Two-thirds of thymectomized C57BL/6 mice had an EAE relapse post anti-CD52 treatment, while no surgery and sham surgery euthymic controls remained relapse-free. These data demonstrate that thymus function can alter the effectiveness of anti-CD52 treatment.
    Keywords Thymectomy ; Recent thymic emigrants ; Multiple sclerosis ; EAE ; Alemtuzumab ; Anti-CD52 ; Specialties of internal medicine ; RC581-951
    Subject code 570
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Inducing forgetting of unwanted memories through subliminal reactivation

    Zijian Zhu / Michael C. Anderson / Yingying Wang

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: Classical forgetting methods typically re-expose people to reminders of their unwanted memories. Here, the authors disrupt unpleasant memories by subliminally reactivating them as participants suppress retrieval of unrelated neutral memories, avoiding ... ...

    Abstract Classical forgetting methods typically re-expose people to reminders of their unwanted memories. Here, the authors disrupt unpleasant memories by subliminally reactivating them as participants suppress retrieval of unrelated neutral memories, avoiding the need for conscious exposure.
    Keywords Science ; Q
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: 307 Patients expectations of benefits from large-panel genomic tumor testing in rural community oncology practices

    Eric C. Anderson / John DiPlazzo / Jens Rueter / Paul Han

    Journal of Clinical and Translational Science, Vol 6, Pp 53-

    2022  Volume 54

    Abstract: OBJECTIVES/GOALS: Large-panel genomic tumor testing (GTT) is a new technology that promises to make cancer treatment more precise. However, patients may have unrealistic expectations of its benefits. The goal of this project is to assess expectations for ...

    Abstract OBJECTIVES/GOALS: Large-panel genomic tumor testing (GTT) is a new technology that promises to make cancer treatment more precise. However, patients may have unrealistic expectations of its benefits. The goal of this project is to assess expectations for GTT among cancer patients in community oncology practices. METHODS/STUDY POPULATION: A survey assessing expectations of the benefits of GTT was administered to cancer patients participating in a statewide study of GTT implementation, prior to receiving test results. Descriptive and regression analyses were conducted to assess expectations and the factors associated with these expectations. The study sample (N = 1,139) consisted of patients with a range of cancer types (22% gynecologic, 14% lung, 10% colon, 10% breast,and 46% other malignancies). Mean age was 64 years (standard deviation = 11); 668 (59%) were women; 71% had no college degree; 57% came from households with less than $50,000 US dollars household income; and 73% lived in a rural area. RESULTS/ANTICIPATED RESULTS: Generally, patients had high expectations that they would benefit from GTT (M = 2.81 on 0-4 scale) and positive attitudes toward it (M = 2.98 on 0-4 scale). Patients also had relatively poor knowledge about GTT (48% correct answers on an objective test of GTT knowledge). Greater expectations for GTT were associated with lower knowledge (b = –0.46; p < .001), more positive attitudes (b = 0.40; < .001), and lower education (b = –0.53; < .001). DISCUSSION/SIGNIFICANCE: This research suggests patients have high expectations that they will benefit from GTT, which is associated with low knowledge, positive attitudes, and low education. Interventions may be needed to boost understanding and moderate expectations, particularly for disadvantaged patients.
    Keywords Medicine ; R
    Subject code 616
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Cambridge University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Just street trees? Street trees increase local biodiversity and biomass in higher income, denser neighborhoods

    Elsa C. Anderson / Dexter H. Locke / Steward T. A. Pickett / Shannon L. LaDeau

    Ecosphere, Vol 14, Iss 2, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Tree canopy cover is a critical component of the urban environment that supports ecosystem services at multiple spatial and temporal scales. Increasing tree canopy across a matrix of public and private land is challenging. As such, ... ...

    Abstract Abstract Tree canopy cover is a critical component of the urban environment that supports ecosystem services at multiple spatial and temporal scales. Increasing tree canopy across a matrix of public and private land is challenging. As such, municipalities often plant trees along streets in public rights‐of‐way where there are fewer barriers to establishment, and composition and biomass of street trees are inextricably linked to human decisions, management, and care. In this study, we investigated the contributions of street trees to the broader urban forest, inclusive of tree canopy distributed across both public and private parcels in Baltimore, MD, USA. We assess how species composition, biodiversity, and biomass of street trees specifically augment the urban forest at local and citywide scales. Furthermore, we evaluate how street tree contributions to the urban forest vary with social and demographic characteristics of local residential communities. Our analyses demonstrate that street trees significantly enhanced citywide metrics of the urban forests' richness and tree biomass, adding an average six unique species per site. However, street tree contributions did not ameliorate low tree canopy locations, and more street tree biomass was generally aligned with higher urban forest cover. Furthermore, species richness, abundance, and biomass added by street trees were all positively related to local household income and population density. Our results corroborate previous findings that wealthier urban neighborhoods often have greater tree abundance and canopy cover and, additionally, suggest that investment in municipally managed street trees may be reinforcing inequities in distribution and function of the urban forest. This suggests a need for greater attention to where and why street tree plantings occur, what species are selected, and how planted tree survival is maintained by and for residents in different neighborhoods.
    Keywords Baltimore ; Baltimore Ecosystem Study ; community composition ; social–ecological systems ; urban forest ; Ecology ; QH540-549.5
    Subject code 333
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Management of Soil Constraints to Improve Crop Performance in Water-Limited Environments

    Geoffrey C. Anderson / Edward G. Barrett-Lennard

    Agronomy, Vol 11, Iss 2558, p

    2021  Volume 2558

    Abstract: One current challenge for agricultural production in water-limited environments is to develop agronomic management practices that can overcome soil constraints and provide an economic return to the grower in both the short and long-term [.] ...

    Abstract One current challenge for agricultural production in water-limited environments is to develop agronomic management practices that can overcome soil constraints and provide an economic return to the grower in both the short and long-term [.]
    Keywords n/a ; Agriculture ; S
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Regulation of the Pseudomonas syringae Type III Secretion System by Host Environment Signals

    Megan R. O’Malley / Jeffrey C. Anderson

    Microorganisms, Vol 9, Iss 1227, p

    2021  Volume 1227

    Abstract: Pseudomonas syringae are Gram-negative, plant pathogenic bacteria that use a type III secretion system (T3SS) to disarm host immune responses and promote bacterial growth within plant tissues. Despite the critical role for type III secretion in promoting ...

    Abstract Pseudomonas syringae are Gram-negative, plant pathogenic bacteria that use a type III secretion system (T3SS) to disarm host immune responses and promote bacterial growth within plant tissues. Despite the critical role for type III secretion in promoting virulence, T3SS-encoding genes are not constitutively expressed by P. syringae and must instead be induced during infection. While it has been known for many years that culturing P. syringae in synthetic minimal media can induce the T3SS, relatively little is known about host signals that regulate the deployment of the T3SS during infection. The recent identification of specific plant-derived amino acids and organic acids that induce T3SS-inducing genes in P. syringae has provided new insights into host sensing mechanisms. This review summarizes current knowledge of the regulatory machinery governing T3SS deployment in P. syringae , including master regulators HrpRS and HrpL encoded within the T3SS pathogenicity island, and the environmental factors that modulate the abundance and/or activity of these key regulators. We highlight putative receptors and regulatory networks involved in linking the perception of host signals to the regulation of the core HrpRS–HrpL pathway. Positive and negative regulation of T3SS deployment is also discussed within the context of P. syringae infection, where contributions from distinct host signals and regulatory networks likely enable the fine-tuning of T3SS deployment within host tissues. Last, we propose future research directions necessary to construct a comprehensive model that (a) links the perception of host metabolite signals to T3SS deployment and (b) places these host–pathogen signaling events in the overall context of P. syringae infection.
    Keywords Pseudomonas syringae ; type III secretion system (T3SS) ; plant pathogens ; plant–microbe interactions ; host–pathogen signaling ; bacterial pathogenesis ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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