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Article ; Online: Large-scale control of the retroflection of the Labrador Current

Mathilde Jutras / Carolina O. Dufour / Alfonso Mucci / Lauryn C. Talbot

Nature Communications, Vol 14, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract The Labrador Current transports cold, relatively fresh, and well-oxygenated waters within the subpolar North Atlantic and towards the eastern American continental shelf. The relative contribution of these waters to either region depends on the ... ...

Abstract	Abstract The Labrador Current transports cold, relatively fresh, and well-oxygenated waters within the subpolar North Atlantic and towards the eastern American continental shelf. The relative contribution of these waters to either region depends on the eastward retroflection of the Labrador Current at the Grand Banks of Newfoundland. Here, we develop a retroflection index based on the pathway of virtual Lagrangian particles and show that strong retroflection generally occurs when a large-scale circulation adjustment, related to the subpolar gyre, accelerates the Labrador Current and shifts the Gulf Stream northward, partly driven by a northward shift of the wind patterns in the western North Atlantic. Starting in 2008, a particularly strong northward shift of the Gulf Stream dominates the other drivers. A mechanistic understanding of the drivers of the Labrador Current retroflection should help predict changes in the water properties in both export regions, and anticipate their impacts on marine life and deep-water formation.
Keywords	Science ; Q
Subject code	551
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Author Correction

Mathilde Jutras / Carolina O. Dufour / Alfonso Mucci / Lauryn C. Talbot

Nature Communications, Vol 14, Iss 1, Pp 1-

Large-scale control of the retroflection of the Labrador Current

2023 Volume 1

Keywords	Science ; Q
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy

Styliani Vakrou / Yamin Liu / Li Zhu / Gabriela V. Greenland / Bahadir Simsek / Virginia B. Hebl / Yufan Guan / Kirubel Woldemichael / Conover C. Talbot / Miguel A. Aon / Ryuya Fukunaga / M. Roselle Abraham

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 19

Abstract: Abstract Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity. We investigated the molecular basis of the cardiac phenotype in two mouse models at established disease stage (mouse-HCM), and human myectomy tissue (human-HCM). We ... ...

Abstract	Abstract Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity. We investigated the molecular basis of the cardiac phenotype in two mouse models at established disease stage (mouse-HCM), and human myectomy tissue (human-HCM). We analyzed the transcriptome in 2 mouse models with non-obstructive HCM (R403Q-MyHC, R92W-TnT)/littermate-control hearts at 24 weeks of age, and in myectomy tissue of patients with obstructive HCM/control hearts (GSE36961, GSE36946). Additionally, we examined myocyte redox, cardiac mitochondrial DNA copy number (mtDNA-CN), mt-respiration, mt-ROS generation/scavenging and mt-Ca2+ handling in mice. We identified distinct allele-specific gene expression in mouse-HCM, and marked differences between mouse-HCM and human-HCM. Only two genes (CASQ1, GPT1) were similarly dysregulated in both mutant mice and human-HCM. No signaling pathway or transcription factor was predicted to be similarly dysregulated (by Ingenuity Pathway Analysis) in both mutant mice and human-HCM. Losartan was a predicted therapy only in TnT-mutant mice. KEGG pathway analysis revealed enrichment for several metabolic pathways, but only pyruvate metabolism was enriched in both mutant mice and human-HCM. Both mutant mouse myocytes demonstrated evidence of an oxidized redox environment. Mitochondrial complex I RCR was lower in both mutant mice compared to controls. MyHC-mutant mice had similar mtDNA-CN and mt-Ca2+ handling, but TnT-mutant mice exhibited lower mtDNA-CN and impaired mt-Ca2+ handling, compared to littermate-controls. Molecular profiling reveals differences in gene expression, transcriptional regulation, intracellular signaling and mt-number/function in 2 mouse models at established disease stage. Further studies are needed to confirm differences in gene expression between mouse and human-HCM, and to examine whether cardiac phenotype, genotype and/or species differences underlie the divergence in molecular profiles.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Computational prediction and experimental confirmation of rhombohedral structures in Bi₁.₅CdM₁.₅O₇ (M = Nb, Ta) pyrochlores

Perenlei, G / P. C. Talbot / W. N. Martens / J. Riches / J. A. Alarco

RSC advances. 2017 Mar. 09, v. 7, no. 26

2017

Abstract: In this study, computationally predicted band gaps and structures using density functional theory (DFT) in Bi₁.₅CdM₁.₅O₇ (M = Nb, Ta) pyrochlores are confirmed by experimental data on synthesized samples. Ordered Cd substitutions in the B-site of the ... ...

Abstract	In this study, computationally predicted band gaps and structures using density functional theory (DFT) in Bi₁.₅CdM₁.₅O₇ (M = Nb, Ta) pyrochlores are confirmed by experimental data on synthesized samples. Ordered Cd substitutions in the B-site of the pyrochlore structures are required to achieve electronic band gaps in the calculated energy band structures, when using full plane waves for DFT calculations, which are supported by a significantly lower total enthalpy. The computationally predicted band gap values are closely matched to experimental band gaps estimated from optical absorption spectra in the UV-Vis. In addition to the prediction of electronic structures, the models also indicate that the large ionic radius of the Cd-cation leads to symmetry modification from the archetypal cubic pyrochlore structure in Bi₁.₅CdM₁.₅O₇ (M = Nb, Ta). A rhombohedral structure and localized superlattice order are confirmed using X-ray diffraction (XRD) and transmission electron microscopy (TEM) analysis. Energy dispersive X-ray spectroscopy profiles across the superlattice domain interfaces, which are constant within experimental uncertainty, indicate that domain formation is not compositionally driven but likely a mechanism to alleviate strain build up. Raman and FTIR spectroscopy analyses on these two compounds display strong similarities suggesting that peaks and activities belong to the same structure type.
Keywords	Fourier transform infrared spectroscopy ; Raman spectroscopy ; X-ray diffraction ; cadmium ; density functional theory ; energy-dispersive X-ray analysis ; enthalpy ; models ; prediction ; spectral analysis ; transmission electron microscopy ; uncertainty
Language	English
Dates of publication	2017-0309
Size	p. 15632-15643.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c6ra27633d
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analyzing bovine OCT4 and NANOG enhancer activity in pluripotent stem cells using fluorescent protein reporters.

Delun Huang / Ling Wang / Neil C Talbot / Chang Huang / Liping Pu / Xiuling Zhao / Xiuchun Tian / Ming Zhang / Young Tang

PLoS ONE, Vol 13, Iss 10, p e

2018 Volume 0203923

Abstract: Green fluorescent protein (GFP) reporters controlled by the regulatory region of OCT4 and NANOG-two master regulators for pluripotency are widely used in studies of pluripotent stem cell establishment and embryo development. Alongside the challenge in ... ...

Abstract	Green fluorescent protein (GFP) reporters controlled by the regulatory region of OCT4 and NANOG-two master regulators for pluripotency are widely used in studies of pluripotent stem cell establishment and embryo development. Alongside the challenge in establishing bovine pluripotent stem cells, the application of bovine-specific gene reporters has rarely been explored. Using lentivirus-based GFP reporter, we investigated the upstream regulatory regions of bovine OCT4 and NANOG. These reporters show activity in both naïve- and primed-state pluripotency when infected into mouse and human embryonic stem cells (ESCs), respectively. Consistent with what is found in humans and mice, the bovine OCT4-distal enhancer (bOCT4-DE) but not the proximal enhancer (bOCT4-PE) region is preferentially activated in naïve-state pluripotency. Furthermore, the bOCT4-DE region is silenced upon conversion of naive-state ESCs into primed-state epiblast stem cells (EpiSCs). Co-infection of mouse fibroblasts with the reprograming factors for induced pluripotent stem cell (iPSC) induction leads to the generation of GFP positive colonies, demonstrating that these GFP reporters can serve as live indicators for induced pluripotent cell establishment. We further proved that the bovine OCT4 distal enhancer is active in bovine blastocysts. We established the lentiviral-based fluorescent reporters controlled by bovine OCT4 and NANOG enhancer sequences. These reporter constructs show activity in naïve- and primed-pluripotent states. These reporters may serve as versatile tools for bovine ESC/iPSC generation and identification, as well as for developmental studies of bovine embryos.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: ZebraShare

April DeLaurier / Douglas G. Howe / Leyla Ruzicka / Adam N. Carte / Lacie Mishoe Hernandez / Kali J Wiggins / Mika M. Gallati / Kayce Vanpelt / Frances Loyo Rosado / Katlin G. Pugh / Chasey J. Shabdue / Khadijah Jihad / Summer B. Thyme / Jared C. Talbot

PeerJ, Vol 9, p e

a new venue for rapid dissemination of zebrafish mutant data

2021 Volume 11007

Abstract: Background In the past decade, the zebrafish community has widely embraced targeted mutagenesis technologies, resulting in an abundance of mutant lines. While many lines have proven to be useful for investigating gene function, many have also shown no ... ...

Abstract	Background In the past decade, the zebrafish community has widely embraced targeted mutagenesis technologies, resulting in an abundance of mutant lines. While many lines have proven to be useful for investigating gene function, many have also shown no apparent phenotype, or phenotypes not of interest to the originating lab. In order for labs to document and share information about these lines, we have created ZebraShare as a new resource offered within ZFIN. Methods ZebraShare involves a form-based submission process generated by ZFIN. The ZebraShare interface (https://zfin.org/action/zebrashare) can be accessed on ZFIN under “Submit Data”. Users download the Submission Workbook and complete the required fields, then submit the completed workbook with associated images and captions, generating a new ZFIN publication record. ZFIN curators add the submitted phenotype and mutant information to the ZFIN database, provide mapping information about mutations, and cross reference this information across the appropriate ZFIN databases. We present here examples of ZebraShare submissions, including phf21aa, kdm1a, ctnnd1, snu13a, and snu13b mutant lines. Results Users can find ZebraShare submissions by searching ZFIN for specific alleles or line designations, just as for alleles submitted through the normal process. We present several potential examples of submission types to ZebraShare including a phenotypic mutants, mildly phenotypic, and early lethal mutants. Mutants for kdm1a show no apparent skeletal phenotype, and phf21aa mutants show only a mild skeletal phenotype, yet these genes have specific human disease relevance and therefore may be useful for further studies. The p120-catenin encoding gene, ctnnd1, was knocked out to investigate a potential role in brain development or function. The homozygous ctnnd1 mutant disintegrates during early somitogenesis and the heterozygote has localized defects, revealing vital roles in early development. Two snu13 genes were knocked out to investigate a role in muscle formation. ...
Keywords	Zebrafish ; nhp2l1 ; lsd1 ; kdm1a ; snu13 ; phf21a ; Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: New Spin on Organic Radical Batteries–An Isoindoline Nitroxide-Based High-Voltage Cathode Material

Hansen, Kai-Anders / Jawahar Nerkar / Komba Thomas / Steven E. Bottle / Anthony P. O’Mullane / Peter C. Talbot / James P. Blinco

ACS applied materials & interfaces. 2018 Feb. 07, v. 10, no. 9

2018

Abstract: Organic electrode materials are a highly promising and environmentally benign class of battery materials with radical polymers being at the forefront of this research. Herein, we report the first example of the 1,1,3,3-tetramethylisoindolin-2-yloxyl ... ...

Abstract	Organic electrode materials are a highly promising and environmentally benign class of battery materials with radical polymers being at the forefront of this research. Herein, we report the first example of the 1,1,3,3-tetramethylisoindolin-2-yloxyl class of nitroxides as an organic electrode material and the synthesis and application of a novel styrenic nitroxide polymer, poly(5-vinyl-1,1,3,3-tetramethylisoindolin-2-yloxyl) (PVTMIO). The polymer was synthesized from the precursor monomer, 2-methoxy-5-vinyl-1,1,3,3-tetramethylisoindoline, and subsequent oxidative deprotection yielded the electroactive radical species. Cyclic voltammetry revealed a high oxidation potential of 3.7 V versus Li, placing it among the top of the nitroxide class of electrode materials. The suitability of PVTMIO for utilization in a high-voltage organic radical battery was confirmed with a discharge capacity of 104.7 mAh g–¹, high rate performance, and stability under cycling conditions (90% capacity retention after 100 cycles), making it one of the highest reported organic p-dopable cathode materials.
Keywords	batteries ; cathodes ; oxidation ; polymers
Language	English
Dates of publication	2018-0207
Size	p. 7982-7988.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.7b18252
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Magnetic cell labeling of primary and stem cell-derived pig hepatocytes for MRI-based cell tracking of hepatocyte transplantation.

Dwayne R Roach / Wesley M Garrett / Glenn Welch / Thomas J Caperna / Neil C Talbot / Erik M Shapiro

PLoS ONE, Vol 10, Iss 4, p e

2015 Volume 0123282

Abstract: Pig hepatocytes are an important investigational tool for optimizing hepatocyte transplantation schemes in both allogeneic and xenogeneic transplant scenarios. MRI can be used to serially monitor the transplanted cells, but only if the hepatocytes can be ...

Abstract	Pig hepatocytes are an important investigational tool for optimizing hepatocyte transplantation schemes in both allogeneic and xenogeneic transplant scenarios. MRI can be used to serially monitor the transplanted cells, but only if the hepatocytes can be labeled with a magnetic particle. In this work, we describe culture conditions for magnetic cell labeling of cells from two different pig hepatocyte cell sources; primary pig hepatocytes (ppHEP) and stem cell-derived hepatocytes (PICM-19FF). The magnetic particle is a micron-sized iron oxide particle (MPIO) that has been extensively studied for magnetic cell labeling for MRI-based cell tracking. ppHEP could endocytose MPIO with labeling percentages as high as 70%, achieving iron content as high as ~55 pg/cell, with >75% viability. PICM-19FF had labeling >97%, achieving iron content ~38 pg/cell, with viability >99%. Extensive morphological and functional assays indicated that magnetic cell labeling was benign to the cells. The results encourage the use of MRI-based cell tracking for the development and clinical use of hepatocyte transplantation methodologies. Further, these results generally highlight the importance of functional cell assays in the evaluation of contrast agent biocompatibility.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish

Berberoglu, Michael A / David M. Langenau / InÃªs M. Tenente / Jared C. Talbot / Kimberly J. Hromowyk / Sharon L. Amacher / Thomas L. Gallagher / Zachary T. Morrow

Developmental biology. 2017 Apr. 15, v. 424

2017

Abstract: Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is ... ...

Abstract	Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is great interest in identifying additional factors that regulate satellite cell proliferation, differentiation, and/or skeletal muscle regeneration. Due to the powerful regenerative capacity of many zebrafish tissues, even in adults, we are exploring the regenerative potential of adult zebrafish skeletal muscle. Here, we show that adult zebrafish skeletal muscle contains cells similar to mammalian satellite cells. Adult zebrafish satellite-like cells have dense heterochromatin, express Pax7 and Pax3, proliferate in response to injury, and show peak myogenic responses 4â5 days post-injury (dpi). Furthermore, using a pax7a-driven GFP reporter, we present evidence implicating satellite-like cells as a possible source of new muscle. In lieu of central nucleation, which distinguishes regenerating myofibers in mammals, we describe several characteristics that robustly identify newly-forming myofibers from surrounding fibers in injured adult zebrafish muscle. These characteristics include partially overlapping expression in satellite-like cells and regenerating myofibers of two RNA-binding proteins Rbfox2 and Rbfoxl1, known to regulate embryonic muscle development and function. Finally, by analyzing pax7a; pax7b double mutant zebrafish, we show that Pax7 is required for adult skeletal muscle repair, as it is in the mouse.
Keywords	adults ; cell proliferation ; Danio rerio ; heterochromatin ; mice ; muscle development ; muscles ; mutants ; RNA-binding proteins ; skeletal muscle ; stem cells ; transcription factors
Language	English
Dates of publication	2017-0415
Size	p. 162-180.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1114-9
ISSN	1095-564X ; 0012-1606
ISSN (online)	1095-564X
ISSN	0012-1606
DOI	10.1016/j.ydbio.2017.03.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Contemporary limnology of the rapidly changing glacierized watershed of the world’s largest High Arctic lake

K. A. St. Pierre / V. L. St. Louis / I. Lehnherr / S. L. Schiff / D. C. G. Muir / A. J. Poulain / J. P. Smol / C. Talbot / M. Ma / D. L. Findlay / W. J. Findlay / S. E. Arnott / Alex S. Gardner

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 15

Abstract: Abstract Glacial runoff is predicted to increase in many parts of the Arctic with climate change, yet little is known about the biogeochemical impacts of meltwaters on downstream freshwater ecosystems. Here we document the contemporary limnology of the ... ...

Abstract	Abstract Glacial runoff is predicted to increase in many parts of the Arctic with climate change, yet little is known about the biogeochemical impacts of meltwaters on downstream freshwater ecosystems. Here we document the contemporary limnology of the rapidly changing glacierized watershed of the world’s largest High Arctic lake (Lake Hazen), where warming since 2007 has increased delivery of glacial meltwaters to the lake by up to 10-times. Annually, glacial meltwaters accounted for 62–98% of dissolved nutrient inputs to the lake, depending on the chemical species and year. Lake Hazen was a strong sink for NO3 −-NO2 −, NH4 + and DOC, but a source of DIC to its outflow the Ruggles River. Most nutrients entering Lake Hazen were, however, particle-bound and directly transported well below the photic zone via dense turbidity currents, thus reinforcing ultraoligotrophy in the lake rather than overcoming it. For the first time, we apply the land-to-ocean aquatic continuum framework in a large glacierized Arctic watershed, and provide a detailed and holistic description of the physical, chemical and biological limnology of the rapidly changing Lake Hazen watershed. Our findings highlight the sensitivity of freshwater ecosystems to the changing cryosphere, with implications for future water quality and productivity at high latitudes.
Keywords	Medicine ; R ; Science ; Q
Subject code	550
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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