Article ; Online: Serial measurements of lymphocytes, D-dimer, LDH, and CRP do not improve the ability to predict COVID-19 adverse outcomes.
The Journal of international medical research
2023 Volume 51, Issue 5, Page(s) 3000605231173795
Abstract: Objective: We evaluated the discriminatory ability of variations in lymphocyte, D-dimer, C-reactive protein (CRP), and lactate dehydrogenase (LDH) serum levels at 48 to 72 hours of hospitalization compared with baseline measurements to predict ... ...
| Abstract | Objective: We evaluated the discriminatory ability of variations in lymphocyte, D-dimer, C-reactive protein (CRP), and lactate dehydrogenase (LDH) serum levels at 48 to 72 hours of hospitalization compared with baseline measurements to predict unfavorable clinical outcomes in patients with COVID-19. Methods: We analyzed diagnostic test results based on a retrospective cohort to determine the ability of variations (gradients or ratios) in patients' lymphocyte, D-dimer, CRP, and LDH serum levels taken 48 to 72 hours after hospital admission to predict adverse outcomes such as death, mechanical ventilation, or intensive care unit (ICU) admission developing. Results: Among 810 patients (56.1% men, age 61.6 ± 16.2 years), 37.5% had at least one adverse outcome; 28.2% required ICU admission, 26.5% required mechanical ventilation, and 19.4% died during hospitalization. In comparing baseline measurements with measurements at 48 to 72 hours, D-dimer, lymphocyte delta, LDH, and CRP had similar discriminatory ability (area under the receiver operating characteristic curve [AUC] 0.57 vs. 0.56, 0.53 vs. 0.57, 0.64 vs. 0.66, and 0.62 vs. 0.65, respectively). Conclusions: Measuring serum risk markers upon hospital admission can be used to evaluate risk of adverse outcomes in hospitalized patients with COVID-19. Repeating these measurements at 48 to 72 hours does not improve discriminatory ability. |
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| MeSH term(s) | Male ; Humans ; Middle Aged ; Aged ; Female ; COVID-19/diagnosis ; C-Reactive Protein/analysis ; Retrospective Studies ; Biomarkers ; Lymphocytes |
| Chemical Substances | C-Reactive Protein (9007-41-4) ; fibrin fragment D ; Biomarkers |
| Language | English |
| Publishing date | 2023-05-11 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 184023-x |
| ISSN | 1473-2300 ; 0300-0605 ; 0142-2596 |
| ISSN (online) | 1473-2300 |
| ISSN | 0300-0605 ; 0142-2596 |
| DOI | 10.1177/03000605231173795 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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