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  1. Article ; Online: Orexin: a Missing Link Between Sleep Disorders and Heart Failure?

    Pan, Stephen / Cabral, Carolina S / Ashley, Euan A / Perez, Marco V

    Current heart failure reports

    2017  Volume 14, Issue 2, Page(s) 100–105

    Abstract: Purpose of review: Sleep disorders represent a significant comorbidity in the heart failure population, and there is mounting evidence that treatment of sleep disorders such as obstructive sleep apnea can significantly improve cardiac function. However, ...

    Abstract Purpose of review: Sleep disorders represent a significant comorbidity in the heart failure population, and there is mounting evidence that treatment of sleep disorders such as obstructive sleep apnea can significantly improve cardiac function. However, the link between these two disorders is still not entirely clear.
    Recent findings: Recently, a novel neurohormonal pathway has been elucidated involving signaling molecules now collectively known as the orexins, which have been implicated in regulating autonomic function during sleep/wake cycles. Further evidence has mounted that orexin signaling is deeply perturbed in the setting of sleep disorders, and furthermore that abnormal orexin signaling may be implicated in the pathology of heart failure. The orexin signaling pathway represents an enticing novel target for both the treatment of sleep disorders as well as heart failure, and may represent one facet of the "missing link" between these two prevalent and often comorbid diseases.
    Language English
    Publishing date 2017-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-017-0322-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5936: Show issues Location:
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  2. Article ; Online: An in vivo map of bone morphogenetic protein 2 post-transcriptional repression in the heart.

    Kruithof, Boudewijn P T / Xu, Junwang / Fritz, David T / Cabral, Carolina S / Gaussin, Vinciane / Rogers, Melissa B

    Genesis (New York, N.Y. : 2000)

    2011  Volume 49, Issue 11, Page(s) 841–850

    Abstract: The Bmp2 3'untranslated region (UTR) sequence bears a sequence conserved between mammals and fishes that can post-transcriptionally activate or repress protein synthesis. We developed a map of embryonic cells in the mouse where this potent Bmp2 ... ...

    Abstract The Bmp2 3'untranslated region (UTR) sequence bears a sequence conserved between mammals and fishes that can post-transcriptionally activate or repress protein synthesis. We developed a map of embryonic cells in the mouse where this potent Bmp2 regulatory sequence functions by using a lacZ reporter transgene with a 3'UTR bearing two loxP sites flanking the ultra-conserved sequence. Cre-recombinase-mediated deletion of the ultra-conserved sequence caused strong ectopic expression in proepicardium, epicardium and epicardium-derived cells (EPDC) and in tissues with known epicardial contributions (coronary vessels and valves). Transient transfections of reporters in the epicardial/mesothelial cell (EMC) line confirmed this repression. Ectopic expression of the recombined transgene also occurred in the aorta, outlet septum, posterior cardiac plexus, cardiac and extracardiac nerves and neural ganglia. Bmp2 is dynamically regulated in the developing heart. 3'UTR-mediated mechanisms that restrain BMP2 synthesis may be relevant to congenital heart and vasculature malformations and to adult diseases involving aberrant BMP2 synthesis.
    MeSH term(s) 3' Untranslated Regions ; Animals ; Bone Morphogenetic Protein 2/genetics ; Bone Morphogenetic Protein 2/metabolism ; Cell Line ; Conserved Sequence ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Embryo, Mammalian/physiology ; Embryonic Development ; Gene Expression Regulation, Developmental ; Genes, Reporter ; Heart/embryology ; Heart/innervation ; Heart/physiology ; Immunohistochemistry ; Integrases/metabolism ; Lac Operon ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic/genetics ; Mice, Transgenic/metabolism ; Neurofilament Proteins/genetics ; Neurofilament Proteins/metabolism ; Pericardium/cytology ; Pericardium/embryology ; Pericardium/metabolism ; Pericardium/physiology ; Protein Processing, Post-Translational ; Rats ; Regulatory Sequences, Nucleic Acid ; Sequence Deletion ; Transcription, Genetic ; Transfection ; Transgenes
    Chemical Substances 3' Untranslated Regions ; Bmp2 protein, mouse ; Bone Morphogenetic Protein 2 ; Neurofilament Proteins ; neurofilament protein M (111365-29-8) ; Cre recombinase (EC 2.7.7.-) ; Integrases (EC 2.7.7.-)
    Language English
    Publishing date 2011-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2004544-X
    ISSN 1526-968X ; 1526-954X
    ISSN (online) 1526-968X
    ISSN 1526-954X
    DOI 10.1002/dvg.20757
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2772: Show issues Location:
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  3. Article ; Online: X-linked incontinentia pigmenti or Bloch-Sulzberger syndrome: a case report.

    Pereira, Marcela A C / Mesquita, Lismary A de F / Budel, Anelise R / Cabral, Carolina S P / Feltrim, Amanda de S

    Anais brasileiros de dermatologia

    2010  Volume 85, Issue 3, Page(s) 372–375

    Abstract: Incontinentia pigmenti is a rare X-linked genodermatosis that affects mainly female neonates. Skin manifestations are the most common and occur in four quite distinct phases. A female infant presented vesiculobullous lesions on trunk and limbs, and a ... ...

    Abstract Incontinentia pigmenti is a rare X-linked genodermatosis that affects mainly female neonates. Skin manifestations are the most common and occur in four quite distinct phases. A female infant presented vesiculobullous lesions on trunk and limbs, and a verrucous lesion on the right palm. Biopsy revealed eosinophil exocytosis and pigment incontinence, confirming the clinical hypothesis. Although uncommon, incontinentia pigmenti should be taken into consideration as a possible differential diagnosis when vesiculobullous and verrucous lesions are present in childhood.
    MeSH term(s) Female ; Genetic Diseases, X-Linked/diagnosis ; Humans ; Incontinentia Pigmenti/diagnosis ; Infant
    Language Portuguese
    Publishing date 2010-07-26
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/s0365-05962010000300013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Zs.MO 344: Show issues

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