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Article ; Online: From Doctors to Patients: The Importance of Valuing Mental Health in the Workplace of Physicians from the National Health Service.

Alho, Ana Margarida / Cabral, Miguel

2023 Volume 36, Issue 6, Page(s) 446–447

MeSH term(s)	Humans ; State Medicine ; Mental Health ; Portugal ; Physicians/psychology ; Workplace/psychology
Language	English
Publishing date	2023-05-11
Publishing country	Portugal
Document type	Letter ; Comment
ZDB-ID	603078-6
ISSN	1646-0758 ; 0870-399X
ISSN (online)	1646-0758
ISSN	0870-399X
DOI	10.20344/amp.19146
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Article: Thermal Desorption of 2,4,6-Trichloroanisole from Cork.

Monteiro, Susana / Bundaleski, Nenad / Lopes, Paulo / Cabral, Miguel / Teodoro, Orlando M N D

Foods (Basel, Switzerland)

2023 Volume 12, Issue 18

Abstract: While extensive efforts have been made over the past two decades to understand how cork becomes contaminated by 2,4,6-trichloroanisole (TCA), the nature of its bond to cork remains unclear. A deeper understanding of this interaction is crucial in ... ...

Abstract	While extensive efforts have been made over the past two decades to understand how cork becomes contaminated by 2,4,6-trichloroanisole (TCA), the nature of its bond to cork remains unclear. A deeper understanding of this interaction is crucial in designing processes to effectively remove TCA from cork stoppers. This study presents an investigation into the thermal desorption of TCA from cork under vacuum conditions. To facilitate detection by a quadrupole mass spectrometer, samples were artificially contaminated with sufficient TCA. A calibration system was developed to determine the absolute rate of TCA released from the cork. Desorption spectra revealed two peaks at 80 °C and 170 °C. Despite the known variability of cork, repeated measurements demonstrated reasonable repeatability. The low-temperature peak decreased with time and after preheating the sample to 50 °C. It is proposed that the high-temperature peak corresponds to TCA bonded to the cork material. Experiments with naturally contaminated cork stoppers revealed a significant reduction in the amount of releasable TCA following a vacuum-heating process. This study provides an insightful discussion on the adsorption of TCA on cork and proposes an estimate for the adsorption energy. Furthermore, it discloses a process capable of removing TCA from natural cork stoppers.
Language	English
Publishing date	2023-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12183450
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Article: Prey species and abundance affect growth and photosynthetic performance of the polyphagous sea slug

Cartaxana, Paulo / Morelli, Luca / Cassin, Elena / Havurinne, Vesa / Cabral, Miguel / Cruz, Sónia

Royal Society open science

2023 Volume 10, Issue 8, Page(s) 230810

Abstract: Some sacoglossan sea slugs steal functional macroalgal chloroplasts (kleptoplasts). In this study, we investigated the effects of algal prey species and abundance on the growth and photosynthetic capacity of the tropical polyphagous sea ... ...

Abstract	Some sacoglossan sea slugs steal functional macroalgal chloroplasts (kleptoplasts). In this study, we investigated the effects of algal prey species and abundance on the growth and photosynthetic capacity of the tropical polyphagous sea slug
Language	English
Publishing date	2023-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2787755-3
ISSN	2054-5703
ISSN	2054-5703
DOI	10.1098/rsos.230810
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Article: Cross Contamination of 2,4,6-Trichloroanisole in Cork Stoppers

Monteiro, Susana / Bundaleski, Nenad / Malheiro, Ana / Cabral, Miguel / Teodoro, Orlando M.N.D.

Journal of agricultural and food chemistry. 2022 May 25, v. 70, no. 22

2022

Abstract: Cork stoppers are the preferred choice for sealing bottled wines around the world. However, the quality of cork stoppers is also defined by the presence of 2,4,6-trichloroanisole (TCA), which gives the wine an unpleasant moldy/musty taste. It is a matter ...

Abstract	Cork stoppers are the preferred choice for sealing bottled wines around the world. However, the quality of cork stoppers is also defined by the presence of 2,4,6-trichloroanisole (TCA), which gives the wine an unpleasant moldy/musty taste. It is a matter of concern for both cork stopper manufacturers and wine producers whether TCA can be transported between stoppers. As little is known about cross contamination between stoppers, this work provides enough experimental data to discuss the extent of TCA transfer in naturally contaminated stoppers in the liquid and gas phase that can be useful to the cork industry and the wine industry. We found that when a clean stopper is soaked together with a contaminated one in hydro-alcoholic solution, 12% of the TCA can be transferred. In gas-phase contamination, only stoppers with 12 ng/L, or more, contaminate clean stoppers when enclosed together for several days. In a second experiment, where clean corks were exposed to a controlled contaminated environment, it was found that TCA contamination was not confined to the outermost layer of the stoppers. Based on these findings, some recommendations are given to prevent TCA cross contamination between stoppers during the cork stopper manufacturing, storage, wine making, and bottling.
Keywords	cork ; cork stoppers ; cross contamination ; food chemistry ; liquids ; molds (fungi) ; taste ; wine industry
Language	English
Dates of publication	2022-0525
Size	p. 6747-6754.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c02493
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Distribuição de Género em Cargos de Liderança na Área Médica em Portugal: O Exemplo das Candidaturas aos Órgãos da Ordem dos Médicos 2017-2019.

Cabral, Miguel / Paixão, Margarida / Leite, Andreia

Acta medica portuguesa

2020 Volume 34, Issue 5, Page(s) 342–346

Abstract: Introduction: Gender equality is one of the sustainable development goals. Low participation of women in leadership roles is an example of gender inequality. In Portugal, there are few studies regarding gender inequality in medical leadership roles. ... ...

Title translation	Gender Distribution in Medical Leadership Roles in Portugal: The Example of Candidacy to Bodies of the Portuguese Medical Association 2017-2019.
Abstract	Introduction: Gender equality is one of the sustainable development goals. Low participation of women in leadership roles is an example of gender inequality. In Portugal, there are few studies regarding gender inequality in medical leadership roles. Therefore, we aimed to analyse gender distribution of candidates to regional bodies of the Portuguese Medical Association. Material and methods: We extracted data from the candidates to the regional bodies of the Portuguese Medical Association (2017 - 2019 mandate) from the Association's magazine (issue number 175). We calculated the percentage of women candidates, overall and stratified by list, region and roles. We obtained observed-vs-expected ratios overall and by region, and respective 95% confidence intervals, assuming a Poisson distribution. Finally, we conducted a sensitivity analysis, excluding substitute candidates. Results: Women accounted for 37% of the candidates (regional variation: 29% - 51%). The national observed-vs-expected ratio was 0.74 (95% confidence interval: 0.58; 0.92), mainly driven by the ratio from the South Region: 0.58 (95% confidence interval: 0.41; 0.80). Women ran mainly for alternate candidates and secretary positions (56% and 54% respectively). Discussion: Gender differences were identified, particularly in the South, regarding the frequency and type of candidacy. Previous works have identified maternity, the social role of women and perceptions regarding the leadership roles as possible reasons to explain such differences. Our analysis is limited to specific leadership roles and an election moment; further studies should be pursued. Conclusion: We identified a lower than expected participation of women in the elections for the Portuguese Medical Association. When they run, women are found mainly in less relevant positions or with less potential to be elected (secretary or alternate candidate). A deeper understanding and measures to fight gender inequality in leadership roles are required.
MeSH term(s)	Female ; Gender Identity ; Humans ; Leadership ; Male ; Physicians ; Portugal ; Sexism ; Societies, Medical ; Women
Language	Portuguese
Publishing date	2020-12-09
Publishing country	Portugal
Document type	Journal Article
ZDB-ID	603078-6
ISSN	1646-0758 ; 0870-399X
ISSN (online)	1646-0758
ISSN	0870-399X
DOI	10.20344/amp.12955
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Article ; Online: Cross Contamination of 2,4,6-Trichloroanisole in Cork Stoppers.

Monteiro, Susana / Bundaleski, Nenad / Malheiro, Ana / Cabral, Miguel / Teodoro, Orlando M N D

Journal of agricultural and food chemistry

2022 Volume 70, Issue 22, Page(s) 6747–6754

Abstract	Cork stoppers are the preferred choice for sealing bottled wines around the world. However, the quality of cork stoppers is also defined by the presence of 2,4,6-trichloroanisole (TCA), which gives the wine an unpleasant moldy/musty taste. It is a matter of concern for both cork stopper manufacturers and wine producers whether TCA can be transported between stoppers. As little is known about cross contamination between stoppers, this work provides enough experimental data to discuss the extent of TCA transfer in naturally contaminated stoppers in the liquid and gas phase that can be useful to the cork industry and the wine industry. We found that when a clean stopper is soaked together with a contaminated one in hydro-alcoholic solution, 12% of the TCA can be transferred. In gas-phase contamination, only stoppers with 12 ng/L, or more, contaminate clean stoppers when enclosed together for several days. In a second experiment, where clean corks were exposed to a controlled contaminated environment, it was found that TCA contamination was not confined to the outermost layer of the stoppers. Based on these findings, some recommendations are given to prevent TCA cross contamination between stoppers during the cork stopper manufacturing, storage, wine making, and bottling.
MeSH term(s)	Anisoles ; Food Contamination/analysis ; Taste ; Wine/analysis
Chemical Substances	Anisoles ; 2,4,6-trichloroanisole (31O3X41254)
Language	English
Publishing date	2022-05-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c02493
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Camino crítico en pacientes hospitalizados por insuficiencia cardíaca aguda.

Burgos, Lucrecia M / Benzadón, Mariano / Cabral, Miguel H / Rivadeneira Lanfranchi, Victoria H / Balbiano, Mauricio / Diez, Mirta

Medicina

2022 Volume 82, Issue 5, Page(s) 810–812

Title translation	A critical pathway in patients hospitalized with an acute heart failure.
MeSH term(s)	Acute Disease ; Critical Pathways ; Heart Failure ; Hospitalization ; Humans
Language	Spanish
Publishing date	2022-09-28
Publishing country	Argentina
Document type	Letter
ZDB-ID	411586-7
ISSN	1669-9106 ; 0025-7680 ; 0325-951X
ISSN (online)	1669-9106
ISSN	0025-7680 ; 0325-951X
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Article ; Online: COVID-19 in heart transplant recipients: Outcomes according to vaccination status.

Burgos, Lucrecia María / Baro Vila, Rocio Consuelo / Cabral, Miguel Hector / Buscio, Maria / Vrancic, Mariano / Botto, Fernando / Diez, Mirta

Transplant infectious disease : an official journal of the Transplantation Society

2022 Volume 24, Issue 2, Page(s) e13817

MeSH term(s)	COVID-19/prevention & control ; Heart Transplantation/adverse effects ; Humans ; Organ Transplantation ; Transplant Recipients ; Vaccination
Language	English
Publishing date	2022-03-12
Publishing country	Denmark
Document type	Letter
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.13817
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Article: The Impact of Storage Conditions and Bottle Orientation on the Evolution of Phenolic and Volatile Compounds of Vintage Port Wine

Azevedo, Joana / Pinto, Joana / Teixeira, Natércia / Oliveira, Joana / Cabral, Miguel / Guedes de Pinho, Paula / Lopes, Paulo / Mateus, Nuno / de Freitas, Victor

Foods. 2022 Sept. 08, v. 11, no. 18

2022

Abstract: This work evaluates the influence of the cellar conditions and bottle orientation, on the phenolic and volatile composition of a Vintage Port wine, sealed with natural cork stoppers, for 44 months post-bottling. The storage was performed in two different ...

Abstract	This work evaluates the influence of the cellar conditions and bottle orientation, on the phenolic and volatile composition of a Vintage Port wine, sealed with natural cork stoppers, for 44 months post-bottling. The storage was performed in two different cellars, namely a cellar A with controlled temperature and humidity, and a cellar B, representing a traditional cellar, with uncontrolled temperature and humidity. The impact of bottle orientation was studied in cellar A, where the bottles were stored in horizontal and vertical positions. The phenolic and volatile composition of the bottled Vintage Port wine were analyzed after 6, 15 and 44 months. The results unveiled that the cellar conditions and bottle orientation had an impact in Port wine composition which was higher at 44 months post-bottling. The samples stored in the traditional cellar unveiled significantly higher yellow tones, lower tannin specific activity, and higher levels of furfural and 5-methylfurfural. Furthermore, the samples stored in the horizontal position revealed significant higher levels of total proanthocyanidins and higher tannin specific activity than the samples stored in the vertical position. Interestingly, for the first time to our knowledge, an ellagitannin-derived compound (Corklin) was detected in Vintage Port wines stored in the horizontal position, which results from the reaction of cork constituents with phenolic compounds present in wines.
Keywords	cork ; furfural ; humidity ; port wines ; proanthocyanidins ; temperature ; volatile compounds
Language	English
Dates of publication	2022-0908
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods11182770
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Article ; Online: Responsiveness to pulmonary rehabilitation in COPD is associated with changes in microbiota.

Melo-Dias, Sara / Cabral, Miguel / Furtado, Andreia / Souto-Miranda, Sara / Mendes, Maria Aurora / Cravo, João / Almeida, Catarina Rodrigues / Marques, Alda / Sousa, Ana

Respiratory research

2023 Volume 24, Issue 1, Page(s) 29

Abstract: Background: Pulmonary Rehabilitation (PR) is one of the most cost-effective therapies for chronic obstructive pulmonary disease (COPD) management. There are, however, people who do not respond to PR and reasons for non-response are mostly unknown. PR is ...

Abstract	Background: Pulmonary Rehabilitation (PR) is one of the most cost-effective therapies for chronic obstructive pulmonary disease (COPD) management. There are, however, people who do not respond to PR and reasons for non-response are mostly unknown. PR is likely to change the airway microbiota and this could play a role in its responsiveness. In this study we have explored the association between PR effectiveness and specific alterations in oral microbiota and inflammation. Methods: A prospective longitudinal study was conducted. Data on exercise capacity, dyspnoea, impact of disease and 418 saliva samples were collected from 76 patients, half of whom participated in a 12-weeks PR programme. Responders and non-responders to PR (dyspnoea, exercise-capacity and impact of disease) were defined based on minimal clinically important differences. Results: Changes in microbiota, including Prevotella melaninogenica and Streptococcus were observed upon PR. Prevotella, previously found to be depleted in severe COPD, increased during the first month of PR in responders. This increase was negatively correlated with Streptococcus and Lautropia, known to be enriched in severe cases of COPD. Simultaneously, an anti-inflammatory commensal of the respiratory tract, Rothia, correlated strongly and negatively with several pro-inflammatory markers, whose levels were generally boosted by PR. Conversely, in non-responders, the observed decline in Prevotella correlated negatively with Streptococcus and Lautropia whose fluctuations co-occurred with several pro-inflammatory markers. Conclusions: PR is associated with changes in oral microbiota. Specifically, PR increases salivary Prevotella melaninogenica and avoids the decline in Rothia and the increase in Streptococcus and Lautropia in responders, which may contribute to the benefits of PR.
MeSH term(s)	Humans ; Prospective Studies ; Longitudinal Studies ; Pulmonary Disease, Chronic Obstructive ; Dyspnea/rehabilitation
Language	English
Publishing date	2023-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-993X
ISSN (online)	1465-993X
ISSN	1465-993X
DOI	10.1186/s12931-023-02339-z
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