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  1. Article: Veterinary Public Health in Italy: From Healthy Animals to Healthy Food, Contribution to Improve Economy in Developing Countries.

    Cacaci, Margherita / Lelli, Rossella Colomba

    Advances in experimental medicine and biology

    2017  Volume 1057, Page(s) 63–72

    Abstract: The role of the veterinarian as a public health officer is intrinsic to the history and the culture of veterinary organization in Italy. The Veterinary service being part of the Health administration since the birth of the Italian State in the XIX ... ...

    Abstract The role of the veterinarian as a public health officer is intrinsic to the history and the culture of veterinary organization in Italy. The Veterinary service being part of the Health administration since the birth of the Italian State in the XIX Century. In the second half of the last century the birth of the Italian National Health Service confirmed that the function of the Italian veterinary service was to analyze and reduce the risks for the human population connected to the relationship man-animal-environment, animal health, food safety and security. The Italian Veterinary Medicine School curricula, reflected this "model" of veterinarian as well. In the majority of countries in the world, Veterinary Services are organized within the Agriculture Administration with the main function to assure animal health and wellbeing. After the so-called "Mad-cow crisis" the awareness of the direct and essential role of veterinary services in the prevention of human illness has been officially recognized and in the third millennium the old concept of "one health" and "human-animal interface" has gained popularity worldwide.The concept of Veterinary Public Health, has evolved at International level and has incorporated the more than a century old vision of the Italian Veterinary medicine and it is defined as "the sum of the contributions to the physical, mental and social development of people through the knowledge and application of veterinary science" (WHO, Future trends in veterinary public health. Gruppo di lavoro OMS: TE, Italy, 1999, Available from: http://www.who.int/zoonoses/vph/en/ . Last visited 16 Feb 2016, 1999).On the subject of Cooperation, Sustainability and Public Health, the EXPO 2015 event and the activities of international organizations WHO, FAO and World Organization for Animal Health are refocusing at present their worldwide mandate to protect human health and the economy of both the poorest Countries and the developed countries, according to the "new" concept of Veterinary Public Health.Focus of Italian Veterinary Services activity is connected to research, diagnosis and epidemiological analysis of infectious diseases, including zoonosis, food safety as well as food security.
    MeSH term(s) Animals ; Developing Countries ; Female ; Food Safety ; Humans ; Italy ; Public Health ; Veterinary Medicine ; Zoonoses
    Language English
    Publishing date 2017-05-15
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/5584_2017_54
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Pilot study on cultural and metagenomic analysis of bile and biliary stentslead to unveiling the key players in stent occlusion.

    Cacaci, Margherita / De Maio, Flavio / Matteo, Maria Valeria / Posteraro, Brunella / Di Vito, Maura / Menchinelli, Giulia / Tringali, Andrea / Monzo, Francesca Romana / Torelli, Riccardo / Costamagna, Guido / Spada, Cristiano / Bugli, Francesca / Sanguinetti, Maurizio / Boskoski, Ivo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3344

    Abstract: Endoscopic Retrograde Cholangio-Pancreatography (ERCP) with biliary stenting is a minimally invasive medical procedure employed to address both malignant and benign obstructions within the biliary tract. Benign biliary strictures (BBSs), typically ... ...

    Abstract Endoscopic Retrograde Cholangio-Pancreatography (ERCP) with biliary stenting is a minimally invasive medical procedure employed to address both malignant and benign obstructions within the biliary tract. Benign biliary strictures (BBSs), typically arising from surgical interventions such as liver transplants and cholecystectomy, as well as chronic inflammatory conditions, present a common clinical challenge. The current gold standard for treating BBSs involves the periodic insertion of plastic stents at intervals of 3-4 months, spanning a course of approximately one year. Unfortunately, stent occlusion emerges as a prevalent issue within this treatment paradigm, leading to the recurrence of symptoms and necessitating repeated ERCPs. In response to this clinical concern, we initiated a pilot study, delving into the microbial composition present in bile and on the inner surfaces of plastic stents. This investigation encompassed 22 patients afflicted by BBSs who had previously undergone ERCP with plastic stent placement. Our preliminary findings offered promising insights into the microbial culprits behind stent occlusion, with Enterobacter and Lactobacillus spp. standing out as prominent bacterial species known for their biofilm-forming tendencies on stent surfaces. These revelations hold promise for potential interventions, including targeted antimicrobial therapies aimed at curtailing bacterial growth on stents and the development of advanced stent materials boasting anti-biofilm properties.
    MeSH term(s) Humans ; Bile ; Pilot Projects ; Treatment Outcome ; Cholestasis/surgery ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Biliary Tract ; Stents ; Retrospective Studies
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-51480-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antimicrobial peptides for tackling cystic fibrosis related bacterial infections: A review.

    Bugli, Francesca / Martini, Cecilia / Di Vito, Maura / Cacaci, Margherita / Catalucci, Daniele / Gori, Alessandro / Iafisco, Michele / Sanguinetti, Maurizio / Vitali, Alberto

    Microbiological research

    2022  Volume 263, Page(s) 127152

    Abstract: Antibiotic resistance is a serious health and social problem that will have a substantial impact in the coming years on the world health and economy. Thus, the increasing demand for innovative antibiotics, has prompted many researchers in the medical, ... ...

    Abstract Antibiotic resistance is a serious health and social problem that will have a substantial impact in the coming years on the world health and economy. Thus, the increasing demand for innovative antibiotics, has prompted many researchers in the medical, microbiological, and biochemical fields to exploit the properties of antimicrobial peptides (AMPs). When properly used, designed, and conveyed, AMPs can really represent a valid alternative to conventional drugs especially in situations that are particularly difficult to treat such as chronic infections found in Cystic Fibrosis (CF) patients. In this review we focused on the applications of AMPs in the specific field of CF, illustrating different types of peptides from natural, naturally modified, synthetic as well as the different strategies used to overcome the barriers, and the physiological conditions in which AMPs must operate.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Peptides ; Bacterial Infections/drug therapy ; Cystic Fibrosis/drug therapy ; Drug Resistance, Microbial ; Humans ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; Antimicrobial Peptides
    Language English
    Publishing date 2022-07-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2022.127152
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Antimicrobial peptides for tackling cystic fibrosis related bacterial infections: A review

    Bugli, Francesca / Martini, Cecilia / Di Vito, Maura / Cacaci, Margherita / Catalucci, Daniele / Gori, Alessandro / Iafisco, Michele / Sanguinetti, Maurizio / Vitali, Alberto

    Microbiological research. 2022 Oct., v. 263

    2022  

    Abstract: Antibiotic resistance is a serious health and social problem that will have a substantial impact in the coming years on the world health and economy. Thus, the increasing demand for innovative antibiotics, has prompted many researchers in the medical, ... ...

    Abstract Antibiotic resistance is a serious health and social problem that will have a substantial impact in the coming years on the world health and economy. Thus, the increasing demand for innovative antibiotics, has prompted many researchers in the medical, microbiological, and biochemical fields to exploit the properties of antimicrobial peptides (AMPs). When properly used, designed, and conveyed, AMPs can really represent a valid alternative to conventional drugs especially in situations that are particularly difficult to treat such as chronic infections found in Cystic Fibrosis (CF) patients. In this review we focused on the applications of AMPs in the specific field of CF, illustrating different types of peptides from natural, naturally modified, synthetic as well as the different strategies used to overcome the barriers, and the physiological conditions in which AMPs must operate.
    Keywords antibiotic resistance ; antimicrobial peptides ; cystic fibrosis ; research
    Language English
    Dates of publication 2022-10
    Publishing place Elsevier GmbH
    Document type Article
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2022.127152
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: New Data on the

    Cacaci, Margherita / Menchinelli, Giulia / Torelli, Riccardo / Sanglard, Dominique / Sanguinetti, Maurizio / Posteraro, Brunella

    Antimicrobial agents and chemotherapy

    2020  Volume 64, Issue 12

    MeSH term(s) Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use ; Candida ; Drug Resistance, Fungal/genetics ; Fluconazole/pharmacology ; Imidazoles/pharmacology ; Microbial Sensitivity Tests
    Chemical Substances Antifungal Agents ; Imidazoles ; Fluconazole (8VZV102JFY) ; fenticonazole (QG05NRB077)
    Language English
    Publishing date 2020-11-17
    Publishing country United States
    Document type Letter
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.01459-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Curcumin-Functionalized Graphene Oxide Strongly Prevents

    Cacaci, Margherita / Squitieri, Damiano / Palmieri, Valentina / Torelli, Riccardo / Perini, Giordano / Campolo, Michela / Di Vito, Maura / Papi, Massimiliano / Posteraro, Brunella / Sanguinetti, Maurizio / Bugli, Francesca

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: ... Candida ... ...

    Abstract Candida parapsilosis
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16020275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Shaping Silver Nanoparticles' Size through the Carrier Composition: Synthesis and Antimicrobial Activity.

    Cacaci, Margherita / Biagiotti, Giacomo / Toniolo, Gianluca / Albino, Martin / Sangregorio, Claudio / Severi, Mirko / Di Vito, Maura / Squitieri, Damiano / Contiero, Luca / Paggi, Marco / Marelli, Marcello / Cicchi, Stefano / Bugli, Francesca / Richichi, Barbara

    Nanomaterials (Basel, Switzerland)

    2023  Volume 13, Issue 10

    Abstract: The increasing resistance of bacteria to conventional antibiotics represents a severe global emergency for human health. The broad-spectrum antibacterial activity of silver has been known for a long time, and silver at the nanoscale shows enhanced ... ...

    Abstract The increasing resistance of bacteria to conventional antibiotics represents a severe global emergency for human health. The broad-spectrum antibacterial activity of silver has been known for a long time, and silver at the nanoscale shows enhanced antibacterial activity. This has prompted research into the development of silver-based nanomaterials for applications in clinical settings. In this work, the synthesis of three different silver nanoparticles (AgNPs) hybrids using both organic and inorganic supports with intrinsic antibacterial properties is described. The tuning of the AgNPs' shape and size according to the type of bioactive support was also investigated. Specifically, the commercially available sulfated cellulose nanocrystal (CNC), the salicylic acid functionalized reduced graphene oxide (rGO-SA), and the commercially available titanium dioxide (TiO
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano13101585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Cinnamaldehyde Loaded Poly(lactide-co-glycolide) (PLGA) Microparticles for Antifungal Delivery Application against Resistant

    Rizzo, Silvia / Di Vito, Maura / Mazzinelli, Elena / Favuzzi, Ilaria / Torelli, Riccardo / Cacaci, Margherita / Arcovito, Alessandro / Sanguinetti, Maurizio / Garzoli, Stefania / Nocca, Giuseppina / Bugli, Francesca

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 13

    Abstract: Researchers have explored natural products to combat the antibiotic resistance of various microorganisms. Cinnamaldehyde (CIN), a major component of cinnamon essential oil (CC-EO), has been found to effectively inhibit the growth of bacteria, fungi, and ... ...

    Abstract Researchers have explored natural products to combat the antibiotic resistance of various microorganisms. Cinnamaldehyde (CIN), a major component of cinnamon essential oil (CC-EO), has been found to effectively inhibit the growth of bacteria, fungi, and mildew, as well as their production of toxins. Therefore, this study aimed to create a delivery system for CIN using PLGA microparticles (CIN-MPs), and to compare the antifungal activity of the carried and free CIN, particularly against antibiotic-resistant strains of
    Language English
    Publishing date 2023-06-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12132437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: β-Lactam Exposure Triggers Reactive Oxygen Species Formation in Enterococcus faecalis via the Respiratory Chain Component DMK.

    Léger, Loïc / Budin-Verneuil, Aurélie / Cacaci, Margherita / Benachour, Abdellah / Hartke, Axel / Verneuil, Nicolas

    Cell reports

    2019  Volume 29, Issue 8, Page(s) 2184–2191.e3

    Abstract: Whereas the primary actions of β-lactams are well characterized, their downstream effects are less well understood. Although their targets are extracellular, β-lactams stimulate respiration in Escherichia coli leading to increased intracellular ... ...

    Abstract Whereas the primary actions of β-lactams are well characterized, their downstream effects are less well understood. Although their targets are extracellular, β-lactams stimulate respiration in Escherichia coli leading to increased intracellular accumulation of reactive oxygen species (ROS). Here, we show that β-lactams over a large concentration range trigger a strong increase in ROS production in Enterococcus faecalis under aerobic, but not anaerobic, conditions. Both amoxicillin, to which the bacterium is susceptible, and cefotaxime, to which E. faecalis is resistant, triggers this response. This stimulation of ROS formation depends mainly on demethylmenaquinone (DMK), a component of the E. faecalis respiratory chain, but in contrast to E. coli is observed only in the absence of respiration. Our results suggest that in E. faecalis, β-lactams increase electron flux through the respiratory chain, thereby stimulating the auto-oxidation of reduced DMK in the absence of respiration, which triggers increased extracellular ROS production.
    MeSH term(s) Amoxicillin/metabolism ; Enterococcus faecalis/drug effects ; Enterococcus faecalis/metabolism ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Oxidative Stress/drug effects ; Reactive Oxygen Species/metabolism ; Vitamin K 2/analogs & derivatives ; Vitamin K 2/pharmacology ; beta-Lactams/pharmacology
    Chemical Substances Reactive Oxygen Species ; beta-Lactams ; Vitamin K 2 (11032-49-8) ; demethylmenaquinone (29790-47-4) ; Amoxicillin (804826J2HU)
    Language English
    Publishing date 2019-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.10.080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Graphene Oxide Coatings as Tools to Prevent Microbial Biofilm Formation on Medical Device.

    Cacaci, Margherita / Martini, Cecilia / Guarino, Cinzia / Torelli, Riccardo / Bugli, Francesca / Sanguinetti, Maurizio

    Advances in experimental medicine and biology

    2019  Volume 1282, Page(s) 21–35

    Abstract: The clinical challenge on surface engineering of medical devices to prevent microorganisms adhesion and biofilm formation, has become an essential aspect for medical implants. Antibacterial properties of Graphene Oxide (GO) have been demonstrated across ... ...

    Abstract The clinical challenge on surface engineering of medical devices to prevent microorganisms adhesion and biofilm formation, has become an essential aspect for medical implants. Antibacterial properties of Graphene Oxide (GO) have been demonstrated across a broad spectrum of bacteria, and the different mechanisms of action with which this nanomaterial interacts with the microbial surface have been elucidated in detail. Innovative protective coatings based on graphene film and hydrogel could represent an innovative solution for the prevention of nosocomial pathogens colonization on implantable device. This brief review mainly focuses on the applications of graphene in nanomedicine with a particular deepening on the antibacterial properties of GO and GO-based nanomaterials. In order to evaluate the possible future applications of GO as an anti-biofilm coating material for medical devices, studies on the ability of graphene coated surface to prevent microbial adhesion are also discussed. A concise review on in vitro toxicity and in vivo safety is also presented.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Biofilms/drug effects ; Coated Materials, Biocompatible/pharmacology ; Equipment and Supplies/microbiology ; Graphite/pharmacology ; Humans
    Chemical Substances Anti-Bacterial Agents ; Coated Materials, Biocompatible ; graphene oxide ; Graphite (7782-42-5)
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/5584_2019_434
    Database MEDical Literature Analysis and Retrieval System OnLINE

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