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  1. Article ; Online: Re: Prevalence of Pulmonary Embolism in ED patients with Suspected COVID-19: The Truth Remains Unknown.

    Freund, Yonathan / Drogrey, Marie / Cachanado, Marine / Bloom, Ben

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2020  Volume 27, Issue 11, Page(s) 1218

    Keywords covid19
    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Authors' reply.

    Naccache, Jean-Marc / Cachanado, Marine / Rousseau, Alexandra / Nunes, Hilario

    The Lancet. Respiratory medicine

    2021  Volume 10, Issue 1, Page(s) e4

    Language English
    Publishing date 2021-12-28
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00493-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Re: Prevalence of Pulmonary Embolism in ED patients with Suspected COVID-19: The Truth Remains Unknown

    Freund, Yonathan / Drogrey, Marie / Cachanado, Marine / Bloom, Ben

    Acad. emerg. med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #798362
    Database COVID19

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  4. Article ; Online: Re

    Freund, Yonathan / Drogrey, Marie / Cachanado, Marine / Bloom, Ben

    Academic Emergency Medicine ; ISSN 1069-6563 1553-2712

    Prevalence of Pulmonary Embolism in ED patients with Suspected COVID‐19: The Truth Remains Unknown

    2020  

    Keywords Emergency Medicine ; General Medicine ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/acem.14138
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Comparison of the safety and efficacy of YEARS, PEGeD, 4PEPS or the sole item "PE is the most likely diagnosis" strategies for the diagnosis of pulmonary embolism in the emergency department: post-hoc analysis of two European cohort studies.

    Roussel, Mélanie / Gorlicki, Judith / Douillet, Delphine / Moumneh, Thomas / Bérard, Laurence / Cachanado, Marine / Chauvin, Anthony / Roy, Pierre-Marie / Freund, Yonathan

    European journal of emergency medicine : official journal of the European Society for Emergency Medicine

    2022  Volume 29, Issue 5, Page(s) 341–347

    Abstract: Background: The optimal strategy for the diagnosis of pulmonary embolism (PE) in the emergency department (ED) remains debated. To reduce the need of imaging testing, several rules have been recently validated using an elevated D-dimer threshold.: ... ...

    Abstract Background: The optimal strategy for the diagnosis of pulmonary embolism (PE) in the emergency department (ED) remains debated. To reduce the need of imaging testing, several rules have been recently validated using an elevated D-dimer threshold.
    Objective: To validate the safety of different diagnostic strategies and compare the efficacy in terms of chest imaging testing.
    Design and patients: Post-hoc analysis of individual data of 3330 adult patients without a high clinical probability of PE in the ED followed-up at 3 months in France and Spain (1916 from the PROPER cohort, 1414 from the MODIGLIANI cohort).
    Exposure: Four diagnostic strategies with an elevated D-dimer threshold if PE is unlikely. The YEARS combined with Pulmonary Embolism Rule-out Criteria (PERC) the pulmonary embolism graduated D-dimer (PEGeD) combined with PERC and the 4-level pulmonary embolism probability score (4PEPS) rules were assessed. A modified simplified (MODS) rule with a simplified YEARS reduced to the sole item of "Is PE the most likely diagnosis" combined with PERC was also tested.
    Outcome measure and analysis: The primary outcome was the proportion of diagnosed PE or deep venous thrombosis at 3 months in patients in whom PE could have been excluded without chest imaging according to the tested strategy. The safety of a strategy was confirmed if the failure rate was less than 1.85%. The secondary outcome was the use of imaging testing according to each rule.
    Results: Among 3330 analyzed patients, 150 (4.5%) had a PE. The number of missed PEs were 25, 29, 30 and 26 for the PERC+YEARS, PERC+PEGeD, 4PEPS and MODS rules respectively, with a failure rate of 0.75% (95% CI 0.51% to 1.10%), 0.87% (0.61% to 1.25%), 0.90% (0.63% to 1.28%) and 0.78% (0.53% to 1.14%) respectively. There was no significant difference in the failure rate between rules. Except for a significant lower use of chest imaging for 4PEPS compared to YEARS (14.9% vs 16.3%, difference -1.4% [95%CI -2.1% to -0.8%]), there was no difference in the proportion of imaging testing.
    Conclusion: In this post-hoc analysis of patients with suspicion of PE, YEARS and PEGeD combined with PERC, and 4PEPS were safe to exclude PE. The safety of the modified simplified MODS strategy was also confirmed. There was no significant difference of the failure rate between strategies.
    MeSH term(s) Adult ; Cohort Studies ; Emergency Service, Hospital ; Humans ; Multiple Organ Failure ; Pulmonary Embolism/diagnosis ; Spain
    Language English
    Publishing date 2022-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1233544-7
    ISSN 1473-5695 ; 0969-9546
    ISSN (online) 1473-5695
    ISSN 0969-9546
    DOI 10.1097/MEJ.0000000000000967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Restrictive vs Liberal Blood Transfusions for Patients with Acute Myocardial Infarction and Anaemia by Heart Failure Status: An RCT Subgroup Analysis.

    Ducrocq, Gregory / Cachanado, Marine / Simon, Tabassome / Puymirat, Etienne / Lemesle, Gilles / Lattuca, Benoit / Ariza-Solé, Albert / Silvain, Johanne / Ferrari, Emile / Gonzalez-Juanatey, Jose R / Martínez-Sellés, Manuel / Lermusier, Thibault / Coste, Pierre / Vanzetto, Gerald / Cottin, Yves / Dillinger, Jean G / Calvo, Gonzalo / Steg, Philippe Gabriel

    The Canadian journal of cardiology

    2024  

    Abstract: Background: Red blood cell transfusion can cause fluid overload. We evaluated the interaction between heart failure (HF) at baseline and transfusion strategy on outcomes in acute myocardial infarction (AMI).: Methods: We used data from the randomized ...

    Abstract Background: Red blood cell transfusion can cause fluid overload. We evaluated the interaction between heart failure (HF) at baseline and transfusion strategy on outcomes in acute myocardial infarction (AMI).
    Methods: We used data from the randomized REALITY trial (https://www.
    Clinicaltrials: gov/study/NCT02648113), comparing restrictive versus liberal transfusion strategies in patients with AMI and anaemia. HF was defined as history of HF or Killip class > 1 at randomization. Primary outcome was major adverse cardiovascular events (MACE: composite of all-cause death, non-recurrent AMI, stroke, or emergency revascularization prompted by ischaemia) at 30 days.
    Results: Among 658 randomized patients, 311 (47.3%) had HF. HF patients had higher rates of MACE at 30 days and 1 year, and higher rates of non-fatal new-onset HF. There was no interaction between HF and effect of randomized assignment on the primary outcome or non-fatal new-onset HF. A liberal transfusion strategy was associated with increased all-cause death at 30 days and at 1 year in HF patients (P
    Conclusions: HF is frequent in AMI patients with anaemia and is associated with higher risk of MACE (including all-cause death) and non-fatal new-onset HF. While there was no interaction of HF with effect of transfusion strategy on MACE, a liberal transfusion strategy was associated with higher all-cause death that appears driven by a higher risk of early death due to HF.
    Language English
    Publishing date 2024-02-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2024.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: BRAF V600E/RAS Mutations and Lynch Syndrome in Patients With MSI-H/dMMR Metastatic Colorectal Cancer Treated With Immune Checkpoint Inhibitors.

    Colle, Raphael / Lonardi, Sara / Cachanado, Marine / Overman, Michael J / Elez, Elena / Fakih, Marwan / Corti, Francesca / Jayachandran, Priya / Svrcek, Magali / Dardenne, Antoine / Cervantes, Baptiste / Duval, Alex / Cohen, Romain / Pietrantonio, Filippo / André, Thierry

    The oncologist

    2023  Volume 28, Issue 9, Page(s) 771–779

    Abstract: Background: We pooled data from 2 cohorts of immune checkpoint inhibitors-treated microsatellite instability-high/mismatch repair-deficient (MSI/dMMR) metastatic colorectal cancer patients to evaluate the prognostic value of RAS/BRAFV600E mutations and ... ...

    Abstract Background: We pooled data from 2 cohorts of immune checkpoint inhibitors-treated microsatellite instability-high/mismatch repair-deficient (MSI/dMMR) metastatic colorectal cancer patients to evaluate the prognostic value of RAS/BRAFV600E mutations and Lynch syndrome (LS).
    Patients and methods: Patients were defined as LS-linked if germline mutation was detected and as sporadic if loss of MLH1/PMS2 expression with BRAFV600E mutation and/or MLH1 promoter hypermethylation, or biallelic somatic MMR genes mutations were found. Progression-free survival (PFS) and overall survival (OS) were adjusted on prognostic modifiers selected on unadjusted analysis (P < .2) if limited number of events.
    Results: Of 466 included patients, 305 (65.4%) and 161 (34.5%) received, respectively, anti-PD1 alone and anti-PD1+anti-CTLA4 in the total population, 111 (24.0%) were treated in first-line; 129 (28.8%) were BRAFV600E-mutated and 153 (32.8%) RAS-mutated. Median follow-up was 20.9 months. In adjusted analysis of the whole population (PFS/OS events = 186/133), no associations with PFS and OS were observed for BRAFV600E-mutated (PFS HR= 1.20, P = .372; OS HR = 1.06, P = .811) and RAS-mutated patients (PFS HR = 0.93, P = .712, OS HR = 0.75, P = .202). In adjusted analysis in the Lynch/sporadic status-assigned population (n = 242; PFS/OS events = 80/54), LS-liked patients had an improved PFS compared to sporadic cases (HR = 0.49, P = .036). The adjusted HR for OS was 0.56 with no significance (P = .143). No adjustment on BRAFV600E mutation was done due to collinearity.
    Conclusion: In this cohort, RAS/BRAFV600E mutations were not associated with survival while LS conferred an improved PFS.
    MeSH term(s) Humans ; Colorectal Neoplasms, Hereditary Nonpolyposis/drug therapy ; Colorectal Neoplasms, Hereditary Nonpolyposis/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Microsatellite Instability ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Mutation ; Colonic Neoplasms ; DNA Mismatch Repair/genetics
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Immune Checkpoint Inhibitors ; BRAF protein, human (EC 2.7.11.1)
    Language English
    Publishing date 2023-04-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyad082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of transfusion strategy on platelet aggregation and biomarkers in myocardial infarction patients with anemia.

    Silvain, Johanne / Lattuca, Benoit / Puymirat, Etienne / Ducrocq, Gregory / Dillinger, Jean-Guillaume / Lhermusier, Thibault / Procopi, Niki / Cachanado, Marine / Drouet, Elodie / Abergel, Helene / Danchin, Nicolas / Montalescot, Gilles / Simon, Tabassome / Steg, Philippe Gabriel

    European heart journal. Cardiovascular pharmacotherapy

    2023  Volume 9, Issue 7, Page(s) 647–657

    Abstract: Background: Higher rates of thrombotic events have been reported in myocardial infarction (MI) patients requiring blood transfusion. The impact of blood transfusion strategy on thrombosis and inflammation is still unknown.: Objective: To compare the ... ...

    Abstract Background: Higher rates of thrombotic events have been reported in myocardial infarction (MI) patients requiring blood transfusion. The impact of blood transfusion strategy on thrombosis and inflammation is still unknown.
    Objective: To compare the impact of a liberal vs. a restrictive transfusion strategy on P2Y12 platelet reactivity and biomarkers in the multicentric randomized REALITY trial.
    Methods: Patients randomized to a liberal (hemoglobin ≤10 g/dL) or a restrictive (hemoglobin ≤8 g/dL) transfusion strategy had VASP-PRI platelet reactivity measured centrally in a blinded fashion and platelet reactivity unit (PRU) measured locally using encrypted VerifyNow; at baseline and after randomization. Biomarkers of thrombosis (P-selectin, PAI-1, vWF) and inflammation (TNF-α) were also measured. The primary endpoint was the change in the VASP-PRI (difference from baseline and post randomization) between the randomized groups.
    Results: A total of 100 patients randomized were included in this study (n = 50 in each group). Transfused patients received on average 2.4 ± 1.6 units of blood. We found no differences in change of the VASP PRI (difference 1.2% 95% CI (-10.3-12.7%)) or by the PRU (difference 13.0 95% CI (-21.8-47.8)) before and after randomization in both randomized groups. Similar results were found in transfused patients (n = 71) regardless of the randomized group, VASP PRI (difference 1.7%; 95% CI (-9.5-1.7%)) or PRU (difference 27.0; 95% CI (-45.0-0.0)). We did not find an impact of transfusion strategy or transfusion itself in the levels of P-selectin, PAI-1, vWF, and TNF-α.
    Conclusion: In this study, we found no impact of a liberal vs. a restrictive transfusion strategy on platelet reactivity and biomarkers in MI patients with anemia. A conclusion that should be tempered due to missing patients with exploitable biological data that has affected our power to show a difference.
    MeSH term(s) Humans ; Platelet Aggregation ; P-Selectin ; Plasminogen Activator Inhibitor 1 ; Tumor Necrosis Factor-alpha ; von Willebrand Factor ; Anemia ; Myocardial Infarction ; Blood Transfusion ; Hemoglobins ; Thrombosis ; Biomarkers ; Inflammation
    Chemical Substances P-Selectin ; Plasminogen Activator Inhibitor 1 ; Tumor Necrosis Factor-alpha ; von Willebrand Factor ; Hemoglobins ; Biomarkers
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808613-2
    ISSN 2055-6845 ; 2055-6837
    ISSN (online) 2055-6845
    ISSN 2055-6837
    DOI 10.1093/ehjcvp/pvad055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cost-effectiveness of modified diagnostic strategy to safely rule-out pulmonary embolism in the emergency department: a non-inferiority cluster crossover randomized trial (MODIGLIA-NI).

    Nze Ossima, Arnaud / Ngaleu Siaha, Bibi Fabiola / Mimouni, Maroua / Mezaour, Nadia / Darlington, Meryl / Berard, Laurence / Cachanado, Marine / Simon, Tabassome / Freund, Yonathan / Durand-Zaleski, Isabelle

    BMC emergency medicine

    2023  Volume 23, Issue 1, Page(s) 140

    Abstract: Background: The aim of this trial-based economic evaluation was to assess the incremental costs and cost-effectiveness of the modified diagnostic strategy combining the YEARS rule and age-adjusted D-dimer threshold compared with the control (which used ... ...

    Abstract Background: The aim of this trial-based economic evaluation was to assess the incremental costs and cost-effectiveness of the modified diagnostic strategy combining the YEARS rule and age-adjusted D-dimer threshold compared with the control (which used the age-adjusted D-dimer threshold only) for the diagnosis of pulmonary embolism (PE) in the Emergency Department (ED).
    Methods: Economic evaluation from a healthcare system perspective alongside a non-inferiority, crossover, and cluster-randomized trial conducted in 16 EDs in France and two in Spain with three months of follow-up. The primary endpoint was the additional cost of a patient without failure of the diagnostic strategy, defined as venous thromboembolism (VTE) diagnosis at 3months after exclusion of PE during the initial ED visit. Mean differences in 3-month failure and costs were estimated using separate generalized linear-regression mixed models, adjusted for strategy type, period, and the interaction between strategy and period as fixed effects and the hospital as a random effect. The incremental cost-effectiveness ratio (ICER) was obtained by dividing the incremental costs by the incremental frequency of VTE.
    Results: Of the 1,414 included patients, 1,217 (86%) were analyzed in the per-protocol analysis (648 in the intervention group and 623 in the control group). At three months, there were no statistically significant differences in total costs (€-46; 95% CI: €-93 to €0.2), and the failure rate was non inferior in the intervention group (-0.64%, one-sided 97.5% CI: -∞ to 0.21%, non-inferiority margin 1.5%) between groups. The point estimate of the incremental cost-effectiveness ratio (ICER) indicating that each undetected VTE averted in the intervention group is associated with cost savings of €7,142 in comparison with the control group. There was a 93% probability that the intervention was dominant. Similar results were found in the as randomized population.
    Conclusions: Given the observed cost decrease of borderline significance, and according to the 95% confidence ellipses, the intervention strategy has a potential to lead to cost savings as a result of a reduction in the use of chest imaging and of the number of undetected VTE averted. Policy-makers should investigate how these monetary benefits can be distributed across stakeholders.
    Clinicaltrials: Trial registration number ClinicalTrials.gov Identifier: NCT04032769; July 25, 2019.
    MeSH term(s) Humans ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Cost-Benefit Analysis ; Pulmonary Embolism/diagnosis ; Emergency Service, Hospital ; France
    Language English
    Publishing date 2023-11-29
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2050431-7
    ISSN 1471-227X ; 1471-227X
    ISSN (online) 1471-227X
    ISSN 1471-227X
    DOI 10.1186/s12873-023-00910-x
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  10. Article ; Online: Overnight Stay in the Emergency Department and Mortality in Older Patients.

    Roussel, Melanie / Teissandier, Dorian / Yordanov, Youri / Balen, Frederic / Noizet, Marc / Tazarourte, Karim / Bloom, Ben / Catoire, Pierre / Berard, Laurence / Cachanado, Marine / Simon, Tabassome / Laribi, Said / Freund, Yonathan

    JAMA internal medicine

    2023  Volume 183, Issue 12, Page(s) 1378–1385

    Abstract: Importance: Patients in the emergency department (ED) who are waiting for hospital admission on a wheeled cot may be subject to harm. However, mortality and morbidity among older patients who spend the night in the ED while waiting for a bed in a ... ...

    Abstract Importance: Patients in the emergency department (ED) who are waiting for hospital admission on a wheeled cot may be subject to harm. However, mortality and morbidity among older patients who spend the night in the ED while waiting for a bed in a medical ward are unknown.
    Objective: To assess whether older adults who spend a night in the ED waiting for admission to a hospital ward are at increased risk of in-hospital mortality.
    Design, settings, and participants: This was a prospective cohort study of older patients (≥75 years) who visited the ED and were admitted to the hospital on December 12 to 14, 2022, at 97 EDs across France. Two groups were defined and compared: those who stayed in the ED from midnight until 8:00 am (ED group) and those who were admitted to a ward before midnight (ward group).
    Main outcomes and measures: The primary end point was in-hospital mortality, truncated at 30 days. Secondary outcomes included in-hospital adverse events (ie, falls, infection, bleeding, myocardial infarction, stroke, thrombosis, bedsores, and dysnatremia) and hospital length of stay. A generalized linear-regression mixed model was used to compare end points between groups.
    Results: The total sample comprised 1598 patients (median [IQR] age, 86 [80-90] years; 880 [55%] female and 718 [45%] male), with 707 (44%) in the ED group and 891 (56%) in the ward group. Patients who spent the night in the ED had a higher in-hospital mortality rate of 15.7% vs 11.1% (adjusted risk ratio [aRR], 1.39; 95% CI, 1.07-1.81). They also had a higher risk of adverse events compared with the ward group (aRR, 1.24; 95% CI, 1.04-1.49) and increased median length of stay (9 vs 8 days; rate ratio, 1.20; 95% CI, 1.11-1.31). In a prespecified subgroup analysis of patients who required assistance with the activities of daily living, spending the night in the ED was associated with a higher in-hospital mortality rate (aRR, 1.81; 95% CI, 1.25-2.61).
    Conclusions and relevance: The findings of this prospective cohort study indicate that for older patients, waiting overnight in the ED for admission to a ward was associated with increased in-hospital mortality and morbidity, particularly in patients with limited autonomy. Older adults should be prioritized for admission to a ward.
    MeSH term(s) Humans ; Male ; Female ; Aged ; Aged, 80 and over ; Prospective Studies ; Activities of Daily Living ; Hospitalization ; Emergency Service, Hospital ; Hospital Mortality
    Language English
    Publishing date 2023-11-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.5961
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