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  1. Article ; Online: Asociación entre el daño miocárdico y el pronóstico de pacientes hospitalizados por COVID-19, con y sin cardiopatía. Registro CARDIOVID.

    López-Otero, Diego / López-Pais, Javier / Antúnez-Muiños, Pablo José / Cacho-Antonio, Carla / González-Ferrero, Teba / González-Juanatey, José Ramón

    Revista espanola de cardiologia

    2020  Volume 74, Issue 1, Page(s) 105–108

    Title translation Association between myocardial injury and prognosis of COVID-19 hospitalized patients, with or without heart disease. CARDIOVID registry.
    Keywords covid19
    Language Spanish
    Publishing date 2020-09-16
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 128925-1
    ISSN 1579-2242 ; 0300-8932
    ISSN (online) 1579-2242
    ISSN 0300-8932
    DOI 10.1016/j.recesp.2020.08.003
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  2. Article ; Online: Association between myocardial injury and prognosis of COVID-19 hospitalized patients, with or without heart disease. CARDIOVID registry.

    López-Otero, Diego / López-Pais, Javier / Antúnez-Muiños, Pablo José / Cacho-Antonio, Carla / González-Ferrero, Teba / González-Juanatey, José Ramón

    Revista espanola de cardiologia (English ed.)

    2020  Volume 74, Issue 1, Page(s) 105–108

    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; Female ; Heart Diseases/epidemiology ; Heart Diseases/etiology ; Hospitalization/trends ; Humans ; Incidence ; Male ; Middle Aged ; Myocardium ; Pandemics ; Prognosis ; Registries ; SARS-CoV-2 ; Spain/epidemiology
    Keywords covid19
    Language Spanish
    Publishing date 2020-08-15
    Publishing country Spain
    Document type Letter
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2020.08.005
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  3. Article: A New Biomarker Tool for Risk Stratification in "

    Agra-Bermejo, Rosa M / Cacho-Antonio, Carla / Gonzalez-Babarro, Eva / Rozados-Luis, Adriana / Couselo-Seijas, Marinela / Gómez-Otero, Inés / Varela-Román, Alfonso / López-Canoa, José N / Gómez-Rodríguez, Isabel / Pata, María / Eiras, Sonia / González-Juanatey, Jose R

    Frontiers in physiology

    2022  Volume 12, Page(s) 736245

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-01-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.736245
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  4. Article: Association between myocardial injury and prognosis of COVID-19 hospitalized patients, with or without heart disease. CARDIOVID registry

    López-Otero, Diego / López-Pais, Javier / Antúnez-Muiños, Pablo José / Cacho-Antonio, Carla / González-Ferrero, Teba / González-Juanatey, José Ramón

    Rev. esp. de cardiol. (Internet. Engl. ed.)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #713755
    Database COVID19

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  5. Article ; Online: Association between myocardial injury and prognosis of COVID-19 hospitalized patients, with or without heart disease. CARDIOVID registry

    López-Otero, Diego / López-Pais, Javier / Antúnez-Muiños, Pablo José / Cacho-Antonio, Carla / González-Ferrero, Teba / González-Juanatey, José Ramón

    Revista Española de Cardiología (English Edition) ; ISSN 1885-5857

    2020  

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.rec.2020.08.005
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Asociación entre el daño miocárdico y el pronóstico de pacientes hospitalizados por COVID-19, con y sin cardiopatía. Registro CARDIOVID

    López-Otero, Diego / López-Pais, Javier / Antúnez-Muiños, Pablo José / Cacho-Antonio, Carla / González-Ferrero, Teba / González-Juanatey, José Ramón

    Revista Española de Cardiología ; ISSN 0300-8932

    2020  

    Keywords Cardiology and Cardiovascular Medicine ; covid19
    Language Spanish
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.1016/j.recesp.2020.08.003
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: CD5L, Macrophage Apoptosis Inhibitor, Was Identified in Epicardial Fat-Secretome and Regulated by Isoproterenol From Patients With Heart Failure.

    Agra-Bermejo, Rosa M / Cacho-Antonio, Carla / Rozados-Luis, Adriana / Couselo-Seijas, Marinela / Fernandez, Angel L / Martinez-Cereijo, J M / Bravo, S B / Gonzalez-Juanatey, Jose R / Eiras, Sonia

    Frontiers in physiology

    2020  Volume 11, Page(s) 620

    Abstract: Objectives: Neurohormonal dysfunction, which can regulate epicardial fat activity, is one of the main promoters of atrial fibrillation (AF) in patients with heart failure (HF). Our aim was to study the epicardial fat mediators for AF in patients with HF ...

    Abstract Objectives: Neurohormonal dysfunction, which can regulate epicardial fat activity, is one of the main promoters of atrial fibrillation (AF) in patients with heart failure (HF). Our aim was to study the epicardial fat mediators for AF in patients with HF and its catecholaminergic regulation.
    Methods: We have included 29 patients with HF who underwent cardiac surgery and were followed up for 5 years. Released proteins by epicardial adipose tissue (EAT) after isoproterenol treatment were identified by nano-high-performance liquid chromatography (HPLC) and triple time-of-flight (TOF) analysis. Common and differential identified proteins in groups of patients with AF before and after surgery were determined by the FunRich tool. Plasma and epicardial fat biopsy proteins were quantified by western blot.
    Results: Our results identified 17 common released proteins by EAT, after isoproterenol treatment, from HF patients who suffered AF or developed new-onset AF during follow-up. Mostly, they were involved on inflammatory response and extracellular matrix. One of them was CD5L, a macrophage apoptosis inhibitor. Its secretion by isoproterenol treatment was validated on western blot. The CD5L levels on epicardial fat were also higher in the group of male patients who present or develop AF (0.44 ± 0.05 vs. 0.18 ± 0.15;
    Conclusion: Our results suggest the role of epicardial fat CD5L as a mediator of AF and its possible paracrine effect by catecholaminergic activity.
    Language English
    Publishing date 2020-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.00620
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  8. Article ; Online: The COVID-19 lab score: an accurate dynamic tool to predict in-hospital outcomes in COVID-19 patients.

    Antunez Muiños, Pablo Jose / López Otero, Diego / Amat-Santos, Ignacio J / López País, Javier / Aparisi, Alvaro / Cacho Antonio, Carla E / Catalá, Pablo / González Ferrero, Teba / Cabezón, Gonzalo / Otero García, Oscar / Gil, José Francisco / Pérez Poza, Marta / Candela, Jordi / Rojas, Gino / Jiménez Ramos, Víctor / Veras, Carlos / San Román, J Alberto / González-Juanatey, José R

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 9361

    Abstract: Deterioration is sometimes unexpected in SARS-CoV2 infection. The aim of our study is to establish laboratory predictors of mortality in COVID-19 disease which can help to identify high risk patients. All patients admitted to hospital due to Covid-19 ... ...

    Abstract Deterioration is sometimes unexpected in SARS-CoV2 infection. The aim of our study is to establish laboratory predictors of mortality in COVID-19 disease which can help to identify high risk patients. All patients admitted to hospital due to Covid-19 disease were included. Laboratory biomarkers that contributed with significant predictive value for predicting mortality to the clinical model were included. Cut-off points were established, and finally a risk score was built. 893 patients were included. Median age was 68.2 ± 15.2 years. 87(9.7%) were admitted to Intensive Care Unit (ICU) and 72(8.1%) needed mechanical ventilation support. 171(19.1%) patients died. A Covid-19 Lab score ranging from 0 to 30 points was calculated on the basis of a multivariate logistic regression model in order to predict mortality with a weighted score that included haemoglobin, erythrocytes, leukocytes, neutrophils, lymphocytes, creatinine, C-reactive protein, interleukin-6, procalcitonin, lactate dehydrogenase (LDH), and D-dimer. Three groups were established. Low mortality risk group under 12 points, 12 to 18 were included as moderate risk, and high risk group were those with 19 or more points. Low risk group as reference, moderate and high patients showed mortality OR 4.75(CI95% 2.60-8.68) and 23.86(CI 95% 13.61-41.84), respectively. C-statistic was 0-85(0.82-0.88) and Hosmer-Lemeshow p-value 0.63. Covid-19 Lab score can very easily predict mortality in patients at any moment during admission secondary to SARS-CoV2 infection. It is a simple and dynamic score, and it can be very easily replicated. It could help physicians to identify high risk patients to foresee clinical deterioration.
    MeSH term(s) Aged ; Biomarkers/analysis ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/pathology ; COVID-19/therapy ; Female ; Hospitalization ; Humans ; Male ; Multivariate Analysis ; Retrospective Studies ; Risk Assessment ; SARS-CoV-2/physiology ; Spain/epidemiology ; Treatment Outcome
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-04-30
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-88679-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Prognostic Impact of Change in Nutritional Risk on Mortality and Heart Failure After Transcatheter Aortic Valve Replacement.

    González Ferreiro, Rocío / López Otero, Diego / Álvarez Rodríguez, Leyre / Otero García, Óscar / Pérez Poza, Marta / Antúnez Muiños, Pablo José / Cacho Antonio, Carla / López Pais, Javier / Juskowa, Mária / Cid Álvarez, Ana Belén / Trillo Nouche, Ramiro / Sanmartín Pena, Xoan Carlos / Sánchez Fernández, Pedro Luis / Cruz-González, Ignacio / González Juanatey, José Ramón

    Circulation. Cardiovascular interventions

    2021  Volume 14, Issue 2, Page(s) e009342

    Abstract: Background: Limited data are available regarding change in the nutritional status after transcatheter aortic valve replacement (TAVR). This study evaluated the prognostic impact of the change in the geriatric nutritional risk index following TAVR.: ... ...

    Abstract Background: Limited data are available regarding change in the nutritional status after transcatheter aortic valve replacement (TAVR). This study evaluated the prognostic impact of the change in the geriatric nutritional risk index following TAVR.
    Methods: TAVR patients were analyzed in a prospective and observational study. To analyze the change in nutritional status, geriatric nutritional risk index of the patients was calculated on the day of TAVR and at 3-month follow-up. The impact of the change in nutritional risk index after TAVR on all-cause mortality, heart failure hospitalization (HF-h), and the composite of all-cause death and HF hospitalization was analyzed using the Cox Proportional Hazards model.
    Results: Four hundred thirty-three patients were included. After TAVR, 68.4% (n=182) patients with baseline nutritional risk improved compared with 31.6% (n=84) who remained at nutritional risk. The change from no-nutritional risk to nutritional risk after TAVR occurred in 15.0% (n=25), while 85.0% (n=142) remained without risk of malnutrition. During follow-up, 157 (36.3%) patients died and 172 patients (39.7%) were hospitalized due to HF. Patients who continued to be at nutritional risk had a higher risk of mortality (hazard ratio [HR], 2.10 [95% CI, 1.30-3.39],
    Conclusions: Remaining at nutritional risk after TAVR confers a poor prognosis and is associated with an increased risk of mortality and HF-h, while the change from risk of malnutrition to non-nutritional risk after TAVR was associated with a halving of the risk of mortality and HF-h. Further studies are needed to identify whether patients at nutritional risk would benefit from nutritional intervention during processes of care of TAVR programs.
    MeSH term(s) Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Heart Failure/therapy ; Humans ; Prognosis ; Prospective Studies ; Risk Factors ; Severity of Illness Index ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2450797-0
    ISSN 1941-7632 ; 1941-7640
    ISSN (online) 1941-7632
    ISSN 1941-7640
    DOI 10.1161/CIRCINTERVENTIONS.120.009342
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  10. Article ; Online: Prognostic benefit from an early invasive strategy in patients with non-ST elevation acute coronary syndrome (NSTEACS): evaluation of the new risk stratification in the NSTEACS European guidelines.

    Martinón-Martínez, Jesús / Álvarez Álvarez, Belén / González Ferrero, Teba / García-Rodeja Arias, Federico / Otero García, Óscar / Cacho Antonio, Carla / Abou Jokh Casas, Charigan / Zuazola, Pilar / Cordero, Alberto / Escribano, David / Cid Alvarez, Belén / Iglesias Álvarez, Diego / Agra Bermejo, Rosa / Rigueiro Veloso, Pedro / García Acuña, José María / Gude Sampedro, Francisco / González Juanatey, José Ramón

    Clinical research in cardiology : official journal of the German Cardiac Society

    2021  Volume 110, Issue 9, Page(s) 1464–1472

    Abstract: Objectives: The objective of our work is to evaluate the prognostic benefit of an early invasive strategy in patients with high-risk NSTACS according to the recommendations of the 2020 clinical practice guidelines during long-term follow-up.: Methods!# ...

    Abstract Objectives: The objective of our work is to evaluate the prognostic benefit of an early invasive strategy in patients with high-risk NSTACS according to the recommendations of the 2020 clinical practice guidelines during long-term follow-up.
    Methods: This retrospective observational study included 6454 consecutive NSTEACS patients. We analyze the effects of early coronary angiography (< 24 h) in patients with: (a) GRACE risk score > 140 and (b) patients with "established NSTEMI" (non ST-segment elevation myocardial infarction defined by an increase in troponins) or dynamic ST-T-segment changes with a GRACE risk score < 140.
    Results: From 2003 to 2017, 6454 patients with "new high-risk NSTEACS" were admitted, and 6031 (93.45%) of these underwent coronary angiography. After inverse probability of treatment weighting, the long-term cumulative probability of being free of all-cause mortality, cardiovascular mortality and MACE differed significantly due to an early coronary intervention in patients with NSTEACS and GRACE > 140 [HR 0.62 (IC 95% 0.57-0.67), HR 0.62 (IC 95% 0.56-0.68), HR 0.57 (IC 95% 0.53-0.61), respectively]. In patients with NSTEACS and GRACE < 140 with established NSTEMI or ST/T-segment changes, the benefit of the early invasive strategy is only observed in the reduction of MACE [HR 0.62 (IC 95% 0.56-0.68)], but not for total mortality [HR 0.96 (IC 95% 0.78-1.2)] and cardiovascular mortality [HR 0.96 (IC 95% 0.75-1.24)].
    Conclusions: An early invasive management is associated with reduced all-cause mortality, cardiovascular mortality and MACE in NSTEACS with high GRACE risk score. However, this benefit is less evident in the subgroup of patients with a GRACE score < 140 with established NSTEMI or ST/T-segment changes.
    MeSH term(s) Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/mortality ; Acute Coronary Syndrome/therapy ; Aged ; Aged, 80 and over ; Coronary Angiography/methods ; Europe ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Non-ST Elevated Myocardial Infarction/diagnostic imaging ; Non-ST Elevated Myocardial Infarction/mortality ; Non-ST Elevated Myocardial Infarction/therapy ; Practice Guidelines as Topic ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors
    Language English
    Publishing date 2021-03-09
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 2213295-8
    ISSN 1861-0692 ; 1861-0684
    ISSN (online) 1861-0692
    ISSN 1861-0684
    DOI 10.1007/s00392-021-01829-8
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