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  1. AU="Caesar, M"
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  3. AU="Brauer, Heidi R."
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  1. Article: Aging or chronic stress impairs working memory and modulates GABA and glutamate gene expression in prelimbic cortex.

    Gandy, Hannah M / Hollis, Fiona / Hernandez, Caesar M / McQuail, Joseph A

    Frontiers in aging neuroscience

    2024  Volume 15, Page(s) 1306496

    Abstract: The glucocorticoid (GC) hypothesis posits that effects of stress and dysregulated hypothalamic-pituitary-adrenal axis activity accumulate over the lifespan and contribute to impairment of neural function and cognition in advanced aging. The validity of ... ...

    Abstract The glucocorticoid (GC) hypothesis posits that effects of stress and dysregulated hypothalamic-pituitary-adrenal axis activity accumulate over the lifespan and contribute to impairment of neural function and cognition in advanced aging. The validity of the GC hypothesis is bolstered by a wealth of studies that investigate aging of the hippocampus and decline of associated mnemonic functions. The prefrontal cortex (PFC) mediates working memory which also decreases with age. While the PFC is susceptible to stress and GCs, few studies have formally assessed the application of the GC hypothesis to PFC aging and working memory. Using parallel behavioral and molecular approaches, we compared the effects of normal aging versus chronic variable stress (CVS) on working memory and expression of genes that encode for effectors of glutamate and GABA signaling in male F344 rats. Using an operant delayed match-to-sample test of PFC-dependent working memory, we determined that normal aging and CVS each significantly impaired mnemonic accuracy and reduced the total number of completed trials. We then determined that normal aging increased expression of
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2558898-9
    ISSN 1663-4365
    ISSN 1663-4365
    DOI 10.3389/fnagi.2023.1306496
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Electrowetting-Induced Coalescence of Sessile Droplets in Viscous Medium.

    Quintero, Juan Sebastian Marin / Majhy, Butunath / Caesar, Markus / Waghmare, Prashant R

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 14, Page(s) 4917–4923

    Abstract: Manipulating the coalescence of microdroplets has recently gained enormous attention in digital microfluidics and biological and chemical industries. Here, coalescence between two sessile droplets is induced by spreading them due to electrowetting. The ... ...

    Abstract Manipulating the coalescence of microdroplets has recently gained enormous attention in digital microfluidics and biological and chemical industries. Here, coalescence between two sessile droplets is induced by spreading them due to electrowetting. The electrocoalescence dynamics is investigated for a wide range of operating parameters such as electrowetting number, Ohnesorge number, driving frequency, and drop to surrounding medium viscosity ratio. Here, the characteristic time scale from the classical lubrication theory is modified with an additional driving and resisting force due to the electrostatic pressure force and liquid-liquid viscous dissipation, respectively. With the revised characteristic time scale, a universal bridge growth is shown between the two merging droplets following a 1/3 power law during early coalescence followed by a long-range linear variation. To ensure precise control on droplet coalescence, a geometric analysis is also performed to define the initial separation distance.
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.2c03194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Die Chemotherapeutika der Nalidixinsäure-Gruppe

    Caesar, Marlis

    e. Dokumentation

    1984  

    Size VI, 168 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1984
    HBZ-ID HT003078696
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    85 D 1612 order for loan Magazin

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  4. Book ; Thesis: Reliability studies of GaN high electron mobility transistors

    Cäsar, Markus

    (Science for systems ; 22)

    2015  

    Author's details Markus Cäsar
    Series title Science for systems ; 22
    Language English
    Size IV, 162 S., zahlr. Ill. u. graph. Darst., 210 mm x 148 mm
    Publisher Fraunhofer Verlag
    Publishing place Stuttgart
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Freiburg i. Br., 2013
    ISBN 383960897X ; 9783839608975
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Impairments in Fear Extinction Memory and Basolateral Amygdala Plasticity in the TgF344-AD Rat Model of Alzheimer's Disease Are Distinct from Nonpathological Aging.

    Hernandez, Caesar M / Jackson, Nateka L / Hernandez, Abbi R / McMahon, Lori L

    eNeuro

    2022  Volume 9, Issue 3

    Abstract: Fear-based disorders such as post-traumatic stress disorder (PTSD) steepen age-related cognitive decline and double the risk for developing Alzheimer's disease (AD). Because of the seemingly hyperactive properties of fear memories, PTSD symptoms can ... ...

    Abstract Fear-based disorders such as post-traumatic stress disorder (PTSD) steepen age-related cognitive decline and double the risk for developing Alzheimer's disease (AD). Because of the seemingly hyperactive properties of fear memories, PTSD symptoms can worsen with age. Perturbations in the synaptic circuitry supporting fear memory extinction are key neural substrates of PTSD. The basolateral amygdala (BLA) is a medial temporal lobe structure that is critical in the encoding, consolidation, and retrieval of fear memories. As little is known about fear extinction memory and BLA synaptic dysfunction within the context of aging and AD, the goal of this study was to investigate how fear extinction memory deficits and basal amygdaloid nucleus (BA) synaptic dysfunction differentially associate in nonpathologic aging and AD in the TgF344AD (TgAD) rat model of AD. Young, middle-aged, and older-aged WT and TgAD rats were trained on a delay fear conditioning and extinction procedure before
    MeSH term(s) Aging/physiology ; Aging/psychology ; Alzheimer Disease/etiology ; Alzheimer Disease/psychology ; Amygdala/physiopathology ; Animals ; Basolateral Nuclear Complex/physiology ; Disease Models, Animal ; Extinction, Psychological/physiology ; Fear/psychology ; Rats ; Stress Disorders, Post-Traumatic/physiopathology ; Stress Disorders, Post-Traumatic/psychology
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0181-22.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Dante Chr

    CAESAR, MICHAEL

    2013  

    Abstract: First published in 1995. Routledge is an imprint of Taylor & Francis, an informa ... ...

    Abstract First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company
    Language English
    Size Online-Ressource (1213 p)
    Publisher Taylor and Francis
    Publishing place Hoboken
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9780415133975 ; 0415133971
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book: Die Chemotherapeutika der Nalidixinsäure-Gruppe

    Caesar, Marlis / Stille, Wolfgang

    e. Dokumentation

    1984  

    Title variant CHEMOTHERAPEUTIKA DER NALIDIXINSAEURE-GRUPPE
    Author's details M. CAESAR U. W. STILLE
    Keywords Nalidixic Acid / analogs & derivatives ; Chemotherapeutikum ; Nalidixinsäure
    Subject CAS 389-08-2 ; Ethyldihydromethyloxonaphthyridincarbonsäure ; Chemotherapeutika
    Size IX, 168 S. : 30 GRAPH. DARST.
    Publisher ZUCKSCHWERDT
    Publishing place MUENCHEN ; BERN ; WIEN
    Document type Book
    HBZ-ID HT002553207
    ISBN 3-88603-070-9 ; 978-3-88603-070-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1984 B 130 order for loan Magazin

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  8. Article ; Online: GABA

    Hernandez, Caesar M / McQuail, Joseph A / Ten Eyck, Tyler W / Wheeler, Alexa-Rae / Labiste, Chase C / Setlow, Barry / Bizon, Jennifer L

    Neuropharmacology

    2022  Volume 209, Page(s) 109001

    Abstract: The ability to decide adaptively between immediate vs. delayed gratification (intertemporal choice) is critical for well-being and is associated with a range of factors that influence quality of life. In contrast to young adults, many older adults show ... ...

    Abstract The ability to decide adaptively between immediate vs. delayed gratification (intertemporal choice) is critical for well-being and is associated with a range of factors that influence quality of life. In contrast to young adults, many older adults show enhanced preference for delayed gratification; however, the neural mechanisms underlying this age difference in intertemporal choice are largely un-studied. Changes in signaling through GABA
    MeSH term(s) Animals ; Baclofen/pharmacology ; Basolateral Nuclear Complex/physiology ; Choice Behavior/physiology ; Decision Making/physiology ; Delay Discounting/physiology ; Male ; Quality of Life ; Rats ; Receptors, GABA-B ; Reward
    Chemical Substances Receptors, GABA-B ; Baclofen (H789N3FKE8)
    Language English
    Publishing date 2022-02-19
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2022.109001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui I Zs.242: Show issues Location:
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  9. Book ; Online: Application of Deep Q Learning with Simulation Results for Elevator Optimization

    Cao, Zheng / Guo, Raymond / Tuguinay, Caesar M. / Pock, Mark / Gao, Jiayi / Wang, Ziyu

    2022  

    Abstract: This paper presents a methodology for combining programming and mathematics to optimize elevator wait times. Based on simulated user data generated according to the canonical three-peak model of elevator traffic, we first develop a naive model from an ... ...

    Abstract This paper presents a methodology for combining programming and mathematics to optimize elevator wait times. Based on simulated user data generated according to the canonical three-peak model of elevator traffic, we first develop a naive model from an intuitive understanding of the logic behind elevators. We take into consideration a general array of features including capacity, acceleration, and maximum wait time thresholds to adequately model realistic circumstances. Using the same evaluation framework, we proceed to develop a Deep Q Learning model in an attempt to match the hard-coded naive approach for elevator control. Throughout the majority of the paper, we work under a Markov Decision Process (MDP) schema, but later explore how the assumption fails to characterize the highly stochastic overall Elevator Group Control System (EGCS).

    Comment: 16 pages
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Mathematics - Optimization and Control ; 68T07 ; 90-10 ; 93-04 ; I.6 ; G.1.6 ; J.2
    Subject code 006
    Publishing date 2022-09-30
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: A Neuroscience Primer for Integrating Geroscience With the Neurobiology of Aging.

    Hernandez, Caesar M / Hernandez, Abigail R / Hoffman, Jessica M / King, Peter H / McMahon, Lori L / Buford, Thomas W / Carter, Christy / Bizon, Jennifer L / Burke, Sara N

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2023  Volume 77, Issue 1, Page(s) e19–e33

    Abstract: Neuroscience has a rich history of studies focusing on neurobiology of aging. However, much of the aging studies in neuroscience occur outside of the gerosciences. The goal of this primer is 2-fold: first, to briefly highlight some of the history of ... ...

    Abstract Neuroscience has a rich history of studies focusing on neurobiology of aging. However, much of the aging studies in neuroscience occur outside of the gerosciences. The goal of this primer is 2-fold: first, to briefly highlight some of the history of aging neurobiology and second, to introduce to geroscientists the broad spectrum of methodological approaches neuroscientists use to study the neurobiology of aging. This primer is accompanied by a corresponding geroscience primer, as well as a perspective on the current challenges and triumphs of the current divide across these 2 fields. This series of manuscripts is intended to foster enhanced collaborations between neuroscientists and geroscientists with the intent of strengthening the field of cognitive aging through inclusion of parameters from both areas of expertise.
    MeSH term(s) Cognitive Aging ; Geroscience
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glab301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.242/A: Show issues Location:
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