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  1. Article ; Online: Low-intensity pulsed ultrasound increases neurotrophic factors secretion and suppresses inflammation in

    Fontana, Francesco / Iacoponi, Francesco / Orlando, Fabio / Pratellesi, Tiziano / Cafarelli, Andrea / Ricotti, Leonardo

    Journal of neural engineering

    2023  Volume 20, Issue 2

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Humans ; Interleukin-8 ; Interleukin-10 ; Tumor Necrosis Factor-alpha ; Peripheral Nervous System Diseases/therapy ; Reactive Oxygen Species ; Hydrogen Peroxide ; Mechanotransduction, Cellular ; Inflammation/therapy ; Cytokines ; Anti-Inflammatory Agents ; Ultrasonic Waves
    Chemical Substances Interleukin-8 ; Interleukin-10 (130068-27-8) ; Tumor Necrosis Factor-alpha ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Cytokines ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/acc54e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6071: Show issues Location:
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  2. Article ; Online: Optimal low-intensity pulsed ultrasound stimulation for promoting anti-inflammatory effects in macrophages.

    Iacoponi, Francesco / Cafarelli, Andrea / Fontana, Francesco / Pratellesi, Tiziano / Dumont, Erik / Barravecchia, Ivana / Angeloni, Debora / Ricotti, Leonardo

    APL bioengineering

    2023  Volume 7, Issue 1, Page(s) 16114

    Abstract: In this paper, we stimulated M1-like macrophages (obtained from U937 cells) with low-intensity pulsed ultrasound (LIPUS) to lower pro-inflammatory cytokine production. A systematic screening of different frequencies, intensities, duty cycles, and ... ...

    Abstract In this paper, we stimulated M1-like macrophages (obtained from U937 cells) with low-intensity pulsed ultrasound (LIPUS) to lower pro-inflammatory cytokine production. A systematic screening of different frequencies, intensities, duty cycles, and exposure times was performed. The optimal stimulation conditions leading to a marked decrease in the release of inflammatory cytokines were determined to be 38 kHz, 250 mW/cm
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article
    ISSN 2473-2877
    ISSN (online) 2473-2877
    DOI 10.1063/5.0137881
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  3. Article: Pulsatile Drug Delivery System Triggered by Acoustic Radiation Force.

    Ciancia, Sabrina / Cafarelli, Andrea / Zahoranova, Anna / Menciassi, Arianna / Ricotti, Leonardo

    Frontiers in bioengineering and biotechnology

    2020  Volume 8, Page(s) 317

    Abstract: Since biological systems exhibit a circadian rhythm (24-hour cycle), they are susceptible to the timing of drug administration. Indeed, several disorders require a therapy that synchronizes with the onset of symptoms. A targeted therapy with spatially ... ...

    Abstract Since biological systems exhibit a circadian rhythm (24-hour cycle), they are susceptible to the timing of drug administration. Indeed, several disorders require a therapy that synchronizes with the onset of symptoms. A targeted therapy with spatially and temporally precise controlled drug release can guarantee a considerable gain in terms of efficacy and safety of the treatment compared to traditional pharmacological methods, especially for chronotherapeutic disorders. This paper presents a proof of concept of an innovative pulsatile drug delivery system remotely triggered by the acoustic radiation force of ultrasound. The device consists of a case, in which a drug-loaded gel can be embedded, and a sliding top that can be moved on demand by the application of an acoustic stimulus, thus enabling drug release. Results demonstrate for the first time that ultrasound acoustic radiation force (up to 0.1 N) can be used for an efficient pulsatile drug delivery (up to 20 μg of drug released for each shot).
    Language English
    Publishing date 2020-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2020.00317
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  4. Article ; Online: Acoustic Coupling Quantification in Ultrasound-Guided Focused Ultrasound Surgery: Simulation-Based Evaluation and Experimental Feasibility Study.

    Morchi, Laura / Mariani, Andrea / Diodato, Alessandro / Tognarelli, Selene / Cafarelli, Andrea / Menciassi, Arianna

    Ultrasound in medicine & biology

    2020  Volume 46, Issue 12, Page(s) 3305–3316

    Abstract: Adequate acoustic coupling between the therapeutic transducer and the patient's body is essential for safe and efficient focused ultrasound surgery (FUS). There is currently no quantitative method for acoustic coupling verification in ultrasound-guided ... ...

    Abstract Adequate acoustic coupling between the therapeutic transducer and the patient's body is essential for safe and efficient focused ultrasound surgery (FUS). There is currently no quantitative method for acoustic coupling verification in ultrasound-guided FUS. In this work, a quantitative method was developed and a related metric was introduced: the acoustic coupling coefficient. This metric associates the adequacy of the acoustic coupling with the reflected signals recorded through an imaging probe during a low-energy sonication. The acoustic coupling issue was simulated in silico and validated through in vitro tests. Our results indicated a sigmoidal behavior of the introduced metric as the contact surface between the coupling system and the patient's skin increases. The proposed method could be a safety-check criterion for verifying the adequacy of the acoustic coupling before starting the FUS treatment, thus ensuring efficient energy transmission to the target and preventing damage to both the patient and the instrumentation.
    MeSH term(s) Acoustics ; Computer Simulation ; Feasibility Studies ; High-Intensity Focused Ultrasound Ablation/methods ; Surgery, Computer-Assisted ; Ultrasonography, Interventional
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2020.08.028
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Piezoelectric Nanomaterials Activated by Ultrasound: The Pathway from Discovery to Future Clinical Adoption.

    Cafarelli, Andrea / Marino, Attilio / Vannozzi, Lorenzo / Puigmartí-Luis, Josep / Pané, Salvador / Ciofani, Gianni / Ricotti, Leonardo

    ACS nano

    2021  Volume 15, Issue 7, Page(s) 11066–11086

    Abstract: Electrical stimulation has shown great promise in biomedical applications, such as regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical end effectors such as electrodes requires connectors and batteries, which ... ...

    Abstract Electrical stimulation has shown great promise in biomedical applications, such as regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical end effectors such as electrodes requires connectors and batteries, which dramatically hamper the translation of electrical stimulation technologies in several scenarios. Piezoelectric nanomaterials can overcome the limitations of current electrical stimulation procedures as they can be wirelessly activated by external energy sources such as ultrasound. Wireless electrical stimulation mediated by piezoelectric nanoarchitectures constitutes an innovative paradigm enabling the induction of electrical cues within the body in a localized, wireless, and minimally invasive fashion. In this review, we highlight the fundamental mechanisms of acoustically mediated piezoelectric stimulation and its applications in the biomedical area. Yet, the adoption of this technology in a clinical practice is in its infancy, as several open issues, such as piezoelectric properties measurement, control of the ultrasound dose in vitro, modeling and measurement of the piezo effects, knowledge on the triggered bioeffects, therapy targeting, biocompatibility studies, and control of the ultrasound dose delivered in vivo, must be addressed. This article explores the current open challenges in piezoelectric stimulation and proposes strategies that may guide future research efforts in this field toward the translation of this technology to the clinical scene.
    MeSH term(s) Regenerative Medicine ; Electric Stimulation ; Electrodes ; Electricity ; Nanostructures
    Language English
    Publishing date 2021-07-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.1c03087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Acoustic Coupling Quantification in Ultrasound-Guided Focused Ultrasound Surgery: Simulation-Based Evaluation and Experimental Feasibility Study

    Morchi, Laura / Mariani, Andrea / Diodato, Alessandro / Tognarelli, Selene / Cafarelli, Andrea / Menciassi, Arianna

    Ultrasound med. biol

    Abstract: Adequate acoustic coupling between the therapeutic transducer and the patient's body is essential for safe and efficient focused ultrasound surgery (FUS). There is currently no quantitative method for acoustic coupling verification in ultrasound-guided ... ...

    Abstract Adequate acoustic coupling between the therapeutic transducer and the patient's body is essential for safe and efficient focused ultrasound surgery (FUS). There is currently no quantitative method for acoustic coupling verification in ultrasound-guided FUS. In this work, a quantitative method was developed and a related metric was introduced: the acoustic coupling coefficient. This metric associates the adequacy of the acoustic coupling with the reflected signals recorded through an imaging probe during a low-energy sonication. The acoustic coupling issue was simulated in silico and validated through in vitro tests. Our results indicated a sigmoidal behavior of the introduced metric as the contact surface between the coupling system and the patient's skin increases. The proposed method could be a safety-check criterion for verifying the adequacy of the acoustic coupling before starting the FUS treatment, thus ensuring efficient energy transmission to the target and preventing damage to both the patient and the instrumentation.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #33004236
    Database COVID19

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  7. Article ; Online: Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation

    Ricotti, Leonardo / Cafarelli, Andrea / Manferdini, Cristina / Trucco, Diego / Vannozzi, Lorenzo / Gabusi, Elena / Fontana, Francesco / Dolzani, Paolo / Saleh, Yasmin / Lenzi, Enrico / Columbaro, Marta / Piazzi, Manuela / Bertacchini, Jessika / Aliperta, Andrea / Cain, Markys / Gemmi, Mauro / Parlanti, Paola / Jost, Carsten / Fedutik, Yirij /
    Nessim, Gilbert Daniel / Telkhozhayeva, Madina / Teblum, Eti / Dumont, Erik / Delbaldo, Chiara / Codispoti, Giorgia / Martini, Lucia / Tschon, Matilde / Fini, Milena / Lisignoli, Gina

    ACS nano

    2024  Volume 18, Issue 3, Page(s) 2047–2065

    Abstract: The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration of different tissue types. However, it has never been explored for boosting chondrogenesis. ... ...

    Abstract The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration of different tissue types. However, it has never been explored for boosting chondrogenesis. Furthermore, the ultrasound stimulation parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in a nanocomposite hydrogel containing piezoelectric barium titanate nanoparticles and graphene oxide nanoflakes and stimulated with ultrasound waves with precisely controlled parameters (1 MHz and 250 mW/cm
    MeSH term(s) Nanogels ; Chondrogenesis ; Proteomics ; Hydrogels/pharmacology ; Cell Differentiation ; Tissue Engineering
    Chemical Substances Nanogels ; Hydrogels
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c08738
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  8. Article ; Online: Optimal Ultrasound Exposure Conditions for Maximizing C2C12 Muscle Cell Proliferation and Differentiation.

    Salgarella, Alice Rita / Cafarelli, Andrea / Ricotti, Leonardo / Capineri, Lorenzo / Dario, Paolo / Menciassi, Arianna

    Ultrasound in medicine & biology

    2017  Volume 43, Issue 7, Page(s) 1452–1465

    Abstract: Described here is an in vitro systematic investigation of the effects on C2C12 myoblasts of exposure to finely controlled and repeatable low-intensity pulsed ultrasound of different frequencies (500 kHz, 1 MHz, 3 MHz and 5 MHz) and different intensities ( ...

    Abstract Described here is an in vitro systematic investigation of the effects on C2C12 myoblasts of exposure to finely controlled and repeatable low-intensity pulsed ultrasound of different frequencies (500 kHz, 1 MHz, 3 MHz and 5 MHz) and different intensities (250, 500 and 1000 mW/cm
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 186150-5
    ISSN 1879-291X ; 0301-5629
    ISSN (online) 1879-291X
    ISSN 0301-5629
    DOI 10.1016/j.ultrasmedbio.2017.03.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 963: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Piezoelectric Nanomaterials Activated by Ultrasound

    Cafarelli, Andrea / Marino, Attilio / Vannozzi, Lorenzo / Puigmarti-Luis, Josep / Pané, Salvador / Ciofani, Gianni / Ricotti, Leonardo

    ACS Nano, 15 (7)

    The Pathway from Discovery to Future Clinical Adoption

    2021  

    Abstract: Electrical stimulation has shown great promise in biomedical applications, such as regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical end effectors such as electrodes requires connectors and batteries, which ... ...

    Abstract Electrical stimulation has shown great promise in biomedical applications, such as regenerative medicine, neuromodulation, and cancer treatment. Yet, the use of electrical end effectors such as electrodes requires connectors and batteries, which dramatically hamper the translation of electrical stimulation technologies in several scenarios. Piezoelectric nanomaterials can overcome the limitations of current electrical stimulation procedures as they can be wirelessly activated by external energy sources such as ultrasound. Wireless electrical stimulation mediated by piezoelectric nanoarchitectures constitutes an innovative paradigm enabling the induction of electrical cues within the body in a localized, wireless, and minimally invasive fashion. In this review, we highlight the fundamental mechanisms of acoustically mediated piezoelectric stimulation and its applications in the biomedical area. Yet, the adoption of this technology in a clinical practice is in its infancy, as several open issues, such as piezoelectric properties measurement, control of the ultrasound dose in vitro, modeling and measurement of the piezo effects, knowledge on the triggered bioeffects, therapy targeting, biocompatibility studies, and control of the ultrasound dose delivered in vivo, must be addressed. This article explores the current open challenges in piezoelectric stimulation and proposes strategies that may guide future research efforts in this field toward the translation of this technology to the clinical scene.

    ISSN:1936-0851

    ISSN:1936-086X
    Keywords piezoelectric nanomaterials ; ultrasound ; electric stimuli ; piezoelectric effect ; mechanoelectrical transduction ; neuromodulation ; regenerative medicine ; cancer treatment
    Subject code 600
    Language English
    Publishing date 2021-07-27
    Publisher American Chemical Society
    Publishing country ch
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Feedback control of microbubble cavitation for ultrasound-mediated blood-brain barrier disruption in non-human primates under magnetic resonance guidance.

    Kamimura, Hermes As / Flament, Julien / Valette, Julien / Cafarelli, Andrea / Aron Badin, Romina / Hantraye, Philippe / Larrat, Benoît

    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

    2018  Volume 39, Issue 7, Page(s) 1191–1203

    Abstract: Focused ultrasound (FUS) in combination with microbubbles is capable of noninvasive, site-targeted delivery of drugs through the blood-brain barrier (BBB). Although acoustic parameters are reproducible in small animals, their control remains challenging ... ...

    Abstract Focused ultrasound (FUS) in combination with microbubbles is capable of noninvasive, site-targeted delivery of drugs through the blood-brain barrier (BBB). Although acoustic parameters are reproducible in small animals, their control remains challenging in primates due to skull heterogeneity. This study describes a 7-T magnetic resonance (MR)-guided FUS system designed for BBB disruption in non-human primates (NHP) with a robust feedback control based on passive cavitation detection (PCD). Contrast enhanced T
    MeSH term(s) Animals ; Blood-Brain Barrier/diagnostic imaging ; Blood-Brain Barrier/physiology ; Brain/drug effects ; Brain/physiology ; Brain Diseases/drug therapy ; Drug Delivery Systems ; Feedback, Physiological/physiology ; Macaca fascicularis ; Magnetic Resonance Imaging/methods ; Male ; Microbubbles/therapeutic use ; Sonication/methods ; Ultrasonography/methods
    Language English
    Publishing date 2018-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604628-9
    ISSN 1559-7016 ; 0271-678X
    ISSN (online) 1559-7016
    ISSN 0271-678X
    DOI 10.1177/0271678X17753514
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1663: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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