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  1. Article ; Online: North and south: A comprehensive analysis of non-adult growth and health in the industrial revolution (AD 18th-19th C), England.

    Newman, Sophie L / Gowland, Rebecca L / Caffell, Anwen C

    American journal of physical anthropology

    2019  Volume 169, Issue 1, Page(s) 104–121

    Abstract: Objective: Stark health inequalities exist in the present day between the North and South of England, with people in the South, overall, experiencing better health across a range of parameters (e.g., life expectancy and number of years spent in good ... ...

    Abstract Objective: Stark health inequalities exist in the present day between the North and South of England, with people in the South, overall, experiencing better health across a range of parameters (e.g., life expectancy and number of years spent in good health). Bioarchaeological studies of skeletal remains from cemeteries across this geographical divide have the ability to provide a temporal perspective on the etiology, longevity, and nature of this disparity.
    Methods: In total 574 non-adults (0-17 years) from six urban sites (c. AD 1711-1856) were analyzed from the North and South of England. Measurements of long bone length, cortical thickness, and vertebral dimensions were analyzed alongside both skeletal and dental palaeopathological data to assess patterns of disease and growth disruption between skeletal samples.
    Results: There were few significant differences in growth parameters between the six sites in relation to geographical location. However, the northern-based sample Coach Lane (North Shields) demonstrated some of the highest rates of pathology, with metabolic disease being particularly prevalent.
    Discussion: Northern and southern populations suffered alike from the detrimental environmental conditions associated with urban centers of the 18th-19th centuries. However, the elevated prevalence of vitamin D deficiency seen within the Coach Lane sample is indicative of a regionally specific risk that may be related to latitude, and/or the influence of particular industries operating in the North-East.
    MeSH term(s) Adolescent ; Body Height/ethnology ; Child ; Child Development/physiology ; Child Health/ethnology ; Child Health/history ; Child, Preschool ; Dental Enamel Hypoplasia ; England/ethnology ; Femur/anatomy & histology ; History, 18th Century ; History, 19th Century ; Humans ; Industry/history ; Infant ; Paleopathology ; Spine/anatomy & histology ; Stress, Physiological ; Tooth/anatomy & histology ; Vitamin D Deficiency
    Language English
    Publishing date 2019-03-09
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219376-0
    ISSN 1096-8644 ; 0002-9483
    ISSN (online) 1096-8644
    ISSN 0002-9483
    DOI 10.1002/ajpa.23817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.86: Show issues Location:
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  2. Article ; Online: The expendables: Bioarchaeological evidence for pauper apprentices in 19th century England and the health consequences of child labour.

    Gowland, Rebecca L / Caffell, Anwen C / Quade, Leslie / Levene, Alysa / Millard, Andrew R / Holst, Malin / Yapp, Poppy / Delaney, S / Brown, Chloe / Nowell, Geoff / McPherson, Colin / Shaw, Heidi A / Stewart, Nicolas A / Robinson, Sally / Montgomery, Janet / Alexander, Michelle M

    PloS one

    2023  Volume 18, Issue 5, Page(s) e0284970

    Abstract: Child labour is the most common form of child abuse in the world today, with almost half of child workers employed in hazardous industries. The large-scale employment of children during the rapid industrialisation of the late 18th and early 19th ... ...

    Abstract Child labour is the most common form of child abuse in the world today, with almost half of child workers employed in hazardous industries. The large-scale employment of children during the rapid industrialisation of the late 18th and early 19th centuries in England is well documented. During this period, the removal of pauper children from workhouses in cities to work as apprentices in rural mills in the North of England was commonplace. Whilst the experiences of some of these children have been recorded historically, this study provides the first direct evidence of their lives through bioarchaeological analysis. The excavation of a rural churchyard cemetery in the village of Fewston, North Yorkshire, yielded the skeletal remains of 154 individuals, including an unusually large proportion of children aged between 8 to 20 years. A multi-method approach was undertaken, including osteological and palaeopathological examination, stable isotope and amelogenin peptide analysis. The bioarchaeological results were integrated with historical data regarding a local textile mill in operation during the 18th-19th centuries. The results for the children were compared to those obtained from contemporaneous individuals of known identity (from coffin plates) of comparable date. Most of the children exhibited distinctive 'non-local' isotope signatures and a diet low in animal protein when compared to the named local individuals. These children also showed severe growth delays and pathological lesions indicative of early life adversity, as well as respiratory disease, which is a known occupational hazard of mill work. This study has provided unique insights into the harrowing lives of these children; born into poverty and forced to work long hours in dangerous conditions. This analysis provides a stark testimony of the impacts of industrial labour on the health, growth and mortality risk of children, with implications for the present as well as our understanding of the past.
    MeSH term(s) Humans ; History, 19th Century ; Child Labor ; England ; Industry/history ; Isotopes ; Poverty
    Chemical Substances Isotopes
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Scottish soldiers from the Battle of Dunbar 1650: A prosopographical approach to a skeletal assemblage.

    Millard, Andrew R / Annis, Richard G / Caffell, Anwen C / Dodd, Laura L / Fischer, Roman / Gerrard, Christopher M / Graves, C Pamela / Hendy, Jessica / Mackenzie, Lisa / Montgomery, Janet / Nowell, Geoff M / Radini, Anita / Beaumont, Julia / Koon, Hannah E C / Speller, Camilla F

    PloS one

    2020  Volume 15, Issue 12, Page(s) e0243369

    Abstract: After the Battle Dunbar between English and Scottish forces in 1650, captured Scottish soldiers were imprisoned in Durham and many hundreds died there within a few weeks. The partial skeletal remains of 28 of these men were discovered in 2013. Building ... ...

    Abstract After the Battle Dunbar between English and Scottish forces in 1650, captured Scottish soldiers were imprisoned in Durham and many hundreds died there within a few weeks. The partial skeletal remains of 28 of these men were discovered in 2013. Building on previous osteological work, here we report wide-ranging scientific studies of the remains to address the following questions: Did they have comparable diet, health and disease throughout their lives? Did they have common histories of movement (or lack of movement) during their childhoods? Can we create a collective biography of these men? Strontium and oxygen isotope analysis of tooth enamel investigated childhood movement. Carbon and nitrogen isotope analysis of incrementally sampled dentine addressed childhood diet and nutrition. Metaproteomic analysis of dental calculus investigated oral microbiomes and food residues; this was complemented by microscopic analysis of debris in calculus from ingested materials. Selected individuals were examined for dental microwear. The extent of hydroxylation of proline in collagen was examined as a potential biomarker for scurvy. An osteobiography for each man was created using the full range of data generated about him, and these were synthesised using an approach based on the historical method for a collective biography or prosopography. The childhood residences of the men were primarily within the Midland Valley of Scotland, though some spent parts of their childhood outside the British Isles. This is concordant with the known recruitment areas of the Scottish army in 1650. Their diets included oats, brassicas and milk but little seafood, as expected for lowland rather than highland diets of the period. Childhood periods of starvation or illness were almost ubiquitous, but not simultaneous, suggesting regionally variable food shortages in the 1620s and 1630s. It is likely there was widespread low-level scurvy, ameliorating in later years of life, which suggests historically unrecorded shortages of fruit and vegetables in the early 1640s. Almost all men were exposed to burnt plant matter, probably as inhaled soot, and this may relate to the high proportion of them with of sinusitis. Interpersonal violence causing skeletal trauma was rare. Based on commonalities in their osteobiographies, we argue that these men were drawn from the same stratum of society. This study is perhaps the most extensive to date of individuals from 17th century Scotland. Combined with a precise historical context it allows the lives of these men to be investigated and compared to the historical record with unprecedented precision. It illustrates the power of archaeological science methods to confirm, challenge and complement historical evidence.
    MeSH term(s) Archaeology ; Dental Enamel/metabolism ; Diet/history ; Energy Intake ; History, 17th Century ; Humans ; Male ; Military Personnel ; Scotland ; Scurvy/history ; Scurvy/metabolism ; Scurvy/pathology
    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0243369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Genotype of a historic strain of Mycobacterium tuberculosis.

    Bouwman, Abigail S / Kennedy, Sandra L / Müller, Romy / Stephens, Richard H / Holst, Malin / Caffell, Anwen C / Roberts, Charlotte A / Brown, Terence A

    Proceedings of the National Academy of Sciences of the United States of America

    2012  Volume 109, Issue 45, Page(s) 18511–18516

    Abstract: The use of ancient DNA in paleopathological studies of tuberculosis has largely been restricted to confirmation of disease identifications made by skeletal analysis; few attempts at obtaining genotype data from archaeological samples have been made ... ...

    Abstract The use of ancient DNA in paleopathological studies of tuberculosis has largely been restricted to confirmation of disease identifications made by skeletal analysis; few attempts at obtaining genotype data from archaeological samples have been made because of the need to perform different PCRs for each genetic locus being studied in an ancient DNA extract. We used a next generation sequencing approach involving hybridization capture directed at specific polymorphic regions of the Mycobacterium tuberculosis genome to identify a detailed genotype for a historic strain of M. tuberculosis from an individual buried in the 19th century St. George's Crypt, Leeds, West Yorkshire, England. We obtained 664,500 sequencing by oligonucleotide ligation and detection (SOLiD) reads that mapped to the targeted regions of the M. tuberculosis genome; the coverage included 218 of 247 SNPs, 10 of 11 insertion/deletion regions, and the repeat elements IS1081 and IS6110. The accuracy of the SOLiD data was checked by conventional PCRs directed at 11 SNPs and two insertion/deletions. The data placed the historic strain of M. tuberculosis in a group that is uncommon today, but it is known to have been present in North America in the early 20th century. Our results show the use of hybridization capture followed by next generation sequencing as a means of obtaining detailed genotypes of ancient varieties of M. tuberculosis, potentially enabling meaningful comparisons between strains from different geographic locations and different periods in the past.
    MeSH term(s) Bacterial Typing Techniques ; Base Sequence ; England ; Female ; Genome, Bacterial/genetics ; Genotype ; Humans ; Molecular Sequence Data ; Mycobacterium tuberculosis/genetics ; Oligonucleotides/genetics ; Paleontology ; Phylogeny ; Polymerase Chain Reaction ; Sequence Alignment ; Sequence Analysis, DNA
    Chemical Substances Oligonucleotides
    Language English
    Publishing date 2012-10-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1209444109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Genotype of a historic strain of Mycobacterium tuberculosis

    Bouwman, Abigail S. / Kennedy, Sandra L. / Müller, Romy / Stephens, Richard H. / Holst, Malin / Caffell, Anwen C. / Roberts, Charlotte A. / Brown, Terence A.

    Proceedings of the National Academy of Sciences of the United States of America

    Volume v. 109,, Issue no. 4

    Abstract: The use of ancient DNA in paleopathological studies of tuberculosis has largely been restricted to confirmation of disease identifications made by skeletal analysis; few attempts at obtaining genotype data from archaeological samples have been made ... ...

    Abstract The use of ancient DNA in paleopathological studies of tuberculosis has largely been restricted to confirmation of disease identifications made by skeletal analysis; few attempts at obtaining genotype data from archaeological samples have been made because of the need to perform different PCRs for each genetic locus being studied in an ancient DNA extract. We used a next generation sequencing approach involving hybridization capture directed at specific polymorphic regions of the Mycobacterium tuberculosis genome to identify a detailed genotype for a historic strain of M. tuberculosis from an individual buried in the 19th century St. George’s Crypt, Leeds, West Yorkshire, England. We obtained 664,500 sequencing by oligonucleotide ligation and detection (SOLiD) reads that mapped to the targeted regions of the M. tuberculosis genome; the coverage included 218 of 247 SNPs, 10 of 11 insertion/deletion regions, and the repeat elements IS1081 and IS6110. The accuracy of the SOLiD data was checked by conventional PCRs directed at 11 SNPs and two insertion/deletions. The data placed the historic strain of M. tuberculosis in a group that is uncommon today, but it is known to have been present in North America in the early 20th century. Our results show the use of hybridization capture followed by next generation sequencing as a means of obtaining detailed genotypes of ancient varieties of M. tuberculosis , potentially enabling meaningful comparisons between strains from different geographic locations and different periods in the past.
    Keywords tuberculosis ; single nucleotide polymorphism ; oligonucleotides ; DNA ; loci ; genotype ; hybridization ; genome ; polymerase chain reaction ; high-throughput nucleotide sequencing ; Mycobacterium tuberculosis
    Language English
    Document type Article
    ISSN 0027-8424
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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