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  1. Article ; Online: Noninvasive Characterization of Metabolic Changes in Ischemic Stroke Using Z-spectrum-fitted Multiparametric Chemical Exchange Saturation Transfer-weighted Magnetic Resonance Imaging.

    Wang, Zhen-Xiong / Wei, Xin-Hua / Cai, Ke-Jia / Zhu, Wen-Zhen / Su, Chang-Liang

    Current medical science

    2023  Volume 43, Issue 5, Page(s) 970–978

    Abstract: Objective: This study aimed to noninvasively characterize the metabolic alterations in ischemic brain tissues using Z-spectrum-fitted multiparametric chemical exchange saturation transfer-weighted magnetic resonance imaging (CEST-MRI).: Methods: ... ...

    Abstract Objective: This study aimed to noninvasively characterize the metabolic alterations in ischemic brain tissues using Z-spectrum-fitted multiparametric chemical exchange saturation transfer-weighted magnetic resonance imaging (CEST-MRI).
    Methods: Three sets of Z-spectrum data with saturation power (B
    Results: Ischemic lesions showed increased APT
    Conclusion: The Z-spectrum-fitted multiparametric CEST-MRI can comprehensively detect metabolic alterations in ischemic brain tissues.
    Language English
    Publishing date 2023-09-11
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-023-2785-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Neurite Orientation Dispersion and Density Imaging of Rat Brain Microstructural Changes due to Middle Cerebral Artery Occlusion at a 3T MRI.

    Wang, Zhen-Xiong / Zhu, Wen-Zhen / Zhang, Shun / Shaghaghi, Mehran / Cai, Ke-Jia

    Current medical science

    2021  Volume 41, Issue 1, Page(s) 167–172

    Abstract: The purpose of this work was to demonstrate the feasibility of neurite orientation dispersion and density imaging (NODDI) in characterizing the brain tissue microstructural changes of middle cerebral artery occlusion (MCAO) in rats at 3T MRI, and to ... ...

    Abstract The purpose of this work was to demonstrate the feasibility of neurite orientation dispersion and density imaging (NODDI) in characterizing the brain tissue microstructural changes of middle cerebral artery occlusion (MCAO) in rats at 3T MRI, and to validate NODDI metrics with histology. A multi-shell diffusion MRI protocol was performed on 11 MCAO rats and 10 control rats at different post-operation time points of 0.5, 2, 6, 12, 24 and 72 h. NODDI orientation dispersion index (ODI) and intracellular volume fraction (V
    MeSH term(s) Animals ; Brain/diagnostic imaging ; Brain/pathology ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Male ; Neurites/pathology ; Rats ; Rats, Wistar ; Sensitivity and Specificity
    Language English
    Publishing date 2021-02-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-021-2332-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Cosmetic improvement in various acute skin defects treated with tissue-engineered skin.

    Nie, Xin / Zhang, Jie Yong / Cai, Ke Jia / Yang, Ming Hong / Xiao, An Hou / Da Hu, Hai / Liu, Lin Ya / Wang, Han Jia / Wen, Ning / Jin, Yan

    Artificial organs

    2007  Volume 31, Issue 9, Page(s) 703–710

    Abstract: Acute skin defects often cause many adverse events such as abnormal pigmentation and scar formation, the satisfactory healing of which remains a significant clinical challenge. Over the past several decades, a number of skin equivalents have been ... ...

    Abstract Acute skin defects often cause many adverse events such as abnormal pigmentation and scar formation, the satisfactory healing of which remains a significant clinical challenge. Over the past several decades, a number of skin equivalents have been available for clinical purposes to promote wound closure. However, the true values of skin equivalent - tissue-engineered skin (TE-skin) composed of neonatal fibroblasts and keratinocytes - in improving the quality of wound healing are not yet elucidated. A total of 158 patients were enrolled, 129 of which were used in this study. In these patients, acute skin defects were treated with TE-skin as experimental group, and treated with Vaseline primary dressing as control group. The differences in average healing times between the two groups were determined with statistical analysis according to different depths of skin defects. Wound quality, including pigmentation, cicatrization, and pliability, was assessed by investigators from different clinical centers over a 6-month period. The cosmetic outcome of the wound was further evaluated with histological method. In the study, the average time of wound closure in the experimental group was significantly shortened by 6.5 to 20 days according to different depths of skin defects. The cosmetic quality of reconstructed skin was satisfactory, with the patients enjoying better pliability, less abnormal pigmentation, and cicatrization. Safety analysis demonstrated that the wounds treated with TE-skin did not show clinical or laboratory evidence of rejection during the trial. These results indicate that TE-skin is a suitable and clinically effective treatment for various acute skin defects. Furthermore, the TE-skin appears to produce more satisfactory cosmetic results when compared with the conventional therapy.
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological Dressings/adverse effects ; Cells, Cultured ; Child ; Child, Preschool ; China ; Female ; Fibroblasts ; Humans ; Infant ; Keratinocytes ; Male ; Middle Aged ; Patient Satisfaction ; Skin Diseases/pathology ; Skin Diseases/physiopathology ; Skin Diseases/therapy ; Skin, Artificial/adverse effects ; Time Factors ; Tissue Engineering/methods ; Treatment Outcome ; Wound Healing
    Language English
    Publishing date 2007-09
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 441812-8
    ISSN 1525-1594 ; 0160-564X
    ISSN (online) 1525-1594
    ISSN 0160-564X
    DOI 10.1111/j.1525-1594.2007.00443.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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