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Article ; Online: Comparative analysis of the effectiveness difference of SARS-COV-2 mRNA vaccine in different populations in the real world: A review.

Cai, Sihui / Chang, Chunyan / Zhang, Xiuhong / Qiao, Weizhen

2023 Volume 102, Issue 34, Page(s) e34805

Abstract: Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around the world. Vaccines are an important means to prevent the spread of COVID-19 and reduce severe disease and mortality. Currently, ... ...

Abstract	Coronavirus disease 2019 (COVID-19) has ravaged the world since December 2019. Up to now, it is still prevalent around the world. Vaccines are an important means to prevent the spread of COVID-19 and reduce severe disease and mortality. Currently, different types of novel coronavirus vaccines are still being developed and improved, and the relevant vaccines that have been approved for marketing have been widely vaccinated around the world. As vaccination coverage continues to grow, concerns about the efficacy and safety of vaccines after real-world use have grown. Some clinical studies have shown that vaccine effectiveness is closely related to antibody response after vaccination. Among them, the advantages of COVID-19 messenger ribonucleic acid (mRNA) vaccine, such as better adaptability to variant strains and better immune response ability, have attracted great attention. However, different populations with different genders, ages, previous COVID-19 infection history, underlying diseases and treatments will show different antibody responses after mRNA vaccination, which will affect the protection of the vaccine. Based on this, this paper reviews the reports related severe acute respiratory syndrome Coronavirus 2 mRNA vaccines, and summarizes the effectiveness of vaccines in different populations and different disease states and looked forward to the precise vaccination strategy of the vaccine in the future.
MeSH term(s)	Female ; Male ; Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; RNA, Messenger ; mRNA Vaccines
Chemical Substances	COVID-19 Vaccines ; RNA, Messenger ; mRNA Vaccines
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034805
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Molecular mechanisms and cellular functions of liquid-liquid phase separation during antiviral immune responses.

Yang, Shuai / Shen, Weishan / Hu, Jiajia / Cai, Sihui / Zhang, Chenqiu / Jin, Shouheng / Guan, Xiangdong / Wu, Jianfeng / Wu, Yaoxing / Cui, Jun

Frontiers in immunology

2023 Volume 14, Page(s) 1162211

Abstract: Spatiotemporal separation of cellular components is vital to ensure biochemical processes. Membrane-bound organelles such as mitochondria and nuclei play a major role in isolating intracellular components, while membraneless organelles (MLOs) are ... ...

Abstract	Spatiotemporal separation of cellular components is vital to ensure biochemical processes. Membrane-bound organelles such as mitochondria and nuclei play a major role in isolating intracellular components, while membraneless organelles (MLOs) are accumulatively uncovered
MeSH term(s)	Antiviral Agents ; Cell Nucleus ; Immunity
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-05-10
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1162211
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Article ; Online: Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice.

Zheng, Yanyan / Wang, Liqiu / Liu, Qingxiang / Xian, Huifang / Zhang, Chenqiu / Cai, Sihui / Yang, Shuai / Jin, Shouheng / Cui, Jun

Nature microbiology

2023 Volume 8, Issue 5, Page(s) 958–972

Abstract: Microglia and astrocytes are subgroups of brain glia cells that support and protect neurons within the central nervous system (CNS). At early stages of viral infection in the CNS, they are predominant responding cells and lead to recruitment of ... ...

Abstract	Microglia and astrocytes are subgroups of brain glia cells that support and protect neurons within the central nervous system (CNS). At early stages of viral infection in the CNS, they are predominant responding cells and lead to recruitment of peripheral immune cells for viral clearance. Inhibitor of nuclear factor κB kinase subunit epsilon (IKKi) is critical for type I interferon signalling and inflammation, which modulate heterogenic immune responses during CNS infection. Balanced autophagy is vital to maintain brain integrity, yet regulation of autophagy and immune activity within brain glia cells is poorly understood. Here we identify SHISA9 as an autophagy cargo receptor that mediates the autophagy-dependent degradation of IKKi during herpes simplex virus type 1 infection. IKKi is recognized by SHISA9 through unanchored K48-linked poly-ubiquitin chains and bridged to autophagosome membrane components GABARAPL1. Single-cell RNA sequencing analysis shows that SHISA9 has temporal characteristics while modulating both antiviral and inflammatory responses in microglia and astrocytes at different stages during viral infection. We found that Shisa9
MeSH term(s)	Animals ; Mice ; Autophagy ; Brain/metabolism ; Central Nervous System ; Neuroinflammatory Diseases/metabolism ; Virus Diseases/metabolism
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-023-01357-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The needs and concerns of clinical educators in radiography education in the face of COVID-19 pandemic.

Tay, Yi Xiang / Cai, Sihui / Chow, Hwei Chuin / Lai, Christopher

Journal of medical imaging and radiation sciences

2020 Volume 52, Issue 1, Page(s) 3–8

MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Clinical Clerkship ; Clinical Competence ; Humans ; Infection Control ; Pandemics ; Radiography ; Radiology/education ; SARS-CoV-2 ; Singapore/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2426513-5
ISSN	1876-7982 ; 1939-8654
ISSN (online)	1876-7982
ISSN	1939-8654
DOI	10.1016/j.jmir.2020.10.004
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Article: Challenges and optimization strategies in medical imaging service delivery during COVID-19.

Tay, Yi Xiang / Kothan, Suchart / Kada, Sundaran / Cai, Sihui / Lai, Christopher Wai Keung

World journal of radiology

2021 Volume 13, Issue 5, Page(s) 102–121

Abstract: In coronavirus disease 2019 (COVID-19), medical imaging plays an essential role in the diagnosis, management and disease progression surveillance. Chest radiography and computed tomography are commonly used imaging techniques globally during this ... ...

Abstract	In coronavirus disease 2019 (COVID-19), medical imaging plays an essential role in the diagnosis, management and disease progression surveillance. Chest radiography and computed tomography are commonly used imaging techniques globally during this pandemic. As the pandemic continues to unfold, many healthcare systems worldwide struggle to balance the heavy strain due to overwhelming demand for healthcare resources. Changes are required across the entire healthcare system and medical imaging departments are no exception. The COVID-19 pandemic had a devastating impact on medical imaging practices. It is now time to pay further attention to the profound challenges of COVID-19 on medical imaging services and develop effective strategies to get ahead of the crisis. Additionally, preparation for operations and survival in the post-pandemic future are necessary considerations. This review aims to comprehensively examine the challenges and optimization of delivering medical imaging services in relation to the current COVID-19 global pandemic, including the role of medical imaging during these challenging times and potential future directions post-COVID-19.
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573705-3
ISSN	1949-8470
ISSN	1949-8470
DOI	10.4329/wjr.v13.i5.102
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Article ; Online: OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity.

Xie, Weihong / Tian, Shuo / Yang, Jiahui / Cai, Sihui / Jin, Shouheng / Zhou, Tao / Wu, Yaoxing / Chen, Zhiyun / Ji, Yanqin / Cui, Jun

Autophagy

2022 Volume 18, Issue 10, Page(s) 2288–2302

Abstract: Deubiquitination plays an important role in the regulation of the crosstalk between macroautophagy/autophagy and innate immune signaling, yet its regulatory mechanisms are not fully understood. Here we identify the deubiquitinase OTUD7B as a negative ... ...

Abstract	Deubiquitination plays an important role in the regulation of the crosstalk between macroautophagy/autophagy and innate immune signaling, yet its regulatory mechanisms are not fully understood. Here we identify the deubiquitinase OTUD7B as a negative regulator of antiviral immunity by targeting IRF3 (interferon regulatory factor 3) for selective autophagic degradation. Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin chains at lysine 7 (K7) to enhance SQSTM1 oligomerization. Moreover, viral infection increased the expression of OTUD7B, which forms a negative feedback loop by promoting IRF3 degradation to balance type I interferon (IFN) signaling. Taken together, our study reveals a specific role of OTUD7B in mediating the activation of cargo receptors in a substrate-dependent manner, which could be a potential target against excessive immune responses.
MeSH term(s)	Antiviral Agents ; Autophagy ; Deubiquitinating Enzymes/metabolism ; Dextrans/metabolism ; Green Fluorescent Proteins/metabolism ; I-kappa B Kinase ; Immunity, Innate/genetics ; Interferon Regulatory Factor-3/metabolism ; Interferon Type I/metabolism ; Lysine ; Nucleotidyltransferases/metabolism ; Pathogen-Associated Molecular Pattern Molecules ; RNA, Small Interfering ; Sequestosome-1 Protein/metabolism ; Ubiquitins/metabolism
Chemical Substances	Antiviral Agents ; Dextrans ; Interferon Regulatory Factor-3 ; Interferon Type I ; Pathogen-Associated Molecular Pattern Molecules ; RNA, Small Interfering ; Sequestosome-1 Protein ; Ubiquitins ; Green Fluorescent Proteins (147336-22-9) ; I-kappa B Kinase (EC 2.7.11.10) ; Nucleotidyltransferases (EC 2.7.7.-) ; Deubiquitinating Enzymes (EC 3.4.19.12) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2022.2026098
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis.

Zhi, Feng / Li, Bowen / Zhang, Chuanxia / Xia, Fan / Wang, Rong / Xie, Weihong / Cai, Sihui / Zhang, Dawei / Kong, Ren / Hu, Yiqiao / Yang, Yilin / Peng, Ya / Cui, Jun

Nature communications

2023 Volume 14, Issue 1, Page(s) 6069

Abstract: The PI3K/AKT pathway plays an essential role in tumour development. NOD-like receptors (NLRs) regulate innate immunity and are implicated in cancer, but whether they are involved in PI3K/AKT pathway regulation is poorly understood. Here, we report that ... ...

Abstract	The PI3K/AKT pathway plays an essential role in tumour development. NOD-like receptors (NLRs) regulate innate immunity and are implicated in cancer, but whether they are involved in PI3K/AKT pathway regulation is poorly understood. Here, we report that NLRP6 potentiates the PI3K/AKT pathway by binding and destabilizing p85α, the regulatory subunit of PI3K. Mechanistically, NLRP6 recruits the E3 ligase RBX1 to p85α and ubiquitinates lysine 256 on p85α, which is recognized by the autophagy cargo receptor OPTN, causing selective autophagic degradation of p85α and subsequent activation of the PI3K/AKT pathway by reducing PTEN stability. We further show that loss of NLRP6 suppresses cell proliferation, colony formation, cell migration, and tumour growth in glioblastoma cells in vitro and in vivo. Disruption of the NLRP6/p85α interaction using the Pep9 peptide inhibits the PI3K/AKT pathway and generates potent antitumour effects. Collectively, our results suggest that NLRP6 promotes p85α degradation via selective autophagy to drive tumorigenesis, and the interaction between NLRP6 and p85α can be a promising therapeutic target for tumour treatment.
MeSH term(s)	Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction ; Carcinogenesis ; Autophagy ; Intracellular Signaling Peptides and Proteins/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; NLRP6 protein, human ; Intracellular Signaling Peptides and Proteins
Language	English
Publishing date	2023-09-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41739-z
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Article ; Online: Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex.

Cai, Sihui / Zhang, Chenqiu / Zhuang, Zhen / Zhang, Shengnan / Ma, Ling / Yang, Shuai / Zhou, Tao / Wang, Zheyu / Xie, Weihong / Jin, Shouheng / Zhao, Jincun / Guan, Xiangdong / Wu, Jianfeng / Cui, Jun / Wu, Yaoxing

Signal transduction and targeted therapy

2023 Volume 8, Issue 1, Page(s) 170

Abstract: Currently, the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide. COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon (IFN-I) signal, along with limited activation of antiviral immune responses as ... ...

Abstract	Currently, the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide. COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon (IFN-I) signal, along with limited activation of antiviral immune responses as well as enhanced viral infectivity. Dramatic progresses have been made in revealing the multiple strategies employed by SARS-CoV-2 in impairing canonical RNA sensing pathways. However, it remains to be determined about the SARS-CoV-2 antagonism of cGAS-mediated activation of IFN responses during infection. In the current study, we figure out that SARS-CoV-2 infection leads to the accumulation of released mitochondria DNA (mtDNA), which in turn triggers cGAS to activate IFN-I signaling. As countermeasures, SARS-CoV-2 nucleocapsid (N) protein restricts the DNA recognition capacity of cGAS to impair cGAS-induced IFN-I signaling. Mechanically, N protein disrupts the assembly of cGAS with its co-factor G3BP1 by undergoing DNA-induced liquid-liquid phase separation (LLPS), subsequently impairs the double-strand DNA (dsDNA) detection ability of cGAS. Taken together, our findings unravel a novel antagonistic strategy by which SARS-CoV-2 reduces DNA-triggered IFN-I pathway through interfering with cGAS-DNA phase separation.
MeSH term(s)	Humans ; COVID-19/genetics ; DNA ; DNA Helicases/genetics ; Interferon Type I/genetics ; Nucleocapsid Proteins/genetics ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Poly-ADP-Ribose Binding Proteins/genetics ; RNA Helicases/genetics ; RNA Recognition Motif Proteins/genetics ; SARS-CoV-2/genetics
Chemical Substances	DNA (9007-49-2) ; DNA Helicases (EC 3.6.4.-) ; G3BP1 protein, human (EC 3.6.4.12) ; Interferon Type I ; Nucleocapsid Proteins ; Nucleotidyltransferases (EC 2.7.7.-) ; Poly-ADP-Ribose Binding Proteins ; RNA Helicases (EC 3.6.4.13) ; RNA Recognition Motif Proteins ; cGAS protein, human (EC 2.7.7.-) ; nucleocapsid phosphoprotein, SARS-CoV-2
Language	English
Publishing date	2023-04-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2886872-9
ISSN	2059-3635 ; 2095-9907
ISSN (online)	2059-3635
ISSN	2095-9907
DOI	10.1038/s41392-023-01420-9
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Article ; Online: cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence.

Li, Xiaocui / Li, Xiaojuan / Xie, Chen / Cai, Sihui / Li, Mengqiu / Jin, Heping / Wu, Shu / Cui, Jun / Liu, Haiying / Zhao, Yong

Protein & cell

2021 Volume 13, Issue 1, Page(s) 47–64

Abstract: As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in ... ...

Abstract	As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DSB) repair and protecting short telomeres from end-to-end fusion independent of the canonical cGAS-STING pathway. cGAS associates with telomeric/subtelomeric DNA during mitosis when TRF1/TRF2/POT1 are deficient on telomeres. Depletion of cGAS leads to mitotic chromosome end-to-end fusions predominantly occurring between short telomeres. Mechanistically, cGAS interacts with CDK1 and positions them to chromosome ends. Thus, CDK1 inhibits mitotic non-homologous end joining (NHEJ) by blocking the recruitment of RNF8. cGAS-deficient human primary cells are defective in entering replicative senescence and display chromosome end-to-end fusions, genome instability and prolonged growth arrest. Altogether, cGAS safeguards genome stability by controlling mitotic DSB repair to inhibit mitotic chromosome end-to-end fusions, thus facilitating replicative senescence.
MeSH term(s)	Cellular Senescence ; Chromosomes, Human/genetics ; Chromosomes, Human/metabolism ; Genomic Instability ; HeLa Cells ; Humans ; Mitosis ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Telomere/genetics ; Telomere/metabolism
Chemical Substances	Nucleotidyltransferases (EC 2.7.7.-) ; cGAS protein, human (EC 2.7.7.-)
Language	English
Publishing date	2021-10-22
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2543451-2
ISSN	1674-8018 ; 1674-800X
ISSN (online)	1674-8018
ISSN	1674-800X
DOI	10.1007/s13238-021-00879-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The needs and concerns of clinical educators in radiography education in the face of COVID-19 pandemic

Tay, Yi Xiang / Cai, Sihui / Chow, Hwei Chuin / Lai, Christopher

Journal of medical imaging and radiation sciences (Online)

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #872270
Database	COVID19

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