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  1. Article: A comparative study of the antioxidant and intestinal protective effects of extracts from different parts of Java tea (Orthosiphon stamineus)

    Cai, Xuan

    Food Science & Nutrition, 6(3):579-584

    2018  

    Abstract: The aim of this study was to compare the free radical scavenging ability and intestinal epithelial cell protective effects of Java tea (Orthosiphon stamineus) root extracts (ORE), stem extracts (OSE), and leaf extracts (OLE) to determine the potential of ...

    Abstract The aim of this study was to compare the free radical scavenging ability and intestinal epithelial cell protective effects of Java tea (Orthosiphon stamineus) root extracts (ORE), stem extracts (OSE), and leaf extracts (OLE) to determine the potential of Java tea by‐products. The Java tea extracts were prepared using a standard water–ethanol method. The antioxidant activity and intestinal protective effects were tested by H2O2‐induced cell model and high‐fat diet‐induced mice model, respectively. The results showed that the total phenolic acid and flavonoid content and relative content were different in the ORE, OSE, and OLE. ORE had the highest total polyphenol and flavonoid content, the highest free radical scavenging rate, and the highest intracellular free radical scavenging rate. However, the yeast content in the ORE was lower than that in the OSE and OLE. All the Java tea extracts protected mouse intestine from high‐fat diet‐induced oxidative injury. This study indicates the potential of Java tea extracts as food or feed additives to protect the intestine from oxidative stress.
    Keywords Java tea ; Orthosiphon stamineus ; antioxidant ; intestinal epithelial cell ; mice
    Language English
    Document type Article
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  2. Book: Mapping irrigated areas in the Limpopo Province, South Africa

    Cai, Xueliang

    (IWMI working paper ; 172)

    2017  

    Author's details Xueliang Cai [und 3 weitere]
    Series title IWMI working paper ; 172
    IWMI working papers
    Collection IWMI working papers
    Language English
    Size ix, 27 Seiten, Diagramme, Karten
    Publisher International Water Management Institute (IWMI)
    Publishing place Colombo
    Publishing country Sri Lanka
    Document type Book
    HBZ-ID HT019341370
    ISBN 978-92-9090-851-7 ; 92-9090-851-3
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    174/42 available for loan (reading room) Freihandmagazin (U1)

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  3. Book: Laparoscopic hepatectomy

    Cai, Xiujun

    atlas and techniques

    2015  

    Author's details Xiujun Cai
    Language English
    Size XXVIII, 302 S. : zahlr. Ill.
    Publisher Zhejiang Univ. Press u.a.
    Publishing place Hangzhou
    Publishing country China
    Document type Book
    HBZ-ID HT018651687
    ISBN 978-94-017-9839-6 ; 978-7-308-14361-5 ; 9789401798402 ; 94-017-9839-7 ; 7-308-14361-9 ; 9401798400
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 1913 available for loan (reading room) Lesesaal EG

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  4. Article: [Advances in the diagnosis and management of sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation].

    Cai, X / Zhang, X H

    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

    2022  Volume 42, Issue 12, Page(s) 1052–1056

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Hepatic Veno-Occlusive Disease/diagnosis ; Hepatic Veno-Occlusive Disease/etiology ; Hepatic Veno-Occlusive Disease/therapy ; Humans ; Transplantation Conditioning
    Language Chinese
    Publishing date 2022-01-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 2997162-7
    ISSN 0253-2727 ; 0253-2727
    ISSN (online) 0253-2727
    ISSN 0253-2727
    DOI 10.3760/cma.j.issn.0253-2727.2021.12.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: An assessment of crop water productivity in the Indus and Ganges river basins

    Cai, Xueliang

    current status and scope for improvement

    (IWMI research report ; 140)

    2010  

    Author's details Xueliang Cai
    Series title IWMI research report ; 140
    Research report / International Water Management Institute
    Collection Research report / International Water Management Institute
    Language English
    Size VII, 22 S. : graph. Darst., Kt.
    Publisher IWMI
    Publishing place Colombo
    Publishing country Sri Lanka
    Document type Book
    HBZ-ID HT017202856
    ISBN 978-92-9090-735-0 ; 92-9090-735-5
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    124/474 available for loan (reading room) Freihandmagazin (U1)

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  6. Article: Enrichment and Diversification of the Wheat Genome via Alien Introgression.

    Boehm, Jeffrey / Cai, Xiwen

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Wheat, including durum and common wheat, respectively, is an allopolyploid with two or three homoeologous subgenomes originating from diploid wild ancestral species. The wheat genome's polyploid origin consisting of just three diploid ancestors has ... ...

    Abstract Wheat, including durum and common wheat, respectively, is an allopolyploid with two or three homoeologous subgenomes originating from diploid wild ancestral species. The wheat genome's polyploid origin consisting of just three diploid ancestors has constrained its genetic variation, which has bottlenecked improvement. However, wheat has a large number of relatives, including cultivated crop species (e.g., barley and rye), wild grass species, and ancestral species. Moreover, each ancestor and relative has many other related subspecies that have evolved to inhabit specific geographic areas. Cumulatively, they represent an invaluable source of genetic diversity and variation available to enrich and diversify the wheat genome. The ancestral species share one or more homologous genomes with wheat, which can be utilized in breeding efforts through typical meiotic homologous recombination. Additionally, genome introgressions of distant relatives can be moved into wheat using chromosome engineering-based approaches that feature induced meiotic homoeologous recombination. Recent advances in genomics have dramatically improved the efficacy and throughput of chromosome engineering for alien introgressions, which has served to boost the genetic potential of the wheat genome in breeding efforts. Here, we report research strategies and progress made using alien introgressions toward the enrichment and diversification of the wheat genome in the genomics era.
    Language English
    Publishing date 2024-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13030339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Maxillary first molar with two distobuccal root canals and cervical deformity: A case report.

    Cai, Xue / Tang, Rentao

    Clinical case reports

    2024  Volume 12, Issue 2, Page(s) e8555

    Abstract: The second distobuccal canal in the maxillary first molar is often missed because of the low prevalence rate (0%-4%). The article reports this kind of variation in one case. Promising outcomes have continued up to the present (2-year follow-up). ...

    Abstract The second distobuccal canal in the maxillary first molar is often missed because of the low prevalence rate (0%-4%). The article reports this kind of variation in one case. Promising outcomes have continued up to the present (2-year follow-up).
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Neural Instantiation of an Abstract Cognitive Map for Economic Choice.

    Cai, Xinying

    Neuroscience

    2021  Volume 477, Page(s) 106–114

    Abstract: Since the discovery of cognitive maps in rodent hippocampus (HC), the cognitive map has evolved from originally referring to spatial representations encoding locations and objects in Euclidean spaces to a general low-dimensional organization of ... ...

    Abstract Since the discovery of cognitive maps in rodent hippocampus (HC), the cognitive map has evolved from originally referring to spatial representations encoding locations and objects in Euclidean spaces to a general low-dimensional organization of information along selected feature dimensions. A cognitive map includes hypothetical constructs that bridge between environmental stimuli and the final overt behavior. To neuroeconomists, utility and utility functions are such constructs with neurobiological basis that drive choice behavior. Emergence of distinct functional neuron groups in the primate orbitofrontal cortex (OFC) during simple economic choice indicates the formation of an abstract cognitive map for organizing information of goods for value computation. Experimental evidence suggests that organization of neuronal activity in such cognitive map reflects the abstraction of core task features. Thus, such map can be adapted to accommodate economic choices under various task contexts.
    MeSH term(s) Adaptation, Physiological ; Animals ; Choice Behavior ; Cognition ; Neurons ; Prefrontal Cortex
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2021.09.011
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
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  9. Article ; Online: Baicalein targets STMN1 to inhibit the progression of nasopharyngeal carcinoma via regulating the Wnt/β-catenin pathway.

    Li, Zheng / Cai, Xiaohang

    Environmental toxicology

    2024  Volume 39, Issue 5, Page(s) 3003–3013

    Abstract: Backgrounds: Nasopharyngeal carcinoma is a common malignancy in the head and neck. Baicalein has been reported to exert the anticancer effects on various cancers. In this study, our aim was to explore the function of baicalein in the development of ... ...

    Abstract Backgrounds: Nasopharyngeal carcinoma is a common malignancy in the head and neck. Baicalein has been reported to exert the anticancer effects on various cancers. In this study, our aim was to explore the function of baicalein in the development of nasopharyngeal carcinoma and further investigate the potential underlying mechanisms.
    Methods: Cell Counting Kit (CCK)-8 assay, EdU assay, sphere formation assay, flow cytometry, and transwell invasion assay were conducted to determine cell proliferation, stemness, apoptosis, and invasion, respectively. Western blot was performed to examine the protein levels of PCNA, MMP9, STMN1, β-catenin, and Wnt3A. The mRNA level of STMN1 was assessed using real-time quantitative polymerase chain reaction (RT-qPCR). Xenograft tumor model was carried out to evaluate the effects of baicalein on tumor growth in vivo. Immunohistochemistry (IHC) assay was used to detect the levels of PCNA, MMP9, and STMN1 in tumor tissues from mice.
    Results: Baicalein significantly induced cell apoptosis and impeded cell proliferation, invasion, and stemness of nasopharyngeal carcinoma cells. STMN1 was highly expressed in nasopharyngeal carcinoma, and baicalein could directly downregulate STMN1 expression. STMN1 knockdown hampered the progression of nasopharyngeal carcinoma cells. Moreover, the effects of baicalein on cell proliferation, stemness, invasion, and apoptosis in nasopharyngeal carcinoma cells were harbored by STMN1 overexpression. Baicalein regulated STMN1 to inhibit the activation of the Wnt/β-catenin pathway. SKL2001, an agonist of the Wnt/β-catenin pathway, could reverse the effects of STMN1 knockdown on the progression of nasopharyngeal carcinoma. In addition, baicalein markedly impeded tumor growth in vivo.
    Conclusion: Baicalein regulated the STMN1/Wnt/β-catenin pathway to restrain the development of nasopharyngeal carcinoma.
    MeSH term(s) Humans ; Animals ; Mice ; Nasopharyngeal Carcinoma/pathology ; Matrix Metalloproteinase 9/metabolism ; beta Catenin/genetics ; beta Catenin/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Cell Line, Tumor ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/genetics ; Cell Proliferation ; Cell Movement/genetics ; Gene Expression Regulation, Neoplastic ; Apoptosis/genetics ; Stathmin/genetics ; Stathmin/metabolism ; Stathmin/pharmacology ; Flavanones
    Chemical Substances baicalein (49QAH60606) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; beta Catenin ; Proliferating Cell Nuclear Antigen ; STMN1 protein, human ; Stathmin ; Flavanones
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24173
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    Zs.A 2676: Show issues Location:
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  10. Article: [Identification of key molecules in miRNA-mRNA regulatory network associated with high-grade serous ovarian cancer recurrence using bioinformatic analysis].

    Zhang, P / He, M / Zeng, Y / Cai, X

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2023  Volume 43, Issue 1, Page(s) 8–16

    Abstract: Objective: To investigate the correlation of the potential functional microRNA (miRNA)-mRNA regulatory network with recurrence of high-grade serous ovarian carcinoma (HGSOC) and its biological significance.: Methods: This study was performed based on ...

    Abstract Objective: To investigate the correlation of the potential functional microRNA (miRNA)-mRNA regulatory network with recurrence of high-grade serous ovarian carcinoma (HGSOC) and its biological significance.
    Methods: This study was performed based on the data of 354 patients with HGSOC from the Cancer Genome Atlas database. In these patients, HGSOC was divided into different subtypes based on the pathways identified by GO analysis, and the correlations of the subtypes with HGSOC recurrence and differentially expressed miRNAs and mRNAs were assessed. Two relapse-related datasets were identified using the Gene Set Enrichment (GSE) database, from which the differentially expressed miRNAs were identified by intersection with the TCGA data. The target genes of these miRNAs were predicted using miRWalk 2.0 database, and these common differentially expressed miRNAs and mRNAs were used to construct the key miRNA-mRNA network associated with HGSOC recurrence. The expression of miR-506-3p and SNAI2 in two ovarian cancer cell lines was detected using RT-qPCR and Western blotting, and their targeted binding was verified using a double luciferase assay. The effect of miR-506-3p expression modulation on ovarian cancer cell migration was detected using scratch assay and Transwell assay.
    Results: We screened 303 GO terms of HGSOC-related pathways and identified two HGSOC subtypes (C1 and C2). The subtype C1 was associated with a significantly higher recurrence rate than C2. The differentially expressed genes between C1 and C2 subtypes were mainly enriched in epithelial-mesenchymal transition (EMT). Five miRNAs were identified as potential regulators of EMT, and a total of 41 target genes were found to be involved in the differential expressions of EMT pathway between C1 and C2 subtypes. The key miRNA-mRNA network associated with HGSOC recurrence was constructed based on these 5 miRNAs and 41 mRNAs. MiR-506-3p was confirmed to bind to SNAI2, and up-regulation of miR-506-3p significantly inhibited SNAI2 expression and reduced migration and invasion of SKOV3 and CAOV3 cells (
    Conclusion: MiR-506-3p and SNAI2 are the key molecules associated with HGSOC recurrence. MiR-506-3p may affect EMT of ovarian cancer cells by regulating cell migration and invasion via SNAI2, and its expression level has predictive value for HGSOC recurrence.
    MeSH term(s) Humans ; Female ; MicroRNAs/genetics ; Neoplasm Recurrence, Local/genetics ; Ovarian Neoplasms/genetics ; Computational Biology
    Chemical Substances MicroRNAs ; MIRN506 microRNA, human
    Language Chinese
    Publishing date 2023-03-01
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    DOI 10.12122/j.issn.1673-4254.2023.01.02
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