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  1. Article ; Online: The association between circulating fatty acids and stroke in hypertensive patients.

    Peng, Hao / Cai, Xiao-Qin / Zhen, Juanying / Shen, Jiangshan Jane / Shen, Heng-Shan / Wu, Xin-Han / Zhou, Yi-Bin / Ren, Lijie / Wu, Jun / Xu, Aimin / Tsang, Tim K / Cheung, Bernard Man Yung / Li, Chao

    The American journal of the medical sciences

    2024  

    Abstract: Background: Stroke is prevalent in hypertensive population. It has been suggested that unsaturated fatty acids (USFA) have protective effect on stroke. The effect of saturated fatty acids (SFAs) on stroke is still unclear. Therefore, we studied the ... ...

    Abstract Background: Stroke is prevalent in hypertensive population. It has been suggested that unsaturated fatty acids (USFA) have protective effect on stroke. The effect of saturated fatty acids (SFAs) on stroke is still unclear. Therefore, we studied the relationship between circulating fatty acids and acute ischemic stroke (AIS) in hypertensive patients.
    Methods: Eighty-nine pairs including 100 men and 78 women matched by sex and age were recruited. Each pair included a hypertensive patient within 48h of AIS onset and a hypertensive patient without stroke. Six circulating fatty acids were methylated before concentration determination which was repeated twice with percent recovery estimated.
    Results: There were differences in educational level (P = 0.002) and occupation (P < 0.001) between stroke and non-stroke participants. All the 6 fatty acid levels were higher in non-stroke participants (P = 0.017 for palmitoleic acid, 0.001 for palmitic acid, <0.001 for linoleic acid, <0.001 for behenic acid, <0.001 for nervonic acid and 0.002 for lignoceric acid). In logistic regression analysis, AIS was inversely associated with fatty acid levels except for lignoceric acid. After adjustment for education and occupation, the palmitoleic acid and palmitic acid levels were no longer inversely associated with AIS. After further adjustment for systolic blood pressure, smoking, drinking, total cholesterol and triglyceride, the inverse associations of linoleic acid (OR = 0.965, 95%CI = 0.942-0.990, P = 0.005), behenic acid (OR = 0.778, 95%CI = 0.664-0.939, P = 0.009), nervonic acid (OR = 0.323, 95%CI = 0.121-0.860, P = 0.024) with AIS remained significant.
    Conclusions: Circulating fatty acids except lignoceric acid were inversely associated with AIS. Both USFAs and SFAs may have beneficial effect on stroke prevention in hypertensive population.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2024.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prognostic value of TTF-1 expression in patients with non-small cell lung cancer: A meta-analysis.

    Qian, Hai-hua / Xu, Tian-shu / Cai, Xiao-qin / Ji, Tian-li / Guo, Hai-xia

    Clinica chimica acta; international journal of clinical chemistry

    2015  Volume 451, Issue Pt B, Page(s) 208–214

    Abstract: Background: Observational studies on the prognostic role of thyroid transcription factor 1 (TTF-1) in non-small-cell lung cancer (NSCLC) are controversial.: Methods: To clarify the impact of TTF-1 in NSCLC survival, we performed this meta-analysis ... ...

    Abstract Background: Observational studies on the prognostic role of thyroid transcription factor 1 (TTF-1) in non-small-cell lung cancer (NSCLC) are controversial.
    Methods: To clarify the impact of TTF-1 in NSCLC survival, we performed this meta-analysis that included eligible studies. The combined hazard ratios and their corresponding 95% confidence intervals were calculated in terms of overall survival.
    Results: A total of 17 studies with 2235 patients were evaluable for this meta-analysis. The studies were categorized by histology, disease stage and patient race. Our results suggested that TTF-1 overexpression had a favorable impact on survival of patients with NSCLC, the HR (95% CI) was 0.49 (0.42 to 0.55) overall, 0.46 (0.38-0.54) in Asian patients, 0.52 (0.42-0.63) in non-Asian patients, 0.45 (0.38-0.52) in adenocarcinoma, 0.63 (0.39-0.86) in stage I NSCLC, and 0.43 (0.33-0.53) in stage IIIb-IV NSCLC. The data collected were not sufficient to determine the prognostic value of VEGF in patients with squamous cell lung carcinomas. But there was a high heterogeneity between the studies.
    Conclusion: TTF-1 overexpression indicates a favorable prognosis for patients with NSCLC, this effect appears also significant when the analysis is restricted in lung AC patients, stage I and stage IIIb-IV NSCLC.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/metabolism ; DNA-Binding Proteins/biosynthesis ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/metabolism ; Prognosis ; Survival Analysis ; Transcription Factors
    Chemical Substances DNA-Binding Proteins ; TTF1 protein, human ; Transcription Factors
    Language English
    Publishing date 2015-12-07
    Publishing country Netherlands
    Document type Journal Article ; Meta-Analysis ; Review
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2015.01.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities.

    Dong, Jian-Yong / Ma, Xi-Yan / Cai, Xiao-Qin / Yan, Peng-Cheng / Yue, Lei / Lin, Chen / Shao, Wei-Wei

    Phytochemistry

    2013  Volume 85, Page(s) 122–128

    Abstract: Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide( ...

    Abstract Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC₅₀ values ranged from 6.80 to 39.97 μM, and SI values ranged from 6.35 to 37.25.
    MeSH term(s) Animals ; Antiviral Agents/chemistry ; Cell Line ; Curcuma/chemistry ; Dogs ; Humans ; Influenza, Human/drug therapy ; Magnetic Resonance Spectroscopy ; Molecular Structure ; Sesquiterpenes/chemistry ; Sesquiterpenes, Guaiane/chemistry
    Chemical Substances Antiviral Agents ; Sesquiterpenes ; Sesquiterpenes, Guaiane ; cadinane ; guaiane
    Language English
    Publishing date 2013-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2012.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities

    Dong, Jian-Yong / Ma, Xi-Yan / Cai, Xiao-Qin / Yan, Peng-Cheng / Yue, Lei / Lin, Chen / Shao, Wei-Wei

    Phytochemistry. 2013 Jan., v. 85

    2013  

    Abstract: Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide( ...

    Abstract Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1–10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC₅₀ values ranged from 6.80 to 39.97μM, and SI values ranged from 6.35 to 37.25.
    Keywords Curcuma ; Orthomyxoviridae ; X-ray diffraction ; antiviral properties ; inhibitory concentration 50 ; nuclear magnetic resonance spectroscopy ; rhizomes ; sesquiterpenoids
    Language English
    Dates of publication 2013-01
    Size p. 122-128.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2012.09.008
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Breviscapine attenuates acute pancreatitis by inhibiting expression of PKC and NF-B in pancreas

    Hong Zhang, Cui-Zhu Cai, Xiao-Qin Zhang, Tao Li, Xiao-Yun Jia, Bao-Lan Li, Liang Song, Xiao-Jun Ma

    World Journal of Gastroenterology, Vol 17, Iss 14, Pp 1825-

    2011  Volume 1830

    Abstract: AIM: To study the effect of breviscapine (Bre) on activity of protein kinase Cα (PKCα) and nuclear factor (NF)-κB in pancreas, and the mechanism of Bre attenuating acute pancreatitis (AP).METHODS: One hundred and eight rats were randomly divided into ... ...

    Abstract AIM: To study the effect of breviscapine (Bre) on activity of protein kinase Cα (PKCα) and nuclear factor (NF)-κB in pancreas, and the mechanism of Bre attenuating acute pancreatitis (AP).METHODS: One hundred and eight rats were randomly divided into acute necrotizing pancreatitis (ANP) group, Bre group (ANP + Bre group) and sham operation (SO) group, 36 rats in each group. ANP model was induced by a retrograde injection of 4% sodium deoxycholate into the bilio-pancreatic duct. Fifteen minutes after the ANP model was induced, the rats in Bre group were intraperitoneally injected with Bre (0.4 mg/100 g body weight or 0.1 mL/100 g body weight). Survival time and mortality of rats were calculated. Serum amylase and malondialdehyde levels were measured, volume of ascites was recorded and morphology of pancreas and lung was evaluated at 1, 5 and 10 h, after the ANP model was induced, respectively. Expressions of PKCα and subunit p65 of NF-κB in pancreas were detected by immunohistochemistry and Western blotting.RESULTS: The life span of rats was longer and the mortality was lower in Bre group than in ANP group 13.51 ±5.46 vs 25.36 ± 8.11 (P < 0.05). The amylase and MDA levels as well as the volume of ascites were lower and the pathological changes in pancreas and lung were less in Bre group than ANP group (P < 0.05), indicating that the pancreatitis is less severe in Bre group than ANP group. The activation of PKCα and NF-κB p65 in pancreas was induced rapidly and reached their peak at 1 h or 5 h after ANP, but their activity in Bre group was significantly inhibited.CONCLUSION: Bre exerts its therapeutic effect on AP by inhibiting the activation of PKCα and NF-κB p65 in pancreas.
    Keywords Breviscapine ; Acute pancreatitis ; Protein kinase Cα ; Nuclear factor-κB ; Rat ; Diseases of the digestive system. Gastroenterology ; RC799-869 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Gastroenterology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Subject code 630
    Language English
    Publishing date 2011-04-01T00:00:00Z
    Publisher Baishideng Publishing Group Co. Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities

    Dong, Jian-Yong / Ma, Xi-Yan / Cai, Xiao-Qin / Yan, Peng-Cheng / Yue, Lei / Lin, Chen / Shao, Wei-Wei

    Phytochemistry

    Volume v. 85

    Abstract: Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide( ...

    Abstract Five sesquiterpenoids, 1α,8α-epidioxy-4α-hydroxy- 5αH-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4β-hydroxy-1α,5βH-7(11)-guaen-8,10-olide (2), 8α-hydroxy-1α, 4β,7βH-guai-10(15)-en- 5β,8β-endoxide(3), 7β,8α-dihydroxy-1α,4αH-guai-10(15)-en-5β,8β-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1–10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC₅₀ values ranged from 6.80 to 39.97μM, and SI values ranged from 6.35 to 37.25.
    Keywords sesquiterpenoids ; antiviral properties ; Curcuma ; inhibitory concentration 50 ; X-ray diffraction ; Orthomyxoviridae ; nuclear magnetic resonance spectroscopy ; rhizomes
    Language English
    Document type Article
    ISSN 0031-9422
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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